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公开(公告)号：US20190270705A1
公开(公告)日：2019-09-05
申请号：US16461793
申请日：2017-11-20
发明人： Fernanda Laezza , Jia Zhou , Zhiqing Liu , Syed Ali
IPC分类号： C07D207/16 , C07D417/12 , C07D413/12 , C07C237/52
摘要： The present invention relates to novel small molecule modulators of Nav1.6 channels of the general formulae (I), (II), (III) and (IV), and the uses thereof.
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2.发明公开公开(公告)号：US20240360100A1
公开(公告)日：2024-10-31
申请号：US18684645
申请日：2022-08-18
IPC分类号： C07D401/12 , A61K31/4525 , A61K31/454 , A61K31/4545 , A61K31/496 , A61K31/5377 , A61K31/541 , C07D211/60 , C07D405/12 , C07D413/12 , C07D417/12
CPC分类号： C07D401/12 , A61K31/4525 , A61K31/454 , A61K31/4545 , A61K31/496 , A61K31/5377 , A61K31/541 , C07D211/60 , C07D405/12 , C07D413/12 , C07D417/12
摘要： Disclosed herein are serotonin (5-hydroxytryptamine) 5-HT2A receptor and/or 5-HT2C receptor allosteric modulators, the preparation thereof and use thereof.
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3.发明授权公开(公告)号：US09539256B2
公开(公告)日：2017-01-10
申请号：US14377574
申请日：2013-02-08
发明人： Xiaodong Cheng , Jia Zhou , Tamara Tsalkova , Fang Mei , Haijun Chen
IPC分类号： A61K31/513 , A61K31/42 , A61K31/4709 , A61K45/06 , A61K31/136 , A61K31/10 , A61K31/277 , A61K31/505
CPC分类号： A61K31/513 , A61K31/10 , A61K31/136 , A61K31/277 , A61K31/42 , A61K31/4709 , A61K31/505 , A61K45/06
摘要： Embodiments of the invention are directed to compounds that inhibit an activity of EP AC proteins and methods of using the same. The inventors have developed a sensitive and robust high throughput screening (HTS) assay for the purpose of identifying EPAC specific inhibitors (Tsalkova et al. (2012) PLOS ONE 7(1):e30441).
摘要翻译： 本发明的实施方案涉及抑制EPAC蛋白活性的化合物及其使用方法。 为了鉴定EPAC特异性抑制剂（Tsalkova等（2012）PLOS ONE 7（1）：e30441），本发明人开发了一种灵敏而强大的高通量筛选（HTS）测定法。
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![Substituted 4,6-dihydrospiro[[1,2,3]triazolo[4,5-b]pyridine-7,3'-indoline]-2',5(3H)-dione analogues](/abs-image/US/2024/09/03/US12077540B2/abs.jpg.150x150.jpg)
4.发明授权公开(公告)号：US12077540B2
公开(公告)日：2024-09-03
申请号：US17856915
申请日：2022-07-01
发明人： Jia Zhou , Pei-Yong Shi , Jimin Xu , Xuping Xie
IPC分类号： A61K31/438 , A61P31/14 , C07D471/20 , C07D495/04
CPC分类号： C07D471/20 , A61K31/438 , A61P31/14 , C07D495/04
摘要： A series of substituted 4,6-dihydrospiro[[1,2,3]triazolo[4,5-b]pyridine-7,3′-indoline]-2′,5(3H)-dione analogues, the use thereof and the preparation thereof.
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公开(公告)号：US12043602B2
公开(公告)日：2024-07-23
申请号：US17437024
申请日：2020-03-05
发明人： John F. Hancock , Jia Zhou , Dharini van der Hoeven , Jeffrey A. Frost , Na Ye , Pingyuan Wang
IPC分类号： C07D295/13
CPC分类号： C07D295/13
摘要： The invention relates generally to the following novel fendiline derivatives, and the preparation and use thereof: Formula I (I) and Formula II (II)
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公开(公告)号：US20230150929A1
公开(公告)日：2023-05-18
申请号：US17912485
申请日：2021-03-17
IPC分类号： C07C311/51 , C07D215/20 , C07D215/22 , C07D239/78 , C07D217/04 , C07D487/04 , C07D213/74 , C07D209/04 , C07D231/56 , C07D213/61 , C07D231/12 , C07D307/38
CPC分类号： C07C311/51 , C07D209/04 , C07D213/61 , C07D213/74 , C07D215/20 , C07D215/22 , C07D217/04 , C07D231/12 , C07D231/56 , C07D239/78 , C07D307/38 , C07D487/04 , C07C2602/10
摘要： The invention relates generally to novel EPAC1 activators, such as Formula I and II and the preparation thereof as well as the use of EPAC1 activators disclosed herein as to selectively activate EPAC1 in cells.
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![SUBSTITUTED 4,6-DIHYDROSPIRO[[1,2,3]TRIAZOLO[4,5-B]PYRIDINE-7,3'-INDOLINE]-2',5(3H)-DIONE ANALOGUES](/abs-image/US/2023/02/23/US20230056205A1/abs.jpg.150x150.jpg)
7.发明申请公开(公告)号：US20230056205A1
公开(公告)日：2023-02-23
申请号：US17856915
申请日：2022-07-01
发明人： Jia Zhou , Pei-Yong Shi , Jimin Xu , Xuping Xie
IPC分类号： C07D471/20 , A61P31/14 , C07D495/04
摘要： A series of substituted 4,6-dihydrospiro[[1,2,3]triazolo[4,5-b]pyridine-7,3'-indoline]-2',5(3H)-dione analogues, the use thereof and the preparation thereof.
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公开(公告)号：US20220177440A1
公开(公告)日：2022-06-09
申请号：US17437024
申请日：2020-03-05
发明人： John F. Hancock , Jia Zhou , Dharnii van der Hoeven , Jeffrey A. Frost , Na Ye , Pingyuan Wang
IPC分类号： C07D295/13
摘要： The invention relates generally to the following novel fendiline derivatives, and the preparation and use thereof: Formula I (I) and Formula II (II)
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公开(公告)号：US10457662B2
公开(公告)日：2019-10-29
申请号：US15575676
申请日：2016-05-20
申请人： The Regents of the University of Michigan , The Board of Regents of The University of Texas System
发明人： Nouri Neamati , Jia Zhou , Yuting Kuang , Na Ye
IPC分类号： A61K31/165 , C07C233/64 , C07D401/04 , A61K31/4706 , A61K31/497 , A61K31/501 , A61K31/506 , C07D215/40 , C07D401/14 , C07D401/12 , C07D239/28 , C07D241/24 , C07D471/04 , A61K31/4709 , A61K31/498 , A61K31/5377 , A61K45/06
摘要： This invention is in the field of medicinal chemistry. In particular, the invention relates to novel small molecule compounds having a quinolin-8-yl-nicotinamide structure (e.g., a compound having Formula I: which are useful in treating, ameliorating, or preventing various forms of cancer (e.g., pancreatic cancer).
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公开(公告)号：US20180282296A1
公开(公告)日：2018-10-04
申请号：US15575676
申请日：2016-05-20
申请人： The Regents of the University of Michigan , The Board of Regents of The University of Texas System
发明人： Nouri Neamati , Jia Zhou , Yuting Kuang , Na Ye
IPC分类号： C07D401/04 , A61K45/06 , A61K31/497 , A61K31/4709 , A61K31/506 , A61K31/498 , C07D471/04 , A61K31/5377 , C07D401/14
CPC分类号： C07D401/04 , A61K31/4706 , A61K31/4709 , A61K31/497 , A61K31/498 , A61K31/501 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D215/40 , C07D239/28 , C07D241/24 , C07D401/12 , C07D401/14 , C07D471/04
摘要： This invention is in the field of medicinal chemistry. In particular, the invention relates to novel small molecule compounds having a quinolin-8-yl-nicotinamide structure which are useful in treating, ameliorating, or preventing various forms of cancer (e.g., pancreatic cancer).
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