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    Preparation Of Malto-Oligosaccharides
    4.
    发明申请
    Preparation Of Malto-Oligosaccharides 审中-公开
    麦芽低聚糖的制备

    公开(公告)号：US20150353979A1

    公开(公告)日：2015-12-10

    申请号：US14826354

    申请日：2015-08-14

    Applicant: Grain Processing Corporation

    Inventor： Steven L. Ramsden ,  Zachary J. Halloran ,  Albert J. Pollmeier ,  Jeff M. Underwood

    IPC: C12P19/14 ,  C12P19/04 ,  C13K7/00

    CPC classification number: C12P19/14 ,  C08B30/044 ,  C08B30/18 ,  C12P19/04 ,  C12Y302/01001 ,  C13K7/00

    Abstract: Disclosed is a method for preparing a mixture of malto-oligosaccharides. Generally, a dry-milled corn fraction, such as a corn flour from which germ and fiber have been removed, is subjected to hydrolysis, typically catalyzed with acid or an enzyme such as an α-amylase enzyme, under conditions suitable to form a mixture of malto-oligosaccharides. A gluten fraction is removed and the enzyme is inactivated, such as with heat. The mixture of malto-oligosaccharides then may be recovered from remaining solids and purified.

    Abstract translation: 公开了一种制备麦芽低聚糖混合物的方法。 一般来说，干法磨碎的玉米级分，例如去除胚芽和纤维的玉米粉，经过水解，通常用酸或酶如α-淀粉酶在适于形成混合物的条件下催化 的麦芽寡糖。 除去谷蛋白部分，并使酶失活，例如加热。 然后可以从剩余的固体中回收麦芽寡糖的混合物并纯化。

    Tumor lesion regression and conversion in situ into autologous tumor vaccines by compositions that result in anti-Gal antibody binding
    5.
    发明授权
    Tumor lesion regression and conversion in situ into autologous tumor vaccines by compositions that result in anti-Gal antibody binding 有权
    肿瘤病变回归，并通过导致抗Gal抗体结合的组合物原位转化成自体肿瘤疫苗

    公开(公告)号：US07820628B2

    公开(公告)日：2010-10-26

    申请号：US11355804

    申请日：2006-02-16

    Applicant: Uri Galili

    Inventor： Uri Galili

    IPC: A61K31/70 ,  A61K31/715 ,  C07H1/00 ,  C13K5/00 ,  C13K7/00

    CPC classification number: A61K31/739

    Abstract: The present invention discloses that an intratumoral injection of: i) glycolipids with α-gal epitope; ii) gene vectors comprising an α1,3galactosyltransferase gene; or iii) a mixture of α1,3galactosyltransferase, neuraminidase, and uridine diphosphate galactose results in tumor regression and/or destruction. Binding of the natural anti-Gal antibody to de novo expressed tumoral α-gal epitopes induces inflammation resulting in an anti-Gal antibody mediated opsonization of tumor cells and their uptake by antigen presenting cells. These antigen presenting cells migrate to draining lymph nodes and activate tumor specific T cells thereby converting the treated tumor lesions into in situ autologous tumor vaccines. This therapy can be applied to patients with multiple lesions and in neo-adjuvant therapy to patients before tumor resection. In addition to the regression and/or destruction of the treated tumor, such a vaccine will help in the immune mediated destruction of micrometastases that are not detectable during the removal of the treated tumor.

    Abstract translation: 本发明公开了肿瘤内注射：i）具有α-gal表位的糖脂; ii）包含α1,3半乳糖基转移酶基因的基因载体; 或iii）α1,3半乳糖转移酶，神经氨酸酶和尿苷二磷酸半乳糖的混合物导致肿瘤消退和/或破坏。 天然抗-Gal抗体与从头表达的肿瘤α-gal表位的结合诱导炎症，导致抗Gal抗体介导的肿瘤细胞的调理作用及其通过抗原呈递细胞的摄取。 这些抗原呈递细胞迁移到引流淋巴结并激活肿瘤特异性T细胞，从而将治疗的肿瘤损伤转化为原位自体肿瘤疫苗。 这种治疗方法可以应用于肿瘤切除术前患者多发病灶和新辅助治疗。 除了处理的肿瘤的消退和/或破坏之外，这样的疫苗将有助于免疫介导的微转移的破坏，其在去除治疗的肿瘤期间是不可检测的。

    GLYCOLIPIDS OF BRANCHED CHAIN ALKYL OLIGOSACCHARIDES FOR LIQUID CRYSTAL AND RELATED APPLICATIONS
    6.
    发明申请
    GLYCOLIPIDS OF BRANCHED CHAIN ALKYL OLIGOSACCHARIDES FOR LIQUID CRYSTAL AND RELATED APPLICATIONS 有权
    用于液晶的分支链烷基低聚物的甘氨酸和相关应用

    公开(公告)号：US20090036669A1

    公开(公告)日：2009-02-05

    申请号：US11908791

    申请日：2006-02-20

    Applicant: Rauzah Hashim ,  Thorsten Heidelberg ,  Hind Hassan ,  Nasrul Zamani Mohd Rodzi ,  Rusnah Syahila Dauli Hussen ,  Ahmad Sazali Hamzah ,  Shahidan Radiman ,  Volkmar Vili ,  Matthias Wulf ,  Seiji Ujiie

    Inventor： Rauzah Hashim ,  Thorsten Heidelberg ,  Hind Hassan ,  Nasrul Zamani Mohd Rodzi ,  Rusnah Syahila Dauli Hussen ,  Ahmad Sazali Hamzah ,  Shahidan Radiman ,  Volkmar Vili ,  Matthias Wulf ,  Seiji Ujiie

    IPC: C13K7/00

    CPC classification number: C07H15/04 ,  C09K19/0422

    Abstract: Glycolipids of branched chain alkyl oligosaccharides according to this patent comprise of a primary alcohol branched in the 2-position and an oligosaccharide, covalently bond to the alcohol in either α- or β-linkage (shown in Formula I and Formula II). These compounds show particularly interesting phase behavior not found for the corresponding straight chain counterparts. The properties involve an ambient temperature liquid crystalline appearance and thermotropic liquid crystal phase polymorphism. Upon the latter, the formation of cubic phases is considered most interesting with respect to life science applications, e.g. liposome for drug delivery. Depending on the choice of sugar head group and alkyl tail, various levels of water miscibility may be adjusted to meet applications requirements (complete solubility for emulsifier applications, e.g. cosmetic creams, to limited water swelling only, e.g. for the preparation of artificial membranes). The closed structural relationship to natural lipids also make branched chain alkyl oligosaccharides valuable subjects for biochemical investigations, e.g. membrane studies. The range of possible applications for glycolipids of branched chain alkyl oligosaccharides involve material science liquid crystal applications, e.g, optical switches, as well as surfactants and the life science applications.

    Abstract translation: 根据该专利的支链烷基寡糖的糖脂包含在2-位上分支的伯醇和寡糖，以α-或β-键（式I和式II所示）共价键合到醇上。 这些化合物表现出对于相应的直链对应物没有发现的特别有趣的相行为。 性质包括环境温度液晶外观和热致液晶相多态性。 在后者中，立方相的形成在生命科学应用方面被认为是最有趣的。 用于药物递送的脂质体。 根据糖头基和烷基尾的选择，可以调节不同水平的水混溶性以满足应用要求（对于乳化剂应用（例如化妆品乳液，仅限于有限的水溶胀，例如制备人造膜）的完全溶解度）。 与天然脂质的封闭结构关系也使支链烷基寡糖成为生物化学研究的有价值的对象，例如。 膜研究。 支链烷基寡糖的糖脂的可能应用范围涉及材料科学液晶应用，例如光学开关，以及表面活性剂和生命科学应用。

    Process for purifying maltose solution
    8.
    发明授权
    Process for purifying maltose solution 失效
    麦芽糖溶液纯化方法

    公开(公告)号：US4182634A

    公开(公告)日：1980-01-08

    申请号：US898073

    申请日：1978-04-20

    Applicant: Masaru Yamada ,  Atsushi Mori ,  Yoshiyasu Sato ,  Kenichi Terayama ,  Shogo Miyatani

    Inventor： Masaru Yamada ,  Atsushi Mori ,  Yoshiyasu Sato ,  Kenichi Terayama ,  Shogo Miyatani

    IPC: C08L5/00 ,  C13K7/00 ,  C13D3/12

    CPC classification number: C13K7/00

    Abstract: From a maltose solution of a purity of 75 to 90%, a high-purity maltose solution having a maltose purity of more than 98.5% is obtained in a high yield by preparatorily treating activated carbon with the aqueous solution of an organic solvent, adding the same organic solvent to the maltose solution under treatment until the concentration of the organic solvent equals that in the aqueous solution used for the treatment of the activated carbon, and subsequently bringing the resultant solution into contact with the activated carbon for thereby allowing the activated carbon to adsorb selectively out of the solution only the saccharides such as maltotriose and maltotetraose which are composed of three or more glucoses.

    Abstract translation: 从纯度为75〜90％的麦芽糖溶液，通过用有机溶剂的水溶液预处理活性炭，以高产率获得麦芽糖纯度高于98.5％的高纯度麦芽糖溶液，加入 与处理的麦芽糖溶液相同的有机溶剂，直到有机溶剂的浓度等于用于处理活性炭的水溶液的浓度，随后使所得溶液与活性炭接触，从而使活性炭 从溶液中仅选择由三种或更多种葡萄糖组成的糖类如麦芽三糖和麦芽四糖。

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