公开(公告)号：US5110738A

公开(公告)日：1992-05-05

申请号：US132687

申请日：1987-12-14

申请人： Tatsuya Takano ,  Ryoichi Hashida ,  Keiji Nakagami ,  Junji Kimura

发明人： Tatsuya Takano ,  Ryoichi Hashida ,  Keiji Nakagami ,  Junji Kimura

IPC分类号： G01N33/577 ,  A61K38/00 ,  A61K39/395 ,  A61P9/10 ,  C07K14/005 ,  C07K14/195 ,  C07K16/00 ,  C07K16/18 ,  C07K19/00 ,  C12N5/10 ,  C12N15/02 ,  C12P21/08 ,  C12R1/91

CPC分类号： C07K16/18 ,  A61K38/00 ,  Y10S530/809

摘要： The present invention is concerned with a monoclonal antibody capable of preferentially recognizing arteriosclerotic lesions and prepared from a hybridoma obtained by fusing myeloma cells and cells capable of producing antibodies against arteriosclerotic lesions, such as spleen cells, peripheral lymphocyte of thymus and peripheral vascular cells, the antibody can be to use as an agent for detecting the presence of arteriosclerotic lesions and for treating arteriosclerosis.

摘要翻译： 本发明涉及能够优先识别动脉硬化病变的单克隆抗体，其由通过融合骨髓瘤细胞和能够产生针对动脉硬化病变的抗体的细胞获得的杂交瘤制备，所述细胞如脾细胞，胸腺周边淋巴细胞和外周血管细胞， 抗体可以用作检测动脉硬化病变的存在并用于治疗动脉硬化的药剂。