公开(公告)号：US11013818B2

公开(公告)日：2021-05-25

申请号：US16114187

申请日：2018-08-27

Applicant: The Board of Regents of the University of Texas System

Inventor： Jinming Gao ,  Gang Huang ,  Tian Zhao ,  Xinpeng Ma ,  Yiguang Wang ,  Yang Li ,  Baran D. Sumer

IPC: A61K49/00 ,  C09B69/10 ,  G01N33/84 ,  G01N33/58 ,  G01N21/64 ,  C08F8/42 ,  C08F8/34 ,  C08F8/32 ,  C08F8/30

Abstract: The present disclosure relates to polymers which contain a hydrophobic and hydrophilic segment which is sensitive to pH. In some aspects, the polymers form a micelle which is sensitive to pH and results in a change in fluorescence based upon the particular pH. In some aspects, the disclosure also provides methods of using the polymers for the imaging of cellular or extracellular environment or delivering a drug.

公开(公告)号：US11376324B2

公开(公告)日：2022-07-05

申请号：US16081911

申请日：2017-03-02

Applicant: The Board of Regents of the University of Texas System

Inventor： Jinming Gao ,  Zhijian Chen ,  Min Luo ,  Zhaohui Wang ,  Hua Wang ,  Haocheng Cai ,  Gang Huang ,  Yang-Xin Fu

IPC: A61K39/39 ,  A61K39/00 ,  A61K9/51 ,  A61K47/32 ,  A61K47/58 ,  B82Y5/00 ,  A61K9/00 ,  A61K45/06 ,  A61K39/145

Abstract: In some aspects, the present disclosure provides vaccine compositions comprising an antigen and a diblock copolymer wherein the diblock copolymer is pH responsive. In some embodiments, these compositions activate the STING and/or the interferon receptor pathways. In some embodiments, the diblock copolymer hits a pKa from about 6 to about 7.5. Also provided herein are methods of treatment using these compositions to treat an infectious disease or cancer.

公开(公告)号：US11723990B2

公开(公告)日：2023-08-15

申请号：US17231922

申请日：2021-04-15

Applicant: The Board of Regents of the University of Texas System

Inventor： Jinming Gao ,  Gang Huang ,  Tian Zhao ,  Xinpeng Ma ,  Yiguang Wang ,  Yang Li ,  Baran D. Sumer

IPC: A61K8/73 ,  A61K8/06 ,  A61K49/00 ,  G01N21/64 ,  C08F8/30 ,  C08F8/32 ,  C08F8/34 ,  C08F8/42 ,  C09B69/10 ,  G01N33/58 ,  G01N33/84

CPC classification number: A61K49/0054 ,  A61K49/0021 ,  A61K49/0032 ,  A61K49/0041 ,  C08F8/30 ,  C08F8/32 ,  C08F8/34 ,  C08F8/42 ,  C09B69/103 ,  C09B69/105 ,  C09B69/106 ,  C09B69/109 ,  G01N21/643 ,  G01N21/6428 ,  G01N21/6456 ,  G01N33/582 ,  G01N33/84 ,  G01N2021/6432 ,  G01N2021/6439 ,  G01N2021/6441

Abstract: The present disclosure relates to polymers which contain a hydrophobic and hydrophilic segment which is sensitive to pH. In some aspects, the polymers form a micelle which is sensitive to pH and results in a change in fluorescence based upon the particular pH. In some aspects, the disclosure also provides methods of using the polymers for the imaging of cellular or extracellular environment or delivering a drug.

公开(公告)号：US10829427B2

公开(公告)日：2020-11-10

申请号：US16063347

申请日：2016-12-16

Applicant: The Board of Regents of the University of Texas System

Inventor： Jinming Gao ,  Yuliang Liu ,  Qi Wei ,  Xinpeng Ma ,  Gang Huang

IPC: C07C50/32 ,  C07C311/08 ,  C07C311/21 ,  C07C225/30 ,  C07C233/91 ,  C07C233/18 ,  C07C271/30 ,  C07C205/46 ,  C07C311/09 ,  C07C233/31 ,  C07D317/70 ,  C07C311/51 ,  A61K9/00 ,  A61K9/51 ,  A61P35/00 ,  C07C233/33 ,  C07C233/42 ,  C07D295/116

Abstract: Provided herein are naphthoquinones compounds such as those with a hydrogen bond donating group of the formula (I): wherein: R1, R2, R3, R4, R5, and n are as defined herein. Also provided herein are pharmaceutical composition of the present compounds and methods of treatment using the compounds including their use in the treatment of cancer.

公开(公告)号：US10098971B2

公开(公告)日：2018-10-16

申请号：US15369701

申请日：2016-12-05

Applicant: The Board of Regents of the University of Texas System

Inventor： Jinming Gao ,  Gang Huang ,  Tian Zhao ,  Xinpeng Ma ,  Yiguang Wang ,  Yang Li ,  Baran D. Sumer

IPC: A61K49/00 ,  G01N33/84 ,  G01N33/58 ,  C08F8/30 ,  C08F8/42 ,  C08F8/32 ,  C08F8/34 ,  C09B69/10 ,  G01N21/64

Abstract: The present disclosure relates to polymers which contain a hydrophobic and hydrophilic segment which is sensitive to pH. In some aspects, the polymers form a micelle which is sensitive to pH and results in a change in fluorescence based upon the particular pH. In some aspects, the disclosure also provides methods of using the polymers for the imaging of cellular or extracellular environment or delivering a drug.