公开(公告)号：US11013818B2

公开(公告)日：2021-05-25

申请号：US16114187

申请日：2018-08-27

Applicant: The Board of Regents of the University of Texas System

Inventor： Jinming Gao ,  Gang Huang ,  Tian Zhao ,  Xinpeng Ma ,  Yiguang Wang ,  Yang Li ,  Baran D. Sumer

IPC: A61K49/00 ,  C09B69/10 ,  G01N33/84 ,  G01N33/58 ,  G01N21/64 ,  C08F8/42 ,  C08F8/34 ,  C08F8/32 ,  C08F8/30

Abstract: The present disclosure relates to polymers which contain a hydrophobic and hydrophilic segment which is sensitive to pH. In some aspects, the polymers form a micelle which is sensitive to pH and results in a change in fluorescence based upon the particular pH. In some aspects, the disclosure also provides methods of using the polymers for the imaging of cellular or extracellular environment or delivering a drug.

公开(公告)号：US09751970B2

公开(公告)日：2017-09-05

申请号：US15072522

申请日：2016-03-17

Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Jinming Gao ,  David Boothman ,  Kejin Zhou ,  Xiaonan Huang ,  Yiguang Wang

IPC: A61K8/00 ,  C08F293/00 ,  C07D311/92 ,  A61K9/127 ,  A61K47/48 ,  A61K9/50 ,  A61K31/337 ,  A61K31/704 ,  A61K31/352 ,  A61K9/107 ,  A61K49/00 ,  C08F220/34

CPC classification number: C08F293/005 ,  A61K9/1075 ,  A61K9/1273 ,  A61K9/5031 ,  A61K31/337 ,  A61K31/352 ,  A61K31/704 ,  A61K47/58 ,  A61K47/62 ,  A61K47/6811 ,  A61K47/6845 ,  A61K49/0032 ,  A61K49/005 ,  A61K49/0054 ,  A61K49/0056 ,  A61K49/0082 ,  C07D311/92 ,  C08F220/34 ,  C08F2438/01

Abstract: Provided herein are block copolymers comprising a hydrophilic polymer segment and a hydrophobic polymer segment, wherein the hydrophilic polymer segment comprises a polymer selected from the group consisting of: poly(ethylene oxide) (PEO), poly(methacrylate phosphatidyl choline) (MPC), and polyvinylpyrrolidone (PVP), wherein the hydrophobic polymer segment comprises wherein R′ is —H or —CH3, wherein R is —NR1R2, wherein R1 and R2 are alkyl groups, wherein R1 and R2 are the same or different, wherein R1 and R2 together have from 5 to 16 carbons, wherein R1 and R2 may optionally join to form a ring, wherein n is 1 to about 10, and wherein x is about 20 to about 200 in total. Also provided are pH-sensitive micelle compositions for therapeutic and diagnostic applications.

公开(公告)号：US10017598B2

公开(公告)日：2018-07-10

申请号：US15662184

申请日：2017-07-27

Applicant: The Board of Regents of the University of Texas System

Inventor： Jinming Gao ,  David Boothman ,  Kejin Zhou ,  Xiaonan Huang ,  Yiguang Wang

IPC: A61K8/00 ,  C08F293/00 ,  C07D311/92 ,  A61K9/127 ,  A61K9/50 ,  A61K31/337 ,  A61K31/704 ,  A61K49/00 ,  A61K31/352 ,  A61K9/107 ,  A61K47/58 ,  A61K47/62 ,  A61K47/68 ,  C08F220/34

CPC classification number: C08F293/005 ,  A61K9/1075 ,  A61K9/1273 ,  A61K9/5031 ,  A61K31/337 ,  A61K31/352 ,  A61K31/704 ,  A61K47/58 ,  A61K47/62 ,  A61K47/6811 ,  A61K47/6845 ,  A61K49/0032 ,  A61K49/005 ,  A61K49/0054 ,  A61K49/0056 ,  A61K49/0082 ,  C07D311/92 ,  C08F220/34 ,  C08F2438/01

Abstract: Provided herein are block copolymers comprising a hydrophilic polymer segment and a hydrophobic polymer segment, wherein the hydrophilic polymer segment comprises a polymer selected from the group consisting of: poly(ethylene oxide) (PEO), poly(methacrylate phosphatidyl choline) (MPC), and polyvinylpyrrolidone (PVP), wherein the hydrophobic polymer segment comprises wherein R′ is —H or —CH3, wherein R is —NR1R2, wherein R1 and R2 are alkyl groups, wherein R1 and R2 are the same or different, wherein R1 and R2 together have from 5 to 16 carbons, wherein R1 and R2 may optionally join to form a ring, wherein n is 1 to about 10, and wherein x is about 20 to about 200 in total. Also provided are pH-sensitive micelle compositions for therapeutic and diagnostic applications.

公开(公告)号：US11723990B2

公开(公告)日：2023-08-15

申请号：US17231922

申请日：2021-04-15

Applicant: The Board of Regents of the University of Texas System

Inventor： Jinming Gao ,  Gang Huang ,  Tian Zhao ,  Xinpeng Ma ,  Yiguang Wang ,  Yang Li ,  Baran D. Sumer

IPC: A61K8/73 ,  A61K8/06 ,  A61K49/00 ,  G01N21/64 ,  C08F8/30 ,  C08F8/32 ,  C08F8/34 ,  C08F8/42 ,  C09B69/10 ,  G01N33/58 ,  G01N33/84

CPC classification number: A61K49/0054 ,  A61K49/0021 ,  A61K49/0032 ,  A61K49/0041 ,  C08F8/30 ,  C08F8/32 ,  C08F8/34 ,  C08F8/42 ,  C09B69/103 ,  C09B69/105 ,  C09B69/106 ,  C09B69/109 ,  G01N21/643 ,  G01N21/6428 ,  G01N21/6456 ,  G01N33/582 ,  G01N33/84 ,  G01N2021/6432 ,  G01N2021/6439 ,  G01N2021/6441

Abstract: The present disclosure relates to polymers which contain a hydrophobic and hydrophilic segment which is sensitive to pH. In some aspects, the polymers form a micelle which is sensitive to pH and results in a change in fluorescence based upon the particular pH. In some aspects, the disclosure also provides methods of using the polymers for the imaging of cellular or extracellular environment or delivering a drug.

公开(公告)号：US11447593B2

公开(公告)日：2022-09-20

申请号：US16814845

申请日：2020-03-10

Applicant: The Board of Regents of the University of Texas System

Inventor： Jinming Gao ,  David Boothman ,  Kejin Zhou ,  Xiaonan Huang ,  Yiguang Wang

IPC: A61K49/00 ,  C08F293/00 ,  C07D311/92 ,  A61K47/58 ,  A61K47/62 ,  A61K9/127 ,  A61K31/352 ,  A61P35/00 ,  C08F299/02 ,  A61K47/69 ,  C08G81/02 ,  G01N33/58 ,  A61K9/50 ,  A61K31/337 ,  A61K31/704 ,  A61K9/107 ,  A61K47/68

Abstract: Provided herein are block copolymers comprising a hydrophilic polymer segment and a hydrophobic polymer segment, wherein the hydrophilic polymer segment comprises a polymer selected from the group consisting of: poly(ethylene oxide) (PEO), poly(methacrylate phosphatidyl choline) (MPC), and polyvinylpyrrolidone (PVP), wherein the hydrophobic polymer segment comprises wherein R′ is —H or —CH3, wherein R is —NR1R2, wherein R1 and R2 are alkyl groups, wherein R1 and R2 are the same or different, wherein R1 and R2 together have from 5 to 16 carbons, wherein R1 and R2 may optionally join to form a ring, wherein n is 1 to about 10, and wherein x is about 20 to about 200 in total. Also provided are pH-sensitive micelle compositions for therapeutic and diagnostic applications.

公开(公告)号：US11098150B2

公开(公告)日：2021-08-24

申请号：US16006885

申请日：2018-06-13

Applicant: The Board of Regents of the University of Texas System

Inventor： Jinming Gao ,  David Boothman ,  Kejin Zhou ,  Xiaonan Huang ,  Yiguang Wang

IPC: A61K49/00 ,  C08F293/00 ,  C07D311/92 ,  A61K47/58 ,  A61K47/62 ,  A61K9/127 ,  A61K31/352 ,  A61P35/00 ,  C08F299/02 ,  A61K47/69 ,  C08G81/02 ,  G01N33/58 ,  A61K9/50 ,  A61K31/337 ,  A61K31/704 ,  A61K9/107 ,  A61K47/68 ,  C08F220/34

Abstract: Provided herein are block copolymers comprising a hydrophilic polymer segment and a hydrophobic polymer segment, wherein the hydrophilic polymer segment comprises a polymer selected from the group consisting of: poly(ethylene oxide) (PEO), poly(methacrylate phosphatidyl choline) (MPC), and polyvinylpyrrolidone (PVP), wherein the hydrophobic polymer segment comprises wherein R′ is —H or —CH3, wherein R is —NR1R2, wherein R1 and R2 are alkyl groups, wherein R1 and R2 are the same or different, wherein R1 and R2 together have from 5 to 16 carbons, wherein R1 and R2 may optionally join to form a ring, wherein n is 1 to about 10, and wherein x is about 20 to about 200 in total. Also provided are pH-sensitive micelle compositions for therapeutic and diagnostic applications.

公开(公告)号：US10098971B2

公开(公告)日：2018-10-16

申请号：US15369701

申请日：2016-12-05

Applicant: The Board of Regents of the University of Texas System

Inventor： Jinming Gao ,  Gang Huang ,  Tian Zhao ,  Xinpeng Ma ,  Yiguang Wang ,  Yang Li ,  Baran D. Sumer

IPC: A61K49/00 ,  G01N33/84 ,  G01N33/58 ,  C08F8/30 ,  C08F8/42 ,  C08F8/32 ,  C08F8/34 ,  C09B69/10 ,  G01N21/64

Abstract: The present disclosure relates to polymers which contain a hydrophobic and hydrophilic segment which is sensitive to pH. In some aspects, the polymers form a micelle which is sensitive to pH and results in a change in fluorescence based upon the particular pH. In some aspects, the disclosure also provides methods of using the polymers for the imaging of cellular or extracellular environment or delivering a drug.

公开(公告)号：US12091486B2

公开(公告)日：2024-09-17

申请号：US17810591

申请日：2022-07-01

Applicant: The Board of Regents of The University of Texas System

Inventor： Jinming Gao ,  David Boothman ,  Kejin Zhou ,  Xiaonan Huang ,  Yiguang Wang

IPC: C08F293/00 ,  A61K9/107 ,  A61K9/127 ,  A61K9/50 ,  A61K31/337 ,  A61K31/352 ,  A61K31/704 ,  A61K47/58 ,  A61K47/62 ,  A61K47/68 ,  A61K47/69 ,  A61K49/00 ,  A61P35/00 ,  C07D311/92 ,  C08F299/02 ,  C08G81/02 ,  G01N33/58

CPC classification number: C08F293/005 ,  A61K9/1075 ,  A61K9/1273 ,  A61K9/5031 ,  A61K31/337 ,  A61K31/352 ,  A61K31/704 ,  A61K47/58 ,  A61K47/62 ,  A61K47/6811 ,  A61K47/6845 ,  A61K47/6907 ,  A61K49/0032 ,  A61K49/0054 ,  A61K49/0056 ,  A61K49/0082 ,  A61P35/00 ,  C07D311/92 ,  C08F299/024 ,  C08G81/025 ,  G01N33/582 ,  A61K49/005 ,  C08F2438/01

Abstract: Provided herein are block copolymers comprising a hydrophilic polymer segment and a hydrophobic polymer segment, wherein the hydrophilic polymer segment comprises a polymer selected from the group consisting of: poly(ethylene oxide) (PEO), poly(methacrylate phosphatidyl choline) (MPC), and polyvinylpyrrolidone (PVP), wherein the hydrophobic polymer segment comprises




wherein R′ is —H or —CH3, wherein R is —NR1R2, wherein R1 and R2 are alkyl groups, wherein R1 and R2 are the same or different, wherein R1 and R2 together have from 5 to 16 carbons, wherein R1 and R2 may optionally join to form a ring, wherein n is 1 to about 10, and wherein x is about 20 to about 200 in total. Also provided are pH-sensitive micelle compositions for therapeutic and diagnostic applications.