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公开(公告)号：US07754701B2
公开(公告)日：2010-07-13
申请号：US10512212
申请日：2003-04-24
申请人： Takuya Shiomi , Yasuhide Okuhara , Akiko Tamura , Kyoko Tomita , Norihiro Shigematsu , Hiroto Kikuchi , Tsutomu Aritsuka , Fusao Tomita
发明人： Takuya Shiomi , Yasuhide Okuhara , Akiko Tamura , Kyoko Tomita , Norihiro Shigematsu , Hiroto Kikuchi , Tsutomu Aritsuka , Fusao Tomita
CPC分类号： A61K31/352 , A61K31/122 , A61K31/7016 , A61K33/06 , A61K33/42 , Y10S514/835 , Y10S514/892 , A61K2300/00
摘要： The present invention relates to a difructose anhydride (DFA)-containing composition and use thereof. DFA is a cyclic disaccharide in which the reducing termini of two fructose molecules bind each other to hydroxyl groups at the other nonreducing termini.According to the present invention, it has been revealed that DFA is effective in accelerating the absorption of magnesium, zinc or copper, accelerating bone formation, accelerating diuretic action, and improving bowel movement and is useful in inhibiting dental caries.A composition of the present invention can be used as a composition for a medicinal product and a food or drink product (including feed for animal use). Examples of a medicinal product and a food or drink product for human or animal use include formulated powder milk, parenteral nutrients, health food and drink products, and additives for feed and are not particularly limited as long as they are ultimately in an orally administrable form.
摘要翻译： 本发明涉及含有缩水甘油酸（DFA）的组合物及其用途。 DFA是一种环状二糖，其中两个果糖分子的还原末端在另一个非还原末端彼此结合成羟基。 根据本发明，已经表明DFA可以有效地加速镁，锌或铜的吸收，促进骨形成，加速利尿作用，改善肠运动，并且可用于抑制龋齿。 本发明的组合物可以用作药物和食品或饮料产品（包括动物饲料）的组合物。 用于人或动物用途的药用产品和食品或饮料产品的实例包括配制的粉末奶，胃肠外营养物，保健食品和饮料产品以及用于饲料的添加剂，没有特别限制，只要它们最终以口服的形式即可 。
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公开(公告)号：US08492363B2
公开(公告)日：2013-07-23
申请号：US12788209
申请日：2010-05-26
申请人： Takuya Shiomi , Yasuhide Okuhara , Akiko Tamura , Kyoko Tomita , Norihiro Shigematsu , Hiroto Kikuchi , Tsutomu Aritsuka , Fusao Tomita
发明人： Takuya Shiomi , Yasuhide Okuhara , Akiko Tamura , Kyoko Tomita , Norihiro Shigematsu , Hiroto Kikuchi , Tsutomu Aritsuka , Fusao Tomita
IPC分类号： A01N43/04 , A61K31/715 , A61K31/70
CPC分类号： A61K31/352 , A61K31/122 , A61K31/7016 , A61K33/06 , A61K33/42 , Y10S514/835 , Y10S514/892 , A61K2300/00
摘要： A method for increasing the absorption of magnesium, zinc, and/or copper through the intestines of a subject desiring such an increase, includes administering to the subject a difructose anhydride (DFA) in an amount effective to increase the absorption of magnesium, zinc, and/or copper present in the intestines.
摘要翻译： 增加镁，锌和/或铜通过需要这种增加的受试者的肠的吸收的方法包括向受试者施用有效增加镁，锌，锌和/或铜的吸收量的未结晶酸酐（DFA） 和/或铜存在于肠中。
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公开(公告)号：US20060069062A1
公开(公告)日：2006-03-30
申请号：US10512212
申请日：2003-04-24
申请人： Takuya Shiomi , Yasuhide Okuhara , Akiko Tamura , Kyoko Tomita , Norihiro Shigematsu , Hiroto Kikuchi , Tsutomu Aritsuka , Fusao Tomita
发明人： Takuya Shiomi , Yasuhide Okuhara , Akiko Tamura , Kyoko Tomita , Norihiro Shigematsu , Hiroto Kikuchi , Tsutomu Aritsuka , Fusao Tomita
IPC分类号： A61K31/7012 , A61K31/353 , A61K31/366 , A61K31/59 , A61K31/12
CPC分类号： A61K31/352 , A61K31/122 , A61K31/7016 , A61K33/06 , A61K33/42 , Y10S514/835 , Y10S514/892 , A61K2300/00
摘要： The present invention relates to a difructose anhydride (DFA)-containing composition and use thereof. DFA is a cyclic disaccharide in which the reducing termini of two fructose molecules bind each other to hydroxyl groups at the other nonreducing termini. According to the present invention, it has been revealed that DFA is effective in accelerating the absorption of magnesium, zinc or copper, accelerating bone formation, accelerating diuretic action, and improving bowel movement and is useful in inhibiting dental caries. A composition of the present invention can be used as a composition for a medicinal product and a food or drink product (including feed for animal use). Examples of a medicinal product and a food or drink product for human or animal use include formulated powder milk, parenteral nutrients, health food and drink products, and additives for feed and are not particularly limited as long as they are ultimately in an orally administrable form.
摘要翻译： 本发明涉及含有缩水甘油酸（DFA）的组合物及其用途。 DFA是一种环状二糖，其中两个果糖分子的还原末端在另一个非还原末端彼此结合成羟基。 根据本发明，已经表明DFA可以有效地加速镁，锌或铜的吸收，促进骨形成，加速利尿作用，改善肠运动，并且可用于抑制龋齿。 本发明的组合物可以用作药物和食品或饮料产品（包括动物饲料）的组合物。 用于人或动物用途的药用产品和食品或饮料产品的实例包括配制的粉末奶，肠胃外营养物，保健食品和饮料产品以及用于饲料的添加剂，并没有特别限制，只要它们最终以口服的形式即可 。
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公开(公告)号：US07964581B2
公开(公告)日：2011-06-21
申请号：US12788159
申请日：2010-05-26
申请人： Takuya Shiomi , Yasuhide Okuhara , Akiko Tamura , Kyoko Tomita , Norihiro Shigematsu , Hiroto Kikuchi , Tsutomu Aritsuka , Fusao Tomita
发明人： Takuya Shiomi , Yasuhide Okuhara , Akiko Tamura , Kyoko Tomita , Norihiro Shigematsu , Hiroto Kikuchi , Tsutomu Aritsuka , Fusao Tomita
IPC分类号： A01N43/04 , A61K31/715 , A61K31/70
CPC分类号： A61K31/352 , A61K31/122 , A61K31/7016 , A61K33/06 , A61K33/42 , Y10S514/835 , Y10S514/892 , A61K2300/00
摘要： A method for improving bowel movement of a subject desiring such an improvement, includes administering to the subject a defructose anhydride (DFA) in an amount effective to improve bowel movement.
摘要翻译： 一种改善需要这种改善的受试者的肠运动的方法包括以有效改善肠运动的量向受试者施用未结果酸酐（DFA）。
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公开(公告)号：US07998710B2
公开(公告)日：2011-08-16
申请号：US10516307
申请日：2004-03-02
申请人： Hiroto Kikuchi , Hiroaki Sakurai , Norimitsu Takagi , Tsutomu Aritsuka , Yoshihiro Senba , Fusao Tomita , Kozo Asano
发明人： Hiroto Kikuchi , Hiroaki Sakurai , Norimitsu Takagi , Tsutomu Aritsuka , Yoshihiro Senba , Fusao Tomita , Kozo Asano
CPC分类号： C12N9/1051 , C07H1/06 , C07H3/10 , C12P19/12
摘要： In the invention, highly pure crystals of difructose dianhydride III (di-D-fructofuranose-1,2′:2,3′-dianhydride; hereinafter referred to as DFA III) are produced by adding 5% or less of powdered active carbon to a DFA III containing purified solution containing DFA III of 90% or more purity at a concentration of R-Bx 10-60, preferably 40-55, and after stirring, applying the mixture to solid-liquid separation (filtration with diatomaceous, filtration through a membrane filter, ultrafiltration, or continuous centrifugal separation) and concentrating the separated liquid part, followed by immediate crystallization.In the process of the invention, DFA III crystals can be produced efficiently and industrially, and the resulting crystals can be used for various purposes in pharmaceuticals or food and drink since they have no smell. This is characteristics of the invention different from the prior art products.
摘要翻译： 在本发明中，通过将5％以下的粉状活性炭加入到高分子量的二缩水甘油醚III（二-D-呋喃果糖 - 1,2'：2,3'-二酐;以下称为DFA III）中， 在含有浓度为R-Bx10-60，优选40-55的90％或更高纯度的DFA III的含有DFA III的纯化溶液中，并且在搅拌后，将混合物施加到固液分离（用硅藻土过滤，通过 膜过滤器，超滤或连续离心分离）并浓缩分离的液体部分，然后立即结晶。 在本发明的方法中，可以有效和工业地生产DFA III晶体，并且所得晶体可用于药物或食品和饮料中的各种目的，因为它们没有气味。 这是与现有技术产品不同的本发明的特征。
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公开(公告)号：US20060051845A1
公开(公告)日：2006-03-09
申请号：US10516307
申请日：2004-03-02
申请人： Hiroto Kikuchi , Hiroaki Sakurai , Norimitsu Takagi , Tsutomu Aritsuka , Yoshihiro Senba , Fusao Tomita , Kozo Asano
发明人： Hiroto Kikuchi , Hiroaki Sakurai , Norimitsu Takagi , Tsutomu Aritsuka , Yoshihiro Senba , Fusao Tomita , Kozo Asano
CPC分类号： C12N9/1051 , C07H1/06 , C07H3/10 , C12P19/12
摘要： In the invention, highly pure crystals of difructose dianhydride III (di-D-fructofuranose-1,2′:2,3 ′-dianhydride; hereinafter referred to as DFA III) are produced by adding 5% or less of powdered active carbon to a DFA III containing purified solution containing DFA III of 90% or more purity at a concentration of R-Bx 10-60, preferably 40-55, and after stirring, applying the mixture to solid-liquid separation (filtration with diatomaceous, filtration through a membrane filter, ultrafiltration, or continuous centrifugal separation) and concentrating the separated liquid part, followed by immediate crystallization. In the process of the invention, DFA III crystals can be produced efficiently and industrially, and the resulting crystals can be used for various purposes in pharmaceuticals or food and drink since they have no smell. This is characteristics of the invention different from the prior art products.
摘要翻译： 在本发明中，通过将5％以下的粉状活性炭加入到高分子量的二硬脂酸二酐III（二-D-呋喃果糖 - 1,2'：2,3'-二氢化钠;以下称为DFA III）中， 在含有浓度为R-Bx10-60，优选40-55的90％或更高纯度的DFA III的含有DFA III的纯化溶液中，并且在搅拌后，将混合物施加到固液分离（用硅藻土过滤，通过 膜过滤器，超滤或连续离心分离）并浓缩分离的液体部分，然后立即结晶。 在本发明的方法中，可以有效和工业地生产DFA III晶体，并且所得晶体可用于药物或食品和饮料中的各种目的，因为它们没有气味。 这是与现有技术产品不同的本发明的特征。
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公开(公告)号：US20110300581A1
公开(公告)日：2011-12-08
申请号：US13210595
申请日：2011-08-16
摘要： A process for producing the crystals of difructose dianhydride III (DFA III), namely a indigestible disaccharide where two fructose molecules are bonded to each other at positions 1,2′ and 2,3′ (di-D-fructofuranose-1,2′:2,3′-dianhydride), where solutions containing DFA III are adjusted to and/or maintained at pH 5 or more, preferably pH 5 to 8, and more preferably 6 to 8. DFA III can be produced industrially without lowering the crystal yield even when the crystallization thereof is done in a recycling system; additionally by adjusting the total fructose content in mother solutions for (crude) crystallization to 5% or less per a solid content basis and adjusting the fructose content to 1% or less, DFA III can more effectively be produced.
摘要翻译： 一种制备二缩水甘油二酸酐III（DFA III）晶体的方法，即一种难消化的二糖，其中两个果糖分子在1,2'和2,3'位置彼此键合（二-D-呋喃果糖-1,2' ：2,3'-二酐），其中将含有DFA III的溶液调节至和/或维持在pH 5或更高，优选pH 5至8，更优选6至8。DFA III可在工业上生产而不降低晶体 即使在循环系统中进行结晶化也可产生; 另外通过将（粗）结晶的母溶液中的总果糖含量调节至每固体含量为5％或更少，并将果糖含量调节至1％或更低，可以更有效地产生DFA III。
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公开(公告)号：US20070287835A1
公开(公告)日：2007-12-13
申请号：US11722936
申请日：2004-12-28
IPC分类号： C07H1/06
摘要： The invention provides a process for producing the crystals of difructose dianhydride III (DFA III), namely a indigestible disaccharide where two fructose molecules are bonded to each other at positions 1,2′ and 2,3′(di-D-fructofuranose-1,2′:2,3′-dianhydride), where solutions containing DFA III are adjusted to and/or maintained at pH 5 or more, preferably pH 5 to 8, and more preferably 6 to 8. In accordance with th invention, DFA III can be produced industrially without lowering the crystal yield even when the crystallization thereof is done in a recycling system; additionally by adjusting the total fructose content in mother solutions for (crude) crystallization to 5% or less per a solid content basis and adjusting the fructose content to 1% or less, DFA III can more effectively be produced.
摘要翻译： 本发明提供了一种制备二缩水甘油二酸酐III（DFA III）晶体的方法，即不可消化的二糖，其中两个果糖分子在1,2'和2,3'位置彼此键合（二-D-呋喃果糖-1 ，2'：2,3'-二酐），其中将含有DFA III的溶液调节至和/或维持在pH 5或更高，优选pH 5至8，更优选6至8。根据本发明，DFA 即使在循环系统中进行结晶化，III也可以在工业上生产而不降低晶体产率; 另外通过将（粗）结晶的母溶液中的总果糖含量调节至每固体含量为5％或更少，并将果糖含量调节至1％或更低，可以更有效地产生DFA III。
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公开(公告)号：US08304534B2
公开(公告)日：2012-11-06
申请号：US13210595
申请日：2011-08-16
摘要： A process for producing the crystals of difructose dianhydride III (DFA III), namely a indigestible disaccharide where two fructose molecules are bonded to each other at positions 1, 2′ and 2,3′ (di-D-fructofuranose-1,2′:2,3′-dianhydride), where solutions containing DFA III are adjusted to and/or maintained at pH 5 or more, preferably pH 5 to 8, and more preferably 6 to 8. DFA III can be produced industrially without lowering the crystal yield even when the crystallization thereof is done in a recycling system; additionally by adjusting the total fructose content in mother solutions for (crude) crystallization to 5% or less per a solid content basis and adjusting the fructose content to 1% or less, DFA III can more effectively be produced.
摘要翻译： 一种生产二缩水甘油二酸酐III（DFA III）晶体的方法，即一种不可消化的二糖，其中两个果糖分子在1,2'和2,3'位置彼此键合（二-D-呋喃果糖-1,2' ：2,3'-二酐），其中将含有DFA III的溶液调节至和/或维持在pH 5或更高，优选pH 5至8，更优选6至8。DFA III可在工业上生产而不降低晶体 即使在循环系统中进行结晶化也可产生; 另外通过将（粗）结晶的母溶液中的总果糖含量调节至每固体含量为5％或更少，并将果糖含量调节至1％或更低，可以更有效地产生DFA III。
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公开(公告)号：US08039615B2
公开(公告)日：2011-10-18
申请号：US11722936
申请日：2004-12-28
摘要： The invention provides a process for producing the crystals of difructose dianhydride III (DFA III), namely a indigestible disaccharide where two fructose molecules are bonded to each other at positions 1,2′ and 2,3′ (di-D-fructofuranose-1,2′,2,3′-dianhydride), where solutions containing DFA III are adjusted to and/or maintained at pH 5 or more, preferably pH 5 to 8, and more preferably 6 to 8. In accordance with the invention, DFA III can be produced industrially without lowering the crystal yield even when the crystallization thereof is done in a recycling system; additionally by adjusting the total fructose content in mother solutions for (crude) crystallization to 5% or less per a solid content basis and adjusting the fructose content to 1% or less, DFA III can more effectively be produced.
摘要翻译： 本发明提供了一种制备二缩水甘油二酸酐III（DFA III）晶体的方法，即不可消化的二糖，其中两个果糖分子在1,2'和2,3'位置彼此键合（二-D-呋喃果糖-1 ，2'，2,3'-二酐），其中将含有DFA III的溶液调节至和/或维持在pH 5或更高，优选pH 5至8，更优选6至8。根据本发明，DFA 即使在循环系统中进行结晶化，III也可以在工业上生产而不降低晶体产率; 另外通过将（粗）结晶的母溶液中的总果糖含量调节至每固体含量为5％或更少，并将果糖含量调节至1％或更低，可以更有效地产生DFA III。
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