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1.发明申请MARKER FOR DETECTION AND/OR DISCRIMINATION OF NON-ALCOHOLIC STEATOHEPATITIS, METHOD FOR DETECTION AND/OR DISCRIMINATION OF NON-ALCOHOLIC STEATOHEPATITIS, AND KIT FOR USE IN THE METHOD 审中-公开用于检测和/或鉴别非酒精性静止蛋白的标记物，用于检测和/或鉴别非酒精性肠胃蛋白酶的方法和用于该方法的试剂盒公开(公告)号：US20130089871A1
公开(公告)日：2013-04-11
申请号：US13703740
申请日：2011-06-13
IPC分类号： C12Q1/52
CPC分类号： C12Q1/52 , G01N33/573 , G01N2333/91188 , G01N2800/085
摘要： The detection of a non-alcoholic steatohepatitis patient and the accurate discrimination between a normal person and a non-alcoholic steatohepatitis patient can be achieved by measuring alanine-glyoxylate amino transferase in a sample.
摘要翻译： 非酒精性脂肪性肝炎患者的检测以及正常人和非酒精性脂肪性肝炎患者之间的准确辨别可以通过测定样品中的丙氨酸 - 乙醛酸氨基转移酶来实现。
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2.发明授权Marker proteins for diagnosing liver disease and method of diagnosing liver disease using the same 有权用于诊断肝脏疾病的标记蛋白和使用该疾病诊断肝脏疾病的方法公开(公告)号：US07517951B2
公开(公告)日：2009-04-14
申请号：US10538916
申请日：2003-12-24
申请人： Fumio Nomura , Kazuyuki Sogawa , Takeshi Tomonaga , Takenori Ochiai , Hideaki Shimada , Tatsuya Ohashi , Katsuhiro Katayama
发明人： Fumio Nomura , Kazuyuki Sogawa , Takeshi Tomonaga , Takenori Ochiai , Hideaki Shimada , Tatsuya Ohashi , Katsuhiro Katayama
CPC分类号： G01N33/6893 , G01N2333/75 , G01N2333/775 , G01N2800/08
摘要： Using the protein chip technology, biological samples such as sera are subjected to proteome analysis. Thus, a protein which is a human fibrinogen α-E chain decomposition product and has a molecular weight of 5,900, a protein which is an apolipoprotein AII decomposition product and has a molecular weight of 7,800, and a protein which is an apolipoprotein AI decomposition product and has a molecular weight of 28,000, each showing an increase or a decrease with the habit of drinking, are newly found out. By detecting or quantifying these proteins, a liver disease in a subject such as one having a problem of drinking can be diagnosed at the early stage.
摘要翻译： 使用蛋白质芯片技术，生物样品如血清进行蛋白质组分析。 因此，作为人纤维蛋白原α-E链分解产物的分子量为5900的蛋白质，作为载脂蛋白AII分解产物，分子量为7800的蛋白质，以及作为载脂蛋白AI分解产物的蛋白质 并且新发现的分子量为28,000，分别显示饮酒习惯的增加或减少。 通过检测或定量这些蛋白质，可以在早期诊断患有饮酒问题的受试者的肝脏疾病。
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3.发明授权Method of immunoassay tartrate resistant acid phosphatase 5b and kit to be used therein 有权免疫测定酒石酸盐抗性酸性磷酸酶5b及其使用的试剂盒的方法公开(公告)号：US07465556B2
公开(公告)日：2008-12-16
申请号：US10546608
申请日：2004-02-20
IPC分类号： C12Q1/42 , G01N33/573 , G01N33/53 , G01N33/535
CPC分类号： G01N33/573 , Y10S436/815
摘要： Specific and accurate immunoassay of tartrate resistant acid phosphatase 5b (TRACP 5b) in a specimen may be carried out by bonding TRACP 5b in the specimen to an antibody, subjecting the TRACP 5b bonded to the antibody to enzyme reaction with a 2-halo-4-nitrophenylphosphoric acid or a salt thereof, a substrate for TRACP 5b, and then assaying the enzymatic activity of TRACP 5b.
摘要翻译： 样品中酒石酸盐酸性磷酸酶5b（TRACP 5b）的特异性和准确的免疫测定可以通过将样品中的TRACP 5b结合到抗体上进行，将与抗体结合的TRACP 5b与2-卤代-4 - 硝基苯基磷酸或其盐，TRACP 5b的底物，然后测定TRACP 5b的酶活性。
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4.发明授权Substrates for determination of enzyme activity and intermediates for synthesis of the substrates as well as process for producing the intermediates 失效用于确定酶活性的基质和用于合成基质的中间体，以及用于生产中间体的方法
公开(公告)号：US5115099A
公开(公告)日：1992-05-19
申请号：US365418
申请日：1989-06-13
申请人： Katsumasa Kuroiwa , Hitoshi Matsuura , Katsuhiro Katayama , Shuichi Nakatsuyama , Takeshi Nagasawa , Koji Endo
发明人： Katsumasa Kuroiwa , Hitoshi Matsuura , Katsuhiro Katayama , Shuichi Nakatsuyama , Takeshi Nagasawa , Koji Endo
CPC分类号： C07K5/0205 , C07K5/0819 , C07K5/0825
摘要： Novel compounds represented by the following formula: ##STR1## wherein A represents a specific amino acid residue are excellent as substrates for determination of enzyme activity such as trypsin, etc. The compounds can be synthesized from novel arginyl-3-tert-alkyloxycarbonyl-4-nitroanilides by a novel process comprising a selective deprotection step whereby the protecting group on the .alpha.-amine group of arginine is removed in the presence of a hydrochloric acid, acetic acid and dimethylformamide mixture, but a tert-alkyl protecting group on the --COOH group of the nitroanilide ring is not removed by this step.
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5.发明授权公开(公告)号：US08952215B2
公开(公告)日：2015-02-10
申请号：US12090702
申请日：2006-10-18
申请人： Toshiki Tamura , Isao Kobayashi , Toshio Kanda , Keiro Uchino , Katsuhiro Katayama , Tatsuya Ohashi , Iwao Kiyokawa , Hisae Arai , Noriyuki Funahashi
发明人： Toshiki Tamura , Isao Kobayashi , Toshio Kanda , Keiro Uchino , Katsuhiro Katayama , Tatsuya Ohashi , Iwao Kiyokawa , Hisae Arai , Noriyuki Funahashi
IPC分类号： C12N15/00 , C07H21/04 , C07K16/00 , A01K67/033 , A01K67/04 , C07K14/435 , C12N15/85
CPC分类号： C07K16/00 , A01K67/0335 , A01K67/04 , A01K2217/05 , A01K2227/703 , A01K2267/01 , C07K14/43586 , C07K2317/10 , C07K2317/20 , C07K2319/02 , C12N15/8509 , C12N2830/002 , C12N2830/003
摘要： The present inventors produced transgenic silkworms which comprise a promoter of a DNA encoding a protein specifically expressed in the silk gland and a DNA encoding a recombinant antibody whose expression is regulated directly or indirectly by the promoter, and which secrete the recombinant antibody into the silk gland. The recombinant antibodies produced from the silk gland of the transgenic silkworms were confirmed to be active.
摘要翻译： 本发明人生产了转基因蚕，其包含编码丝腺特异性表达的蛋白质的DNA的启动子和编码重组抗体的DNA，其表达由启动子直接或间接调节，并将重组抗体分泌到丝腺中 。 从转基因蚕丝腺产生的重组抗体被证实是活性的。
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公开(公告)号：US07544516B2
公开(公告)日：2009-06-09
申请号：US11169749
申请日：2005-06-30
申请人： Kenta Noda , Ryo Kojima , Katsuhiro Katayama
发明人： Kenta Noda , Ryo Kojima , Katsuhiro Katayama
IPC分类号： G01N30/74
摘要： A method for determination of calcium in a sample derived from a living body, by the reaction of calcium in the sample with Chlorophosphonazo-III or a compound analogous thereto in the presence of vanadate ions, followed by determination of calcium in the sample on the basis of an optical change caused by the reaction product, is excellent in various respects as follows: it is free from the problem of absorption of carbonic acid gas caused by a high pH; it is free from the problem of use of a toxic reagent containing arsenic; it makes it possible to subject a large number of samples to determination in a short time because it can be applied to an autoanalyzer; and it permits determination in a wide range because of low sample blank values.
摘要翻译： 通过在钒酸根离子存在下，将样品中的钙与氯膦腈III或类似化合物的反应，测定来自活体的样品中的钙的方法，然后基于样品中的钙测定 由反应产物引起的光学变化，在各个方面优异如下：它没有由高pH引起的碳酸气体吸收的问题; 没有使用含砷的有毒试剂的问题; 它可以在很短的时间内对大量样品进行测定，因为它可以应用于自动分析仪; 并且由于样品空白值较低，可以在宽范围内进行测定。
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7.发明申请Method of immunoassaying taritrate resistant acid phosphatase 5b and kit to be used therein 有权免疫测定耐盐酸酸性磷酸酶5b及其使用的试剂盒的方法公开(公告)号：US20060154317A1
公开(公告)日：2006-07-13
申请号：US10546608
申请日：2004-02-20
IPC分类号： G01N33/537 , G01N33/53 , G01N33/543
CPC分类号： G01N33/573 , Y10S436/815
摘要： Specific and accurate immunoassay of tartrate resistant acid phosphatase 5b (TRACP 5b) in a specimen may be carried out by bonding TRACP 5b in the specimen to an antibody, subjecting the TRACP 5b bonded to the antibody to enzyme reaction with a 2-halo-4-nitrophenylphosphoric acid or a salt thereof, a substrate for TRACP 5b, and then assaying the enzymatic activity of TRACP 5b.
摘要翻译： 样品中酒石酸盐酸性磷酸酶5b（TRACP 5b）的特异性和准确的免疫测定可以通过将样品中的TRACP 5b结合到抗体上进行，将与抗体结合的TRACP 5b与2-卤代-4 - 硝基苯基磷酸或其盐，TRACP 5b的底物，然后测定TRACP 5b的酶活性。
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公开(公告)号：US07074903B2
公开(公告)日：2006-07-11
申请号：US10424726
申请日：2003-04-29
IPC分类号： C07K16/40 , C12N5/20 , C12P21/08 , G01N33/543 , G01N33/573
CPC分类号： C07K16/40 , Y10S435/96 , Y10S435/975
摘要： Monocolonal antibodies having a higher reactivity with tartrate-resistant acid phosphatase 5b (TRACP 5b) than tartrate-resistant acid phosphatase 5a (TRACP 5a) and having a higher specificity to TRACP 5b can be obtained by cell fusion using as antigens TRACP 5b purified from human osteoclasts. By using the monoclonal antibody, TRACP 5b in a sample can be detected specifically with a high sensitivity.
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9.发明申请公开(公告)号：US20060116504A1
公开(公告)日：2006-06-01
申请号：US10538916
申请日：2003-12-24
申请人： Fumio Nomura , Kazuyuki Sogawa , Takeshi Tomonaga , Takenori Ochiai , Hideaki Shimada , Tatsuya Oshashi , Katsuhiro Katayama
发明人： Fumio Nomura , Kazuyuki Sogawa , Takeshi Tomonaga , Takenori Ochiai , Hideaki Shimada , Tatsuya Oshashi , Katsuhiro Katayama
IPC分类号： C07K14/47 , G01N33/567
CPC分类号： G01N33/6893 , G01N2333/75 , G01N2333/775 , G01N2800/08
摘要： Using the protein chip technology, biological samples such as sera are subjected to proteome analysis. Thus, a protein which is a human fibrinogen α-E chain decomposition product and has a molecular weight of 5,900, a protein which is an apolipoprotein AII decomposition product and has a molecular weight of 7,800, and a protein which is an apolipoprotein AI decomposition product and has a molecular weight of 28,000, each showing an increase or a decrease with the habit of drinking, are newly found out. By detecting or quantifying these proteins, a liver disease in a subject such as one having a problem of drinking can be diagnosed at the early stage.
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公开(公告)号：US5151372A
公开(公告)日：1992-09-29
申请号：US483903
申请日：1990-02-22
CPC分类号： C12Q1/34 , G01N33/535 , C12Q2334/00 , G01N2333/916 , Y10T436/10 , Y10T436/200833 , Y10T436/203332
摘要： There is provided a method for determination of hydroxyacetophenone derivatives such as 3,5-dichloro-4-hydroxyacetophenone in the presence of protein such as albumins or globulins with high sensitivity. The hydroxyacetophenone derivative can be measured in the neutral to acidic region, whereby the method is not affected by interferrants such as bilirubin or hemoglobin. The hydroxyacetophenone derivatives are useful as the chromogen of synthetic substrates for determining acid phosphatase activity.
摘要翻译： 提供了在蛋白质如白蛋白或球蛋白的存在下高灵敏度地测定羟基苯乙酮衍生物如3,5-二氯-4-羟基苯乙酮的方法。 羟基苯乙酮衍生物可以在中性至酸性区域测量，因此该方法不受诸如胆红素或血红蛋白之类的干扰素的影响。 羟基苯乙酮衍生物可用作确定酸性磷酸酶活性的合成底物的色原体。
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