公开(公告)号：US10054588B2

公开(公告)日：2018-08-21

申请号：US14781885

申请日：2014-04-04

申请人： The Board of Trustees of the Leland Stanford Junior University

发明人： Ryan D. Schubert ,  Robert C. Axtell ,  Jeffrey Edward Dunn

IPC分类号： G01N15/14 ,  A61K31/785 ,  G01N33/569 ,  G01N33/50 ,  A61K38/21 ,  G01N15/10

CPC分类号： G01N33/56972 ,  A61K31/785 ,  A61K38/215 ,  G01N15/14 ,  G01N33/5052 ,  G01N2015/1006 ,  G01N2015/1486 ,  G01N2333/525 ,  G01N2333/565 ,  G01N2469/10 ,  G01N2800/285 ,  G01N2800/52

摘要： Compositions and methods are provided for classification of individuals suffering from a demyelinating disease into groups that are informative of the individual's responsiveness or lack of responsiveness to treatment with a J3-interferon (IFNJ3) acting therapy. In particular, it is shown that the effective immunomodulatory treatment of demyelinating disease with IFNJ3 is associated with an increase in circulating transitional B cells in the patient. Diseases of interest include without limitation inflammatory demyelinating diseases of the central nervous system, e.g. multiple sclerosis, neuromyelitis optica (NMO), experimental autoimmune encephalitis (EAE), acute disseminated encephalomyelitis (ADEM), etc.

公开(公告)号：US20160054320A1

公开(公告)日：2016-02-25

申请号：US14781885

申请日：2014-04-04

申请人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY

发明人： Ryan D. Schubert ,  Robert C. Axtell ,  Jeffrey Edward Dunn

IPC分类号： G01N33/569 ,  A61K31/785 ,  A61K38/21 ,  G01N15/14

CPC分类号： G01N33/56972 ,  A61K31/785 ,  A61K38/215 ,  G01N15/14 ,  G01N33/5052 ,  G01N2015/1006 ,  G01N2015/1486 ,  G01N2333/525 ,  G01N2333/565 ,  G01N2469/10 ,  G01N2800/285 ,  G01N2800/52

摘要： Compositions and methods are provided for classification of individuals suffering from a demyelinating disease into groups that are informative of the individual's responsiveness or lack of responsiveness to treatment with a J3-interferon (IFNJ3) acting therapy. In particular, it is shown that the effective immunomodulatory treatment of demyelinating disease with IFNJ3 is associated with an increase in circulating transitional B cells in the patient. Diseases of interest include without limitation inflammatory demyelinating diseases of the central nervous system, e.g. multiple sclerosis, neuromyelitis optica (NMO), experimental autoimmune encephalitis (EAE), acute disseminated encephalomyelitis (ADEM), etc.

摘要翻译： 提供了组合物和方法，用于将患有脱髓鞘疾病的个体分类为对个体的反应性或对J3-干扰素（IFNJ3）作用治疗的治疗缺乏反应性的信息的组。 特别地，显示用IFNJ3对脱髓鞘疾病的有效免疫调节治疗与患者中循环过渡B细胞的增加相关。 感兴趣的疾病包括但不限于中枢神经系统的炎性脱髓鞘疾病，例如， 多发性硬化，神经性脊髓炎（NMO），实验性自身免疫性脑炎（EAE），急性播散性脑脊髓炎（ADEM）等