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公开(公告)号：US20160215012A1
公开(公告)日：2016-07-28
申请号：US15026520
申请日：2014-10-06
发明人： Martin D. Burke , Stephen Davis , Brice E Uno , Justin Struble , lan Dailey , Kaitlyn C Gray , David M Knapp , Pulin Wang , Nagarjuna Palyam
摘要： Provided are certain derivatives of amphotericin B (AmB) characterized by reduced toxicity and retained anti-fungal activity. Certain of the derivatives are C16 urea derivatives of AmB. Certain of the derivatives are C3, C5, C8, C9, C11, C13, or C15 deoxy derivatives of AmB. Certain of the derivatives include C3′ or C4′ modifications of the mycosamine appendage of AmB. Also provided are methods of making AmB derivatives of the invention, pharmaceutical compositions comprising AmB derivatives of the invention, and methods of use of AmB derivatives of the invention.
摘要翻译： 提供两性霉素B（AmB）的某些衍生物，其特征在于毒性降低并保留抗真菌活性。 某些衍生物是AmB的C16脲衍生物。 某些衍生物是AmB的C3，C5，C8，C9，C11，C13或C15脱氧衍生物。 某些衍生物包括AmB的霉菌素附属物的C3'或C4'修饰物。 还提供了制备本发明的AmB衍生物的方法，包含本发明的AmB衍生物的药物组合物和本发明的AmB衍生物的使用方法。
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公开(公告)号：US20220056066A1
公开(公告)日：2022-02-24
申请号：US17464916
申请日：2021-09-02
发明人： Martin D. Burke , Stephen Davis , Brice E. Uno , Justin Struble , Ian Dailey , Kaitlyn C. Gray , David M. Knapp , Pulin Wang , Nagarjuna Palyam
摘要： Provided are certain derivatives of amphotericin B (AmB) characterized by reduced toxicity and retained anti-fungal activity. Certain of the derivatives are C16 urea derivatives of AmB. Certain of the derivatives are C3, C5, C8, C9, C11, C13, or C15 deoxy derivatives of AmB. Certain of the derivatives include C3′ or C4′ modifications of the mycosamine appendage of AmB. Also provided are methods of making AmB derivatives of the invention, pharmaceutical compositions comprising AmB derivatives of the invention, and methods of use of AmB derivatives of the invention.
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公开(公告)号：US20200002368A1
公开(公告)日：2020-01-02
申请号：US16530109
申请日：2019-08-02
发明人： Martin D. Burke , Stephen Davis , Brice E. Uno , Justin Struble , Ian Dailey , Kaitlyn C. Gray , David M. Knapp , Pulin Wang , Nagarjuna Palyam
摘要： Provided are certain derivatives of amphotericin B (AmB) characterized by reduced toxicity and retained anti-fungal activity. Certain of the derivatives are C16 urea derivatives of AmB. Certain of the derivatives are C3, C5, C8, C9, C11, C13, or C15 deoxy derivatives of AmB. Certain of the derivatives include C3′ or C4′ modifications of the mycosamine appendage of AmB. Also provided are methods of making AmB derivatives of the invention, pharmaceutical compositions comprising AmB derivatives of the invention, and methods of use of AmB derivatives of the invention.
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公开(公告)号：US11970512B2
公开(公告)日：2024-04-30
申请号：US17464916
申请日：2021-09-02
发明人： Martin D. Burke , Stephen Davis , Brice E. Uno , Justin Struble , Ian Dailey , Kaitlyn C. Gray , David M. Knapp , Pulin Wang , Nagarjuna Palyam
摘要： Provided are certain derivatives of amphotericin B (AmB) characterized by reduced toxicity and retained anti-fungal activity. Certain of the derivatives are C16 urea derivatives of AmB. Certain of the derivatives are C3, C5, C8, C9, C11, C13, or C15 deoxy derivatives of AmB. Certain of the derivatives include C3′ or C4′ modifications of the mycosamine appendage of AmB. Also provided are methods of making AmB derivatives of the invention, pharmaceutical compositions comprising AmB derivatives of the invention, and methods of use of AmB derivatives of the invention.
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公开(公告)号：US11117920B2
公开(公告)日：2021-09-14
申请号：US16443728
申请日：2019-06-17
发明人： Martin D. Burke , Stephen Davis , Brice E. Uno , Justin Struble , Ian Dailey , Kaitlyn C. Gray , David M. Knapp , Pulin Wang , Nagarjuna Palyam
摘要： Provided are certain derivatives of amphotericin B (AmB) characterized by reduced toxicity and retained anti-fungal activity. Certain of the derivatives are C16 urea derivatives of AmB. Certain of the derivatives are C3, C5, C8, C9, C11, C13, or C15 deoxy derivatives of AmB. Certain of the derivatives include C3′ or C4′ modifications of the mycosamine appendage of AmB. Also provided are methods of making AmB derivatives of the invention, pharmaceutical compositions comprising AmB derivatives of the invention, and methods of use of AmB derivatives of the invention.
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公开(公告)号：US11028114B2
公开(公告)日：2021-06-08
申请号：US16530109
申请日：2019-08-02
发明人： Martin D. Burke , Stephen Davis , Brice E. Uno , Justin Struble , Ian Dailey , Kaitlyn C. Gray , David M. Knapp , Pulin Wang , Nagarjuna Palyam
摘要： Provided are certain derivatives of amphotericin B (AmB) characterized by reduced toxicity and retained anti-fungal activity. Certain of the derivatives are C16 urea derivatives of AmB. Certain of the derivatives are C3, C5, C8, C9, C11, C13, or C15 deoxy derivatives of AmB. Certain of the derivatives include C3′ or C4′ modifications of the mycosamine appendage of AmB. Also provided are methods of making AmB derivatives of the invention, pharmaceutical compositions comprising AmB derivatives of the invention, and methods of use of AmB derivatives of the invention.
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公开(公告)号：US10323057B2
公开(公告)日：2019-06-18
申请号：US15026520
申请日：2014-10-06
发明人： Martin D. Burke , Stephen Davis , Brice E. Uno , Justin Struble , Ian Dailey , Kaitlyn C. Gray , David M. Knapp , Pulin Wang , Nagarjuna Palyam
摘要： Provided are certain derivatives of amphotericin B (AmB) characterized by reduced toxicity and retained anti-fungal activity. Certain of the derivatives are C16 urea derivatives of AmB. Certain of the derivatives are C3, C5, C8, C9, C11, C13, or C15 deoxy derivatives of AmB. Certain of the derivatives include C3′ or C4′ modifications of the mycosamine appendage of AmB. Also provided are methods of making AmB derivatives of the invention, pharmaceutical compositions comprising AmB derivatives of the invention, and methods of use of AmB derivatives of the invention.
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