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公开(公告)号：US20050026198A1
公开(公告)日：2005-02-03
申请号：US10880427
申请日：2004-06-28
申请人： Tamara Balac Sipes , Susan Freier , Kenneth Dobie
发明人： Tamara Balac Sipes , Susan Freier , Kenneth Dobie
IPC分类号： C07H21/04 , C12N20060101 , C12Q1/68 , G01N33/48 , G01N33/50 , G06F19/20 , G06F19/24 , G06F19/00
摘要： The present invention provides a method of identifying a predictor of antisense oligonucleotide activity by identifying properties of oligonucleotides, evaluating oligonucleotide activity of the oligonucleotides, and correlating oligonucleotide activity with the properties. A high correlation between oligonucleotide activity and a property indicates that the property is a predictor of oligonucleotide activity.
摘要翻译： 本发明提供了通过鉴定寡核苷酸的性质，评价寡核苷酸的寡核苷酸活性以及将寡核苷酸活性与性质相关联来鉴定反义寡核苷酸活性的预测物的方法。 寡核苷酸活性与性质之间的高相关性表明该性质是寡核苷酸活性的预测因子。
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公开(公告)号：US20070066549A1
公开(公告)日：2007-03-22
申请号：US10571339
申请日：2004-09-17
申请人： Susan Freier , Kenneth Dobie , Eric Marcusson , Eric Swayze , Balkrishen Bhat , Jeremy Graff , Bruce Konicek
发明人： Susan Freier , Kenneth Dobie , Eric Marcusson , Eric Swayze , Balkrishen Bhat , Jeremy Graff , Bruce Konicek
IPC分类号： A61K48/00 , A61K38/16 , C07H21/02 , A61K31/704 , A61K31/522 , A61K31/403 , A61K31/4745 , A61K31/7072
CPC分类号： C07H21/00 , A61K38/00 , C12N15/113 , C12N2310/13 , C12N2310/315 , C12N2310/3181 , C12N2310/32 , C12N2310/321 , C12N2310/322 , C12N2310/3231 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/53 , C12N2310/3525 , C12N2310/3521 , C12N2310/3533
摘要： Oligomeric compounds, compositions and methods are provided for modulating the expression of eIF4E. The antisense compounds may be single- or double-stranded and are targeted to nucleic acid encoding eIF4E. Methods of using these compounds for modulation of eIF4E expression and for diagnosis and treatment of diseases and conditions associated with expression of eIF4E are provided.
摘要翻译： 提供低分子化合物，组合物和方法用于调节eIF4E的表达。 反义化合物可以是单链或双链的，并且靶向编码eIF4E的核酸。 提供了使用这些化合物调节eIF4E表达和用于诊断和治疗与eIF4E表达相关的疾病和病症的方法。
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公开(公告)号：US20060154885A1
公开(公告)日：2006-07-13
申请号：US11072846
申请日：2005-03-04
申请人： C. Bennett , Brett Monia , Nicholas Dean , Xiaoxing Xu , Sanjay Bhanot , Brenda Baker , Susan Freier , Lex Cowsert , Robert McKay , Muthiah Manoharan , F. Dorr , Jon Holmlund , Alexander Borchers , Vickie Brown-Driver , Jacqueline Wyatt , Shin Flournoy , Elizabeth Ackermann , Hong Zhang , Andrew Watt , Eric Maracusson , Scott Cooper , Erich Koller , Loren Miraglia , William Ricketts , Kenneth Dobie , Tamara Sipes
发明人： C. Bennett , Brett Monia , Nicholas Dean , Xiaoxing Xu , Sanjay Bhanot , Brenda Baker , Susan Freier , Lex Cowsert , Robert McKay , Muthiah Manoharan , F. Dorr , Jon Holmlund , Alexander Borchers , Vickie Brown-Driver , Jacqueline Wyatt , Shin Flournoy , Elizabeth Ackermann , Hong Zhang , Andrew Watt , Eric Maracusson , Scott Cooper , Erich Koller , Loren Miraglia , William Ricketts , Kenneth Dobie , Tamara Sipes
CPC分类号： C12N15/1138 , A61K48/00 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for modulating the expression of SLC26A2. The compositions comprise oligonucleotides, targeted to nucleic acid encoding SLC26A2. Methods of using these compounds for modulation of SLC26A2 expression and for diagnosis and treatment of disease associated with expression of SLC26A2 are provided.
摘要翻译： 提供化合物，组合物和方法用于调节SLC26A2的表达。 组合物包含针对编码SLC26A2的核酸的寡核苷酸。 提供了使用这些化合物调节SLC26A2表达和用于诊断和治疗与SLC26A2表达相关的疾病的方法。
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公开(公告)号：US20060025373A1
公开(公告)日：2006-02-02
申请号：US11207478
申请日：2005-08-18
申请人： Sanjay Bhanot , Kenneth Dobie , Susan Freier
发明人： Sanjay Bhanot , Kenneth Dobie , Susan Freier
CPC分类号： C07H21/04 , A61K38/00 , C12N15/1138 , C12N2310/11 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12Q1/6883 , C12Q2600/136 , C12Q2600/158 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for modulating the expression of glucocorticoid receptor. The compositions comprise oligonucleotides, targeted to nucleic acid encoding glucocorticoid receptor. Methods of using these compounds for modulation of glucocorticoid receptor expression and for diagnosis and treatment of diseases and conditions associated with expression of glucocorticoid receptor are provided.
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公开(公告)号：US20050227938A1
公开(公告)日：2005-10-13
申请号：US11015193
申请日：2004-12-17
申请人： C. Bennett , Brenda Baker , Nicholas Dean , Brett Monia , Susan Freier , James Karras , Hong Zhang , Susan Murray , Madeline Butler , Erich Koller , Thomas Condon , William Gaarde , Andrew Watt , Mark Graham , Jacqueline Wyatt , Lex Cowsert , Kenneth Dobie , Mark Roach
发明人： C. Bennett , Brenda Baker , Nicholas Dean , Brett Monia , Susan Freier , James Karras , Hong Zhang , Susan Murray , Madeline Butler , Erich Koller , Thomas Condon , William Gaarde , Andrew Watt , Mark Graham , Jacqueline Wyatt , Lex Cowsert , Kenneth Dobie , Mark Roach
IPC分类号： A61K38/00 , A61K48/00 , C07H21/02 , C12N15/113
CPC分类号： C12N15/1138 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/335 , C12N2310/341 , C12N2310/346 , Y02P20/582 , C12N2310/3521 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of TFAP2C. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding TFAP2C. Methods of using these compounds for modulation of TFAP2C expression and for treatment of diseases associated with expression of TFAP2C are provided.
摘要翻译： 提供反义化合物，组合物和方法用于调节TFAP2C的表达。 组合物包含靶向编码TFAP2C的核酸的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节TFAP2C表达和治疗与TFAP2C表达相关的疾病的方法。
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公开(公告)号：US20070020679A1
公开(公告)日：2007-01-25
申请号：US11527876
申请日：2006-09-26
申请人： Donna Ward , Kenneth Dobie , Eric Marcusson , Susan Freier
发明人： Donna Ward , Kenneth Dobie , Eric Marcusson , Susan Freier
IPC分类号： A61K48/00 , C12Q1/68 , C07H21/02 , C07F9/6512
CPC分类号： C07F9/65586 , A61K38/00 , C07F9/65616 , C12N15/113 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for modulating the expression of HIF1α and/or HIF2α. The compositions comprise oligonucleotides, targeted to nucleic acid encoding HIF1α and HIF2α. Methods of using these compounds for modulation of HIF1α and/or HIF2α expression and for diagnosis and treatment of disease associated with expression of HIF1α and/or HIF2α are provided.
摘要翻译： 提供化合物，组合物和方法用于调节HIF1α和/或HIF2α的表达。 组合物包含针对编码HIF1α和HIF2α的核酸的寡核苷酸。 提供了使用这些化合物调节HIF1α和/或HIF2α表达以及用于诊断和治疗与HIF1α和/或HIF2α的表达相关的疾病的方法。
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公开(公告)号：US20050153925A1
公开(公告)日：2005-07-14
申请号：US11013608
申请日：2004-12-16
申请人： C. Bennett , Brett Monia , Nicholas Dean , Susan Freier , Brenda Baker , Donna Ward , William Gaarde , Lex Cowsert , Andrew Watt , Kenneth Dobie
发明人： C. Bennett , Brett Monia , Nicholas Dean , Susan Freier , Brenda Baker , Donna Ward , William Gaarde , Lex Cowsert , Andrew Watt , Kenneth Dobie
CPC分类号： C12N15/1138 , C12N2310/11 , C12N2310/315 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/321 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for modulating the expression of hepatocyte growth factor receptor. The compositions comprise oligonucleotides, targeted to nucleic acid encoding hepatocyte growth factor receptor. Methods of using these compounds for modulation of hepatocyte growth factor receptor expression and for diagnosis and treatment of disease associated with expression of hepatocyte growth factor receptor are provided.
摘要翻译： 提供化合物，组合物和方法用于调节肝细胞生长因子受体的表达。 组合物包含针对编码肝细胞生长因子受体的核酸的寡核苷酸。 提供了使用这些化合物调节肝细胞生长因子受体表达和用于诊断和治疗与肝细胞生长因子受体表达相关的疾病的方法。
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公开(公告)号：US20050124572A1
公开(公告)日：2005-06-09
申请号：US10983197
申请日：2004-11-04
申请人： Susan Freier , Kenneth Dobie
发明人： Susan Freier , Kenneth Dobie
IPC分类号： A61K48/00 , C07H21/02 , C07H21/04 , C12N15/113 , C12Q1/68
CPC分类号： C12N15/1138 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for modulating the expression of Notch2. The compositions comprise oligonucleotides, targeted to nucleic acid encoding Notch2. Methods of using these compounds for modulation of Notch2 expression and for diagnosis and treatment of diseases and conditions associated with expression of Notch2 are provided.
摘要翻译： 提供化合物，组合物和方法用于调节Notch2的表达。 组合物包含靶向编码Notch2的核酸的寡核苷酸。 提供了使用这些化合物调节Notch2表达和用于诊断和治疗与Notch2表达有关的疾病和病症的方法。
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公开(公告)号：US20070238687A1
公开(公告)日：2007-10-11
申请号：US11697262
申请日：2007-04-05
申请人： Sanjay Bhanot , Susan Freier , Kenneth Dobie , Robert McKay
发明人： Sanjay Bhanot , Susan Freier , Kenneth Dobie , Robert McKay
IPC分类号： A61K31/711 , A61K31/7105 , A61K31/7125 , C07H21/02 , C07H21/04
CPC分类号： C12N15/1138 , C07K14/705 , C07K14/723 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for modulating the expression of glucagon receptor. The compositions comprise oligonucleotides, targeted to nucleic acid encoding glucagon receptor. Methods of using these compounds for modulation of glucagon receptor expression and for diagnosis and treatment of disease associated with expression of glucagon receptor are provided.
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公开(公告)号：US20070185044A1
公开(公告)日：2007-08-09
申请号：US10592435
申请日：2005-03-08
申请人： Kenneth Dobie , Susan Freier , Michael Buchmeier , Benjamin Neuman , C. Bennett , Namir Sioufi
发明人： Kenneth Dobie , Susan Freier , Michael Buchmeier , Benjamin Neuman , C. Bennett , Namir Sioufi
IPC分类号： A61K48/00
CPC分类号： C12N15/1137 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12Y304/15001 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for modulating the expression of ACE2. The compositions comprise oligonucleotides, targeted to nucleic acid encoding ACE2. Methods of using these compounds for modulation of ACE2 expression and for diagnosis and treatment of diseases and conditions associated with expression of ACE2 are provided.
摘要翻译： 提供化合物，组合物和方法用于调节ACE2的表达。 组合物包含针对编码ACE2的核酸的寡核苷酸。 提供了使用这些化合物调节ACE2表达和诊断和治疗与ACE2表达相关的疾病和病症的方法。
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