公开(公告)号：US20150139963A1

公开(公告)日：2015-05-21

申请号：US14479385

申请日：2014-09-08

Applicant: Tel HaShomer Medical Research Infrastructure and Services Ltd.

Inventor： Benjamin DEKEL ,  Orit HARARI-STEINBERG

IPC: A61K35/22 ,  C12N5/071

CPC classification number: A61K35/22 ,  C12N5/0686 ,  C12N5/0687 ,  C12N5/0696 ,  C12N15/85 ,  C12N2500/90 ,  C12N2501/06 ,  C12N2501/065 ,  C12N2501/415 ,  C12N2506/25

Abstract: Isolated populations of fetal renal stem cells and progenitor cells are provided. Also provided are methods of generating and using these isolated populations of cells.

Abstract translation: 提供了分离的胎儿肾干细胞和祖细胞。 还提供了产生和使用这些分离的细胞群体的方法。

公开(公告)号：US20210163591A1

公开(公告)日：2021-06-03

申请号：US17263251

申请日：2019-07-25

Applicant: Tel HaShomer Medical Research Infrastructure and Services Ltd. ,  Tageza Biopharmaceuticals Ltd.

Inventor： Benjamin DEKEL ,  Orit HARARI-STEINBERG

IPC: C07K16/28 ,  G01N33/574 ,  A61K35/17 ,  C12Q1/6886 ,  A61K47/68

Abstract: Methods of treating cancer are provided. Accordingly, there is provided a method of treating cancer in a subject in need thereof, the method comprising administering to the subject an effective amount of an agent capable of (i) specifically binding GABRA2, the agent comprising a therapeutic moiety; and/or (ii) downregulating activity and/or expression of said GABRA2. Also provided are compositions, article of manufactures and methods of diagnosing cancer and monitoring cancer treatment.

公开(公告)号：US20180042965A1

公开(公告)日：2018-02-15

申请号：US15728508

申请日：2017-10-10

Applicant: Tel HaShomer Medical Research Infrastructure and Services Ltd.

Inventor： Benjamin DEKEL ,  Orit HARARI-STEINBERG

IPC: A61K35/22 ,  C12N5/074 ,  C12N5/071 ,  C12N15/85

CPC classification number: A61K35/22 ,  C12N5/0686 ,  C12N5/0687 ,  C12N5/0696 ,  C12N15/85 ,  C12N2500/90 ,  C12N2501/06 ,  C12N2501/065 ,  C12N2501/415 ,  C12N2506/25

Abstract: Isolated populations of fetal renal stem cells and progenitor cells are provided. Also provided are methods of generating and using these isolated populations of cells.

公开(公告)号：US20170199195A1

公开(公告)日：2017-07-13

申请号：US15320847

申请日：2015-06-25

Applicant: Tel HaShomer Medical Research Infrastructure and Services Ltd.

Inventor： Benjamin DEKEL ,  Orit HARARI-STEINBERG

IPC: G01N33/574 ,  A61K31/275 ,  C12Q1/68

CPC classification number: G01N33/57407 ,  A61K31/275 ,  C12Q1/6886 ,  C12Q2600/158 ,  G01N33/5073 ,  G01N33/5088 ,  G01N33/57484 ,  G01N2333/90203

Abstract: A method of identifying cancer stem cell markers in a human primary tumor is disclosed. The method comprises: (a) in vivo passaging the primary tumor; and (b) comparing a level of at least one antigen in a first population of passaged tumor cells of the primary tumor with a second population of tumor cells of the primary tumor, wherein an increase in the amount of the antigen in the first population of tumor cells as compared to the amount of the antigen in the second population of tumor cells is indicative of a cancer stem cell marker in the human primary tumor.

公开(公告)号：US20230390339A1

公开(公告)日：2023-12-07

申请号：US18249469

申请日：2021-10-19

Applicant: TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD.

Inventor： Benjamin DEKEL ,  Dorit OMER ,  Orit HARARI-STEINBERG

IPC: A61K35/22 ,  C12N5/071 ,  A61P13/12 ,  G01N33/50

CPC classification number: A61K35/22 ,  C12N5/0686 ,  A61P13/12 ,  G01N33/5082 ,  G01N2333/165 ,  G01N2800/52 ,  C12N2500/40

Abstract: A nephrospheroid comprising urine-derived epithelial cells, the nephrospheroid is capable of forming a tubular nephric tissue upon transplantation. Also provided are methods of producing the nephrospheroid and using same.

公开(公告)号：US20230051170A1

公开(公告)日：2023-02-16

申请号：US17795270

申请日：2021-01-25

Applicant: KIDNEYCURE LTD ,  TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD

Inventor： Masha SIMANOVSKY ,  Benjamin DEKEL

IPC: C12N5/071 ,  A61K35/22 ,  A61P13/12 ,  A61K9/00

Abstract: Embodiments described herein relate to a method for preparing cultured cells, the method comprising: obtaining kidney tissue from a human subject; mechanically dissociating the tissue; subjecting the tissue to enzymatic digestion; incubating the tissue with media in a cell culture plate to form cultured cells.

公开(公告)号：US20160326245A1

公开(公告)日：2016-11-10

申请号：US15109173

申请日：2015-01-01

Applicant: TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD.

Inventor： Benjamin DEKEL ,  Naomi PODE-SHAKKED ,  Orit HARARI-STEINBERG ,  Michal MARK-DANIELI ,  Einav VAX

IPC: C07K16/28 ,  C07K16/30

CPC classification number: C07K16/28 ,  A61K2039/505 ,  C07K16/30 ,  C07K16/3038 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/73

Abstract: The invention provides antibodies or an antigen-binding portion thereof, which recognize the human Frizzled 7 receptor. Further, the invention provides methods of using these antibodies for the treatment cancer in a subject.

Abstract translation: 本发明提供识别人Frizzled 7受体的抗体或其抗原结合部分。 此外，本发明提供了使用这些抗体治疗受试者的癌症的方法。

公开(公告)号：US20140011280A1

公开(公告)日：2014-01-09

申请号：US14027256

申请日：2013-09-16

Applicant: Tel HaShomer Medical Research Infrastructure and Services Ltd.

Inventor： Benjamin DEKEL ,  Orit Harari-Steinberg

IPC: C12N5/074 ,  C12N15/85

CPC classification number: A61K35/22 ,  C12N5/0686 ,  C12N5/0687 ,  C12N5/0696 ,  C12N15/85 ,  C12N2500/90 ,  C12N2501/06 ,  C12N2501/065 ,  C12N2501/415 ,  C12N2506/25

Abstract: A method of reprogramming a differentiated renal cell towards a progenitor phenotype is disclosed. The method comprises up-regulating in the differentiated renal cell an expression of at least one pluripotency associated gene and/or at least one renal stem cell associated gene, thereby reprogramming the differentiated renal cell towards a progenitor phenotype. Cell populations generated thereby and uses thereof are also disclosed.

Abstract translation: 公开了将分化的肾细胞重新编程为祖细胞表型的方法。 所述方法包括在分化的肾细胞中上调至少一个多能性相关基因和/或至少一个肾干细胞相关基因的表达，从而将分化的肾细胞重新编程为祖细胞表型。 还公开了由此产生的细胞群体及其用途。