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1.发明申请METHOD FOR PROMOTING GASTROINTESTINAL FUNCTION AND METHOD FOR SCREENING FOR PROMOTER OF GASTROINTESTINAL FUNCTION 审中-公开促进胃肠功能的方法和筛查胃肠功能促进剂的方法公开(公告)号：US20090018161A1
公开(公告)日：2009-01-15
申请号：US12114125
申请日：2008-05-02
申请人： Tatsuro Tanaka , Hisayuki Uneyama , Shinichi Fujita , Saori Ogawa , Yusuke Amino , Seiji Shiraishi , Koichi Fujita , Tatsuhiro Yamada , Takashi Yamamoto , Takeshi Aihara , Manabu Suzuki
发明人： Tatsuro Tanaka , Hisayuki Uneyama , Shinichi Fujita , Saori Ogawa , Yusuke Amino , Seiji Shiraishi , Koichi Fujita , Tatsuhiro Yamada , Takashi Yamamoto , Takeshi Aihara , Manabu Suzuki
IPC分类号： A61K31/47 , A61K31/16 , A61K31/164 , A61K31/343 , A61K31/4439 , G01N33/53 , A61P1/00 , C12Q1/02 , A61K31/221 , A61K31/357 , A61K31/44
CPC分类号： A61K31/36 , A23L33/10 , A61K31/165 , A61K31/166 , A61K31/343
摘要： The present invention provides a more effective gastrointestinal function promoter. The present invention also provides a method for the prophylaxis or improvement of functional gastrointestinal disorders, a method for appetite regulation and the like. The present invention also provides a method for screening for a substance capable of promoting a gastrointestinal function. The present invention provides a gastrointestinal function promoter containing a T1R agonist as an active ingredient and a method for the prophylaxis or improvement of functional gastrointestinal disorders, a method for appetite regulation and the like by administering a T1R agonist. The present invention also provides a method of screening for a substance capable of promoting a gastrointestinal function which method uses a cell expressing T1R receptor.
摘要翻译： 本发明提供了更有效的胃肠功能促进剂。 本发明还提供了预防或改善功能性胃肠道疾病的方法，食欲调节方法等。 本发明还提供了筛选能够促进胃肠功能的物质的方法。 本发明提供了含有T1R激动剂作为活性成分的胃肠功能促进剂和通过施用T1R激动剂来预防或改善功能性胃肠道疾病的方法，食欲调节方法等。 本发明还提供一种筛选能够促进胃肠功能的方法，该方法使用表达T1R受体的细胞。
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公开(公告)号：US07517996B2
公开(公告)日：2009-04-14
申请号：US11346426
申请日：2006-02-03
申请人： Takashi Yamamoto , Akira Chiba , Koichi Fujita , Yuka Kataba , Koji Ohsumi , Sayaka Asari , Naoyuki Fukuchi , Misato Noguchi , Itsuya Tanabe , Chiori Ijichi , Naoko Oomuta , Yuko Iida , Satoshi Iwayama
发明人： Takashi Yamamoto , Akira Chiba , Koichi Fujita , Yuka Kataba , Koji Ohsumi , Sayaka Asari , Naoyuki Fukuchi , Misato Noguchi , Itsuya Tanabe , Chiori Ijichi , Naoko Oomuta , Yuko Iida , Satoshi Iwayama
IPC分类号： C07D261/04 , A01N43/80
CPC分类号： A61K31/4245 , A61K31/42 , A61K31/422 , A61K31/425 , A61K31/433
摘要： Azole compounds represented by formula I: wherein ring A is isoxazole and the like, R1 is a substituted or unsubstituted aryl group and the like, R2 is a hydrogen atom and the like, and R3 is a substituted or unsubstituted alkyl group and the like, and pharmaceutically acceptable salts thereof inhibit the physiological activity of lysophosphatidic acid (LPA), and are useful as for the prophylaxis or treatment of diseases in which inhibition of the physiological activity of LPA is useful for the prophylaxis or treatment thereof, such as diseases involving the LPA receptor.
摘要翻译： 由式I表示的唑类化合物：其中环A是异恶唑等，R 1是取代或未取代的芳基等，R 2是氢原子等，R 3是取代或未取代的烷基等， 和其药学上可接受的盐抑制溶血磷脂酸（LPA）的生理活性，并且可用于预防或治疗其中抑制LPA的生理活性用于预防或治疗其的疾病，例如涉及 LPA受体。
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公开(公告)号：US06794378B2
公开(公告)日：2004-09-21
申请号：US10029871
申请日：2001-12-31
申请人： Yukio Iino , Koichi Fujita , Ariko Kodaira , Toshihiro Hatanaka , Kenji Takehana , Tsuyoshi Kobayashi , Atsushi Konishi , Takashi Yamamoto
发明人： Yukio Iino , Koichi Fujita , Ariko Kodaira , Toshihiro Hatanaka , Kenji Takehana , Tsuyoshi Kobayashi , Atsushi Konishi , Takashi Yamamoto
IPC分类号： A61K3133
CPC分类号： C07D213/75 , C07D211/58 , C07D237/22 , C07D239/48 , C07D277/46
摘要： The present invention provides an AP-1 activation inhibitor, a NF-kappaB activation inhibitor, an inflammatory cytokine production inhibitor, a production inhibitor for matrix metalloprotease or an inflammatory cell adhesion factor expression inhibitor, which contains a heterocyclic compound or a pharmaceutically acceptable salt thereof as an active ingredient.
摘要翻译： 本发明提供了含有杂环化合物或其药学上可接受的盐的AP-1活化抑制剂，NF-κB活化抑制剂，炎性细胞因子产生抑制剂，基质金属蛋白酶的产生抑制剂或炎症细胞粘附因子表达抑制剂 作为活性成分。
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公开(公告)号：US07462630B2
公开(公告)日：2008-12-09
申请号：US10787175
申请日：2004-02-27
申请人： Takashi Yamamoto , Seiji Niwa , Kayo Otani , Seiji Ohno , Hajime Koganei , Satoshi Iwayama , Akira Takahara , Yukitsugu Ono , Tomoko Takeda , Shinichi Fujita , Keiko Moki
发明人： Takashi Yamamoto , Seiji Niwa , Kayo Otani , Seiji Ohno , Hajime Koganei , Satoshi Iwayama , Akira Takahara , Yukitsugu Ono , Tomoko Takeda , Shinichi Fujita , Keiko Moki
IPC分类号： A61K31/445 , C07D409/14
CPC分类号： C07D295/205 , C07C237/06 , C07C271/20 , C07C271/22 , C07D211/70 , C07D401/04 , C07D401/12 , C07D405/12 , C07D409/04 , C07D417/06
摘要： The invention relates to a compound represented by the following general formula (1) or its analogue, which selectively inhibit N-type calcium channels or its analogue, and to a method for treating pain etc. comprising the compound represented by the following general formula (1) or its analogue to a patient in need of such treatment: wherein, A represents CH═CH, etc., a, b, c and d represents CH etc., R1, R2, R3, R4, R5 and R6 represents H etc., V—W represents C═C, etc., n represents 0 to 3, Y1 represents O etc., B represents —(CH2)vCHR21 wherein v is 0 to 3, R21 represents H, a lower alkyl group or the like, etc., G represents —CO—, a covalent bond, etc., m is 0 to 6, R7 and R8 represents H, a lower alkyl group, —COR18a, —COOR20 wherein R18a and R20 each represents a lower alkyl group or the like, etc.
摘要翻译： 本发明涉及由以下通式（1）表示的化合物或其类似物，其选择性地抑制N-型钙通道或其类似物，以及涉及治疗疼痛等的方法，其包含由以下通式表示的化合物 1）或其与需要这种治疗的患者的类似物：其中A表示CH-CH等，a，b，c和d表示CH等，R 1，R 2，R 3，R 4，R 5和R 6表示H 等等，VW表示CC等，n表示0〜3，Y1表示O等，B表示 - （CH2）vCHR21，其中v为0-3，R21表示H，低级烷基等。 ，G表示-CO-，共价键等，m为0〜6，R7和R8表示H，低级烷基，-COR18a，-COOR20，其中R18a和R20各自表示低级烷基等， 等等
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公开(公告)号：US08278329B2
公开(公告)日：2012-10-02
申请号：US11924997
申请日：2007-10-26
申请人： Takashi Yamamoto , Seiji Niwa , Kayo Otani , Seiji Ohno , Hajime Koganei , Satoshi Iwayama , Akira Takahara , Yukitsugu Ono , Tomoko Takeda , Shinichi Fujita , Keiko Moki
发明人： Takashi Yamamoto , Seiji Niwa , Kayo Otani , Seiji Ohno , Hajime Koganei , Satoshi Iwayama , Akira Takahara , Yukitsugu Ono , Tomoko Takeda , Shinichi Fujita , Keiko Moki
IPC分类号： A61K31/445 , C07D211/18
CPC分类号： C07D295/205 , C07C237/06 , C07C271/20 , C07C271/22 , C07D211/70 , C07D401/04 , C07D401/12 , C07D405/12 , C07D409/04 , C07D417/06
摘要： The invention relates to a compound represented by the following general formula (1) or its analogue, which selectively inhibit N-type calcium channels or its analogue, and to a method for treating pain etc. comprising the compound represented by the following general formula (1) or its analogue to a patient in need of such treatment: wherein, A represents CH═CH, etc., a, b, c and d represents CH etc., R1, R2, R3, R4, R5 and R6 represents H etc., V—W represents C═C, etc., n represents 0 to 3, Y1 represents O etc., B represents —(CH2)vCHR21 wherein v is 0 to 3, R21 represents H, a lower alkyl group or the like, etc., G represents —CO—, a covalent bond, etc., m is 0 to 6, R7 and R8 represents H, a lower alkyl group, —COR18a, —COOR20 wherein R18a and R20 each represents a lower alkyl group or the like, etc.
摘要翻译： 本发明涉及由以下通式（1）表示的化合物或其类似物，其选择性地抑制N-型钙通道或其类似物，以及涉及治疗疼痛等的方法，其包含由以下通式表示的化合物 1）或其与需要这种治疗的患者的类似物：其中A表示CH = CH等，a，b，c和d表示CH等，R 1，R 2，R 3，R 4，R 5和R 6表示H 等等，V-W表示C = C等，n表示0〜3，Y 1表示O等，B表示 - （CH 2）v CHR 21，其中v为0〜3，R 21表示H，低级烷基或 G等表示-CO-，共价键等，m为0〜6，R7和R8表示H，低级烷基，-COR18a，-COOR20，其中R18a和R20各自表示低级烷基 或类似物等
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公开(公告)号：US10239106B2
公开(公告)日：2019-03-26
申请号：US14781151
申请日：2014-04-01
摘要： A spinning method includes supporting a supported portion of a cylindrical work by a work supporting portion; pressing a first roller of a spinning head against a processed portion of the work while revolving the first roller; and performing a forming process that points a tube axis of the processed portion of the work in a given direction by pressing the first roller and a second roller in which a plane of revolution thereof is provided in a different position, in a rotational axis direction of a spindle of the spinning head, than a plane of revolution of the first roller, while revolving the first roller and the second roller, and moving the work supporting portion relative to the spinning head or moving the spinning head relative to the work supporting portion, while the first roller and the second roller work in cooperation with each other to retain the work.
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公开(公告)号：US09176311B2
公开(公告)日：2015-11-03
申请号：US13192803
申请日：2011-07-28
申请人： Takashi Yamamoto
发明人： Takashi Yamamoto
CPC分类号： G02B21/14
摘要： A microscope control device includes an offset processing unit that corrects phase contrast information regarding a phase contrast between corresponding phase contrast images, which is generated based on a set of the phase contrast images of a sample which are captured by a microscope, based on offset information of phase contrasts caused by optical distortions unique to the microscope, and a defocus amount calculation unit that calculates a defocus amount of the sample on the basis of the phase contrast information after offset correction.
摘要翻译： 显微镜控制装置包括偏移处理单元，该偏移处理单元基于偏移信息校正基于由显微镜拍摄的样本的一组相位对比图像而生成的相应对比图像之间的相位对比度的相位对比度信息 由显微镜独有的光学失真引起的相位对比度，以及散焦量计算单元，其基于偏移校正后的相位差信息来计算样本的散焦量。
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公开(公告)号：US20150232877A1
公开(公告)日：2015-08-20
申请号：US14435381
申请日：2013-10-14
发明人： Ruth Cong , Takashi Yamamoto , Yi Zheng
IPC分类号： C12N15/82 , C07K14/245 , C07K14/325
CPC分类号： C12N15/8286 , C07K14/245 , C07K14/325 , C07K2319/20 , C07K2319/35 , C07K2319/55 , Y02A40/162
摘要： Methods and compositions for enhancing the resistance of plants to plant pests are provided. Chimeric pesticidal polypeptides and nucleic acid molecules encoding the chimeric pesticidal polypeptides are provided. The chimeric pesticidal polypeptides comprising a solubility-enhancing polypeptide operably linked to a polypeptide comprising pesticidal activity. The nucleic acid molecules can be used in expression cassettes for making transformed plants with enhanced resistance to plant pests. Further provided are transformed plants, plant tissues, plant cells, other host cells, and seeds as well as pesticidal compositions.
摘要翻译： 提供了用于增强植物对植物害虫的抗性的方法和组合物。 提供嵌合农药多肽和编码嵌合杀虫多肽的核酸分子。 所述嵌合杀虫多肽包含可操作地连接于包含杀虫活性的多肽的溶解度增强多肽。 核酸分子可用于表达盒中，用于制备对植物害虫具有增强抗性的转化植物。 进一步提供了转化植物，植物组织，植物细胞，其他宿主细胞和种子以及杀虫组合物。
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公开(公告)号：US09109231B2
公开(公告)日：2015-08-18
申请号：US13370408
申请日：2012-02-10
申请人： Ericka Bermudez , Ruth Cong , Jingtong Hou , Takashi Yamamoto
发明人： Ericka Bermudez , Ruth Cong , Jingtong Hou , Takashi Yamamoto
IPC分类号： C12N15/82 , C07K14/325 , A01N37/46 , A01N63/02
CPC分类号： C12N15/8286 , A01N37/46 , A01N63/02 , C07K14/325 , Y02A40/162
摘要： Traditionally, the primary method for impacting insect pest populations is the application of broad-spectrum chemical insecticides. However, there is increasing concern about the environmental hazards associated with the production and use of synthetic chemical pesticides. Thus, there is substantial interest in developing alternative pesticides, including biological control of insect pests of agricultural significance using a microbial agent or another species of insect. The present invention provides compositions and methods for such biological control. Modified Cry3 pesticidal polypeptides, polynucleotides encoding such polypeptides, and methods of use are disclosed. The modified polynucleotides provided herein can be used to transform organisms and cells of hosts comprising plant, insects, and microorganisms. The expression of modified polypeptides can provide the host with improved insecticidal activity against one or more insect pathogens.
摘要翻译： 传统上，影响昆虫害虫种群的主要方法是应用广谱化学杀虫剂。 然而，对生产和使用合成化学农药的环境危害越来越受到关注。 因此，使用微生物剂或其他昆虫种类开发替代农药，包括对具有农业意义的害虫的生物防治具有重大意义。 本发明提供了用于这种生物学控制的组合物和方法。 公开了修饰的Cry3杀虫多肽，编码这些多肽的多核苷酸和使用方法。 本文提供的修饰的多核苷酸可用于转化包含植物，昆虫和微生物的宿主的生物体和细胞。 修饰的多肽的表达可以为宿主提供对一种或多种昆虫病原体的改善的杀虫活性。
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公开(公告)号：USD731381S1
公开(公告)日：2015-06-09
申请号：US29478651
申请日：2014-01-07
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