公开(公告)号：US09044480B1

公开(公告)日：2015-06-02

申请号：US13412167

申请日：2012-03-05

申请人： Tami Pilot-Matias ,  Isabelle A. Gaultier ,  Rakesh L. Tripathi ,  Christine A. Collins ,  Daniel E. Cohen ,  Barry M. Bernstein

发明人： Tami Pilot-Matias ,  Isabelle A. Gaultier ,  Rakesh L. Tripathi ,  Christine A. Collins ,  Daniel E. Cohen ,  Barry M. Bernstein

IPC分类号： A61K38/00 ,  A61K31/33 ,  A61K31/44 ,  A61K31/497

CPC分类号： A61K31/497 ,  A61K31/427 ,  A61K2300/00

摘要： The present invention features methods of using Compound I to suppress HCV mutants, treat treatment-experienced HCV patients, and treat HCV patients having non-CC IL28B rs12979860 genotype.

摘要翻译： 本发明的特征在于使用化合物I抑制HCV突变体，治疗经历的HCV患者以及治疗具有非CC IL28B rs12979860基因型的HCV患者的方法。

公开(公告)号：US20070197558A1

公开(公告)日：2007-08-23

申请号：US11613825

申请日：2006-12-20

申请人： David Betebenner ,  David DeGoey ,  Clarence Maring ,  Allan Krueger ,  Nobuhiko Iwasaki ,  Todd Rockway ,  Curt Cooper ,  David Anderson ,  Pamela Donner ,  Brian Green ,  Dale Kempf ,  Dachun Liu ,  Keith McDaniel ,  Darold Madigan ,  Christopher Motter ,  John Pratt ,  Jason Shanley ,  Michael Tufano ,  Rolf Wagner ,  Rong Zhang ,  Akhteruzzaman Molla ,  Hongmei Mo ,  Tami Pilot-Matias ,  Sherie Masse ,  Robert Carrick ,  Wenping He ,  Liangjun Lu ,  David Grampovnik

发明人： David Betebenner ,  David DeGoey ,  Clarence Maring ,  Allan Krueger ,  Nobuhiko Iwasaki ,  Todd Rockway ,  Curt Cooper ,  David Anderson ,  Pamela Donner ,  Brian Green ,  Dale Kempf ,  Dachun Liu ,  Keith McDaniel ,  Darold Madigan ,  Christopher Motter ,  John Pratt ,  Jason Shanley ,  Michael Tufano ,  Rolf Wagner ,  Rong Zhang ,  Akhteruzzaman Molla ,  Hongmei Mo ,  Tami Pilot-Matias ,  Sherie Masse ,  Robert Carrick ,  Wenping He ,  Liangjun Lu ,  David Grampovnik

IPC分类号： A61K31/519 ,  C07D498/02 ,  C07D487/02

CPC分类号： C07D487/04 ,  C07D471/04 ,  C07D475/06 ,  C07D495/04 ,  C07D513/04

摘要： Compounds effective in inhibiting replication of Hepatitis C virus (“HCV”) or other viruses are disclosed. This invention is also directed to compositions comprising such compounds, co-formulation or co-administration of such compounds with other anti-viral or therapeutic agents, processes and intermediates for the syntheses of such compounds, and methods of using such compounds for the treatment of HCV or other viral infections.

摘要翻译： 公开了有效抑制丙型肝炎病毒（“HCV”）或其他病毒复制的化合物。 本发明还涉及包含这些化合物的组合物，这些化合物与其它抗病毒剂或治疗剂的共同配制或共同给药，用于合成这些化合物的方法和中间体，以及使用这些化合物治疗 HCV或其他病毒感染。

公开(公告)号：US20070232645A1

公开(公告)日：2007-10-04

申请号：US11613836

申请日：2006-12-20

申请人： Todd Rockway ,  David Betebenner ,  Allan Krueger ,  Nobuhiko Iwasaki ,  Curt Cooper ,  David Anderson ,  Dale Kempf ,  Darold Madigan ,  Christopher Motter ,  Jason Shanley ,  Michael Tufano ,  Rolf Wagner ,  Rong Zhang ,  Akhteruzzaman Molla ,  Hongmei Mo ,  Tami Pilot-Matias ,  Sherie Masse ,  Robert Carrick ,  Wenping He ,  Liangjun Lu

发明人： Todd Rockway ,  David Betebenner ,  Allan Krueger ,  Nobuhiko Iwasaki ,  Curt Cooper ,  David Anderson ,  Dale Kempf ,  Darold Madigan ,  Christopher Motter ,  Jason Shanley ,  Michael Tufano ,  Rolf Wagner ,  Rong Zhang ,  Akhteruzzaman Molla ,  Hongmei Mo ,  Tami Pilot-Matias ,  Sherie Masse ,  Robert Carrick ,  Wenping He ,  Liangjun Lu

IPC分类号： A61K31/4375 ,  C07D471/02 ,  C12N7/06

CPC分类号： C07D471/04

摘要： Compounds effective in inhibiting replication of Hepatitis C virus (“HCV”) or other viruses are disclosed. This invention is also directed to compositions comprising such compounds, co-formulation or co-administration of such compounds with other anti-viral or therapeutic agents, processes and intermediates for the syntheses of such compounds, and methods of using such compounds for the treatment of HCV or other viral infections.

公开(公告)号：US20070232627A1

公开(公告)日：2007-10-04

申请号：US11613810

申请日：2006-12-20

申请人： David Betebenner ,  David DeGoey ,  Clarence Maring ,  Allan Krueger ,  Nobuhiko Iwasaki ,  Todd Rockway ,  Curt Cooper ,  David Anderson ,  Pamela Donner ,  Brian Green ,  Dale Kempf ,  Dachun Liu ,  Keith McDaniel ,  Darold Madigan ,  Christopher Motter ,  John Pratt ,  Jason Shanley ,  Michael Tufano ,  Rolf Wagner ,  Rong Zhang ,  Akhteruzzaman Molla ,  Hongmei Mo ,  Tami Pilot-Matias ,  Sherie Masse ,  Robert Carrick ,  Wenping He ,  Liangjun Lu ,  David Grampovnik

发明人： David Betebenner ,  David DeGoey ,  Clarence Maring ,  Allan Krueger ,  Nobuhiko Iwasaki ,  Todd Rockway ,  Curt Cooper ,  David Anderson ,  Pamela Donner ,  Brian Green ,  Dale Kempf ,  Dachun Liu ,  Keith McDaniel ,  Darold Madigan ,  Christopher Motter ,  John Pratt ,  Jason Shanley ,  Michael Tufano ,  Rolf Wagner ,  Rong Zhang ,  Akhteruzzaman Molla ,  Hongmei Mo ,  Tami Pilot-Matias ,  Sherie Masse ,  Robert Carrick ,  Wenping He ,  Liangjun Lu ,  David Grampovnik

IPC分类号： A61K31/519 ,  A61K31/4375 ,  C07D239/70 ,  C07D471/02 ,  C12N7/06

CPC分类号： C07D471/04 ,  C07D495/04 ,  C07D513/04

摘要： Compounds effective in inhibiting replication of Hepatitis C virus (“HCV”) or other viruses are disclosed. This invention is also directed to compositions comprising such compounds, co-formulation or co-administration of such compounds with other anti-viral or therapeutic agents, processes and intermediates for the syntheses of such compounds, and methods of using such compounds for the treatment of HCV or other viral infections.

公开(公告)号：US06395472B1

公开(公告)日：2002-05-28

申请号：US09245248

申请日：1999-02-05

申请人： Thomas P. Leary ,  James Erker ,  Michelle Chalmers ,  John Simons ,  Larry Birkenmeyer ,  Scott Muerhoff ,  Tami Pilot-Matias ,  Suresh Desai ,  Isa Mushahwar

发明人： Thomas P. Leary ,  James Erker ,  Michelle Chalmers ,  John Simons ,  Larry Birkenmeyer ,  Scott Muerhoff ,  Tami Pilot-Matias ,  Suresh Desai ,  Isa Mushahwar

IPC分类号： C12Q170

CPC分类号： C12Q1/701 ,  Y10S977/804

摘要： The present invention relates to nucleic oligomer primers or probes useful for detection of TTV in test samples. Also provided are assays which utilize these primers and probes, as well as test kits which contain these oligomer primers and/or probes. In addition, the present invention encompasses the use of TTV nucleotide sequences as nucleic acid vectors and as markers for determining transmission between individuals as well as the route thereof. Additionally, the present invention encompasses a method of detecting TTV infection prior to xenotransplatation of a tissue or organ.

摘要翻译： 本发明涉及用于在测试样品中检测TTV的核酸低聚物引物或探针。 还提供了利用这些引物和探针的测定法，以及含有这些寡聚体引物和/或探针的测试试剂盒。 此外，本发明包括TTV核苷酸序列作为核酸载体的用途以及用于确定个体间传播的标记及其途径。 此外，本发明包括在组织或器官的异种移植之前检测TTV感染的方法。