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5 条记录 (耗时 0.019 秒)

    Substituted phenylalkanoic acids and derivatives
    2.
    发明授权
    Substituted phenylalkanoic acids and derivatives 失效
    取代的苯基链烷酸及其衍生物

    公开(公告)号：US3978071A

    公开(公告)日：1976-08-31

    申请号：US486728

    申请日：1974-07-08

    申请人： Michio Nakanishi ,  Tomio Muro ,  Tohru Nakao ,  Kiyoshi Ogawa

    发明人： Michio Nakanishi ,  Tomio Muro ,  Tohru Nakao ,  Kiyoshi Ogawa

    IPC分类号： C07D471/04 ,  C07D487/04 ,  C07D513/04

    CPC分类号： C07D513/04 ,  C07D471/04 ,  C07D487/04

    摘要： Substituted phenylalkanoic acids and derivatives thereof of the formula: ##SPC1##Wherein each of R.sup.1 and R.sup.2 is a hydrogen atom or an alkyl group having 1 to 4 carbon atoms; each of X.sup.1 and X.sup.2 is a hydrogen atom, a halogen atom, an alkyl group having 1 to 4 carbon atoms or an alkoxy group having 1 to 4 carbon atoms; Y is COOH, COOR (wherein R is an alkyl group having 1 to 4 carbon atoms), CONH.sub.2, CSNH.sub.2, CN or COZ--A--N(R.sup.3)(R.sup.4) (wherein Z is an oxygen atom or an imino group, A is an alkylene group having 2 to 4 carbon atoms and each of R.sup.3 and R.sup.4 is a hydrogen atom or an alkyl group having 1 to 4 carbon atoms, or R.sup.3 and R.sup.4 together with the adjacent nitrogen atom form a saturated heterocycle selected from pyrrolidine, piperidine, morpholine, piperazine and piperazine substituted by an alkyl group having 1 to 4 carbon atoms at the 4-position; and ring P represents a pyridine ring, a pyrimidine ring or a thiazole ring; and pharmaceutically acceptable salts thereof are useful as analgesics, anti-pyrestics and anti-inflammatory agents.

    摘要翻译： 取代的苯基链烷酸及其下式的衍生物：

    Trans-4-amino(alkyl)-1-pyridylcarbamoylcyclohexane compounds and pharmaceutical use thereof
    4.
    发明授权
    Trans-4-amino(alkyl)-1-pyridylcarbamoylcyclohexane compounds and pharmaceutical use thereof 失效
    反式-4-氨基（烷基）-1-吡啶基氨基甲酰基环己烷化合物及其药物用途

    公开(公告)号：US4997834A

    公开(公告)日：1991-03-05

    申请号：US440374

    申请日：1989-11-22

    申请人： Tomio Muro ,  Toshio Seki ,  Masao Abe ,  Jun Inui ,  Hiroyuki Sato

    发明人： Tomio Muro ,  Toshio Seki ,  Masao Abe ,  Jun Inui ,  Hiroyuki Sato

    IPC分类号： C07D213/75 ,  C07D213/82 ,  C07D213/89 ,  C07D401/12

    CPC分类号： C07D213/75 ,  C07D213/82 ,  C07D213/89 ,  C07D401/12

    摘要： A trans-4-amino(alkyl)-1-pyridylcarbamoylcyclohexane compound of the formula: ##STR1## wherein R.sup.1 and R.sup.2 are the same or different, and respectively represent hydrogen, C.sub.1-10 alkyl, C.sub.2-5 alkanoyl, formyl, C.sub.1-4 alkoxy-carbonyl, amidino, C.sub.3-7 cycloalkyl, C.sub.3-7 cycloalkylcarbonyl, phenyl, phenylalkyl, benzoyl, naphthoyl, phenylalkoxycarbonyl, benzylidene, pyridylcarbonyl, piperidyl, pyrrolidylidene or piperidylidene which may be optionally substituted on the ring or R.sup.1 and R.sup.2 together with the adjacent nitrogen atom form 5 to 6-membered cycle which may have oxygen atom, sulfur atom or optionally substituted nitrogen atom in the cycle, or together with the adjacent nitrogen atom form phthalimido, R.sup.3 represents hydrogen or C.sub.1-4 alkyl, R.sup.4 represents hydrogen or C.sub.1-4 alkyl, R.sup.5 represents hydrogen, hydroxy, C.sub.1-4 alkyl or phenylalkoxy. R.sup.6 represents hydrogen or C.sub.1-4 alkyl, A represents single bond, C.sub.1-5 straight chain alkylene, or alkylene which is substituted by C.sub.1-4 alkyl, n represents 0 to 1, an optical isomer thereof and a pharmaceutically acceptable acid addition salt thereof.These compounds possess antihypertensive activity, and coronary, cerebral and kidney circulation-improving activities and are useful as antihypertensive agents and agents for prevention and treatment of circulatory diseases.

    1-[Methylated piperidino(and pyrrolidin-1-yl)]-3-(substituted phenoxy)-2propanols
    5.
    发明授权
    1-[Methylated piperidino(and pyrrolidin-1-yl)]-3-(substituted phenoxy)-2propanols 失效
    1- {8-甲基哌啶子基（和吡咯烷-1-基）{9-3（取代的苯氧基）-2-丙醇

    公开(公告)号：US3954776A

    公开(公告)日：1976-05-04

    申请号：US499948

    申请日：1974-08-23

    申请人： Tomio Muro ,  Sogo Fukuzawa ,  Yasuaki Chihara ,  Tohru Nakao ,  Kiyoshi Ogawa

    发明人： Tomio Muro ,  Sogo Fukuzawa ,  Yasuaki Chihara ,  Tohru Nakao ,  Kiyoshi Ogawa

    IPC分类号： C07D295/092 ,  C07D211/14

    CPC分类号： C07D295/088 ,  Y10S514/818 ,  Y10S514/821

    摘要： 1-[Methylated piperidino (and pyrrolidin-1-yl)]-3-(substituted phenoxy)-2-propanols of the formula: ##SPC1##Wherein R is a 2-thienylmethyl group, a 2-pyridylmethyl group, a 2-pyridyl group, a tetrahydrofurfuryloxy group, a furfuryloxy group, a 2-thienylmethoxy group, a 2-pyridyloxy group or a group of the formula R.sup.5 --X--A--O-- wherein R.sup.5 is a lower alkyl group, X is --O--, --S-- or --SO.sub.2 --, and A is a lower alkylene group or a --CH.sub.2 --C.ident.C--CH.sub.2 -- group, R.sup.1 is a hydrogen atom, a lower alkyl group or a halogen atom, R.sup.2, R.sup.3 and R.sup.4 are each a hydrogen atom or a methyl group, and n is zero or 1, and pharmaceutically acceptable acid addition and quarternary ammonium salts thereof are disclosed. They exhibit antiarrhythmic action, local anaesthetic action, analgesic action and gastric juice secretion inhibiting action.

    摘要翻译： 1- [甲基化哌啶子基（和吡咯烷-1-基）] - 3-（取代的苯氧基）-2-丙醇，其具有下式：