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公开(公告)号：US20110165085A1
公开(公告)日：2011-07-07
申请号：US13018831
申请日：2011-02-01
申请人： Tetsuo NAGANO , Yasuteru URANO , Hirotatsu KOJIMA , Yuuta FUJIKAWA , Tetsuro TAKAMATSU , Yoshinori HARADA
发明人： Tetsuo NAGANO , Yasuteru URANO , Hirotatsu KOJIMA , Yuuta FUJIKAWA , Tetsuro TAKAMATSU , Yoshinori HARADA
CPC分类号： C07D493/10 , A61K49/0043 , A61K49/0052
摘要： A tumor cell or tumor tissue-selective fluorescent staining agent comprising a compound represented by the following general formula (I): wherein R1 and R2 independently represent a C1-C4 alkyl group which may be substituted, a C2-C4 alkenyl group which may be substituted, a C2-C4 alkynyl group which may be substituted, an aryl group which may be substituted, or a heteroaryl group which may be substituted.
摘要翻译： 一种肿瘤细胞或肿瘤组织选择性荧光染色剂，其包含由以下通式（I）表示的化合物：其中R 1和R 2独立地表示可被取代的C 1 -C 4烷基，可以被取代的C 2 -C 4烯基 可被取代的C2-C4炔基，可被取代的芳基或可被取代的杂芳基。
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公开(公告)号：US20080188006A1
公开(公告)日：2008-08-07
申请号：US12099979
申请日：2008-04-09
IPC分类号： G01N33/00
CPC分类号： G01N21/6428 , G01N2021/7786 , Y10T436/14 , Y10T436/19 , Y10T436/196666 , Y10T436/200833
摘要： A method for measuring hypochlorite ion, which comprises the steps of. (A) reacting, with hypochlorite ion, a compound represented by the following general formula (I): wherein R1 represents a 2-carboxyphenyl group which may be substituted; R2 represents a phenyl group which is substituted with a substituted or unsubstituted amino group; X1 and X2 each independently represents either hydrogen atom or a halogen atom; or a salt thereof; and (B) measuring fluorescence of a dearylated compound generated in the aforementioned step (A) or a salt thereof.
摘要翻译： 一种测定次氯酸根离子的方法，包括以下步骤。 （A）与次氯酸根离子反应由以下通式（I）表示的化合物：其中R 1表示可被取代的2-羧基苯基; R 2代表被取代或未取代的氨基取代的苯基; X 1和X 2各自独立地表示氢原子或卤素原子; 或其盐; 和（B）测量在上述步骤（A）中产生的脱芳基化合物的荧光或其盐。
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公开(公告)号：US20110033944A1
公开(公告)日：2011-02-10
申请号：US12910457
申请日：2010-10-22
IPC分类号： G01N21/76
CPC分类号： G01N21/6428 , G01N2021/7786 , Y10T436/14 , Y10T436/19 , Y10T436/196666 , Y10T436/200833
摘要： A method for measuring hypochlorite ion, which comprises the steps of:(A) reacting, with hypochlorite ion, a compound represented by the following general formula (I): wherein R1 represents a 2-carboxyphenyl group which may be substituted; R2 represents a phenyl group which is substituted with a substituted or unsubstituted amino group; X1 and X2 each independently represents either hydrogen atom or a halogen atom; or a salt thereof; and (B) measuring fluorescence of a dearylated compound generated in the aforementioned step (A) or a salt thereof.
摘要翻译： 一种测定次氯酸根离子的方法，包括以下步骤：（A）与次氯酸根离子反应由以下通式（I）表示的化合物：其中R1表示可被取代的2-羧基苯基; R2表示被取代或未取代的氨基取代的苯基; X1和X2各自独立地表示氢原子或卤素原子; 或其盐; 和（B）测量在上述步骤（A）中产生的脱芳基化合物的荧光或其盐。
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公开(公告)号：US20120178174A1
公开(公告)日：2012-07-12
申请号：US13425802
申请日：2012-03-21
申请人： Tetsuo NAGANO , Yu GABE , Yasuteru URANO
发明人： Tetsuo NAGANO , Yu GABE , Yasuteru URANO
CPC分类号： C07F5/022 , C09K11/06 , C09K2211/1055 , G01N31/22 , Y10T436/145555 , Y10T436/177692
摘要： A compound represented by the formula (I) wherein R1 and R2 represent amino groups that substitute at adjacent positions on the benzene ring, wherein one of the amino groups may have one alkyl group; R3 and R4 represent hydrogen atom, a C1-6 alkyl group, or a C1-6 alkoxy group, R5 and R8 independently represent a C1-6 alkyl group, R6 and R9 represent a carboxy-substituted C1-6 alkyl group, an alkoxycarbonyl-substituted C1-6 alkyl group, a sulfo-substituted C1-6 alkyl group, or an alkyl sulfonate-substituted C1-6 alkyl group, and R7 and R10 represent a C1-6 alkyl group, an aryl group, a C1-6 alkoxycarbonyl group, a vinyl group, a thienyl group, or a pyrrolyl group, and an agent for measurement of nitrogen monoxide containing the compound. Said compound can give a fluorescent substance that is free from change in fluorescence intensity in a wide pH range.
摘要翻译： 由式（I）表示的化合物，其中R 1和R 2表示在苯环上的相邻位置取代的氨基，其中一个氨基可以具有一个烷基; R3和R4表示氢原子，C1-6烷基或C1-6烷氧基，R5和R8独立地表示C1-6烷基，R6和R9表示羧基取代的C1-6烷基，烷氧基羰基 取代的C 1-6烷基，磺基取代的C 1-6烷基或烷基磺酸酯取代的C 1-6烷基，R 7和R 10表示C 1-6烷基，芳基，C 1-6 烷氧基羰基，乙烯基，噻吩基或吡咯基，以及含有该化合物的一氧化氮测定用试剂。 所述化合物可以产生在宽pH范围内没有荧光强度变化的荧光物质。
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公开(公告)号：US20110098475A1
公开(公告)日：2011-04-28
申请号：US12914525
申请日：2010-10-28
申请人： Tetsuo NAGANO , Yoko WADA , Yasuteru URANO
发明人： Tetsuo NAGANO , Yoko WADA , Yasuteru URANO
IPC分类号： C07D405/14 , C07D311/90 , C07D311/82
CPC分类号： C07D311/82 , C07D311/90 , C09B11/24
摘要： A fluorescent probe which is represented by the following formula (wherein R1 and R2 represent hydrogen atom, or a substituent for trapping proton, a metal ion, or an active oxygen species; R3 represents a monovalent substituent other than hydrogen atom, carboxy group, or sulfo group; R4 and R5 represent hydrogen atom, a halogen atom, or an alkyl group; R6 to R9 represent an alkyl group; R10 and R11 represent hydrogen atom, a halogen atom, or an alkyl group; M− represents a counter ion; and the combination of R1, R2, and R3 (1) imparts a substantially high electron density to the benzene ring to which they bond so that the compound can be substantially non-fluorescent before trapping proton, a metal ion, or an active oxygen species, and (2) substantially reduces electron density of the benzene ring to which they bond so that the compound after trapping proton, a metal ion, or an active oxygen species can be highly fluorescent after the trapping.
摘要翻译： 由下式表示的荧光探针（其中R1和R2表示氢原子，或用于捕获质子的取代基，金属离子或活性氧类; R3表示除氢原子以外的一价取代基，羧基或 磺基; R 4和R 5表示氢原子，卤原子或烷基; R 6至R 9表示烷基; R 10和R 11表示氢原子，卤素原子或烷基; M表示抗衡离子; 并且R 1，R 2和R 3（1）的组合赋予它们所键合的苯环基本上高的电子密度，使得化合物在捕获质子，金属离子或活性氧物质之前基本上不发生荧光 ，和（2）大大降低了它们键合的苯环的电子密度，使得捕获质子，金属离子或活性氧之后的化合物在捕获后可以是高度荧光的。
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