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    TRANSDERMAL THERAPEUTIC SYSTEM HAVING STABILIZED MEMBRANE
    5.
    发明申请
    TRANSDERMAL THERAPEUTIC SYSTEM HAVING STABILIZED MEMBRANE 有权
    具有稳定性膜的透皮治疗系统

    公开(公告)号：US20120245537A1

    公开(公告)日：2012-09-27

    申请号：US12921988

    申请日：2009-02-28

    申请人： Michael Horstmann ,  Patrick Mohr ,  Mohammad Sameti

    发明人： Michael Horstmann ,  Patrick Mohr ,  Mohammad Sameti

    IPC分类号： A61M35/00 ,  B05D1/36

    CPC分类号： A61K9/7084 ,  A61K9/0014

    摘要： The invention relates to a transdermal therapeutic system made of the following layers: a carrier layer (T), an active ingredient layer (R), a membrane layer (M) and optionally an adhesive layer (K), wherein the carrier layer (T) is impenetrable to the active substance and to water, the active substance layer (R) comprises as an active substance component the salt of an alkali reactive active substance, such as a CNS-active amine in combination with at least one alkali reactive further component, and a polymer component (P1), wherein the active substance is released from the active substance layer (R) only by the moisture entering from the exterior through the membrane layer (M), and the membrane layer (M) is made of a polymer component (P2), allowing a uniform delivery of basic active substances to the skin.

    摘要翻译： 本发明涉及由以下层构成的透皮治疗系统：载体层（T），活性成分层（R），膜层（M）和任选的粘合剂层（K），其中载体层 ）对于活性物质和水是不可穿透的，活性物质层（R）包含作为活性成分的碱反应性活性物质的盐，例如CNS-活性胺与至少一种碱反应性进一步组分 和聚合物组分（P1），其中活性物质仅通过从外部通过膜层（M）进入的水分从活性物质层（R）释放，并且膜层（M）由 聚合物组分（P2），允许将基本活性物质均匀地递送至皮肤。

    Transdermal Therapeutic System Comprising Active Ingredient Particles and Having Increased Active Ingredient Flux
    9.
    发明申请
    Transdermal Therapeutic System Comprising Active Ingredient Particles and Having Increased Active Ingredient Flux 审中-公开
    包含活性成分颗粒并增加活性成分通量的透皮治疗系统

    公开(公告)号：US20090258062A1

    公开(公告)日：2009-10-15

    申请号：US12302065

    申请日：2007-05-30

    申请人： Michael Horstmann ,  Mohammad Sameti ,  Tobias Jung

    发明人： Michael Horstmann ,  Mohammad Sameti ,  Tobias Jung

    IPC分类号： A61K9/70 ,  A61K9/10 ,  A61K31/56

    CPC分类号： A61K9/7069 ,  A61K9/7092

    摘要： The invention relates to a transdermal therapeutic system, preferably a transdermal patch, having an active ingredient-containing matrix formed substantially of a water-insoluble base material, such as rubber and synthetic polymers, into which is incorporated water-soluble and/or water-swellable inclusion bodies, e.g. inclusion bodies formed from polyvinyl alcohol or polyethylene glycol, that further include micronized or nanoscale active ingredient particles.

    摘要翻译： 本发明涉及一种经皮给药系统，优选透皮贴剂，其具有基本上由水不溶性基础材料（例如橡胶和合成聚合物）形成的含活性成分的基质，其中掺入水溶性和/或水溶性基质， 可膨胀的包涵体，例如 由聚乙烯醇或聚乙二醇形成的包含体，其进一步包括微粉化或纳米级活性成分颗粒。