公开(公告)号：US5298642A

公开(公告)日：1994-03-29

申请号：US43577

申请日：1993-04-07

申请人： Takeshi Tozawa ,  Yasunobu Komoda ,  Junji Ohnishi ,  Yukie Masuda ,  Junichi Taniuchi ,  Chihiro Nakanishi ,  Koji Okamoto

发明人： Takeshi Tozawa ,  Yasunobu Komoda ,  Junji Ohnishi ,  Yukie Masuda ,  Junichi Taniuchi ,  Chihiro Nakanishi ,  Koji Okamoto

IPC分类号： B01D15/08 ,  B01J20/281 ,  B01J20/291 ,  C01G55/00 ,  C07B57/00 ,  C07F15/00 ,  G01N30/88

CPC分类号： C07F15/0093

摘要： Disclosed herein is a process of optically resoluting optically active platinum complex compounds which comprises optically resoluting a d-isomer and an 1-isomer of a cis-Pt(II) complex of a 1,2-cyclohexanediamine isomer characterized in that the mixture of the d-isomer and the 1-isomer is optically resoluted by means of high performance liquid chromatography employing a column packed with a chiral filler.The chiral filler include, for example, a cellulose ester derivative, a cellulose carbamate derivative, an amylose carbamate derivative, a polymethacryl acid ester and .beta.- and .gamma.-cyclodextrin.According to the present invention, the optical resolution of a platinum complex compound essentially consisting of the mixture of two optical isomers which cannot be resoluted in accordance with a normal resolution method due to the small structural difference can be easily performed utilizing the characteristics of a chiral filler.

摘要翻译： 本文公开了一种光学拆分光学活性铂络合物的方法，其包括旋光拆分1,2-环己烷二胺异构体的顺式-PP（II）络合物的D-异构体和1-异构体，其特征在于， 通过使用填充有手性填料的柱的高效液相色谱法将1-异构体旋光。 手性填料包括例如纤维素酯衍生物，氨基甲酸纤维素衍生物，直链淀粉氨基甲酸酯衍生物，聚甲基丙烯酸酯和（β） - 和（γ） - 环糊精。 根据本发明，可以容易地利用手性的特征，轻易地进行基本上由两种光学异构体的混合物组成的铂配位化合物的光学拆分，所述两种光学异构体由于结构差异小而根据正常分辨率不能解决 填料。

公开(公告)号：US5600027A

公开(公告)日：1997-02-04

申请号：US529071

申请日：1995-09-15

申请人： Junko Suzuki ,  Satoshi Negishi ,  Seiichi Shirasawa ,  Yukie Masuda

发明人： Junko Suzuki ,  Satoshi Negishi ,  Seiichi Shirasawa ,  Yukie Masuda

IPC分类号： C12P7/62 ,  C12P41/00 ,  C07C29/74

CPC分类号： C12P7/62 ,  C12P41/004

摘要： A process for producing an optically active alcohol having a phenyl group is disclosed, comprising the step of carrying out interesterification between (a) a monoester between a racemic alcohol having a phenyl group and a fatty acid or a diester between a racemic alcohol having a phenyl group and a dibasic acid and (b) an optically inactive non-racemic alcohol having 16 or more carbon atoms in the presence of heat-resistant lipase and in the absence of a solvent under a substantially water-free condition at a temperature of not lower than 81.degree. C. under atmospheric pressure or reduced pressure and the step of separating an optically active alcohol having a phenyl group rich in either one of R- and S-forms from the reaction mixture. Use of heat-resistant lipase makes it possible to use high-melting point materials without using any solvent therefor and to perform interesterification at a high temperature thereby completing the reaction in a reduced time. Further, use of a high-melting point and high-boiling point starting material makes it possible to separate an optically active alcohol from the reaction mixture with high purity in high yield by means of a simple purification step taking advantage of a difference in physical properties.

摘要翻译： 公开了一种制备具有苯基的光学活性醇的方法，包括以下步骤：在（a）具有苯基的外消旋醇与脂肪酸之间的单酯或具有苯基的外消旋醇之间的二酯之间进行酯交换 基和二元酸，和（b）在耐热脂肪酶存在下具有16个或更多个碳原子的光学非活性的非外消旋醇，并且在不存在溶剂的条件下，在基本上无水条件下，温度不低于 在大气压或减压下的温度为81℃，并且从反应混合物中分离具有富R和S-形式的苯基的光学活性醇的步骤。 使用耐热脂肪酶使得可以使用高熔点材料而不使用任何溶剂，并在高温下进行酯交换，从而在缩短的时间内完成反应。 此外，使用高熔点和高沸点原料可以通过利用物理性质的差异的简单纯化步骤以高产率从反应混合物中分离光学活性醇 。

公开(公告)号：US5696299A

公开(公告)日：1997-12-09

申请号：US529059

申请日：1995-09-15

申请人： Satoshi Negishi ,  Seiichi Shirasawa ,  Junko Suzuki ,  Yukie Masuda

发明人： Satoshi Negishi ,  Seiichi Shirasawa ,  Junko Suzuki ,  Yukie Masuda

IPC分类号： C12P7/62 ,  C12P41/00 ,  C07C33/18 ,  C07C33/46

CPC分类号： C12P7/62 ,  C12P41/004

摘要： A process for producing an optically active alcohol comprising carrying out interesterification between a racemic alcohol and an ester selected from the group consisting of (a) a diester between a lower monohydric alcohol and a saturated dicarboxylic acid having 14 or more carbon atoms, (b) a triglyceride of a saturated fatty acid having 16 or more carbon atoms, and (c) a monoester between a lower monohydric alcohol and a saturated fatty acid having 18 or more carbon atoms in the presence of lipase, preferably heat-resistant lipase, and in the presence or absence of a solvent, preferably in the absence of a solvent, under a substantially water-free condition, separating an optically active alcohol rich in either one of R- and S-forms from the reaction mixture, and adding an optically inactive non-racemic alcohol to the residue of the previous step to carry out interesterification under the same conditions as in the previous reaction to separate the other enantiomer. According to the present invention a racemic alcohol can easily be resolved into each enantiomer with high purity in good yield.

摘要翻译： 一种光学活性醇的制造方法，其包括在外消旋醇与选自（a）低级一元醇和具有14个或更多个碳原子的饱和二羧酸之间的二酯的酯中进行酯交换，（b） 具有16个或更多个碳原子的饱和脂肪酸的甘油三酯，和（c）在脂肪酶，优选耐热脂肪酶存在下，具有18个或更多个碳原子的低级一元醇和饱和脂肪酸之间的单酯，以及 在基本无水条件下，优选在不存在溶剂的情况下存在或不存在溶剂，从反应混合物中分离富含R-和S-形式的任何一种的光学活性醇，并加入光学惰性 将非外消旋醇与前述步骤的残余物进行酯交换，在与之前反应相同的条件下进行酯交换以分离另一种对映异构体。 根据本发明，外消旋醇可以容易地以良好的产率分离成高纯度的每种对映异构体。