公开(公告)号：US08119837B2

公开(公告)日：2012-02-21

申请号：US12613580

申请日：2009-11-06

申请人： Takushi Azemi ,  Yoshiyuki Koizumi

发明人： Takushi Azemi ,  Yoshiyuki Koizumi

IPC分类号： C07C323/22

CPC分类号： C07C319/20 ,  C07C323/58

摘要： A process for producing methionine, while corrosion of a pipe and a reaction vessel is well inhibited, is provided including the following steps (1) to (3), wherein a content of thiols in 3 -methylthiopropanal is 500 ppm or less, based on the propanal, and a content of hydrogen sulfide in 3-methylthiopropanal is 60 ppm or less, based on the propanal; step (1) in which 3 -methylthiopropanal is reacted with hydrogen cyanide in the presence of a base to give 2 -hydroxy -4-methylthiobutanenitrile; step (2) in which the 2-hydroxy-4-methylthiobutanenitrile obtained in step (1) is reacted with ammonium carbonate to give 5-(β-methylmercaptoethyl) hydantoin; and step (3) in which the 5-(β-methylmercaptoethyl)hydantoin obtained in step (2) is hydrolyzed in the presence of a basic potassium compound to give methionine.

摘要翻译： 提供了一种制备甲硫氨酸的方法，同时对管和反应容器的腐蚀被很好地抑制，包括以下步骤（1）至（3），其中3-甲硫基丙醛中的硫醇含量为500ppm以下，基于 丙醛和3-甲硫基丙醛中的硫化氢含量为60ppm以下，基于丙醛; 步骤（1）其中3-甲硫基丙醛与氰化氢在碱存在下反应，得到2-羟基-4-甲硫基丁腈; 步骤（2）其中将步骤（1）中获得的2-羟基-4-甲硫基丁腈与碳酸铵反应，得到5-（β-甲基巯基乙基）乙内酰脲; 和步骤（3），其中在碱性钾化合物的存在下水解在步骤（2）中获得的5-（（乙基 - 甲基巯基乙基）乙内酰脲，得到甲硫氨酸。

公开(公告)号：US08101797B2

公开(公告)日：2012-01-24

申请号：US12613568

申请日：2009-11-06

申请人： Yoshiyuki Koizumi ,  Akinori Goto ,  Takushi Azemi

发明人： Yoshiyuki Koizumi ,  Akinori Goto ,  Takushi Azemi

IPC分类号： C07C323/03

CPC分类号： C07C319/20 ,  C07C319/28 ,  C07C323/58

摘要： A process for producing methionine advantageously in view of cost, while efficiently recovering useful components, is provided including the following steps: (1) hydrolyzing 5-[2-(methylthio)ethyl]imidazolidine-2,4-dione in the presence of a basic potassium compound; (2) introducing carbon dioxide into the reaction solution obtained in the step (1) to thereby precipitate methionine, and separating the resulting slurry into a precipitate and a mother liquor; (3) concentrating the mother liquor obtained in the step (2), mixing the resulting concentrate with a lower alcohol, introducing carbon dioxide into the resulting mixture to thereby precipitate methionine and potassium hydrogencarbonate, and separating the resulting slurry into a precipitate and a mother liquor; and (4) concentrating the mother liquor obtained in the step (3), treating the resulting concentrate by heating at a temperature of from 150 to 200° C., and recycling the treated solution for use in step (2).

摘要翻译： 提供有益于成本考虑成本有效回收有用成分的方法，包括以下步骤：（1）水解5- [2-（甲硫基）乙基]咪唑烷-2,4-二酮在 碱性钾化合物; （2）将二氧化碳引入到步骤（1）中得到的反应溶液中，从而使甲硫氨酸沉淀，并将得到的浆料分离成沉淀物和母液; （3）浓缩步骤（2）中获得的母液，将所得浓缩物与低级醇混合，将二氧化碳引入所得混合物中，从而沉淀甲硫氨酸和碳酸氢钾，并将所得浆液分离成沉淀物和母体 酒; 和（4）浓缩步骤（3）中得到的母液，在150〜200℃的温度下加热处理所得浓缩物，并循环使用步骤（2）中处理的溶液。

公开(公告)号：US08217197B2

公开(公告)日：2012-07-10

申请号：US12613575

申请日：2009-11-06

申请人： Yoshiyuki Koizumi ,  Akinori Goto ,  Takushi Azemi

发明人： Yoshiyuki Koizumi ,  Akinori Goto ,  Takushi Azemi

IPC分类号： C07C323/00

CPC分类号： C07C319/28 ,  C07C319/20 ,  C07C323/58

摘要： A process for producing methionine advantageously in view of cost, while efficiently recovering useful components, is provided, including the following steps (1) hydrolyzing 5-[2-(methylthio)ethyl]imidazolidine-2,4-dione in the presence of a basic potassium compound; (2) introducing carbon dioxide into the reaction solution obtained in step (1) to thereby precipitate methionine, and separating the resulting slurry into a precipitate and a mother liquor; (3) concentrating the mother liquor obtained in step (2), mixing the resulting concentrate with a lower alcohol, introducing carbon dioxide into the resulting mixture to thereby precipitate methionine and potassium hydrogencarbonate, and separating the resulting slurry into a precipitate and a mother liquor; and (4) concentrating the mother liquor obtained in step (3), treating the resulting concentrate by heating at a temperature of from 150 to 200° C., and recycling the treated solution for use in step (3).

摘要翻译： 提供了有利于成本考虑成本有效回收有用成分的方法，包括以下步骤（1）在5-（2-甲硫基）乙基]咪唑烷-2,4-二酮在 碱性钾化合物; （2）将二氧化碳引入到步骤（1）中获得的反应溶液中，从而使甲硫氨酸沉淀，并将所得浆液分离成沉淀物和母液; （3）浓缩步骤（2）中获得的母液，将得到的浓缩物与低级醇混合，将二氧化碳引入所得混合物中，从而沉淀甲硫氨酸和碳酸氢钾，并将所得浆料分离成沉淀物和母液 ; （4）浓缩步骤（3）中得到的母液，在150〜200℃的温度下加热处理得到的浓缩物，并循环处理后的步骤（3）中使用的溶液。

公开(公告)号：US08106237B2

公开(公告)日：2012-01-31

申请号：US12480288

申请日：2009-06-08

申请人： Yoshiyuki Koizumi ,  Fumio Kubo

发明人： Yoshiyuki Koizumi ,  Fumio Kubo

IPC分类号： C07C323/03

CPC分类号： C07C319/20 ,  C07C319/28 ,  C07C323/58

摘要： The present invention provides a process for producing methionine, which comprises steps of: hydrolyzing 5-[2-(methylthio)ethyl]imidazolidine-2,4-dione in the presence of a basic potassium compound in a non-stirred continuous first reaction tank, and heat-treating the reaction solution after hydrolysis in a second reaction tank. According to the process of the present invention, a methionine crystal with a higher bulk density can be produced.

摘要翻译： 本发明提供了产生甲硫氨酸的方法，其包括以下步骤：在非搅拌连续的第一反应槽中，在碱性钾化合物的存在下水解5- [2-（甲硫基）乙基]咪唑烷-2,4-二酮 并在第二反应槽中水解后对反应溶液进行热处理。 根据本发明的方法，可以生产出具有较高堆积密度的蛋氨酸晶体。

公开(公告)号：US20090306426A1

公开(公告)日：2009-12-10

申请号：US12480288

申请日：2009-06-08

申请人： Yoshiyuki Koizumi ,  Fumio Kubo

发明人： Yoshiyuki Koizumi ,  Fumio Kubo

IPC分类号： C07C323/03

CPC分类号： C07C319/20 ,  C07C319/28 ,  C07C323/58

摘要： The present invention provides a process for producing methionine, which comprises steps of: hydrolyzing 5-[2-(methylthio)ethyl]imidazolidine-2,4-dione in the presence of a basic potassium compound in a non-stirred continuous first reaction tank, and heat-treating the reaction solution after hydrolysis in a second reaction tank. According to the process of the present invention, a methionine crystal with a higher bulk density can be produced.

摘要翻译： 本发明提供了产生甲硫氨酸的方法，其包括以下步骤：在非搅拌连续的第一反应槽中，在碱性钾化合物的存在下水解5- [2-（甲硫基）乙基]咪唑烷-2,4-二酮 并在第二反应槽中水解后对反应溶液进行热处理。 根据本发明的方法，可以生产出具有较高堆积密度的蛋氨酸晶体。

公开(公告)号：US06435567B2

公开(公告)日：2002-08-20

申请号：US09760729

申请日：2001-01-17

申请人： Yasuhiro Kikumori ,  Yoshiyuki Koizumi

发明人： Yasuhiro Kikumori ,  Yoshiyuki Koizumi

IPC分类号： F16L3900

CPC分类号： F16L25/0045 ,  F16L25/0036 ,  Y10S285/903 ,  Y10S285/921

摘要： A coupling structure for a tube having first and second tube members coupled to each other includes a come-out preventing member adapted to be held at an outer periphery of the first tube member and restricted in its movement in a longitudinal direction of the first tube member at a tip end portion on a coupling side of the first tube member, and an engaging member adapted to protrude from an end portion on a coupling side of the second tube member. The come-out preventing member and the engaging member are respectively provided with first engaging portions and second engaging portions to engage the come-out preventing member and the engaging member to each other and to prevent the first and second tube members from being separated.

摘要翻译： 用于具有彼此联接的第一和第二管构件的管的联接结构包括防脱出构件，其适于保持在第一管构件的外周并且限制其在第一管构件的纵向方向上的运动 在第一管构件的联接侧的末端部分处，以及适于从第二管构件的联接侧的端部突出的接合构件。 防脱出构件和接合构件分别设置有第一接合部和第二接合部，以将防止脱出构件和接合构件彼此接合，并且防止第一和第二管构件分离。

公开(公告)号：US06561419B1

公开(公告)日：2003-05-13

申请号：US09427649

申请日：1999-10-27

申请人： Yoshiyuki Koizumi ,  Shingo Watanabe ,  Kazunori Matsumoto

发明人： Yoshiyuki Koizumi ,  Shingo Watanabe ,  Kazunori Matsumoto

IPC分类号： G06K708

CPC分类号： G06K7/084

摘要： A magnetic code reading device and magnetic code reading method in an ATM or the like which after detecting a readout magnetic waveform including jitter, performs necessary transaction processing without performing uniform error processing in a predetermined case. The device includes a magnetic head having a magnetic sensor for writing and reading, magnetic code onto/from a magnetic recording medium, a timing disk for generating a timing pulse in correspondence with a moving distance of the magnetic head, and a controller for controlling the magnetic head and the timing disk, wherein upon reading of magnetic code on the magnetic recording medium where predetermined information is written in correspondence with the timing pulse, if jitter appears at relatively fixed intervals, corresponding to a rotational period of the timing disk, in a series of readout magnetic waveforms detected by the magnetic sensor, the controller recognizes the magnetic code based on the series of readout magnetic waveforms including the jitter, while if jitter is not related to the rotational period of the timing disk, the controller performs reading error processing.

摘要翻译： 在检测到包含抖动的读出磁波之后的ATM等中的磁代码读取装置和磁代码读取方法，在预定的情况下不进行均匀的错误处理，进行必要的事务处理。 该装置包括具有用于写入和读取磁性传感器的磁头，磁记录介质上的磁代码，用于产生与磁头的移动距离对应的定时脉冲的定时盘，以及控制器 磁头和定时盘，其中在读取与记录脉冲相对应的预定信息的磁记录介质上的磁代码时，如果以相对固定的间隔出现抖动，则对应于定时盘的旋转周期， 一系列由磁传感器检测到的读出磁波，控制器基于包括抖动的一系列读出磁波来识别磁代码，而如果抖动与定时盘的旋转周期无关，则控制器执行读取错误处理 。