公开(公告)号：US10077421B2

公开(公告)日：2018-09-18

申请号：US14696022

申请日：2015-04-24

申请人： Terumo BCT, Inc.

发明人： John Kearns, III ,  Stanley Liang Chen ,  Daniel Adam Godrick ,  Jon A. Dodd ,  Kristina E. Fuerst

IPC分类号： C12M1/34 ,  C12Q3/00 ,  G01F1/05 ,  G01G11/06 ,  G01G17/06 ,  G01F9/00 ,  G01F15/00 ,  C12M1/00 ,  G01G19/52

CPC分类号： C12M41/44 ,  C12M29/16 ,  C12M41/00 ,  C12Q3/00 ,  G01F1/05 ,  G01F9/003 ,  G01F15/001 ,  G01F15/003 ,  G01G11/06 ,  G01G17/06 ,  G01G19/52

摘要： Embodiments are described that relate to flow rate measuring systems that may be used in cell expansion systems (CES) and in methods for controlling fluid input into systems such as a CES.

公开(公告)号：US11608486B2

公开(公告)日：2023-03-21

申请号：US15852689

申请日：2017-12-22

申请人： Terumo BCT, Inc.

发明人： Mark E. Jones ,  Brian J. Nankervis ,  Kristina E. Fuerst ,  Jon A. Dodd

IPC分类号： C12M1/42 ,  C12M1/12 ,  C12M3/00 ,  C12M3/06

摘要： Embodiments for loading and expanding particular cell types are described. Embodiments may include the use of hollow fiber membranes with particular characteristic such as hollow fibers with inner diameters that provide mechanical stimulus (e.g., radius of curvature greater than a dimension of a cell). In addition, embodiments may provide for manipulation of flow rates and other features that also provide mechanical stimuli and promote or enhance the growth of particular types of cells.