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公开(公告)号：US4452736A
公开(公告)日：1984-06-05
申请号：US417377
申请日：1982-09-13
CPC分类号： C07K5/0808 , C07K5/0806 , C07K5/0815 , C07K5/0819 , C12Q1/37 , C12Q2337/10 , C12Q2337/12 , G01N2333/968
摘要： A novel substrate for measuring plasmin which has chromophoric and fluoroescent properties against plasmin or a plasmin-like enzyme, which is characterized by being a compound of the formula or a salt thereof: ##STR1## wherein ##STR2## wherein ##STR3## .
摘要翻译： 一种用于测量纤溶酶的新型底物，其具有针对纤溶酶或纤溶酶样酶的发色和荧光特性，其特征在于下式化合物或其盐：其中m = 1,2,3或4， 其中R1 =
（n = 0,1,2或3，R3 = H或CH3），（CH2）nCH（CH3）2（n = 0,1,2或3 R2 =（CH2）n + 1CH3（n = 0,1,2或3）图像（n = 0,1,2或3，R4，R4和R4“为H或CH3） 。 -
公开(公告)号：US4605614A
公开(公告)日：1986-08-12
申请号：US579868
申请日：1984-02-13
CPC分类号： C07K5/0808 , C07K5/0806 , C07K5/0815 , C07K5/0819 , C12Q1/37 , C12Q2337/10 , C12Q2337/12 , G01N2333/968
摘要： A method for measuring the activity of plasmin in plasma which comprises reacting a compound of the following formula or a salt thereof; ##STR1## with plasmin in a buffer solution having a pH of 7.2 to 7.6 and quantitatively determining the reaction product thereof.
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3.发明授权
公开(公告)号：US4336331A
公开(公告)日：1982-06-22
申请号：US245817
申请日：1981-03-20
申请人： Takeshi Nagasawa , Katsumasa Kuroiwa , Katsuyuki Takabayashi , Norimasa Takizawa , Kazuyo Hagihara , Tadami Akatsuka
发明人： Takeshi Nagasawa , Katsumasa Kuroiwa , Katsuyuki Takabayashi , Norimasa Takizawa , Kazuyo Hagihara , Tadami Akatsuka
CPC分类号： C12Q1/48 , C07C237/04 , G01N2333/9108 , Y02P20/55
摘要： Novel L-.gamma.-glutamyl-3-carboxy-4-hydroxyanilide of the formula, ##STR1## an acid addition salt thereof, or an alkali metal or amine salt thereof, which is useful for determining the activity of .gamma.-glutamyl transpeptidase.
摘要翻译： 具有下式的新型L-γ-谷氨酰基-3-羧基-4-羟基酰苯胺，其可用于测定γ-谷氨酰转肽酶的活性，其为其酸加成盐或其碱金属或胺盐。
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公开(公告)号：US4520100A
公开(公告)日：1985-05-28
申请号：US578805
申请日：1984-02-10
CPC分类号： C07K5/0804 , C07K5/0812 , C12Q1/56 , C12Q2337/10 , G01N2333/974
摘要： A novel substrate for measuring thrombin which has chromophoric and fluorescent properties on thrombin or a thrombin-like enzymes and is represented by a compound of the following general formula or a salt thereof: ##STR1## wherein R represents ##STR2##
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公开(公告)号：US4717659A
公开(公告)日：1988-01-05
申请号：US731069
申请日：1985-05-06
IPC分类号： C12Q1/46
CPC分类号： C12Q1/46 , C12Q2334/00
摘要： In a method for determining cholinesterase (hereinafter referred to as ChE) activity, the improvement comprising by using, as a substrate, a protocatechuoylcholine derivative represented by the general formula (I), ##STR1## (wherein X is a halogen atom). The method for determining ChE activity according to the present invention is free from defects of the conventional methods, has many advantages and characteristics, permits accurate and simple determination of ChE activity, and can sufficiently contribute to determination of ChE activity in daily clinical examinations.
摘要翻译： 在用于测定胆碱酯酶（以下称为ChE）活性的方法中，所述改进包括通过使用由通式（I）表示的原儿茶酸酰胆碱衍生物，其中X为卤素原子作为底物。 根据本发明的确定ChE活性的方法没有常规方法的缺点，具有许多优点和特征，允许准确和简单地测定ChE活性，并且可以有效地确定日常临床检查中的ChE活性。
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公开(公告)号：US4450105A
公开(公告)日：1984-05-22
申请号：US406025
申请日：1982-08-06
CPC分类号： C07K5/0804 , C07K5/0812 , C12Q1/56 , C12Q2337/10 , G01N2333/974
摘要： A novel substrate for measuring thrombin which has chromophoric and fluorescent properties on thrombin or a thrombin-like enzymes and is represented by a compound of the following general formula or a salt thereof: ##STR1##
摘要翻译： 用于测定凝血酶或凝血酶样酶具有发色和荧光性质的凝血酶的新型底物，由以下通式的化合物或其盐表示：其中
> + TR -
7.发明授权
公开(公告)号：US4281181A
公开(公告)日：1981-07-28
申请号：US94072
申请日：1979-11-14
申请人： Takeshi Nagasawa , Katsumasa Kuroiwa , Katsuyuki Takabayashi , Norimasa Takizawa , Kazuyo Hagihara , Tadami Akatsuka
发明人： Takeshi Nagasawa , Katsumasa Kuroiwa , Katsuyuki Takabayashi , Norimasa Takizawa , Kazuyo Hagihara , Tadami Akatsuka
IPC分类号： C12Q1/48 , C07C237/04 , C12Q1/00 , G01N33/48 , G01N33/52 , C07C101/72
CPC分类号： C12Q1/48 , C07C237/04 , G01N2333/9108 , Y02P20/55
摘要： Novel L-.gamma.-glutamyl-3-carboxy-4-hydroxyanilide of the formula, ##STR1## an acid addition salt thereof, or an alkali metal or amine salt thereof, which is useful for determining the activity of .gamma.-glutamyl transpeptidase.
摘要翻译： 具有下式的新型L-γ-谷氨酰基-3-羧基-4-羟基酰苯胺，其可用于测定γ-谷氨酰转肽酶的活性，其为其酸加成盐或其碱金属或胺盐。
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公开(公告)号：US4529709A
公开(公告)日：1985-07-16
申请号：US493820
申请日：1983-05-12
CPC分类号： G01N31/22 , C12Q1/37 , C12Q1/48 , Y10S436/904 , Y10T436/173845
摘要： A method for the determination of 5-aminosalicylic acid, which comprises measuring the color developed in an alkaline medium by an oxidative condensation product formed by the condensation of an o-alkylphenol represented by the general formula ##STR1## (wherein R.sub.1 represents an ethyl, isopropyl or sec-butyl group) with 5-aminosalicylic acid of the formula ##STR2## in the presence of a peroxide.
摘要翻译： 一种测定5-氨基水杨酸的方法，该方法包括通过由通式“IMAGE”表示的邻烷基苯酚（其中R1表示乙基， 异丙基或仲丁基）与式“IMAGE”的5-氨基水杨酸在过氧化物存在下反应。
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