公开(公告)号：US5973198A

公开(公告)日：1999-10-26

申请号：US32953

申请日：1998-03-02

申请人： Tetsuya Shiozaki ,  Kenji Ikudome

发明人： Tetsuya Shiozaki ,  Kenji Ikudome

IPC分类号： C01C1/24 ,  C07C319/20 ,  C07C323/52 ,  C07C327/06 ,  C07C51/16 ,  C07C315/00

CPC分类号： C01C1/24 ,  C07C319/20

摘要： A process for producing 2-hydroxy-4-methylthiobutanoic acid which includes conducting hydration and successive hydrolysis of 2-hydroxy-4-methylthiobutyronitrile in a reaction system containing 2-hydroxy-4-methylthiobutyronitrile and sulfuric acid, ammonium bisulfate being added to the reaction system at the time of the hydration and/or the hydrolysis, acquiring 2-hydroxy-4-methylthiobutanoic acid from the resulting organic layer, adding a water-miscible organic solvent to the by-produced aqueous layer to deposit ammonium sulfate, and separating and removing the ammonium sulfate from ammonium bisulfate, thereby permitting recycling and reusing of ammonium bisulfate, reduces the amount of sulfuric acid used, produces substantially no waste water containing sulfates and is of a low production cost and environmentally friendly.

摘要翻译： 一种生产2-羟基-4-甲硫基丁酸的方法，包括在含有2-羟基-4-甲硫基丁腈和硫酸，硫酸氢铵的反应体系中进行水合和连续水解2-羟基-4-甲硫基丁腈 在水合和/或水解时，从所得有机层获得2-羟基-4-甲基硫代丁酸，向副产物水层中加入水混溶性有机溶剂沉积硫酸铵，并分离和 从硫酸氢铵中除去硫酸铵，从而允许硫酸氢铵的再循环和再利用，减少硫酸的使用量，基本上不产生含有硫酸盐的废水，且生产成本低，环保。

公开(公告)号：US06649794B2

公开(公告)日：2003-11-18

申请号：US10182836

申请日：2002-08-02

申请人： Kenji Ikudome ,  Tetsuya Shiozaki

发明人： Kenji Ikudome ,  Tetsuya Shiozaki

IPC分类号： C07C5106

CPC分类号： C07C319/20 ,  C07C323/52

摘要： A method for producing a 2-hydroxy-4-methylthiobutanoic acid is provided, the method comprising the steps of: hydrolyzing a 2-hydroxy-4-methylthiobutanenitrile and/or a 2-hydroxy-4-methylthiobutanamide in the presence of a sulfuric acid to obtain a reaction mixture containing a 2-hydroxy-4-methylthiobutanoic acid; mixing the reaction mixture with a basic alkaline metal compound to obtain a mixture comprising an oil layer containing the 2-hydroxy-4-methylthiobutanoic acid and a water layer; and separating the oil layer containing the 2-hydroxy-4-methylthiobutanoic acid from the mixture. In accordance with the present invention, a 2-hydroxy-4-methylthiobutanoic acid is obtained with excellent operability and efficiency without using an organic solvent.

摘要翻译： 提供2-羟基-4-甲硫基丁酸的制备方法，该方法包括以下步骤：在硫酸存在下水解2-羟基-4-甲硫基丁腈和/或2-羟基-4-甲硫基丁酰胺 得到含有2-羟基-4-甲硫基丁酸的反应混合物; 将反应混合物与碱性碱金属化合物混合，得到含有2-羟基-4-甲硫基丁酸的油层和水层的混合物; 并从混合物中分离含有2-羟基-4-甲硫基丁酸的油层。 根据本发明，不使用有机溶剂，获得了具有优异的可操作性和效率的2-羟基-4-甲基硫代丁酸。

公开(公告)号：US06627773B1

公开(公告)日：2003-09-30

申请号：US09869412

申请日：2001-06-28

申请人： Kenji Ikudome ,  Tetsuya Shiozaki

发明人： Kenji Ikudome ,  Tetsuya Shiozaki

IPC分类号： C07C38100

CPC分类号： C07C319/20 ,  C07C323/52

摘要： A process for producing 2-hydroxy-4-methylthiobutanoic acid is provided wherein 2-hydroxy-4-methylthiobutyronitrile is converted to 2-hydroxy-4-methylthiobutanamide by using sulfuric acid, then adding an aqueous solution containing ammonium bisulfate and ammonium sulfate to the reaction liquid to obtain an oil layer containing 2-hydroxy-4-methylthiobutanoic acid and an aqueous layer containing ammonium bisulfate and ammonium sulfate, then a part of the ammonium salts is separated from the aqueous layer, and the aqueous layer containing ammonium bisulfate and ammonium sulfate thus obtained is recycled as the aqueous solution containing ammonium bisulfate and ammonium sulfate described above. According to the present invention, 2-hydroxy-4-methylthiobutanoic acid of high quality can be obtained without requiring organic solvents and with a greatly reduced amount of waste water.

摘要翻译： 提供2-羟基-4-甲硫基丁酸的制备方法，其中2-羟基-4-甲硫基丁腈通过使用硫酸转化为2-羟基-4-甲硫基丁酰胺，然后加入含硫酸氢铵和硫酸铵的水溶液至 反应液，得到含有2-羟基-4-甲硫基丁酸的油层和含有硫酸氢铵和硫酸铵的水层，然后将一部分铵盐与水层分离，含有硫酸氢铵和铵的水层 硫酸盐作为含有上述硫酸氢铵和硫酸铵的水溶液再循环。根据本发明，可以获得高质量的2-羟基-4-甲硫基丁酸而不需要有机溶剂并且大大减少废物量 水。

公开(公告)号：US20090076054A1

公开(公告)日：2009-03-19

申请号：US11914843

申请日：2006-05-30

申请人： Tetsuya Shiozaki

发明人： Tetsuya Shiozaki

IPC分类号： A61K31/4375 ,  C12Q1/22

CPC分类号： G01N33/56911 ,  G01N33/579

摘要： An object of the present invention is to provide a method capable of detecting and quantifying endotoxin in a sample in which endotoxin derived from gram-negative bacteria cannot be accurately detected or quantified by the method described in Commentary of the Japanese Pharmacopoeia Fourteenth Edition, Hirokawa Publishing Co. 2001 B-63. It has been found that the above object can be achieved by performing an endotoxin test using a lysate reagent in which the lysate reagent is added into a sample in the presence of albumin and/or globulin.

摘要翻译： 本发明的目的是提供一种能够检测和定量来自革兰氏阴性细菌的内毒素不能通过日本药典第十四版，广川出版社的评注中记载的方法精确检测或定量的样品中的内毒素的检测方法 Co. 2001 B-63。 已经发现，可以通过使用裂解物试剂进行内毒素试验来实现上述目的，其中在白蛋白和/或球蛋白存在下将裂解物试剂加入到样品中。

公开(公告)号：US4272435A

公开(公告)日：1981-06-09

申请号：US945504

申请日：1978-09-25

申请人： Teruo Matsuda ,  Shigeo Wake ,  Tetsuya Shiozaki

发明人： Teruo Matsuda ,  Shigeo Wake ,  Tetsuya Shiozaki

IPC分类号： C07C255/65 ,  C08F4/04 ,  C07C107/00 ,  C07C107/02 ,  C07C107/04

CPC分类号： C07C255/65

摘要： Azo compounds of the formula, ##STR1## wherein each of R.sub.1 and R.sub.2 is selected from the group consisting of (1) C.sub.1 -C.sub.8 aliphatic hydrocarbons unsubstituted or substituted with carboxyl, hydroxyl or alkoxy of the formula --OR.sub.4 in which R.sub.4 is a C.sub.1 -C.sub.4 aliphatic hydrocarbon, (2) C.sub.3 -C.sub.8 alicyclic hydrocarbons, (3) C.sub.6 -C.sub.10 aromatic hydrocarbons and (4) C.sub.4 -C.sub.12 alicyclic hydrocarbons formed by combining R.sub.1 and R.sub.2 together with the adjacent carbon atom, and R.sub.3 is selected from the group consisting of nitrile, esters of the formula --COOR.sub.4 in which R.sub.4 is a C.sub.1 -C.sub.4 aliphatic hydrocarbon, a carboxylate of the formula --COOM in which M is an alkali metal or alkaline earth metal, and a carboxylamido, which are useful as foaming agents or radical polymerization initiator, are prepared in a high yield by reacting a corresponding amino compound with a metal hypohalite or with an alkyl hypohalite in the presence of an alkali, using a phase transfer catalyst in a heterogeneous medium comprising water and organic solvent, the phase transfer catalyst being one member selected from the group consisting of organic quaternary ammonium salts, organic quaternary phosphonium salts and macrocyclic polyethers.

摘要翻译： 下式的偶氮化合物，其中R 1和R 2各自选自（1）未被取代或被羧基取代的C 1 -C 8脂族烃，或由式-OR 4取代的羟基或烷氧基，其中R 4是C 1 -C 4脂族烃，（2）C 3 -C 8脂环烃，（3）C 6 -C 10芳烃和（4）通过将R 1和R 2与相邻碳原子结合而形成的C 4 -C 12脂环族烃，并且R 3选自 由腈组成的组，其中R 4是C 1 -C 4脂族烃的式-COOR 4的酯，其中M是碱金属或碱土金属的式-COOM的羧酸酯和可用作起泡剂的羧酰胺基 通过使相应的氨基化合物与金属次卤酸盐或与烷基次卤酸盐在碱存在下反应，通过在包含水和有机物的非均相介质中使用相转移催化剂，以高产率制备试剂或自由基聚合引发剂 lvent，相转移催化剂是选自有机季铵盐，有机季鏻盐和大环聚醚中的一种。

公开(公告)号：US07799953B2

公开(公告)日：2010-09-21

申请号：US10665006

申请日：2003-09-22

申请人： Tetsuya Shiozaki ,  Toru Haga

发明人： Tetsuya Shiozaki ,  Toru Haga

IPC分类号： C07C323/52 ,  C07C319/18

CPC分类号： C07C319/18 ,  C07C323/22

摘要： A 3-methylthiopropanal is produced by a method comprising the step of supplying an acrolein and a methyl mercaptan together or sequentially with an acidic compound and a basic compound into a reaction system to react the acrolein with the methyl mercaptan, wherein the basic compound is used in an amount of about 0.3 mol or less per mol of the acidic compound. In accordance with the present invention, a 3-methylthiopropanal with high quality is produced while suppressing the production of by-products having high boiling points.

摘要翻译： 通过包括将丙烯醛和甲硫醇一起或依次与酸性化合物和碱性化合物一起供入反应体系以使丙烯醛与甲硫醇反应的方法制备3-甲硫基丙醛，其中使用碱性化合物 其量为每摩尔酸性化合物约0.3摩尔或更少。 根据本发明，在抑制具有高沸点的副产物的生产的同时，生产高品质的3-甲硫基丙醛。

公开(公告)号：US20070055078A1

公开(公告)日：2007-03-08

申请号：US11510827

申请日：2006-08-28

申请人： Tetsuya Shiozaki ,  Go Inoue

发明人： Tetsuya Shiozaki ,  Go Inoue

IPC分类号： C07C323/25

CPC分类号： C07C319/20 ,  A23K20/142 ,  C07C319/28 ,  C07C323/58

摘要： A process for producing methionine by (1) hydrolyzing 5-[2-(methylthio)ethyl]-2,4-imidazolinedione in the presence of a basic potassium compound; (2) precipitating methionine by introducing CO2 into the reaction solution from the step (1) and separating the slurry into the precipitate and a mother liquid; (3) mixing the mother liquid from the step (2) with an alcohol, precipitating methionine and KHCO3 by introducing CO2 into the mixture, and separating the slurry into the precipitate and a mother liquid; and (4) concentrating the mother liquid from the step (3), precipitating methionine and KHCO3 by introducing CO2 into the concentrated solution, and separating the slurry into the precipitate and a mother liquid.

摘要翻译： （1）在碱性钾化合物的存在下水解5- [2-（甲硫基）乙基] -2,4-咪唑啉二酮，制备甲硫氨酸的方法; （2）通过将CO 2引入到步骤（1）的反应溶液中沉淀甲硫氨酸，并将浆液分离成沉淀物和母液; （3）将来自步骤（2）的母液与醇混合，通过将CO 2引入混合物中沉淀甲硫氨酸和KHCO 3 3，并将浆液分离成 沉淀和母液; 和（4）从步骤（3）中浓缩母液，通过将CO 2引入浓缩溶液中沉淀甲硫氨酸和KHCO 3，并将浆液分离成沉淀物 和母液。

公开(公告)号：US4026927A

公开(公告)日：1977-05-31

申请号：US508252

申请日：1974-09-23

申请人： Masuo Murakami ,  Noriyoshi Inukai ,  Hidenori Iwamoto ,  Toshinari Tamura ,  Isao Yanagisawa ,  Osamu Hasegawa ,  Yoshio Ishii ,  Hideya Matsuda ,  Tetsuya Shiozaki ,  Kenichi Tomioka

发明人： Masuo Murakami ,  Noriyoshi Inukai ,  Hidenori Iwamoto ,  Toshinari Tamura ,  Isao Yanagisawa ,  Osamu Hasegawa ,  Yoshio Ishii ,  Hideya Matsuda ,  Tetsuya Shiozaki ,  Kenichi Tomioka

IPC分类号： C07C405/00 ,  C07C177/00

CPC分类号： C07C405/00

摘要： Novel prostaglandin derivatives are provided having the formula: ##STR1## wherein A represents ##STR2## one of R.sub.3 and R.sub.4 represents a hydrogen atom and the other of them represents a lower alkyl group; one of R.sub.5 and R.sub.6 represents a hydrogen atom and the other of them represents a hydroxyl group; and one of R.sub.7 and R.sub.8 represents a hydrogen atom and the other of them represents a lower alkyl group.The compounds of this invention have excellent effects as prostaglandin E.sub.2 and prostaglandin F.sub.2.sub..alpha..

摘要翻译： 提供了具有下式的新型前列腺素衍生物：其中A表示R 3中的一个，R 4表示氢原子，另一个表示低级烷基; R5和R6之一表示氢原子，另一个表示羟基; R 7和R 8中的一个表示氢原子，另一个表示低级烷基。

公开(公告)号：US5445271A

公开(公告)日：1995-08-29

申请号：US244752

申请日：1994-06-09

申请人： Takeyoshi Kakizaki ,  Kenji Ikeda ,  Tetsuya Shiozaki

发明人： Takeyoshi Kakizaki ,  Kenji Ikeda ,  Tetsuya Shiozaki

IPC分类号： B65D25/10 ,  G11B33/04 ,  H01L21/00 ,  H01L21/673 ,  B65D73/00

CPC分类号： H01L21/67366 ,  B65D25/107 ,  G11B33/0444 ,  H01L21/67294

摘要： A wafer carrier box contains a wafer carrier which holds at the same time, a plurality of thin sheets, such as magnetic disks, compact disks, silicon wafers for producing semiconductors, or glass bases for LCDs, for operations including conveying, storing and surface-processing the thin sheets. On wall surfaces of the wafer carrier box and/or wafer carrier are bar codes including processing histories and control directly written by a laser beam. The wafer carrier is formed of a material such as polypropylene containing 0.0001 to 0.5 percent by weight of Si or other material that acts as an exothermic body. The other material may be a catalytic substance normally included in production of the wafer carrier. Deterioration in identification capability, which may occur due to chemical liquids, is eliminated. Therefore damage to the bar code which provides lot identification is prevented and improved processing is achieved.

摘要翻译： PCT No.PCT / JP93 / 01674 Sec。 371日期：1994年6月9日 102（e）日期1994年6月9日PCT提交1993年11月16日PCT公布。 出版物WO94 / 11274 日期：1994年5月26日。晶片载体盒包含同时保持多个薄片，例如磁盘，光盘，用于制造半导体的硅晶片或用于LCD的玻璃基板的晶片载体，用于包括 输送，存储和表面处理薄片。 在晶片载体盒和/或晶片载体的壁表面上是包括处理历史和由激光束直接写入的控制的条形码。 晶片载体由诸如聚丙烯的材料形成，其含有0.0001至0.5重量％的Si或用作放热体的其它材料。 其他材料可以是通常包括在晶片载体生产中的催化物质。 消除了由于化学液体而导致的识别能力恶化。 因此，防止了提供批次识别的条形码的损坏，并且实现了改进的处理。

公开(公告)号：US5262470A

公开(公告)日：1993-11-16

申请号：US789083

申请日：1991-11-07

申请人： Sakae Shimotsuma ,  Tetsuya Shiozaki ,  Akihiro Suzuoka ,  Mie Sasaki

发明人： Sakae Shimotsuma ,  Tetsuya Shiozaki ,  Akihiro Suzuoka ,  Mie Sasaki

IPC分类号： B41M5/26 ,  C08K3/04 ,  C08K5/03 ,  H01B1/06

CPC分类号： B41M5/267 ,  C08K3/04

摘要： A polyester resin composition;(A) which contains(a) a thermoplastic polyester resin, and(b) a carbon black and/or a graphite, and(B) in which the content of the above component (b) is 0.001 to 2% by weight based on the total weight of the components (a) and (b). The polyester resin composition may further contain (c) a bromine-containing flame retardant, (d) an antimony-containing flame retardant aid and (e) an inorganic filler in addition to the components (a) and (b). This polyester resin composition permits marking of fine lines and precise print with a high contrast with a laser light.