公开(公告)号：US20050067280A1

公开(公告)日：2005-03-31

申请号：US10674955

申请日：2003-09-30

申请人： Terence Reid ,  Shridhara Karika ,  Milind Nagale ,  Yi Wang ,  Gurdial Sanghera

发明人： Terence Reid ,  Shridhara Karika ,  Milind Nagale ,  Yi Wang ,  Gurdial Sanghera

IPC分类号： G01N27/403 ,  G01N27/26

CPC分类号： G01N27/3272

摘要： An electrochemical cell for detection and quantification of analytes in a liquid sample, particularly a liquid sample having a small volume. In a preferred embodiment, the electrochemical cell comprises an assembly of conducting layers and insulating layers. The electrochemical cell can be formed by depositing conducting materials and insulating materials in alternating layers on an insulating substrate. It is preferred that the layer furthest from the insulating substrate be an insulating layer to minimize the damage of the conducting layers during handling of the electrochemical cell. A passage can be formed through the conducting layers and the insulating layers to expose the edges of the layers, which collectively form the wall or walls of the passage. The exposed edges of the conducting layers form the electrodes of the electrochemical cell. The electrochemical cell comprises at least one working electrode and at least one other electrode, e.g., a dual-purpose reference/counter electrode. In another embodiment, the assembly of conducting layers and insulating layers can be formed on both major surfaces of the insulating substrate. The assembly can comprise at least one working electrode and at least one other electrode, e.g., a dual-purpose reference/counter electrode.

摘要翻译： 一种电化学电池，用于检测和定量液体样品中的分析物，特别是具有小体积的液体样品。 在优选实施例中，电化学电池包括导电层和绝缘层的组件。 电化学电池可以通过在绝缘基板上交替地沉积导电材料和绝缘材料来形成。 优选地，离绝缘基板最远的层是绝缘层，以在处理电化学电池期间最小化导电层的损伤。 可以通过导电层和绝缘层形成通道以暴露层的边缘，这些边缘共同形成通道的壁或壁。 导电层的暴露边缘形成电化学电池的电极。 电化学电池包括至少一个工作电极和至少一个其它电极，例如双用途参考/对电极。 在另一个实施例中，导电层和绝缘层的组合可以形成在绝缘基板的两个主表面上。 该组件可以包括至少一个工作电极和至少一个其它电极，例如双用途参考/对电极。

公开(公告)号：US5162289A

公开(公告)日：1992-11-10

申请号：US674444

申请日：1991-03-25

申请人： Gillian H. Betts ,  Terence Reid

发明人： Gillian H. Betts ,  Terence Reid

IPC分类号： B41M5/124

CPC分类号： B41M5/124

摘要： A subcoat of plastic pigment particles and a binder is provided beneath the microcapsule coating of otherwise conventional pressure-sensitive copying paper of the CB or CFB type. The plastic pigment particles may be hollow or solid. Inorganic pigment particles are preferably also present in the subcoat. The binder may be a mixture of styrene/butadiene latex and polyvinyl alcohol. The subcoat typically has a coatweight of 3 to 6 g m.sup.-2. The presence of the plastic pigment subcoat improves copying intensity, or permits a desired given copy intensity to be obtained at a lower microcapsule coatweight.

公开(公告)号：US20070029240A1

公开(公告)日：2007-02-08

申请号：US11545373

申请日：2006-10-10

申请人： Terence Reid

发明人： Terence Reid

IPC分类号： C02F3/30

CPC分类号： C02F3/006 ,  C02F3/30 ,  C02F3/301 ,  C02F3/308 ,  C02F2209/04 ,  C02F2209/16 ,  C02F2209/18 ,  C02F2209/44 ,  Y02W10/15 ,  Y10S210/903 ,  Y10S210/906

摘要： The inventions describe a phased activated sludge treatment system that incorporates elements of batch treatment technology into a flow-through treatment process. Control of mixing and aeration systems are independent to facilitate the operation of the main reactor vessel in alternating aerated and anoxic conditions. Conditioning vessels in communication with the main reactor are employed to preferentially control the distribution and balance of nitrogen and phosphorus compounds in the reactor and to remove such biological nutrients concurrently with BOD and TSS in the wastewater. The inventions provide the beneficial results of providing greater operator control of flow-through treatment processes, power saving and reduced operation and maintenance costs in comparison to conventional flow-through treatment technologies.

公开(公告)号：US09447152B2

公开(公告)日：2016-09-20

申请号：US13002717

申请日：2009-07-06

申请人： James Anthony Clarke ,  Lakmal Jayasinghe ,  Terence Reid ,  John Hagan Pryce Bayley

发明人： James Anthony Clarke ,  Lakmal Jayasinghe ,  Terence Reid ,  John Hagan Pryce Bayley

IPC分类号： C12Q1/68 ,  C07K14/245

CPC分类号： C07K14/245 ,  C12Q1/6869 ,  C12Q2565/631

摘要： The invention relates to a mutant α-hemolysin (α-HL) pore which is useful for detecting one or more nucleotides by stochastic sensing. The pore is particularly useful for sequencing DNA or RNA. A molecular adaptor that allows detection of the nucleotide(s) is covalently attached to the pore. The pore is specifically modified to facilitate positioning of the adaptor and may be modified to facilitate covalent attachment.

摘要翻译： 本发明涉及用于通过随机感测检测一个或多个核苷酸的突变α-溶血素（α-HL）孔。 该孔特别适用于测序DNA或RNA。 允许检测核苷酸的分子衔接子共价连接到孔。 孔被特别地修改以便于适配器的定位并且可以被修改以促进共价附着。

公开(公告)号：US20110177498A1

公开(公告)日：2011-07-21

申请号：US13002717

申请日：2009-07-06

申请人： James Clarke ,  Lakmal Jayasinghe ,  Terence Reid ,  Hagan Bayley

发明人： James Clarke ,  Lakmal Jayasinghe ,  Terence Reid ,  Hagan Bayley

IPC分类号： C12Q1/68 ,  C07K14/195 ,  C07H21/04 ,  C12P21/00

CPC分类号： C07K14/245 ,  C12Q1/6869 ,  C12Q2565/631

摘要： The invention relates to a mutant α-hemolysin (α-HL) pore which is useful for detecting one or more nucleotides by stochastic sensing. The pore is particularly useful for sequencing DNA or RNA. A molecular adaptor that allows detection of the nucleotide(s) is covalently attached to the pore. The pore is specifically modified to facilitate positioning of the adaptor and may be modified to facilitate covalent attachment.

摘要翻译： 本发明涉及用于通过随机感测检测一个或多个核苷酸的突变α-溶血素（α-HL）孔。 该孔特别适用于测序DNA或RNA。 允许检测核苷酸的分子衔接子共价连接到孔。 孔被特别地修改以便于适配器的定位并且可以被修改以促进共价附着。

公开(公告)号：US20060049103A1

公开(公告)日：2006-03-09

申请号：US10937863

申请日：2004-09-09

申请人： Terence Reid

发明人： Terence Reid

IPC分类号： C02F3/30

CPC分类号： C02F3/006 ,  C02F3/30 ,  C02F3/301 ,  C02F3/308 ,  C02F2209/04 ,  C02F2209/16 ,  C02F2209/18 ,  C02F2209/44 ,  Y02W10/15 ,  Y10S210/903 ,  Y10S210/906

摘要： The inventions describe a phased activated sludge treatment system that incorporates elements of batch treatment technology into a flow-through treatment process. Control of mixing and aeration systems are independent to facilitate the operation of the main reactor vessel in alternating aerated and anoxic conditions. Conditioning vessels in communication with the main reactor are employed to preferentially control the distribution and balance of nitrogen and phosphorus compounds in the reactor and to remove such biological nutrients concurrently with BOD and TSS in the wastewater. The inventions provide the beneficial results of providing greater operator control of flow-through treatment processes, power saving and reduced operation and maintenance costs in comparison to conventional flow-through treatment technologies.

摘要翻译： 本发明描述了将分批处理技术的元件结合到流通处理过程中的分阶段活性污泥处理系统。 混合和曝气系统的控制是独立的，以便于交替充气和缺氧条件下主反应堆容器的运行。 使用与主反应器连通的调节容器优先控制反应器中氮磷化合物的分布和平衡，并与废水中的BOD和TSS同时除去这些生物营养物质。 与传统的流通处理技术相比，本发明提供了更好的操作者控制流通处理过程，省电和降低操作和维护成本的有益结果。