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    Automated sample collection in supercritical fluid chromatography
    1.
    发明授权
    Automated sample collection in supercritical fluid chromatography 有权
    超临界流体色谱自动样品采集

    公开(公告)号：US06685828B2

    公开(公告)日：2004-02-03

    申请号：US10119529

    申请日：2002-04-09

    申请人： Terry A. Berger ,  Kimber D. Fogelman ,  Kenneth Klein ,  L. Thompson Staats, III ,  Mark Nickerson ,  Paul F. Bente, III

    发明人： Terry A. Berger ,  Kimber D. Fogelman ,  Kenneth Klein ,  L. Thompson Staats, III ,  Mark Nickerson ,  Paul F. Bente, III

    IPC分类号： B01D1508

    CPC分类号： B01D11/0203 ,  B01D15/247 ,  B01D15/40 ,  G01N30/24 ,  G01N30/82

    摘要： A system for collection of liquid phase sample fractions from a supercritical fluid chromatography system is disclosed. The system has different ways of gathering the liquid phase into a collection chamber and provides for automated removal of liquid phase from a collection chamber into separate collection container. A separate pressure scheme is invoked upon the collection chambers to move liquid phase out of a chamber and into the separate collection container. In addition, the invention provides a renewal system for the collection chambers where each chamber returns to an uncontaminated stated by washing with a cleaning solution after removal of collected liquid phase. Spent cleaner from a chamber is purged using the pressure system into a waste stream for disposal.

    摘要翻译： 公开了一种用于从超临界流体色谱系统收集液相样品馏分的系统。 该系统具有将液相收集到收集室中并且提供将液相从收集室自动移除到单独的收集容器中的不同方式。 在收集室上引用单独的压力方案以将液相移出室并进入单独的收集容器。 此外，本发明提供了一种用于收集室的更新系统，其中每个室在去除收集的液相后通过用清洁溶液洗涤而返回到未污染的状态。 使用压力系统将来自室的废清洁剂清洗成废物流以便处理。

    Pump as a pressure source for supercritical fluid chromatography involving pressure regulators and a precision orifice
    2.
    发明授权
    Pump as a pressure source for supercritical fluid chromatography involving pressure regulators and a precision orifice 有权
    泵作为超临界流体色谱的压力源，包括压力调节器和精密孔

    公开(公告)号：US06648609B2

    公开(公告)日：2003-11-18

    申请号：US10117984

    申请日：2002-04-05

    申请人： Terry A. Berger ,  Kimber D. Fogelman ,  Kenneth Klein ,  L. Thompson Staats, III ,  Mark Nickerson ,  Paul F. Bente, III

    发明人： Terry A. Berger ,  Kimber D. Fogelman ,  Kenneth Klein ,  L. Thompson Staats, III ,  Mark Nickerson ,  Paul F. Bente, III

    IPC分类号： F04B4908

    CPC分类号： F04B11/0091 ,  F04B49/225 ,  Y10T137/7838 ,  Y10T137/87917 ,  Y10T137/88054 ,  G01N2030/326 ,  B01D15/40

    摘要： The invention is a device and method in a high-pressure chromatography system, such as a supercritical fluid chromatography (SFC) system, that uses a pump as a pressure source for precision pumping of a compressible fluid. The preferred exemplary embodiment comprises a pressure regulation assembly installed downstream from a compressible fluid pump but prior to combining the compressible flow with a relatively incompressible modifier flow stream. The present invention allows the replacement of an high-grade SFC pump in the compressible fluid flow stream with an inexpensive and imprecise pump. The imprecise pump becomes capable of moving the compressible fluid flow stream in a precise flow rate and pattern. The assembly dampens the damaging effects of an imprecise pump, such as large pressure oscillations caused by flow ripples and noisy pressure signals that do not meet precise SFC pumping requirements.

    摘要翻译： 本发明是高压色谱系统中的装置和方法，例如超临界流体色谱（SFC）系统，其使用泵作为精密泵送可压缩流体的压力源。 优选的示例性实施例包括安装在可压缩流体泵的下游但在将可压缩流与相对不可压缩的修饰剂流动流组合之前的压力调节组件。 本发明允许用便宜且不精确的泵替代可压缩流体流动中的高级SFC泵。 不精确的泵变得能够以精确的流速和模式移动可压缩流体流动流。 该组件会抑制不精确泵的破坏性影响，例如由流动波纹引起的大压力振荡和不符合精确SFC泵送要求的噪声压力信号。

    Rapid sample collection in supercritical fluid chromatography
    4.
    发明授权
    Rapid sample collection in supercritical fluid chromatography 有权
    超临界流体色谱快速采样

    公开(公告)号：US06632353B2

    公开(公告)日：2003-10-14

    申请号：US10113599

    申请日：2002-03-29

    申请人： Terry A. Berger ,  Kimber D. Fogelman ,  L. Thompson Staats, III ,  Mark Nickerson ,  Paul F. Bente, III ,  Kenneth Klein

    发明人： Terry A. Berger ,  Kimber D. Fogelman ,  L. Thompson Staats, III ,  Mark Nickerson ,  Paul F. Bente, III ,  Kenneth Klein

    IPC分类号： B01D1508

    CPC分类号： B01D11/0203 ,  B01D15/247 ,  B01D15/40 ,  G01N1/18 ,  G01N1/405 ,  G01N30/24 ,  G01N30/82 ,  Y10T436/255 ,  Y10T436/2575

    摘要： A process and device for chromatography, such as preparative and analytical supercritical fluid chromatography, or supercritical fluid extraction for a liquid phase SFC collection system that separates and retains eluted components from sample injections. The process efficiently separates liquid and gas phases in the flow stream upstream of a collection vessel and without additional pressure schemes or solvent extractions imposed on the flowstream. Sample fractions are collected from sample component concentration peaks based upon the chromatographic elution of the sample components. Samples are repeatedly the injected into the mobile phase flow stream and collected into large volume collection containers, thereby allowing longer unattended run times and cost-efficient sample purification and recovery.

    摘要翻译： 用于层析的方法和装置，例如制备和分析超临界流体色谱法或用于液相SFC收集系统的超临界流体萃取，其从样品注射中分离并保留洗脱的组分。 该方法有效地分离收集容器上游的流动流中的液相和气相，而没有施加在流动流上的额外的压力方案或溶剂萃取。 基于样品组分的色谱洗脱，从样品组分浓度峰中收集样品级分。 将样品重复注入流动相流中并收集到大容量收集容器中，从而允许更长的无人值守运行时间和经济高效的样品纯化和回收。

    Benzoyl peroxide flocculent materials and methods of their preparation
    6.
    发明授权
    Benzoyl peroxide flocculent materials and methods of their preparation 失效
    过氧化苯甲酰絮凝物及其制备方法

    公开(公告)号：US5998392A

    公开(公告)日：1999-12-07

    申请号：US630520

    申请日：1996-04-10

    申请人： Veronique Simard ,  David Garlen ,  Kenneth Klein

    发明人： Veronique Simard ,  David Garlen ,  Kenneth Klein

    IPC分类号： A61K8/38 ,  A61K8/39 ,  A61K9/00 ,  A61K31/327 ,  A61K31/60 ,  A61K47/10 ,  A61Q19/00 ,  A61K31/605

    CPC分类号： A61Q19/00 ,  A61K31/327 ,  A61K47/10 ,  A61K8/38 ,  A61K8/39 ,  A61K9/0014

    摘要： Improved compositions of benzoyl peroxide are prepared by at least partially dissolving benzoyl peroxide in diethylene glycol monoethyl ether to prepare a premixture which forms a flocculent composition of benzoyl peroxide when admixed with water or an aqueous medium. The improved benzoyl peroxide compositions have a small particle size compared with those prepared by conventional grinding techniques and the time and potential hazards associated with grinding are avoided. The small particle size of the benzoyl peroxide flocculents result in increased surface area of active ingredient on the skin for a given concentration of benzoyl peroxide. The flocculent compositions are used to prepare compositions for the topical treatment of acne or other dermatological disorders.

    摘要翻译： 通过至少部分地将过氧化苯甲酰溶解在二甘醇单乙醚中来制备过氧化苯甲酰的组合物，以制备当与水或水性介质混合时形成过氧化苯甲酰的絮状组合物的预混合物。 与通过常规研磨技术制备的那些相比，改进的过氧化苯甲酰组合物具有小的粒度，并且避免了与研磨相关的时间和潜在危害。 过氧化苯甲酰絮凝剂的小粒径导致给定浓度的过氧化苯甲酰对皮肤上活性成分的表面积增加。 絮状组合物用于制备用于局部治疗痤疮或其它皮肤病的组合物。

    Integrated task management systems and methods for executing rule-based operations
    7.
    发明申请
    Integrated task management systems and methods for executing rule-based operations 有权
    用于执行基于规则的操作的集成任务管理系统和方法

    公开(公告)号：US20050248806A1

    公开(公告)日：2005-11-10

    申请号：US11097578

    申请日：2005-04-01

    申请人： Kenneth Klein ,  Herbert Waite ,  George Starr ,  Nathan Warmbrod

    发明人： Kenneth Klein ,  Herbert Waite ,  George Starr ,  Nathan Warmbrod

    IPC分类号： G06F3/12 ,  G06F15/00 ,  G06F17/00 ,  G06K1/00 ,  G06N5/00 ,  G06N5/02 ,  G06Q10/00 ,  G06F17/60

    CPC分类号： G06F3/126 ,  G06N5/02 ,  G06Q10/10 ,  G06Q50/184

    摘要： A system for integrating multiple software modules configured to produce output according to established business rules is provided. The system in one embodiment coordinates the printing of a variety of labels and reports according to a set of complex business rules. Complex output tasks may be distributed to remote computers in a network for optimum efficiency. The system may be configured to comply with one or more standard database connectivity standards in order to provide a generic interface with foreign systems. The method in one embodiment includes acquiring an input, sending a query to a database, retrieving business rules and associated tasks, and building scripts or commands for each task. This Abstract is provided to comply with the rules, which require an abstract to quickly inform a searcher or other reader about the subject matter of the application. This Abstract is submitted with the understanding that it will not be used to interpret or limit the scope or meaning of the claims.

    摘要翻译： 提供了一种用于集成多个软件模块的系统，用于根据既定的业务规则配置产生输出。 一个实施例中的系统根据一组复杂的业务规则协调各种标签和报告的打印。 复杂的输出任务可以被分发到网络中的远程计算机以获得最佳效率。 该系统可以被配置为符合一个或多个标准数据库连接标准，以提供与外部系统的通用接口。 在一个实施例中的方法包括获取输入，向数据库发送查询，检索业务规则和相关联的任务，以及为每个任务构建脚本或命令。 提供本摘要以符合规则，这些规则需要一个摘要来快速通知搜索者或其他读者关于申请的主题。 提交本摘要的理解是，它不会用于解释或限制权利要求的范围或含义。

    Personal care compositions containing highly branched primary alcohol component
    8.
    发明申请
    Personal care compositions containing highly branched primary alcohol component 审中-公开
    含有高度支化的伯醇组分的个人护理组合物

    公开(公告)号：US20050196362A1

    公开(公告)日：2005-09-08

    申请号：US11069793

    申请日：2005-03-01

    申请人： Jan Elsa Carty ,  Carolyn Ann Burnley ,  Kenneth Klein

    发明人： Jan Elsa Carty ,  Carolyn Ann Burnley ,  Kenneth Klein

    IPC分类号： A61K8/34 ,  A61Q17/04 ,  A61Q19/00 ,  A61K7/42

    CPC分类号： A61Q17/04 ,  A61K8/342 ,  A61Q19/00

    摘要： A personal care composition for topical application to the skin or hair comprising (a) a branched primary alcohol component, having from 8 to 36 carbon atoms and an average number of branches per molecule of from 0.7 to 3.0, said branching comprising methyl and ethyl branches, and said branched primary alcohol component optionally comprising up to 3 moles of alkylene oxide per mole of alcohol; (b) one or more sunscreens; and (c) a cosmetically-acceptable vehicle. The personal care compositions of the invention provide excellent sunscreen protection, stability, viscosity and rheology characteristics, together with emolliency, application and skin feel benefits.

    摘要翻译： 用于局部施用于皮肤或头发的个人护理组合物，其包含（a）具有8至36个碳原子的分支伯醇组分和每分子平均分支数为0.7至3.0，所述支化包括甲基和乙基支链 ，并且所述支化伯醇组分任选地包含每摩尔醇最多3摩尔环氧烷烃; （b）一种或多种防晒剂; 和（c）美容上可接受的载体。 本发明的个人护理组合物提供优异的防晒保护，稳定性，粘度和流变特性，以及润肤性，使用性和皮肤感觉益处。

    Dimethicone copolyol raspberriate as a delivery system for natural antioxidants
    9.
    发明授权
    Dimethicone copolyol raspberriate as a delivery system for natural antioxidants 有权
    作为天然抗氧化剂的输送系统，聚二甲基硅氧烷共聚多元醇

    公开(公告)号：US06630180B1

    公开(公告)日：2003-10-07

    申请号：US10291570

    申请日：2002-11-12

    申请人： Kenneth Klein ,  Irwin Paleksky ,  Anthony J. O'Lenick, Jr.

    发明人： Kenneth Klein ,  Irwin Paleksky ,  Anthony J. O'Lenick, Jr.

    IPC分类号： A61K3578

    CPC分类号： A61K8/894 ,  A61K8/922 ,  A61K2800/522 ,  A61Q17/00 ,  C08G77/46

    摘要： The invention relates to raspberry seed oil derivatives prepared by the reaction of dimethicone copolyol and cold pressed raspberry seed oil. The choice of cold pressed raspberry seed oil as a raw material in the preparation of the compounds is critical, since it has been found that the cold pressed raspberry seed oil contains antioxidants, antimicrobial compounds and which when reacted with a water soluble or water dispersible silicone result in products that deliver said actives to the skin and hair, resulting in protection of the skin and hair from environmental factors such as acid rain, ozone attack and UV degradation.

    摘要翻译： 本发明涉及通过二甲聚硅氧烷共聚醇与冷压覆盆子籽油的反应制备的覆盆子种子油衍生物。 在制备化合物中作为原料的冷压覆盆子籽油的选择是至关重要的，因为已经发现冷压覆盆子籽油含有抗氧化剂，抗微生物化合物，并且当与水溶性或水分散性硅氧烷 导致将所述活性物质递送到皮肤和头发的产品，从而保护皮肤和头发免受诸如酸雨，臭氧袭击和UV降解等环境因素的影响。

    Compositions containing Guerbet lanolin esters and free lanolin alcohol useful in personal care applications
    10.
    发明授权
    Compositions containing Guerbet lanolin esters and free lanolin alcohol useful in personal care applications 有权
    含有Guerbet羊毛脂酯和游离羊毛脂醇的组合物可用于个人护理用途

    公开(公告)号：US07074948B1

    公开(公告)日：2006-07-11

    申请号：US11002347

    申请日：2004-12-03

    申请人： Kenneth Klein

    发明人： Kenneth Klein

    IPC分类号： C11C3/00

    CPC分类号： A61K8/925 ,  A61Q1/06 ,  A61Q5/12 ,  A61Q17/04 ,  A61Q19/00 ,  C11C3/003

    摘要： The present invention relates to the cosmetic use of certain esters, prepared by the reaction of a Guerbet alcohol and lanolin. The result is a cosmetically elegant ester and lanolin alcohol which is a highly functional material in skin care. These compositions provide conditioning effects when applied to the hair and skin.

    摘要翻译： 本发明涉及通过Guerbet醇和羊毛脂反应制备的某些酯的化妆品用途。 结果是一种美容优雅的酯和羊毛脂醇，它是皮肤护理中的高功能材料。 这些组合物当应用于头发和皮肤时提供调理作用。