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公开(公告)号：US20180140809A1
公开(公告)日：2018-05-24
申请号：US15873282
申请日：2018-01-17
发明人： Hiroshi GOTOU , Yasuo KUROSAKI , Eisuke FURUICHI
CPC分类号： A61M25/1029 , A61M2025/1031 , A61M2025/105 , B05C5/0216 , B05C13/02
摘要： A balloon coating method and a balloon coating apparatus are disclosed for forming a coating layer containing a water-insoluble drug on an outer surface of a balloon of a balloon catheter. The balloon coating method including fixing a connection portion between the balloon and an inner tube passing through an inside of the balloon, and moving a dispensing tube relative to the balloon in an axial direction of the balloon while rotating the balloon about an axis of the balloon and while also dispensing the coating liquid containing the water-insoluble drug from the dispensing tube to apply the coating liquid to the outer surface of the balloon.
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2.发明申请BALLOON COATING METHOD, BALLOON ROTATING METHOD AND BALLOON COATING APPARATUS 审中-公开气泡涂布方法，气泡旋转方法和气泡涂布装置公开(公告)号：US20160310708A1
公开(公告)日：2016-10-27
申请号：US15136269
申请日：2016-04-22
发明人： Hiroshi GOTOU , Yasuo KUROSAKI , Eisuke FURUICHI
CPC分类号： A61M25/1029 , A61M2025/1031 , B05C5/0208 , B05C5/0216 , B05C13/025 , B05D1/002 , B05D1/26
摘要： A balloon coating method for forming a coating layer containing a water-insoluble drug on the outer surface of a balloon of a balloon catheter, wherein the balloon catheter includes an elongate shaft possessing a distal portion at which is provided the balloon which is inflatable. The balloon coating method includes: holding the shaft on a support part capable of rotating about an axis of the balloon; and moving a dispensing tube for supplying a coating liquid containing the drug relative to the balloon in an axial direction of the balloon, while rotating the balloon together with the support part, thereby to coat the outer surface of the balloon with the coating liquid.
摘要翻译： 一种用于在球囊导管的球囊的外表面上形成含有不溶于水的药物的涂层的球囊涂覆方法，其中所述球囊导管包括细长轴，所述细长轴具有远侧部分，在所述远端部分设置有可膨胀的气囊。 球囊涂覆方法包括：将轴保持在能够围绕气球的轴线旋转的支撑部分上; 并且在与所述支撑部一起旋转所述气囊的同时，使所述气囊沿所述气囊的轴向移动用于供给包含所述药物的涂布液的分注管，从而将所述气囊的外表面涂布于所述涂布液。
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公开(公告)号：US20180214676A1
公开(公告)日：2018-08-02
申请号：US15937429
申请日：2018-03-27
发明人： Yasuo KUROSAKI , Ryosuke SUZUKI , Eisuke FURUICHI
CPC分类号： A61M25/10 , A61L29/08 , A61L29/16 , A61L2300/416 , A61L2420/02 , A61M25/1029 , A61M2025/1031 , A61M2025/105 , A61M2207/10 , B05B13/0442 , B05C5/0208 , B05C13/025
摘要： A method is disclosed for forming a coating layer on an outer surface of a balloon of a balloon catheter. The method includes supplying a coating solution containing a drug and a solvent through an end portion of a flexible dispensing tube with an opening portion for discharging the coating solution through the end portion of the flexible dispensing tube; keeping in contact an opening portion-formed end portion side of the dispensing tube with the outer surface of the balloon in such a manner as to be oriented in a direction opposite to a rotating direction of the balloon; rotating the balloon about an axis of the balloon; and discharging the coating solution through the opening portion and applying the coating solution to the outer surface of the balloon while the dispensing tube is moved relative to the balloon in an axial direction of the balloon.
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公开(公告)号：US20170021142A1
公开(公告)日：2017-01-26
申请号：US15282563
申请日：2016-09-30
发明人： Yasuo KUROSAKI , Ryosuke SUZUKI , Eisuke FURUICHI
CPC分类号： A61M25/10 , A61L29/08 , A61L29/16 , A61L2300/416 , A61L2420/02 , A61M25/1029 , A61M2025/1031 , A61M2025/105 , A61M2207/10 , B05B13/0442 , B05C5/0208 , B05C13/025
摘要： A positioning method for balloon coating by which the thickness and morphological form of a drug in a coating formed on a balloon can be suitably set. This method is a positioning method for balloon coating for forming a coating layer containing a water-insoluble drug on an outer surface of a balloon of a balloon catheter. The positioning method includes a positioning step in which a dispensing tube is moved, from a state of non-contact with the balloon, in a direction intersecting the extending direction of the dispensing tube, and an opening portion-formed end portion side of the dispensing tube formed at its end portion with an opening portion for discharging a coating solution is thereby placed in contact with the outer surface of the balloon.
摘要翻译： 可以适当地设定用于球囊涂覆的定位方法，通过该定位方法可以适当地设定在气球上形成的涂层中的药物的厚度和形态形式。 该方法是用于在球囊导管的球囊的外表面上形成含有不溶于水的药物的涂层的球囊涂覆的定位方法。 定位方法包括定位步骤，其中分配管从与气囊非接触的状态沿与分配管的延伸方向相交的方向移动，并且分配管的开口部形成端部侧 由此，在其端部形成有用于排出涂布溶液的开口部的管与气球的外表面接触。
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公开(公告)号：US20180147600A1
公开(公告)日：2018-05-31
申请号：US15881050
申请日：2018-01-26
发明人： Yasuo KUROSAKI , Hiroshi GOTO , Eisuke FURUICHI
IPC分类号： B05D1/26 , A61L29/16 , B05C13/02 , B05D1/00 , B05C5/02 , A61M25/10 , A61L29/08 , B05D7/04 , B05B13/04
摘要： A balloon coating method is disclosed for forming a coating layer on an outer surface of a balloon of a balloon catheter. The method includes an application step where a vertically extending dispensing tube for supplying a coating solution containing the water-insoluble drug and a solvent is formed at its end portion with an opening portion for discharging the coating solution therethrough and when an opening portion-formed end portion side of the dispensing tube is kept in contact with the outer surface of the balloon in such a manner as to be oriented to a rotating direction of the balloon while the balloon is rotated about an axis of the balloon, the coating solution is discharged through the opening portion and applied to the outer surface of the balloon while the dispensing tube is moved relative to the balloon in an axial direction of the balloon.
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6.发明申请BALLOON COATING METHOD, COAT LAYER CONTROL METHOD AND BALLOON COATING DEVICE 审中-公开气球涂层方法，套层控制方法和气泡涂层装置公开(公告)号：US20170014601A1
公开(公告)日：2017-01-19
申请号：US15282087
申请日：2016-09-30
发明人： Yasuo KUROSAKI , Eisuke FURUICHI
摘要： A balloon coating method is disclosed for forming a coating layer containing a water-insoluble drug on an outer surface of a balloon of a balloon catheter. The balloon coating method includes an application step in which, where a pipe-shaped dispensing tube formed from a polyolefin for supplying a coating solution containing the water-insoluble drug and a solvent is formed at its end portion with an opening portion for discharging the coating solution therethrough and when the end portion side of the dispensing tube is placed in contact with the outer surface of the balloon while the balloon is rotated about an axis of the balloon, the coating solution is discharged through the opening portion and applied to the outer surface of the balloon while the dispensing tube is moved relative to the balloon in an axial direction of the balloon.
摘要翻译： 公开了一种用于在球囊导管的球囊的外表面上形成含有不溶于水的药物的涂层的球囊涂覆方法。 球囊涂布方法包括以下步骤：在其端部形成由用于供给含有水不溶性药物和溶剂的涂布溶液的聚烯烃形成的管状分配管，其中用于排出涂层的开口部 溶液，并且当气囊围绕气球的轴线旋转时，当分配管的端部侧与气囊的外表面接触时，涂布溶液通过开口部排出并施加到外表面 而分配管相对于球囊在气囊的轴向方向上移动。
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公开(公告)号：US20160296735A1
公开(公告)日：2016-10-13
申请号：US15188266
申请日：2016-06-21
发明人： Hiroshi GOTO , Eisuke FURUICHI , Yasuo KUROSAKI
CPC分类号： A61M25/1029 , A61M25/10 , A61M2025/1031 , A61M2025/105 , B05B12/00
摘要： A balloon coating method and apparatus are disclosed which can perform coating while freely controlling, for example, the thickness of a coating layer and/or the morphological form of a drug. The balloon coating method and the balloon coating apparatus are for forming a coating layer on a surface of a balloon. The balloon coating method includes a pulling step of pulling the balloon in the direction of an axis of the balloon to thereby straighten a bend of the balloon, and a coating step of rotating the balloon about the axis of the balloon, with the balloon maintained in the bend-straightened state, and coating an outer surface of the balloon with a coating liquid containing a drug.
摘要翻译： 公开了可以自由地控制例如涂层的厚度和/或药物的形态形式进行涂覆的球囊涂布方法和装置。 球囊涂布方法和气球涂覆装置用于在气球的表面上形成涂层。 球囊涂覆方法包括拉动气球沿着球囊的轴线的方向拉动从而使球囊弯曲的拉伸步骤，以及气囊围绕气球的轴线旋转的涂覆步骤，气球保持在 弯曲矫直状态，并且用包含药物的涂布液涂覆球囊的外表面。
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公开(公告)号：US20170014860A1
公开(公告)日：2017-01-19
申请号：US15282230
申请日：2016-09-30
发明人： Yasuo KUROSAKI , Hiroshi GOTO , Eisuke FURUICHI
CPC分类号： B05D1/26 , A61L29/08 , A61L29/16 , A61L2300/416 , A61L2420/02 , A61M25/10 , A61M25/1029 , A61M2025/1031 , B05B13/0442 , B05C5/02 , B05C5/0208 , B05C5/0216 , B05C13/025 , B05D1/002 , B05D7/04
摘要： A balloon coating method is disclosed, which includes an application step in which, where a flexible dispensing tube for supplying a coating solution containing the water-insoluble drug and a solvent is formed at its end portion with an opening portion for discharging the coating solution therethrough and when the opening portion-formed end portion side of the dispensing tube is kept in contact with the outer surface of the balloon in such a manner as to be oriented in a direction opposite to a rotating direction of the balloon while the balloon is rotated about an axis of the balloon, the coating solution is discharged through the opening portion and applied to the outer surface of the balloon while the dispensing tube is moved relative to the balloon in an axial direction X of the balloon.
摘要翻译： 公开了一种气球涂布方法，其包括如下步骤：在其端部形成有用于供给含有水不溶性药物和溶剂的涂布溶液的柔性分配管，其具有用于将涂布溶液排出的开口部分 并且当分配管的开口部形成端部侧与气囊的外表面保持接触时，使得在与气囊的旋转方向相反的方向上定向，同时气球旋转约 气囊的轴线，涂布液通过开口部排出，并且在气囊的轴向X相对于气囊移动分配管的同时施加到球囊的外表面。
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9.发明申请BALLOON COATING METHOD, BALLOON ROTATING METHOD AND BALLOON COATING APPARATUS 审中-公开气泡涂布方法，气泡旋转方法和气泡涂布装置公开(公告)号：US20160310990A1
公开(公告)日：2016-10-27
申请号：US15136435
申请日：2016-04-22
发明人： Hiroshi GOTOU , Yasuo KUROSAKI , Eisuke FURUICHI
CPC分类号： A61M25/1029 , A61M2025/1031 , A61M2025/105 , B05D1/002 , B05D1/26 , B05D7/02 , B05D2254/02
摘要： Disclosed herein is a balloon coating method for forming a coating layer containing a water-insoluble drug on an outer surface of a balloon of a balloon catheter, the balloon catheter including the balloon which is inflatable and provided on a distal portion of an elongate shaft. The balloon coating method includes: accommodating the shaft in a groove portion formed in a support base to extend rectilinearly, and closing at least part of the groove portion with a lid portion, thereby to support the shaft such that the shaft can be rotated within the groove portion; and moving a dispensing tube for supplying a coating liquid containing the drug relative to the balloon in an axial direction of the balloon, while rotating the balloon about an axis of the balloon, thereby to coat the outer surface of the balloon with the coating liquid.
摘要翻译： 本发明公开了一种用于在球囊导管的球囊的外表面上形成含有不溶于水的药物的涂层的球囊涂覆方法，所述球囊导管包括可膨胀并设置在细长轴的远端部分上的球囊。 球囊涂布方法包括：将轴容纳在形成在支撑基部中的槽部中以直线延伸，并且用盖部封闭至少部分槽部，从而支撑轴，使得轴能够在 槽部; 并且在气球围绕气球的轴线旋转的同时，使气囊的轴向移动用于供给包含药物的涂布液相对于球囊的分注管，从而将气球的外表面涂布于涂布液。
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公开(公告)号：US20160296969A1
公开(公告)日：2016-10-13
申请号：US15188192
申请日：2016-06-21
发明人： Yasuo KUROSAKI , Eisuke FURUICHI , Hiroshi GOTO
IPC分类号： B05D3/00 , A61L29/08 , A61K31/337 , A61M25/10 , A61L29/16
CPC分类号： B05D3/007 , A61K31/337 , A61L29/08 , A61L29/16 , A61L2300/416 , A61L2420/02 , A61M25/10 , A61M25/1029 , A61M2025/1031 , A61M2025/105 , A61M2207/10 , B05C5/02 , B05C11/1005 , B05C13/025 , B05D1/002 , B05D1/26
摘要： A balloon coating method and a balloon coating apparatus are disclosed by which the thickness and/or morphological form of a drug in a coating formed on a balloon can be appropriately set. The balloon coating method can include moving a coating section for applying a coating liquid containing a drug relative to the balloon in the direction of an axis, while rotating the balloon about the axis of the balloon, thereby to apply the coating liquid to an outer surface of the balloon; detecting the distance of a dried part where the coating liquid applied to the outer surface of the balloon has been dried from the coating section; and controlling moving velocity of the coating section relative to the balloon in such a manner that the distance of the dried part from the coating section is maintained at a preliminarily set designated distance.
摘要翻译： 公开了一种球囊涂覆方法和球囊涂覆装置，通过该装置可以适当地设定在气球上形成的涂层中的药物的厚度和/或形态形式。 球囊涂布方法可以包括在围绕球体的轴线旋转球囊的同时使围绕球体的轴线旋转的方式移动用于在轴线方向上施加相对于球囊的药物的涂布液的涂布部分，从而将涂布液施加到外表面 的气球; 检测施加到所述球囊的外表面的涂布液从所述涂布部干燥的干燥部的距离; 并且以使得干燥部分与涂布部分的距离保持在预先设定的指定距离的方式控制涂布部分相对于气球的移动速度。
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