公开(公告)号：US20090018161A1

公开(公告)日：2009-01-15

申请号：US12114125

申请日：2008-05-02

申请人： Tatsuro Tanaka ,  Hisayuki Uneyama ,  Shinichi Fujita ,  Saori Ogawa ,  Yusuke Amino ,  Seiji Shiraishi ,  Koichi Fujita ,  Tatsuhiro Yamada ,  Takashi Yamamoto ,  Takeshi Aihara ,  Manabu Suzuki

发明人： Tatsuro Tanaka ,  Hisayuki Uneyama ,  Shinichi Fujita ,  Saori Ogawa ,  Yusuke Amino ,  Seiji Shiraishi ,  Koichi Fujita ,  Tatsuhiro Yamada ,  Takashi Yamamoto ,  Takeshi Aihara ,  Manabu Suzuki

IPC分类号： A61K31/47 ,  A61K31/16 ,  A61K31/164 ,  A61K31/343 ,  A61K31/4439 ,  G01N33/53 ,  A61P1/00 ,  C12Q1/02 ,  A61K31/221 ,  A61K31/357 ,  A61K31/44

CPC分类号： A61K31/36 ,  A23L33/10 ,  A61K31/165 ,  A61K31/166 ,  A61K31/343

摘要： The present invention provides a more effective gastrointestinal function promoter. The present invention also provides a method for the prophylaxis or improvement of functional gastrointestinal disorders, a method for appetite regulation and the like. The present invention also provides a method for screening for a substance capable of promoting a gastrointestinal function. The present invention provides a gastrointestinal function promoter containing a T1R agonist as an active ingredient and a method for the prophylaxis or improvement of functional gastrointestinal disorders, a method for appetite regulation and the like by administering a T1R agonist. The present invention also provides a method of screening for a substance capable of promoting a gastrointestinal function which method uses a cell expressing T1R receptor.

摘要翻译： 本发明提供了更有效的胃肠功能促进剂。 本发明还提供了预防或改善功能性胃肠道疾病的方法，食欲调节方法等。 本发明还提供了筛选能够促进胃肠功能的物质的方法。 本发明提供了含有T1R激动剂作为活性成分的胃肠功能促进剂和通过施用T1R激动剂来预防或改善功能性胃肠道疾病的方法，食欲调节方法等。 本发明还提供一种筛选能够促进胃肠功能的方法，该方法使用表达T1R受体的细胞。

公开(公告)号：US20090291910A1

公开(公告)日：2009-11-26

申请号：US12470924

申请日：2009-05-22

申请人： Hisayuki Uneyama ,  Tatsuro Tanaka ,  Kunio Torii ,  Shinichi Fujita

发明人： Hisayuki Uneyama ,  Tatsuro Tanaka ,  Kunio Torii ,  Shinichi Fujita

IPC分类号： A61K31/70 ,  A61K31/195

CPC分类号： A61K31/7088 ,  A23L27/235 ,  A23L33/13 ,  A23V2002/00 ,  A61K31/198 ,  A61K31/7068 ,  A61K31/7072 ,  A61K31/7076 ,  A61K31/708 ,  A61K2300/00 ,  A23V2200/32

摘要： The present invention provides an agent and a food for the prophylaxis or improvement of a functional gastrointestinal disorder, which contains, as an active ingredient, at least one kind selected from glutamic acid, 5′-nucleotide and a salt thereof.

摘要翻译： 本发明提供一种用于预防或改善功能性胃肠道疾病的药剂和食品，其含有选自谷氨酸，5'-核苷酸及其盐中的至少一种作为活性成分。

公开(公告)号：US20070218112A1

公开(公告)日：2007-09-20

申请号：US11687805

申请日：2007-03-19

申请人： Hisayuki Uneyama ,  Tatsuro Tanaka ,  Kunio Torii ,  Shinichi Fujita

发明人： Hisayuki Uneyama ,  Tatsuro Tanaka ,  Kunio Torii ,  Shinichi Fujita

IPC分类号： A61K31/7076 ,  A61K31/7072 ,  A61K31/198 ,  A61K47/00

CPC分类号： A61K31/7088 ,  A23L27/235 ,  A23L33/13 ,  A23V2002/00 ,  A61K31/198 ,  A61K31/7068 ,  A61K31/7072 ,  A61K31/7076 ,  A61K31/708 ,  A61K2300/00 ,  A23V2200/32

摘要： The present invention provides an agent and a food for the prophylaxis or improvement of a functional gastrointestinal disorder, which contains, as an active ingredient, at least one kind selected from glutamic acid, 5′-nucleotide and a salt thereof.

摘要翻译： 本发明提供一种用于预防或改善功能性胃肠道疾病的药剂和食品，其含有选自谷氨酸，5'-核苷酸及其盐中的至少一种作为活性成分。

公开(公告)号：US07993668B2

公开(公告)日：2011-08-09

申请号：US11617137

申请日：2006-12-28

申请人： Tatsuro Tanaka ,  Hisayuki Uneyama ,  Kunio Torii ,  Kiyoshi Miwa

发明人： Tatsuro Tanaka ,  Hisayuki Uneyama ,  Kunio Torii ,  Kiyoshi Miwa

IPC分类号： A61K47/00

CPC分类号： A61K31/708 ,  A23L33/13 ,  A23L33/175 ,  A23V2002/00 ,  A61K9/20 ,  A61K31/7068 ,  A61K31/7072 ,  A61K31/7076 ,  A23V2200/32 ,  A23V2250/06

摘要： As a nutritional composition and a composition for the prophylaxis or improvement of lower gastrointestinal function, which improve lower gastrointestinal function and are effective for the prophylaxis or improvement of diarrhea, gastroesophageal reflux or misswallowing caused by administration of a liquid nutritional supplement, the present invention provides a nutritional composition and a composition for the prophylaxis or improvement of lower gastrointestinal function, which comprise at least one kind selected from glutamic acid, 5′-nucleotide and a salt thereof, wherein, when glutamic acid alone is contained, the content thereof on administration is 0.0013-1.3 w/v % as free glutamic acid.

摘要翻译： 作为营养组合物和用于预防或改善较低胃肠功能的组合物，其改善较低的胃肠功能，并且有效预防或改善由施用液体营养补充剂引起的腹泻，胃食管反流或迷失，本发明提供 用于预防或改善下胃肠功能的营养组合物和组合物，其包含选自谷氨酸，5'-核苷酸及其盐中的至少一种，其中，当含有单独的谷氨酸时，其在施用时的含量 为游离谷氨酸为0.0013-1.3w / v％。

公开(公告)号：US08652563B2

公开(公告)日：2014-02-18

申请号：US12038290

申请日：2008-02-27

申请人： Itaru Kon ,  Naoki Hayashi ,  Tatsuro Tanaka ,  Hisayuki Uneyama ,  Shinji Somekawa

发明人： Itaru Kon ,  Naoki Hayashi ,  Tatsuro Tanaka ,  Hisayuki Uneyama ,  Shinji Somekawa

IPC分类号： A23G3/00

CPC分类号： A23L1/296 ,  A23L33/40 ,  A61K35/20

摘要： The present invention relates to a nutrient composition which contains at least a carbohydrate, a lipid, a protein, and a mineral, and is liquid or semisolid, characterized in that the volume-based median size (d50) of particles in the nutrient composition is 5 to 100 μm and water-insoluble particles having a protein insolubilized by a divalent cation are contained as a major component of the nutrient composition, or a nutrient composition which contains at least a carbohydrate, a lipid, a protein, and a mineral, and is liquid or semisolid, characterized in that water-insoluble particles having a protein insolubilized by a divalent cation are contained as a major component of the nutrient composition and the mass of the protein with respect to the total moles of divalent ions forming the water-insoluble particles is 1.5 to 3 g/mmol.

摘要翻译： 本发明涉及至少含有碳水化合物，脂质，蛋白质和矿物质，并且是液体或半固体的营养组合物，其特征在于，营养组合物中颗粒的基于体积的中值大小（d50）为 作为营养组合物的主要成分，含有至少含有碳水化合物，脂质，蛋白质和矿物质的营养成分，含有5〜100μm的具有不溶于二价阳离子的蛋白质的水不溶性粒子，以及 是液体或半固体，其特征在于含有不溶于二价阳离子的蛋白质的水不溶性颗粒作为营养组合物的主要组分，并且蛋白质的质量相对于形成水不溶性的二价离子的总摩尔数 颗粒为1.5〜3g / mmol。

公开(公告)号：US20110136909A1

公开(公告)日：2011-06-09

申请号：US12972670

申请日：2010-12-20

申请人： Toshifumi Imada ,  Shuzhen Hao ,  Tatsuro Tanaka ,  Miki Tomoe ,  Eiichiro Kimura ,  Hisayuki Uneyama ,  Kunio Torii

发明人： Toshifumi Imada ,  Shuzhen Hao ,  Tatsuro Tanaka ,  Miki Tomoe ,  Eiichiro Kimura ,  Hisayuki Uneyama ,  Kunio Torii

IPC分类号： A61K31/198 ,  A61P3/04 ,  A61P3/00

CPC分类号： A23K20/10 ,  A23L33/175 ,  A23L33/30 ,  A23V2002/00 ,  A61K31/13 ,  A61K31/198 ,  A23V2200/30

摘要： Agents for the inhibition, suppression, or prevention of overeating include glutamic acid and/or at least one of its salts, as is or in a carrier or base, and have superior safety at a low price and further have a favorable flavor and are suited for long-term use. Such agents will amplify or sustain a sense of fullness and, further, are effective against appetite stimulation that arises regardless of a sense of fullness with respect to foods that are, for example, sweet or delicious, especially for a person who has a drive for thinness.

摘要翻译： 用于抑制，抑制或预防暴饮暴食的药剂包括谷氨酸和/或其盐中的至少一种，如本发明或载体或碱基，并且以低价格具有优异的安全性，并且还具有有利的风味并且适合 用于长期使用。 这种代理人将会扩大或维持丰满感，并且进一步有效地防止食欲刺激，而不管对于例如甜味或美味的食物，特别是对于有驱动 薄度

公开(公告)号：US20070218109A1

公开(公告)日：2007-09-20

申请号：US11617137

申请日：2006-12-28

申请人： Tatsuro Tanaka ,  Hisayuki Uneyama ,  Kunio Torii ,  Kiyoshi Miwa

发明人： Tatsuro Tanaka ,  Hisayuki Uneyama ,  Kunio Torii ,  Kiyoshi Miwa

IPC分类号： A61K31/7076 ,  A61K31/7072

CPC分类号： A61K31/708 ,  A23L33/13 ,  A23L33/175 ,  A23V2002/00 ,  A61K9/20 ,  A61K31/7068 ,  A61K31/7072 ,  A61K31/7076 ,  A23V2200/32 ,  A23V2250/06

摘要： As a nutritional composition and a composition for the prophylaxis or improvement of lower gastrointestinal function, which improve lower gastrointestinal function and are effective for the prophylaxis or improvement of diarrhea, gastroesophageal reflux or misswallowing caused by administration of a liquid nutritional supplement, the present invention provides a nutritional composition and a composition for the prophylaxis or improvement of lower gastrointestinal function, which comprise at least one kind selected from glutamic acid, 5′-nucleotide and a salt thereof, wherein, when glutamic acid alone is contained, the content thereof on administration is 0.0013-1.3 w/v % as free glutamic acid.

摘要翻译： 作为营养组合物和用于预防或改善较低胃肠功能的组合物，其改善较低的胃肠功能，并且有效预防或改善由施用液体营养补充剂引起的腹泻，胃食管反流或迷失，本发明提供 用于预防或改善下胃肠功能的营养组合物和组合物，其包含选自谷氨酸，5'-核苷酸及其盐中的至少一种，其中，当含有单独的谷氨酸时，其在施用时的含量 为游离谷氨酸为0.0013-1.3w / v％。

公开(公告)号：US20110265678A1

公开(公告)日：2011-11-03

申请号：US13143288

申请日：2009-12-25

申请人： Koichi Sasamoto ,  Shinya Ueda ,  Koichi Enami ,  Satoshi Aoyagi ,  Tatsuro Tanaka

发明人： Koichi Sasamoto ,  Shinya Ueda ,  Koichi Enami ,  Satoshi Aoyagi ,  Tatsuro Tanaka

IPC分类号： B60R21/264

CPC分类号： B60R21/2644 ,  B60R2021/26011

摘要： A gas generator includes an elongated cylindrical housing, a partition plate partitioning the space within the housing into a gas generating agent storing chamber and a filter chamber in the axial direction, and an igniter. A filter is made of a cylindrical member having a hollow portion extending in the axial direction of the housing. The partition plate includes an annular plate portion covering the end face of the filter closer to the gas generating agent storing chamber, a cylindrical portion continuously extending from the inner circumferential edge of the annular plate portion into the hollow portion of the filter to cover the inner circumferential surface of the filter closer to the end face, and a communication hole defined by the inner circumferential surface of the cylindrical portion and providing communication between the gas generating agent storing chamber and the filter chamber. The cylindrical portion has a cross-sectional area that is changed in accordance with an increase in the distance from the annular plate portion. This configuration can provide a gas generator that can be reduced in size and weight and readily be manufactured without deteriorating the performance.

摘要翻译： 气体发生器包括细长的圆柱形壳体，将壳体内的空间沿轴向分隔成气体发生剂储存室和过滤室的隔板以及点火器。 过滤器由具有在壳体的轴向方向延伸的中空部分的圆柱形构件制成。 分隔板包括覆盖靠近气体发生剂储存室的过滤器的端面的环形板部分，从环形板部分的内周边缘连续延伸到过滤器的中空部分中的圆筒部分，以覆盖内部 所述过滤器的周面越靠近所述端面，所述连通孔由所述圆筒部的内周面形成，并提供所述气体发生剂收纳室与所述过滤室的连通。 圆筒部分具有根据与环形板部分的距离的增加而改变的横截面面积。 该构造可以提供能够减小尺寸和重量并容易制造而不降低性能的气体发生器。