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Patent Agency Ranking
公开(公告)号：US11013818B2
公开(公告)日：2021-05-25
申请号：US16114187
申请日：2018-08-27
Inventor： Jinming Gao , Gang Huang , Tian Zhao , Xinpeng Ma , Yiguang Wang , Yang Li , Baran D. Sumer
IPC: A61K49/00 , C09B69/10 , G01N33/84 , G01N33/58 , G01N21/64 , C08F8/42 , C08F8/34 , C08F8/32 , C08F8/30
Abstract: The present disclosure relates to polymers which contain a hydrophobic and hydrophilic segment which is sensitive to pH. In some aspects, the polymers form a micelle which is sensitive to pH and results in a change in fluorescence based upon the particular pH. In some aspects, the disclosure also provides methods of using the polymers for the imaging of cellular or extracellular environment or delivering a drug.
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公开(公告)号：US11723990B2
公开(公告)日：2023-08-15
申请号：US17231922
申请日：2021-04-15
Inventor： Jinming Gao , Gang Huang , Tian Zhao , Xinpeng Ma , Yiguang Wang , Yang Li , Baran D. Sumer
IPC: A61K8/73 , A61K8/06 , A61K49/00 , G01N21/64 , C08F8/30 , C08F8/32 , C08F8/34 , C08F8/42 , C09B69/10 , G01N33/58 , G01N33/84
CPC classification number: A61K49/0054 , A61K49/0021 , A61K49/0032 , A61K49/0041 , C08F8/30 , C08F8/32 , C08F8/34 , C08F8/42 , C09B69/103 , C09B69/105 , C09B69/106 , C09B69/109 , G01N21/643 , G01N21/6428 , G01N21/6456 , G01N33/582 , G01N33/84 , G01N2021/6432 , G01N2021/6439 , G01N2021/6441
Abstract: The present disclosure relates to polymers which contain a hydrophobic and hydrophilic segment which is sensitive to pH. In some aspects, the polymers form a micelle which is sensitive to pH and results in a change in fluorescence based upon the particular pH. In some aspects, the disclosure also provides methods of using the polymers for the imaging of cellular or extracellular environment or delivering a drug.
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公开(公告)号：US10098971B2
公开(公告)日：2018-10-16
申请号：US15369701
申请日：2016-12-05
Inventor： Jinming Gao , Gang Huang , Tian Zhao , Xinpeng Ma , Yiguang Wang , Yang Li , Baran D. Sumer
IPC: A61K49/00 , G01N33/84 , G01N33/58 , C08F8/30 , C08F8/42 , C08F8/32 , C08F8/34 , C09B69/10 , G01N21/64
Abstract: The present disclosure relates to polymers which contain a hydrophobic and hydrophilic segment which is sensitive to pH. In some aspects, the polymers form a micelle which is sensitive to pH and results in a change in fluorescence based upon the particular pH. In some aspects, the disclosure also provides methods of using the polymers for the imaging of cellular or extracellular environment or delivering a drug.
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公开(公告)号：US09872926B2
公开(公告)日：2018-01-23
申请号：US15297862
申请日：2016-10-19
Inventor： Jinming Gao , Kejin Zhou , Baran D. Sumer
CPC classification number: A61K49/0054 , A61K49/0032 , A61K49/0082 , G01N21/6486 , G01N33/502
Abstract: The present invention relates to pH-tunable, highly activatable multicolored fluorescent nanoplatforms and methods of using the nanoplatforms in a variety of applications including, but not limited to, investigating fundamental cell physiological processes such as pH regulation in endocytic vesicles, endosome/lysosome maturation, and effect of pH on receptor cycling and trafficking of subcellular organelles.
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公开(公告)号：US09511152B2
公开(公告)日：2016-12-06
申请号：US13827197
申请日：2013-03-14
Inventor： Jinming Gao , Kejin Zhou , Baran D. Sumer
CPC classification number: A61K49/0054 , A61K49/0032 , A61K49/0082 , G01N21/6486 , G01N33/502
Abstract: The present invention relates to pH-tunable, highly activatable multicolored fluorescent nanoplatforms and methods of using the nanoplatforms in a variety of applications including, but not limited to, investigating fundamental cell physiological processes such as pH regulation in endocytic vesicles, endosome/lysosome maturation, and effect of pH on receptor cycling and trafficking of subcellular organelles.
Abstract translation: 本发明涉及pH可调节的，高活性的多色荧光纳米平台，以及在各种应用中使用纳米平台的方法，包括但不限于研究基本细胞生理过程，如内吞泡囊中的pH调节，内体/溶酶体成熟， 以及pH对受体循环和运输亚细胞器的影响。
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