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公开(公告)号：US20070032416A1
公开(公告)日：2007-02-08
申请号：US10540179
申请日：2003-12-22
CPC分类号： C07K14/57518
摘要： The invention is based on the discovery that INSP100 is a splice variant of human chorionic somatomammotropin hormone 2 (HCS-B; Q14407) and that INSP104 is a splice variant of human chorionic somatomammotropin hormone 1 (hCS-A;P01243). The invention relates to the use of these proteins and nucleic acid sequences from the encoding genes in the diagnosis, prevention, and treatment of disease. This invention relates to novel proteins, termed INSP100 and INSP104, herein identified as novel splice variants of human Chorionic somatomammotropin hormone 2 (hCS-B; Q14407) and human Chorionic somatomammotropin hormone 1 (hCS-A; P01243) respectively and to the use of these proteins and nucleic acid sequences from the encoding genes in the diagnosis, prevention and treatment of disease. The variants have an altered A-B loop and are therefore predicted to possess altered receptor binding properties. All publications, patents and patent applications cited herein are incorporated in full by reference.
摘要翻译： 本发明基于以下发现：INSP100是人绒毛膜促生长激素激素2（HCS-B; Q14407）的剪接变体，INSP104是人绒毛膜促生长激素1（hCS-A; P01243）的剪接变体。 本发明涉及来自编码基因的这些蛋白质和核酸序列在疾病的诊断，预防和治疗中的用途。 本发明涉及分别命名为INSP 100和INSP 104的新型蛋白质，其分别被鉴定为人绒毛膜促生长激素激素2（hCS-B; Q14407）和人绒毛膜促生长激素1（hCS-A; P 01243）的新型剪接变体， 使用这些蛋白质和核酸序列从编码基因中诊断，预防和治疗疾病。 变体具有改变的A-B环，因此预测具有改变的受体结合性质。 本文引用的所有出版物，专利和专利申请通过引用全部并入。
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公开(公告)号：US20060275293A1
公开(公告)日：2006-12-07
申请号：US10537142
申请日：2003-12-05
CPC分类号： C07K14/61 , A01K2217/05 , A01K2217/075
摘要： This invention relates to a novel protein, termed INSP101, herein identified as a novel splice variant of human pituitary growth hormone and to the use of this protein and nucleic acid sequences from the encoding genes in the diagnosis, prevention, and treatment of disease.
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公开(公告)号：US20100196349A1
公开(公告)日：2010-08-05
申请号：US12095593
申请日：2006-12-04
IPC分类号： A61K39/395 , C07K14/00 , C07H21/00 , C12N15/74 , C12N5/10 , C12Q1/68 , A61K38/16 , A61K35/12 , A61P25/28
CPC分类号： C07K14/4748
摘要： This invention relates to protein INSP 171, herein identified as containing a Reeler domain, and to the use of this protein and the nucleic acid sequence from the encoding gene in the diagnosis, prevention and treatment of disease.
摘要翻译： 本发明涉及本文鉴定为含有卷轴结构域的蛋白质INSP171，以及该蛋白质和来自编码基因的核酸序列在疾病的诊断，预防和治疗中的用途。
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公开(公告)号：US20070128600A1
公开(公告)日：2007-06-07
申请号：US10534242
申请日：2003-11-07
CPC分类号： C07K14/8107
摘要： This invention relates to a protein, termed INSP097, herein identified as a member of the alpha macroglobulin family, in particular as an alpha-2-macroglobulin-like proteinase inhibitor, and to the use of this protein and nucleic acid sequences from the encoding gene in the diagnosis, prevention and treatment of disease.
摘要翻译： 本发明涉及一种称为INSP097的蛋白质，其在本文中被鉴定为α巨球蛋白家族的成员，特别是作为α-2-巨球蛋白样蛋白酶抑制剂，以及该编码基因使用该蛋白质和核酸序列 在诊断，预防和治疗疾病。
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公开(公告)号：US20070141569A1
公开(公告)日：2007-06-21
申请号：US10539962
申请日：2003-12-19
IPC分类号： C12Q1/68 , A61K38/18 , C07K14/475 , C07H21/04 , C12P21/06
CPC分类号： C07K14/61
摘要： This invention relates to a protein, termed INSP105, herein identified as a splice variant of human placental growth hormone and to the use of this protein and nucleic acid sequences from the encoding genes in the diagnosis, prevention and treatment of disease.
摘要翻译： 本发明涉及一种称为INSP105的蛋白质，在本文中被鉴定为人胎盘生长激素的剪接变体，以及来自编码基因的该蛋白质和核酸序列在诊断，预防和治疗疾病中的用途。
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公开(公告)号：US20070021588A1
公开(公告)日：2007-01-25
申请号：US10531751
申请日：2003-10-16
CPC分类号： C07K14/8107
摘要： This invention relates to two proteins, termed INSP087, herein identified as members of the alpha macroglobulin family, in particular as alpha-2-macroglobulin-like proteinase inhibitors, and to the use of these proteins and nucleic acid sequences from the encoding genes in the diagnosis, prevention, and treatment of disease.
摘要翻译： 本发明涉及称为INSP087的两种蛋白质，在本文中被鉴定为α巨球蛋白家族的成员，特别是作为α-2-巨球蛋白样蛋白酶抑制剂，以及来自编码基因的这些蛋白质和核酸序列的使用 诊断，预防和治疗疾病。
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公开(公告)号：US11503888B1
公开(公告)日：2022-11-22
申请号：US16286432
申请日：2019-02-26
申请人： Tania Rodrigues
发明人： Tania Rodrigues
摘要： A carrier for articles has a case with an interior compartment that holds sleeves called pages for holding articles. The pages are accessed when the case is opened. The pages are attached to the case inside the compartment so they may be rotated to access either side. The pages may be detached from the case. A kit comprising a case and a number of detachable and varied pages may be employed to construct a carrier according to the needs of the user.
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