公开(公告)号：US11376324B2

公开(公告)日：2022-07-05

申请号：US16081911

申请日：2017-03-02

Applicant: The Board of Regents of the University of Texas System

Inventor： Jinming Gao ,  Zhijian Chen ,  Min Luo ,  Zhaohui Wang ,  Hua Wang ,  Haocheng Cai ,  Gang Huang ,  Yang-Xin Fu

IPC: A61K39/39 ,  A61K39/00 ,  A61K9/51 ,  A61K47/32 ,  A61K47/58 ,  B82Y5/00 ,  A61K9/00 ,  A61K45/06 ,  A61K39/145

Abstract: In some aspects, the present disclosure provides vaccine compositions comprising an antigen and a diblock copolymer wherein the diblock copolymer is pH responsive. In some embodiments, these compositions activate the STING and/or the interferon receptor pathways. In some embodiments, the diblock copolymer hits a pKa from about 6 to about 7.5. Also provided herein are methods of treatment using these compositions to treat an infectious disease or cancer.