公开(公告)号：US20100292580A1

公开(公告)日：2010-11-18

申请号：US12447194

申请日：2007-10-25

申请人： Terence J. Gilhuly ,  Scott Benjamin ,  David Morgan ,  Pierre Lane ,  Peter Whitehead ,  Ricardo Romero

发明人： Terence J. Gilhuly ,  Scott Benjamin ,  David Morgan ,  Pierre Lane ,  Peter Whitehead ,  Ricardo Romero

IPC分类号： A61B19/08 ,  A61B19/10 ,  A61B1/32 ,  A61B6/00

CPC分类号： A61B17/02 ,  A61B17/42 ,  A61B46/10 ,  A61B2090/036 ,  A61B2090/304

摘要： Septic barriers interposed between a target tissue such as an oral or vaginal cavity, exposed epidermis, or wound or surgical site, and a user and his/her optical interrogation instruments to reduce cross-infection and/or contamination. In certain embodiments, the septic barrier is substantially transparent for viewing purposes and is typically effectively non-fluorescent, particularly when used for investigating autofluorescence or other fluorescence emanating from a target, so as to have little or no effect on the measurements and observations being made. The sepsis barrier can comprises a window through which the user sees the tissue, a frame holding the window, and an attachment structure, such as threads or bayonet attachment, configured to connect the barrier to the instrument. If desired, the system can also have an optional attachment mechanism for permanent or temporary connection of a further instrument to the frame, such as a tissue retractor configured to aid manipulation of the target tissue.

摘要翻译： 插入在诸如口腔或阴道腔的目标组织，暴露的表皮或伤口或手术部位之间的化脓性屏障以及用户和他/她的光学询问仪器以减少交叉感染和/或污染。 在某些实施方案中，脓毒性屏障对于观察目的基本上是透明的，并且通常是有效的非荧光的，特别是当用于研究自发荧光或从目标发出的其它荧光时，对所测量和观察结果几乎没有或没有影响 。 脓毒症屏障可以包括用户看到组织的窗户，保持窗口的框架，以及被配置为将屏障连接到仪器的附接结构，例如螺纹或卡口附件。 如果需要，系统还可以具有用于将另一仪器永久或临时连接到框架的可选附接机构，例如构造成辅助操纵目标组织的组织牵缩器。

公开(公告)号：US20080004497A1

公开(公告)日：2008-01-03

申请号：US11402284

申请日：2006-04-10

申请人： Peter Whitehead ,  Pierre Lane

发明人： Peter Whitehead ,  Pierre Lane

IPC分类号： A61B1/00

CPC分类号： A61B1/303 ,  A61B1/06 ,  A61B1/0653 ,  A61B1/32

摘要： Devices, systems and methods providing speculums constructed to be substantially or completely non-fluorescent. The speculums can be, for example, constructed entirely of non-fluorescent material such as very dark (e.g., black, dark charcoal gray, navy blue) plastic. The speculums can also be any given material and coated with a substantially non-fluorescing material such as a low-fluorescent paint or laminate, or otherwise constructed and configured in any desired manner providing the feature(s) discussed herein.

摘要翻译： 提供构造为基本上或完全非荧光的窥器的装置，系统和方法。 窥器可以例如完全由非荧光材料构成，例如非常暗的（例如，黑色，深色炭灰色，深蓝色）塑料。 窥器也可以是任何给定的材料并且涂覆有基本上不发荧光的材料，例如低荧光漆或层压板，或以任何期望的方式构造和配置以提供本文所讨论的特征。

公开(公告)号：US20080045799A1

公开(公告)日：2008-02-21

申请号：US11786462

申请日：2007-04-10

申请人： Peter Whitehead ,  Terence Gilhuly ,  Pierre Lane

发明人： Peter Whitehead ,  Terence Gilhuly ,  Pierre Lane

IPC分类号： A61B1/06

CPC分类号： A61B5/444 ,  A61B1/06 ,  A61B5/0059 ,  A61B5/0071 ,  A61B5/0088 ,  A61B2560/0443

摘要： An autofluorescence light examination system having a plurality of modular parts includes a main body, a light source, and at least two detachable instruments. The main body is configured to deliver light to a target tissue and contains at least one optical element configured so that a user can directly view the target tissue through the main body while the target tissue is illuminated by the light source. The main body is further configured to accept at least two detachable instruments that are configured to deliver light to at least two different target tissues located at at least two different areas of the body and configured such that a user can directly view the target tissue through the main body while the target tissue is illuminated by the light source.

摘要翻译： 具有多个模块化部件的自发荧光检查系统包括主体，光源和至少两个可拆卸的装置。 主体被配置为将光传送到目标组织并且包含至少一个光学元件，其被配置为使得当目标组织被光源照射时，用户可以通过主体直接观看目标组织。 主体还被配置为接受至少两个可分离的仪器，其被配置为将光传送到位于身体的至少两个不同区域的至少两个不同的目标组织，并且被配置为使得用户可以直接观察目标组织 主体，而目标组织被光源照射。

公开(公告)号：US20050269523A1

公开(公告)日：2005-12-08

申请号：US11185069

申请日：2005-07-19

申请人： Calum MacAulay ,  Pierre Lane

发明人： Calum MacAulay ,  Pierre Lane

IPC分类号： G01N21/27 ,  G01N21/64

CPC分类号： G01N21/274 ,  G01N21/6452 ,  G01N2201/12792

摘要： Microarray readers and methods that compensate for target spots that are too dim or too bright for the microarray reader to accurately measure. The readers adjust the amount of light directed at or received from specific non-acceptable target spots, such that dim spots receive more excitation light and overly bright spots receive less. This increases or decreases, respectively, their measured brightness, which in turn effectively increases the range over which a microarray reader can accurately measure the spots, and can also improve the signal-to-noise ratio and other aspects of the measurements.

摘要翻译： 微阵列阅读器和补偿微阵列阅读器准确测量的目标斑点太暗或太亮的方法。 读者调节指向或从特定不可接受的目标点接收的光量，使得暗点接收更多的激发光并且过亮点接收较少。 它们分别增加或减少它们的测量亮度，这反过来有效地增加了微阵列读取器可精确测量斑点的范围，并且还可以提高测量的信噪比和其他方面。

公开(公告)号：US08668640B2

公开(公告)日：2014-03-11

申请号：US12259232

申请日：2008-10-27

申请人： Calum E. MacAulay ,  Andrew L. P. Dlugan ,  Pierre Lane

发明人： Calum E. MacAulay ,  Andrew L. P. Dlugan ,  Pierre Lane

IPC分类号： A61B1/07 ,  A61B1/00 ,  G02B6/06

CPC分类号： A61B1/00172 ,  A61B1/00165 ,  A61B1/07 ,  G02B6/06 ,  G02B21/0028 ,  G02B21/0032 ,  G02B21/0056 ,  G02B21/0072 ,  G02B23/2453 ,  G02B23/26

摘要： Endoscopes and other viewing devices that control the light that contacts a sample and/or that is detected emanating from a sample. The viewing devices are particularly well suited for in vivo imaging, although other uses are also included. The viewing devices, and methods related thereto, comprise a spatial light modulator in the illumination and/or detection light path so that light transmitted to the target via a bundle of light guides or optical system is transmitted substantially only into the cores of the light guide bundle and not into the cladding surrounding the light guides, filler between the light guides in the bundle, or undesired light guides. Also, methods and apparatus for mapping the pixels of the spatial light modulator to the cores of the light guides in the bundle (preferably at least 3 pixels (e.g., at least 3 mirrors for a digital micromirror device) for each core), as well as for mapping the light guides of one light guide bundle to another.

摘要翻译： 内窥镜和其他观察装置，其控制接触样品的光和/或从样品发出的光。 观察装置特别适用于体内成像，尽管也包括其它用途。 观察装置及其相关方法包括在照明和/或检测光路中的空间光调制器，使得经由一束光导或光学系统传输到目标的光基本上仅被传输到光导的核心 束并且不包围围绕光导的包层，束中的光导之间的填充物或不期望的光导。 此外，用于将空间光调制器的像素映射到束中的光导体的核心（优选地，每个核心的至少3个像素（例如，用于数字微镜器件的至少3个反射镜））的方法和装置）以及 用于将一个光导束的光导映射到另一个。

公开(公告)号：US20070258122A1

公开(公告)日：2007-11-08

申请号：US11576816

申请日：2005-10-05

申请人： Ravil Chamgoulov ,  Pierre Lane ,  Michael Tsiroulnikov ,  Calum Macaulay

发明人： Ravil Chamgoulov ,  Pierre Lane ,  Michael Tsiroulnikov ,  Calum Macaulay

IPC分类号： G02B26/08 ,  G06F19/00

CPC分类号： G02B21/0036 ,  G02B21/0048 ,  G02B21/006

摘要： An optical computed-tomography microscope for three-dimensional (3-D) imaging employs tomographic reconstruction for image acquisition. The microscope has an optical scanner to vary an angle at which a light beam passes through a specimen. A method for limited-angle computed-tomography reconstruction applies a transform to produce an image from a number of projections. The image is iteratively feedback-corrected.

摘要翻译： 用于三维（3-D）成像的光学计算机断层摄影显微镜使用用于图像采集的断层重建。 显微镜具有用于改变光束通过样本的角度的光学扫描器。 用于限定角度计算机断层摄影重建的方法应用变换来从多个投影产生图像。 图像被迭代地反馈校正。