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公开(公告)号:US20070197558A1
公开(公告)日:2007-08-23
申请号:US11613825
申请日:2006-12-20
申请人: David Betebenner , David DeGoey , Clarence Maring , Allan Krueger , Nobuhiko Iwasaki , Todd Rockway , Curt Cooper , David Anderson , Pamela Donner , Brian Green , Dale Kempf , Dachun Liu , Keith McDaniel , Darold Madigan , Christopher Motter , John Pratt , Jason Shanley , Michael Tufano , Rolf Wagner , Rong Zhang , Akhteruzzaman Molla , Hongmei Mo , Tami Pilot-Matias , Sherie Masse , Robert Carrick , Wenping He , Liangjun Lu , David Grampovnik
发明人: David Betebenner , David DeGoey , Clarence Maring , Allan Krueger , Nobuhiko Iwasaki , Todd Rockway , Curt Cooper , David Anderson , Pamela Donner , Brian Green , Dale Kempf , Dachun Liu , Keith McDaniel , Darold Madigan , Christopher Motter , John Pratt , Jason Shanley , Michael Tufano , Rolf Wagner , Rong Zhang , Akhteruzzaman Molla , Hongmei Mo , Tami Pilot-Matias , Sherie Masse , Robert Carrick , Wenping He , Liangjun Lu , David Grampovnik
IPC分类号: A61K31/519 , C07D498/02 , C07D487/02
CPC分类号: C07D487/04 , C07D471/04 , C07D475/06 , C07D495/04 , C07D513/04
摘要: Compounds effective in inhibiting replication of Hepatitis C virus (“HCV”) or other viruses are disclosed. This invention is also directed to compositions comprising such compounds, co-formulation or co-administration of such compounds with other anti-viral or therapeutic agents, processes and intermediates for the syntheses of such compounds, and methods of using such compounds for the treatment of HCV or other viral infections.
摘要翻译: 公开了有效抑制丙型肝炎病毒(“HCV”)或其他病毒复制的化合物。 本发明还涉及包含这些化合物的组合物,这些化合物与其它抗病毒剂或治疗剂的共同配制或共同给药,用于合成这些化合物的方法和中间体,以及使用这些化合物治疗 HCV或其他病毒感染。
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公开(公告)号:US20070232627A1
公开(公告)日:2007-10-04
申请号:US11613810
申请日:2006-12-20
申请人: David Betebenner , David DeGoey , Clarence Maring , Allan Krueger , Nobuhiko Iwasaki , Todd Rockway , Curt Cooper , David Anderson , Pamela Donner , Brian Green , Dale Kempf , Dachun Liu , Keith McDaniel , Darold Madigan , Christopher Motter , John Pratt , Jason Shanley , Michael Tufano , Rolf Wagner , Rong Zhang , Akhteruzzaman Molla , Hongmei Mo , Tami Pilot-Matias , Sherie Masse , Robert Carrick , Wenping He , Liangjun Lu , David Grampovnik
发明人: David Betebenner , David DeGoey , Clarence Maring , Allan Krueger , Nobuhiko Iwasaki , Todd Rockway , Curt Cooper , David Anderson , Pamela Donner , Brian Green , Dale Kempf , Dachun Liu , Keith McDaniel , Darold Madigan , Christopher Motter , John Pratt , Jason Shanley , Michael Tufano , Rolf Wagner , Rong Zhang , Akhteruzzaman Molla , Hongmei Mo , Tami Pilot-Matias , Sherie Masse , Robert Carrick , Wenping He , Liangjun Lu , David Grampovnik
IPC分类号: A61K31/519 , A61K31/4375 , C07D239/70 , C07D471/02 , C12N7/06
CPC分类号: C07D471/04 , C07D495/04 , C07D513/04
摘要: Compounds effective in inhibiting replication of Hepatitis C virus (“HCV”) or other viruses are disclosed. This invention is also directed to compositions comprising such compounds, co-formulation or co-administration of such compounds with other anti-viral or therapeutic agents, processes and intermediates for the syntheses of such compounds, and methods of using such compounds for the treatment of HCV or other viral infections.
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公开(公告)号:US20070232645A1
公开(公告)日:2007-10-04
申请号:US11613836
申请日:2006-12-20
申请人: Todd Rockway , David Betebenner , Allan Krueger , Nobuhiko Iwasaki , Curt Cooper , David Anderson , Dale Kempf , Darold Madigan , Christopher Motter , Jason Shanley , Michael Tufano , Rolf Wagner , Rong Zhang , Akhteruzzaman Molla , Hongmei Mo , Tami Pilot-Matias , Sherie Masse , Robert Carrick , Wenping He , Liangjun Lu
发明人: Todd Rockway , David Betebenner , Allan Krueger , Nobuhiko Iwasaki , Curt Cooper , David Anderson , Dale Kempf , Darold Madigan , Christopher Motter , Jason Shanley , Michael Tufano , Rolf Wagner , Rong Zhang , Akhteruzzaman Molla , Hongmei Mo , Tami Pilot-Matias , Sherie Masse , Robert Carrick , Wenping He , Liangjun Lu
IPC分类号: A61K31/4375 , C07D471/02 , C12N7/06
CPC分类号: C07D471/04
摘要: Compounds effective in inhibiting replication of Hepatitis C virus (“HCV”) or other viruses are disclosed. This invention is also directed to compositions comprising such compounds, co-formulation or co-administration of such compounds with other anti-viral or therapeutic agents, processes and intermediates for the syntheses of such compounds, and methods of using such compounds for the treatment of HCV or other viral infections.
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公开(公告)号:US20050075331A1
公开(公告)日:2005-04-07
申请号:US10679881
申请日:2003-10-06
申请人: John Pratt , David Betebenner , Pamela Donner , Brian Green , Dale Kempf , Keith McDaniel , Clarence Maring , Vincent Stoll , Rong Zhang
发明人: John Pratt , David Betebenner , Pamela Donner , Brian Green , Dale Kempf , Keith McDaniel , Clarence Maring , Vincent Stoll , Rong Zhang
IPC分类号: C07D213/69 , C07D215/22 , C07D401/04 , C07D417/04 , C07D417/14 , C07D471/04 , C07D495/04 , C07D513/04 , C07D519/00 , C07D285/26 , A61K31/549 , C07D285/22
CPC分类号: C07D213/69 , C07D215/22 , C07D401/04 , C07D417/04 , C07D417/14 , C07D471/04 , C07D495/04 , C07D513/04
摘要: The present invention provides an HCV polymerase inhibiting compound having the formula (I) and a composition comprising a therapeutically effective amount of said compound. The present invention also provides a method for inhibiting hepatitis C virus (HCV) polymerase, a method for inhibiting HCV viral replication, and a method for treating or preventing HCV infection. Processes for making said compounds, and synthetic intermediates employed in said processes, are also provided.
摘要翻译: 本发明提供具有式(I)的HCV聚合酶抑制化合物和包含治疗有效量的所述化合物的组合物。 本发明还提供了抑制丙型肝炎病毒(HCV)聚合酶,抑制HCV病毒复制的方法以及治疗或预防HCV感染的方法。 还提供了用于制备所述化合物的方法和在所述方法中使用的合成中间体。
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公开(公告)号:US20050131042A1
公开(公告)日:2005-06-16
申请号:US10733915
申请日:2003-12-11
申请人: Charles Flentge , Hui-Ju Chen , David DeGoey , William Flosi , David Grampovnik , Peggy Huang , Dale Kempf , Larry Klein , Allan Krueger , Darold Madigan , John Randolph , Minghua Sun , Ming Yeung , Chen Zhao
发明人: Charles Flentge , Hui-Ju Chen , David DeGoey , William Flosi , David Grampovnik , Peggy Huang , Dale Kempf , Larry Klein , Allan Krueger , Darold Madigan , John Randolph , Minghua Sun , Ming Yeung , Chen Zhao
IPC分类号: A61K31/175 , A61K31/18 , A61K31/195 , A61K31/277 , A61K31/4168 , A61K31/65 , A61K45/06 , C07C311/17 , C07D213/30 , C07D213/40 , C07D213/78 , C07D233/32 , C07D233/72 , C07D277/28 , C07D277/46 , C07D277/48 , C07D307/20 , C07D307/42 , C07D401/06 , C07D403/06 , C07D403/10 , C07D405/06 , C07D405/10 , C07D409/06 , C07D417/06 , C07D417/14 , C07D471/04 , C07D493/04
CPC分类号: C07D471/04 , A61K31/175 , A61K31/18 , A61K31/195 , A61K31/277 , A61K31/4168 , A61K31/65 , A61K45/06 , C07D213/30 , C07D213/40 , C07D213/78 , C07D233/32 , C07D233/72 , C07D277/28 , C07D277/46 , C07D277/48 , C07D307/20 , C07D307/42 , C07D401/06 , C07D403/06 , C07D403/10 , C07D405/06 , C07D405/10 , C07D409/06 , C07D417/06 , C07D417/14 , C07D493/04 , A61K2300/00
摘要: A compound of the formula is disclosed as an HIV protease inhibitor. Methods and compositions for inhibiting an HIV infection are also disclosed.
摘要翻译: 公开了式的化合物作为HIV蛋白酶抑制剂。 还公开了用于抑制HIV感染的方法和组合物。
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公开(公告)号:US20050159469A1
公开(公告)日:2005-07-21
申请号:US11010177
申请日:2004-12-10
申请人: John Randolph , Hui-Ju Chen , David DeGoey , Charles Flentge , William Flosi , David Grampovnik , Peggy Huang , Douglas Hutchinson , Dale Kempf , Larry Klein , Ming Yeung
发明人: John Randolph , Hui-Ju Chen , David DeGoey , Charles Flentge , William Flosi , David Grampovnik , Peggy Huang , Douglas Hutchinson , Dale Kempf , Larry Klein , Ming Yeung
IPC分类号: A61K31/4166 , A61K31/4178 , C07C243/24 , C07C271/22 , C07D401/06 , C07D401/14 , C07D403/06 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/06 , C07D417/14 , C07D43/02
CPC分类号: C07C271/22 , C07D401/06 , C07D401/14 , C07D403/06 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/06 , C07D417/14
摘要: A compound of the formula is disclosed as an HIV protease inhibitor. Methods and compositions for inhibiting an HIV infection are also disclosed.
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公开(公告)号:US20050148623A1
公开(公告)日:2005-07-07
申请号:US11008713
申请日:2004-12-09
申请人: David DeGoey , Charles Flentge , William Flosi , David Grampovnik , Dale Kempf , Larry Klein , Ming Yeung , John Randolph , Xiu Wang , Su Yu
发明人: David DeGoey , Charles Flentge , William Flosi , David Grampovnik , Dale Kempf , Larry Klein , Ming Yeung , John Randolph , Xiu Wang , Su Yu
IPC分类号: A61K31/4439 , A61K31/4745 , C07C311/16 , C07D213/38 , C07D213/85 , C07D231/08 , C07D239/22 , C07D277/06 , C07D277/30 , C07D307/16 , C07D307/20 , C07D401/06 , C07D401/14 , C07D405/06 , C07D405/12 , C07D417/04 , C07D417/06 , C07D417/12 , C07D417/14 , C07D451/02 , C07D471/02 , C07D471/04 , C07D471/10 , C07D493/04 , C07D498/02 , C07F9/58 , C07F9/655 , C07F9/6558 , C07K5/02 , C07D43/02
CPC分类号: C07D213/56 , A61K31/426 , A61K31/4418 , A61K31/443 , A61K31/444 , A61K45/06 , C07C311/16 , C07D213/38 , C07D213/85 , C07D231/08 , C07D239/22 , C07D277/06 , C07D277/30 , C07D307/16 , C07D307/20 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/06 , C07D405/12 , C07D407/12 , C07D417/04 , C07D417/06 , C07D417/12 , C07D417/14 , C07D451/02 , C07D471/04 , C07D471/10 , C07D493/04 , C07F9/58 , C07F9/65515 , C07F9/65583 , C07K5/0207
摘要: A compound of the formula is disclosed as an HIV protease inhibitor. Methods and compositions for inhibiting an HIV infection are also disclosed.
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公开(公告)号:US20070270383A1
公开(公告)日:2007-11-22
申请号:US11170197
申请日:2005-06-29
申请人: David DeGoey , William Flosi , David Grampovnik , Larry Klein , Dale Kempf , Xiu Wang
发明人: David DeGoey , William Flosi , David Grampovnik , Larry Klein , Dale Kempf , Xiu Wang
IPC分类号: A61K31/675 , A61P31/18 , C07F9/09
CPC分类号: A61K45/06 , A61K31/661 , A61K2300/00
摘要: A compound of the formula is disclosed as a prodrug of an HIV protease inhibitor. Methods and compositions for inhibiting HIV protease activity and treating HIV infection are also disclosed.
摘要翻译: 公开了式的化合物作为HIV蛋白酶抑制剂的前药。 还公开了用于抑制HIV蛋白酶活性和治疗HIV感染的方法和组合物。
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公开(公告)号:US20050131017A1
公开(公告)日:2005-06-16
申请号:US10733946
申请日:2003-12-11
申请人: David DeGoey , Charles Flentge , William Flosi , David Grampovnik , Dale Kempf , Larry Klein
发明人: David DeGoey , Charles Flentge , William Flosi , David Grampovnik , Dale Kempf , Larry Klein
IPC分类号: C07D213/30 , C07D213/40 , C07D401/06 , C07D401/12 , C07D401/14 , C07D417/06 , C07D417/14 , C07D471/04 , C07D493/04 , A61K31/4709 , A61K31/427 , A61K31/4439 , C07D417/02 , C07D43/02
CPC分类号: C07D401/06 , C07D213/30 , C07D213/40 , C07D401/12 , C07D401/14 , C07D417/06 , C07D417/14 , C07D471/04 , C07D493/04
摘要: A compound of the formula is disclosed as an HIV protease inhibitor. Methods and compositions for inhibiting an HIV infection are also disclosed.
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公开(公告)号:US20080139811A1
公开(公告)日:2008-06-12
申请号:US11679227
申请日:2007-02-27
申请人: Hing Sham , Daniel Norbeck , Xiaoqi Chen , David Betebenner , Dale Kempf , Thomas Herrin , Gondi Kumar , Stephen Condon , Arthur Cooper , Daniel Dickman , Steven Hannick , Lawrence Kolaczkowski , Patricia Oliver , Daniel Plata , Peter Stengel , Eric Stoner , Jieh-Heh Tien , Jih-Hua Liu , Ketan Patel
发明人: Hing Sham , Daniel Norbeck , Xiaoqi Chen , David Betebenner , Dale Kempf , Thomas Herrin , Gondi Kumar , Stephen Condon , Arthur Cooper , Daniel Dickman , Steven Hannick , Lawrence Kolaczkowski , Patricia Oliver , Daniel Plata , Peter Stengel , Eric Stoner , Jieh-Heh Tien , Jih-Hua Liu , Ketan Patel
IPC分类号: C07D239/10 , C07D233/32
CPC分类号: C07D207/27 , C07D207/404 , C07D207/408 , C07D223/10 , C07D233/32 , C07D233/42 , C07D239/10 , C07D239/22 , C07D241/08 , C07D241/18 , C07D253/06 , C07D263/22 , C07D307/20 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D407/12 , C07D409/12 , C07D409/14 , C07D417/12
摘要: A compound of the formula: is disclosed as an HIV protease inhibitor. Methods and compositions for inhibiting an HIV infection are also disclosed.
摘要翻译: 公开了下式的化合物作为HIV蛋白酶抑制剂。 还公开了用于抑制HIV感染的方法和组合物。
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