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公开(公告)号：US11492368B2
公开(公告)日：2022-11-08
申请号：US16903173
申请日：2020-06-16
Inventor： Zhijian Chen , Lijun Sun , Jiaxi Wu , Heping Shi , Chuo Chen
IPC: C07H21/02 , A61K39/39 , A61K31/7084 , C12Q1/6876 , C12Q1/25 , G01N33/573 , G01N33/564 , A61K39/00
Abstract: Cyclic-GMP-AMP synthase (cGAS) and cyclic-GMP-AMP (cGAMP), including 2′3-cGAMP, 2′2-cGAMP, 3′2′-cGAMP and 3′3′-GAMP, are used in pharmaceutical formulations (including vaccine adjuvants), drug screens, therapies, and diagnostics.
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公开(公告)号：US10947206B2
公开(公告)日：2021-03-16
申请号：US15953494
申请日：2018-04-15
Inventor： Boyu Zhong , Lijun Sun , Heping Shi , Jing Li , Chuo Chen , Zhijian Chen
IPC: C07D277/34 , C07D417/14 , A61K31/429 , A61K31/4365 , A61K31/4439 , A61K31/506 , A61K31/519 , A61K31/427 , C07D277/40 , A61K31/437 , A61K31/426 , A61K31/381 , A61K31/433 , A61K31/4709 , A61K39/39 , A61K45/06 , A61K31/454 , A61K31/4725 , A61K31/497 , A61K31/4985 , A61K31/501 , C07D277/36 , C07D403/06 , C07D417/04 , C07D417/06 , C07D417/10 , C07D417/12 , C07D471/04 , C07D495/04 , C07D513/04
Abstract: Disclosed are novel compounds of Formula I that are cGAS antagonists, methods of preparation of the compounds, pharmaceutical compositions comprising the compounds, and their use in medical therapy.
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公开(公告)号：US20250115579A1
公开(公告)日：2025-04-10
申请号：US18829953
申请日：2024-09-10
Inventor： Jian Qiu , Qi Wei , Matt Tschantz , Heping Shi , Youtong Wu , Huiling Tan , Lijun Sun , Chuo Chen , Zhijian Chen
IPC: C07D401/14 , C07D215/38 , C07D215/42 , C07D215/46 , C07D401/04 , C07D403/04 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/08 , C07D491/048 , C07F9/6503 , C07F9/6506
Abstract: The present disclosure provides compounds that are cGAS antagonists, methods of preparation of the compounds, pharmaceutical compositions comprising the compounds, and their use in medical therapy.
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公开(公告)号：US12134609B2
公开(公告)日：2024-11-05
申请号：US18334325
申请日：2023-06-13
Inventor： Jian Qiu , Qi Wei , Matt Tschantz , Heping Shi , Youtong Wu , Huiling Tan , Lijun Sun , Chuo Chen , Zhijian Chen
IPC: C07D401/14 , C07D215/38 , C07D215/42 , C07D215/46 , C07D401/04 , C07D403/04 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/08 , C07D491/048 , C07F9/6503 , C07F9/6506
Abstract: The present disclosure provides compounds that are cGAS antagonists, methods of preparation of the compounds, pharmaceutical compositions comprising the compounds, and their use in medical therapy.
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公开(公告)号：US12091387B2
公开(公告)日：2024-09-17
申请号：US18353718
申请日：2023-07-17
Inventor： Qi Wei , Heping Shi , Matt Tschantz , Jian Qiu , Youtong Wu , Huiling Tan , Lijun Sun , Chuo Chen , Zhijian Chen
IPC: C07D215/12 , C07D401/04 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14
CPC classification number: C07D215/12 , C07D401/04 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14
Abstract: The present disclosure provides compounds that are cGAS antagonists, methods of preparation of the compounds, pharmaceutical compositions comprising the compounds, and their use in medical therapy.
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Patent Agency Ranking
公开(公告)号：US10519188B2
公开(公告)日：2019-12-31
申请号：US15953492
申请日：2018-04-15
Inventor： Boyu Zhong , Lijun Sun , Heping Shi , Qi Wei , Yuanwei Dai , Chuo Chen , Zhijian Chen
IPC: C07H21/04 , A61K31/7084 , C07H21/02 , A61K45/06
Abstract: Disclosed are cyclic-di-nucleotide cGAMP analogs, methods of synthesizing the compounds, pharmaceutical compositions comprising the compounds thereof, and use of compounds and compositions in medical therapy.
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公开(公告)号：US11299512B2
公开(公告)日：2022-04-12
申请号：US16438153
申请日：2019-06-11
Inventor： Boyu Zhong , Heping Shi , Yuanwei Dai , Qi Wei , Chuo Chen , Zhijian Chen , Lijun Sun
IPC: C07H21/02 , C07H21/04 , C07H21/00 , A61K31/7084 , A61K45/06
Abstract: Disclosed are cyclic-di-nucleotide cGAMP analogs, methods of synthesizing the compounds, pharmaceutical compositions comprising the compounds thereof, and use of compounds and compositions in medical therapy.
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公开(公告)号：US11213592B2
公开(公告)日：2022-01-04
申请号：US17317864
申请日：2021-05-11
Inventor： Zhijian Chen , Heping Shi , Qi Wei , Chuo Chen , Lijun Sun , Jian Qiu , Youtong Wu
Abstract: The present disclosure relates to, among other things, antibody-drug conjugates comprising a STING agonist cyclic di-nucleotide conjugated to an antibody, preparation methods therefor, and uses therefor.
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公开(公告)号：US20250115564A1
公开(公告)日：2025-04-10
申请号：US18759546
申请日：2024-06-28
Inventor： Boyu Zhong , Lijun Sun , Heping Shi , Jing Li , Chuo Chen , Zhijian Chen
IPC: C07D277/34 , A61K31/381 , A61K31/426 , A61K31/427 , A61K31/429 , A61K31/433 , A61K31/4365 , A61K31/437 , A61K31/4439 , A61K31/454 , A61K31/4709 , A61K31/4725 , A61K31/497 , A61K31/4985 , A61K31/501 , A61K31/506 , A61K31/519 , A61K39/39 , A61K45/06 , C07D277/36 , C07D277/40 , C07D403/06 , C07D417/04 , C07D417/06 , C07D417/10 , C07D417/12 , C07D417/14 , C07D471/04 , C07D495/04 , C07D513/04
Abstract: Disclosed are novel compounds of Formula I that are cGAS antagonists, methods of preparation of the compounds, pharmaceutical compositions comprising the compounds, and their use in medical therapy.
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公开(公告)号：US11376324B2
公开(公告)日：2022-07-05
申请号：US16081911
申请日：2017-03-02
Inventor： Jinming Gao , Zhijian Chen , Min Luo , Zhaohui Wang , Hua Wang , Haocheng Cai , Gang Huang , Yang-Xin Fu
IPC: A61K39/39 , A61K39/00 , A61K9/51 , A61K47/32 , A61K47/58 , B82Y5/00 , A61K9/00 , A61K45/06 , A61K39/145
Abstract: In some aspects, the present disclosure provides vaccine compositions comprising an antigen and a diblock copolymer wherein the diblock copolymer is pH responsive. In some embodiments, these compositions activate the STING and/or the interferon receptor pathways. In some embodiments, the diblock copolymer hits a pKa from about 6 to about 7.5. Also provided herein are methods of treatment using these compositions to treat an infectious disease or cancer.
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