公开(公告)号：US11013818B2

公开(公告)日：2021-05-25

申请号：US16114187

申请日：2018-08-27

Applicant: The Board of Regents of the University of Texas System

Inventor： Jinming Gao ,  Gang Huang ,  Tian Zhao ,  Xinpeng Ma ,  Yiguang Wang ,  Yang Li ,  Baran D. Sumer

IPC: A61K49/00 ,  C09B69/10 ,  G01N33/84 ,  G01N33/58 ,  G01N21/64 ,  C08F8/42 ,  C08F8/34 ,  C08F8/32 ,  C08F8/30

Abstract: The present disclosure relates to polymers which contain a hydrophobic and hydrophilic segment which is sensitive to pH. In some aspects, the polymers form a micelle which is sensitive to pH and results in a change in fluorescence based upon the particular pH. In some aspects, the disclosure also provides methods of using the polymers for the imaging of cellular or extracellular environment or delivering a drug.

公开(公告)号：US10576096B2

公开(公告)日：2020-03-03

申请号：US15834052

申请日：2017-12-06

Applicant: The Board of Regents of the University of Texas System ,  The Board of Trustees of the University of Illinois

Inventor： Paul J. Hergenrother ,  David A. Boothman ,  Joseph S. Bair ,  Lifen Cao ,  Jinming Gao ,  Xiumei Huang ,  Xiuquan Luo ,  Xinpeng Ma ,  Zachary R. Moore ,  Elizabeth I. Parkinson

IPC: A61K31/353 ,  A61K31/4745 ,  A61K31/131 ,  A61K31/706 ,  A61K31/4738 ,  C12Q1/6886 ,  A61K45/06

Abstract: The therapies described herein can be selectively lethal toward a variety of different cancer cell types and cancer conditions in a subject. The combination therapies described herein can be useful for the management, treatment, control, or adjunct treatment of diseases, where the selective legality is beneficial in chemotherapeutic therapy, particularly where the disease is accompanied by elevated levels of NQO1.

公开(公告)号：US11723990B2

公开(公告)日：2023-08-15

申请号：US17231922

申请日：2021-04-15

Applicant: The Board of Regents of the University of Texas System

Inventor： Jinming Gao ,  Gang Huang ,  Tian Zhao ,  Xinpeng Ma ,  Yiguang Wang ,  Yang Li ,  Baran D. Sumer

IPC: A61K8/73 ,  A61K8/06 ,  A61K49/00 ,  G01N21/64 ,  C08F8/30 ,  C08F8/32 ,  C08F8/34 ,  C08F8/42 ,  C09B69/10 ,  G01N33/58 ,  G01N33/84

CPC classification number: A61K49/0054 ,  A61K49/0021 ,  A61K49/0032 ,  A61K49/0041 ,  C08F8/30 ,  C08F8/32 ,  C08F8/34 ,  C08F8/42 ,  C09B69/103 ,  C09B69/105 ,  C09B69/106 ,  C09B69/109 ,  G01N21/643 ,  G01N21/6428 ,  G01N21/6456 ,  G01N33/582 ,  G01N33/84 ,  G01N2021/6432 ,  G01N2021/6439 ,  G01N2021/6441

Abstract: The present disclosure relates to polymers which contain a hydrophobic and hydrophilic segment which is sensitive to pH. In some aspects, the polymers form a micelle which is sensitive to pH and results in a change in fluorescence based upon the particular pH. In some aspects, the disclosure also provides methods of using the polymers for the imaging of cellular or extracellular environment or delivering a drug.

公开(公告)号：US10829427B2

公开(公告)日：2020-11-10

申请号：US16063347

申请日：2016-12-16

Applicant: The Board of Regents of the University of Texas System

Inventor： Jinming Gao ,  Yuliang Liu ,  Qi Wei ,  Xinpeng Ma ,  Gang Huang

IPC: C07C50/32 ,  C07C311/08 ,  C07C311/21 ,  C07C225/30 ,  C07C233/91 ,  C07C233/18 ,  C07C271/30 ,  C07C205/46 ,  C07C311/09 ,  C07C233/31 ,  C07D317/70 ,  C07C311/51 ,  A61K9/00 ,  A61K9/51 ,  A61P35/00 ,  C07C233/33 ,  C07C233/42 ,  C07D295/116

Abstract: Provided herein are naphthoquinones compounds such as those with a hydrogen bond donating group of the formula (I): wherein: R1, R2, R3, R4, R5, and n are as defined herein. Also provided herein are pharmaceutical composition of the present compounds and methods of treatment using the compounds including their use in the treatment of cancer.

公开(公告)号：US10272099B2

公开(公告)日：2019-04-30

申请号：US14783344

申请日：2014-04-08

Applicant: The Board of Regents of the University of Texas System ,  The Board of Trustees of the University of Illinois

Inventor： Paul J. Hergenrother ,  David A. Boothman ,  Joseph S. Bair ,  Lifen Cao ,  Jinming Gao ,  Xiumei Huang ,  Xiuquan Luo ,  Xinpeng Ma ,  Zachary R. Moore ,  Elizabeth I. Parkinson

IPC: A61K31/353 ,  A61K31/4745 ,  A61K31/131 ,  A61K31/706 ,  A61K45/06 ,  C12Q1/6886 ,  A61K31/4738

Abstract: The therapies described herein can be selectively lethal toward a variety of different cancer cell types and cancer conditions in a subject. The combination therapies described herein can be useful for the management, treatment, control, or adjunct treatment of diseases, where the selective lethality is beneficial in chemotherapeutic therapy, particularly where the disease is accompanied by elevated levels of NQO1.

公开(公告)号：US10098971B2

公开(公告)日：2018-10-16

申请号：US15369701

申请日：2016-12-05

Applicant: The Board of Regents of the University of Texas System

Inventor： Jinming Gao ,  Gang Huang ,  Tian Zhao ,  Xinpeng Ma ,  Yiguang Wang ,  Yang Li ,  Baran D. Sumer

IPC: A61K49/00 ,  G01N33/84 ,  G01N33/58 ,  C08F8/30 ,  C08F8/42 ,  C08F8/32 ,  C08F8/34 ,  C09B69/10 ,  G01N21/64

Abstract: The present disclosure relates to polymers which contain a hydrophobic and hydrophilic segment which is sensitive to pH. In some aspects, the polymers form a micelle which is sensitive to pH and results in a change in fluorescence based upon the particular pH. In some aspects, the disclosure also provides methods of using the polymers for the imaging of cellular or extracellular environment or delivering a drug.