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    Process for preparing .beta.-lactam derivative and synthetic intermediate thereof
    4.
    发明授权
    Process for preparing .beta.-lactam derivative and synthetic intermediate thereof 失效
    制备β-内酰胺衍生物及其合成中间体的方法

    公开(公告)号：US5414081A

    公开(公告)日：1995-05-09

    申请号：US18407

    申请日：1993-02-17

    申请人： Hiroshi Horikawa ,  Kazuhiko Kondo ,  Tameo Iwasaki

    发明人： Hiroshi Horikawa ,  Kazuhiko Kondo ,  Tameo Iwasaki

    IPC分类号： C07D463/00 ,  C07D477/00 ,  C07D477/02 ,  C07D477/04 ,  C07D499/06 ,  C07D499/88 ,  C07D499/893 ,  C07D499/897 ,  C07D501/16 ,  C07D501/18 ,  C07D503/04 ,  C07D505/00 ,  C07D513/04 ,  C07D515/04 ,  C07D487/04

    CPC分类号： C07D513/04 ,  C07D477/02 ,  C07D477/04 ,  C07D515/04

    摘要： Disclosed is a process for preparing a .beta.-lactam compound represented by the formula: ##STR1## wherein R.sup.1 represents a hydroxy-substituted lower alkyl group or an amino group each of which may be protected; R.sup.2 represents hydrogen atom or an ester residue; X represents a methylene group which may be substituted by a lower alkyl group, sulfur atom or a group represented by the formula: --A--CH.sub.2 -- where A represents sulfur atom, oxygen atom or methylene group; and W represents an active ester residue of hydroxyl group, or a salt thereof, which comprises the steps of treating a 1-aza-3-thia-bicycloalkane compound represented by the formula: ##STR2## wherein R.sup.1, R.sup.2 and X have the same meanings as defined above, or a salt thereof with a base in the presence of a desulfurizing agent and then reacting the resulting compound with an active esterifying agent of hydroxyl group.

    摘要翻译： 公开了一种制备由下式表示的β-内酰胺化合物的方法：低级烷基或各自可被保护的氨基; R2表示氢原子或酯残基; X表示可以被低级烷基，硫原子或由下式表示的基团取代的亚甲基：-A-CH2-，其中A表示硫原子，氧原子或亚甲基; W表示羟基的活性酯残基或其盐，其包括如下步骤：处理由下式表示的1-氮杂-3-硫杂 - 双环烷烃化合物：其中R1，R2和X 具有与上述相同的含义，或其盐与脱碱剂存在下的碱，然后使所得化合物与羟基的活性酯化剂反应。

    Process for preparing carbapenem derivatives
    5.
    发明授权
    Process for preparing carbapenem derivatives 失效
    碳青霉烯衍生物的制备方法

    公开(公告)号：US5359059A

    公开(公告)日：1994-10-25

    申请号：US100460

    申请日：1993-08-02

    申请人： Tameo Iwasaki ,  Kazuhiko Kondo ,  Hiroshi Horikawa

    发明人： Tameo Iwasaki ,  Kazuhiko Kondo ,  Hiroshi Horikawa

    IPC分类号： C07D477/00 ,  C07D477/04 ,  C07D487/04 ,  C07D499/00

    CPC分类号： C07D477/04

    摘要： Process for preparing carbapenem derivative of the formula [I], which comprises subjecting azetidinone compound of the formula [II] to intramolecular cyclization reaction together with elimination reaction of the group of --SR.sup.4, followed by re-adding said group of --SR.sup.4 to the 2-position of the carbapenem skeleton of the intramolecularly cyclized compound, which is industrially useful as process for preparing carbapenem antimicrobials or synthetic intermediate therefor. ##STR1## wherein R.sup.1 is protected or unprotected hydroxy-substituted lower alkyl group, R.sup.2 is hydrogen atom or ester residue, R.sup.3 is hydrogen atom or lower alkyl group, and the group of --SR.sup.4 is group which can be used as substituent at 2-position of the carbapenem antimicrobials.

    摘要翻译： 制备式[I]的碳青霉烯衍生物的方法，其包括将式[II]的氮杂环丁酮化合物与-SR 4基团的消除反应一起分子内环化反应，然后将所述-SR 4基团重新加入到 分子内环化化合物的碳青霉烯骨架的2-位，其在工业上可用作制备碳青霉烯类抗微生物剂或其合成中间体的方法。 其中R 1为被保护或未被保护的羟基取代的低级烷基，R 2为氢原子或酯残基，R 3为氢原子或低级烷基，-SR 4为基团 其可用作碳青霉烯类抗微生物剂的2-位上的取代基。

    Process for preparing .beta.-lactam derivative and synthetic intermediate
    7.
    发明授权
    Process for preparing .beta.-lactam derivative and synthetic intermediate 失效
    制备β-内酰胺衍生物和合成中间体的方法

    公开(公告)号：US5589592A

    公开(公告)日：1996-12-31

    申请号：US393395

    申请日：1995-04-07

    申请人： Hiroshi Horikawa ,  Kazuhiko Kondo

    发明人： Hiroshi Horikawa ,  Kazuhiko Kondo

    IPC分类号： C07D463/00 ,  C07D477/00 ,  C07D477/02 ,  C07D477/04 ,  C07D499/06 ,  C07D499/88 ,  C07D499/893 ,  C07D499/897 ,  C07D501/16 ,  C07D501/18 ,  C07D503/04 ,  C07D505/00 ,  C07D513/04 ,  C07D515/04

    CPC分类号： C07D513/04 ,  C07D477/02 ,  C07D477/04 ,  C07D515/04

    摘要： Disclosed is a process for preparing a .beta.-lactam compound represented by the formula: ##STR1## wherein R.sup.1 represents a hydroxy-substituted lower alkyl group or an amino group each of which may be protected; R.sup.2 represents hydrogen atom or an ester residue; X represents a methylene group which may be substituted by a lower alkyl group, sulfur atom or a group represented by the formula: --A--CH.sub.2 -- where A represents sulfur atom, oxygen atom or methylene group; and W represents an active ester residue of hydroxyl group,or a salt thereof, which comprises the steps of treating a 1-aza-3-thia-bicycloalkane compound represented by the formula: ##STR2## wherein R.sup.1, R.sup.2 and X have the same meanings as defined above, or a salt thereof with a base in the presence of a desulfurizing agent and then reacting the resulting compound with an active esterifying agent of hydroxyl group.

    摘要翻译： 公开了一种制备由下式表示的β-内酰胺化合物的方法：其中R 1表示羟基取代的低级烷基或各自可被保护的氨基; R2表示氢原子或酯残基; X表示可以被低级烷基，硫原子或由下式表示的基团取代的亚甲基：-A-CH2-，其中A表示硫原子，氧原子或亚甲基; W表示羟基的活性酯残基或其盐，其包括如下步骤：处理由下式表示的1-氮杂-3-硫杂 - 双环烷烃化合物：其中R1，R2和X 具有与上述相同的含义，或其盐与脱碱剂存在下的碱，然后使所得化合物与羟基的活性酯化剂反应。

    ALUMINUM ALLOY FOR DIE CASTINGS AND PRODUCTION PROCESS OF ALUMINUM ALLOY CASTINGS
    9.
    发明申请
    ALUMINUM ALLOY FOR DIE CASTINGS AND PRODUCTION PROCESS OF ALUMINUM ALLOY CASTINGS 审中-公开
    铝合金铝合金铸件和铝合金铸件的生产工艺

    公开(公告)号：US20120073796A1

    公开(公告)日：2012-03-29

    申请号：US13296269

    申请日：2011-11-15

    申请人： Takeshi Nagasaka ,  Tomoyuki Hatano ,  Hiromi Takagi ,  Yoshiki Tan ,  Masatoshi Koumura ,  Hiroshi Horikawa

    发明人： Takeshi Nagasaka ,  Tomoyuki Hatano ,  Hiromi Takagi ,  Yoshiki Tan ,  Masatoshi Koumura ,  Hiroshi Horikawa

    IPC分类号： F28F7/00 ,  B22D25/02 ,  B22D27/15

    CPC分类号： C22C21/08 ,  B22D17/14

    摘要： The present invention provides an aluminum alloy for die castings that has superior castability and corrosion resistance. The amounts of Mn, Fe and Cu contained in the aluminum alloy components for die castings were determined to have a considerable effect on the corrosion resistance of the aluminum alloy. Therefore, the aluminum alloy for die castings of the present invention contains 9.0 to 12.0% by weight of Si, 0.20 to 0.80% by weight of Mg, and 0.7 to 1.1% by weight of Mn+Fe, the Mn/Fe ratio is 1.5 or more, the amount of Cu as impurity is controlled to 0.5% by weight or less, and the remainder is composed of aluminum and unavoidable impurities.

    摘要翻译： 本发明提供一种铸造用铝合金，其具有优异的铸造性和耐腐蚀性。 确定用于压铸件的铝合金部件中所含的Mn，Fe和Cu的量对铝合金的耐腐蚀性具有相当大的影响。 因此，本发明的压铸用铝合金含有9.0〜12.0重量％的Si，0.20〜0.80重量％的Mg和0.7〜1.1重量％的Mn + Fe，Mn / Fe比为1.5 以上，作为杂质的Cu的量控制在0.5重量％以下，其余部分由铝和不可避免的杂质构成。

    High strength aluminum alloy casting and method of production of same
    10.
    发明申请
    High strength aluminum alloy casting and method of production of same 审中-公开
    高强度铝合金铸造及其生产方法相同

    公开(公告)号：US20080083478A1

    公开(公告)日：2008-04-10

    申请号：US11986853

    申请日：2007-11-27

    申请人： Kouji Yamada ,  Tomoyuki Hatano ,  Susumu Miyakawa ,  Hiromi Takagi ,  Hiroshi Horikawa ,  Akio Hashimoto

    发明人： Kouji Yamada ,  Tomoyuki Hatano ,  Susumu Miyakawa ,  Hiromi Takagi ,  Hiroshi Horikawa ,  Akio Hashimoto

    IPC分类号： C22F1/043 ,  B22D18/02

    CPC分类号： C22C21/04 ,  C22F1/043

    摘要： A high strength aluminum alloy casting obtained by casting an aluminum alloy comprised of 7.5 to 11.5 wt % of Si, 3.8 to 4.8 wt % of Cu, 0.45 to 0.65 wt % of Mg, 0.4 to 0.7 wt % of Fe, 0.35 to 0.45 wt % of Mn, and the balance of Al and not more than 0.2 wt % of unavoidable impurities, wherein this aluminum alloy has 0.1 to 0.3 wt % of Ag added to it or contains 0.1 to 1.0 wt % of at least one element selected from the group of second additive elements comprised of Rb, K, Ba, Sr, Zr, Nb, Ta, V, and Pd and rare earth elements, and a method of production of a high strength aluminum alloy casting comprising the steps of filling a melt of an aluminum alloy in a mold to obtain a casting, taking out the aluminum alloy casting from the mold, solubilizing the high strength aluminum alloy casting by heating in a temperature range of 495 to 505° C. for 2 to 6 hours, quenching the high strength aluminum alloy casting after the solubilization, and age hardening the high strength aluminum alloy casting by heating in a temperature range of 160 to 220° C. for 2 to 6 hours after quenching.

    摘要翻译： 通过铸造由7.5〜11.5重量％的Si，3.8〜4.8重量％的Cu，0.45〜0.65重量％的Mg，0.4〜0.7重量％的Fe，0.35〜0.45重量％的铝构成的高强度铝合金铸件 的Mn，余量为Al和不大于0.2重量％的不可避免的杂质，其中该铝合金添加0.1至0.3重量％的Ag或含有0.1至1.0重量％的至少一种选自 由Rb，K，Ba，Sr，Zr，Nb，Ta，V和Pd以及稀土元素组成的第二添加元素组，以及制造高强度铝合金铸造的方法，包括以下步骤： 在模具中获得铝合金以获得铸件，从模具中取出铝合金铸件，通过在495至505℃的温度范围内加热将高强度铝合金铸件溶解2至6小时，淬火高 强度铝合金铸造后溶解，并且老化硬化高强度铝合金cas 在160-220℃的温度范围内加热淬火2至6小时。