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公开(公告)号：US20200002368A1
公开(公告)日：2020-01-02
申请号：US16530109
申请日：2019-08-02
发明人： Martin D. Burke , Stephen Davis , Brice E. Uno , Justin Struble , Ian Dailey , Kaitlyn C. Gray , David M. Knapp , Pulin Wang , Nagarjuna Palyam
摘要： Provided are certain derivatives of amphotericin B (AmB) characterized by reduced toxicity and retained anti-fungal activity. Certain of the derivatives are C16 urea derivatives of AmB. Certain of the derivatives are C3, C5, C8, C9, C11, C13, or C15 deoxy derivatives of AmB. Certain of the derivatives include C3′ or C4′ modifications of the mycosamine appendage of AmB. Also provided are methods of making AmB derivatives of the invention, pharmaceutical compositions comprising AmB derivatives of the invention, and methods of use of AmB derivatives of the invention.
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公开(公告)号：US20220056066A1
公开(公告)日：2022-02-24
申请号：US17464916
申请日：2021-09-02
发明人： Martin D. Burke , Stephen Davis , Brice E. Uno , Justin Struble , Ian Dailey , Kaitlyn C. Gray , David M. Knapp , Pulin Wang , Nagarjuna Palyam
摘要： Provided are certain derivatives of amphotericin B (AmB) characterized by reduced toxicity and retained anti-fungal activity. Certain of the derivatives are C16 urea derivatives of AmB. Certain of the derivatives are C3, C5, C8, C9, C11, C13, or C15 deoxy derivatives of AmB. Certain of the derivatives include C3′ or C4′ modifications of the mycosamine appendage of AmB. Also provided are methods of making AmB derivatives of the invention, pharmaceutical compositions comprising AmB derivatives of the invention, and methods of use of AmB derivatives of the invention.
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公开(公告)号：US11970512B2
公开(公告)日：2024-04-30
申请号：US17464916
申请日：2021-09-02
发明人： Martin D. Burke , Stephen Davis , Brice E. Uno , Justin Struble , Ian Dailey , Kaitlyn C. Gray , David M. Knapp , Pulin Wang , Nagarjuna Palyam
摘要： Provided are certain derivatives of amphotericin B (AmB) characterized by reduced toxicity and retained anti-fungal activity. Certain of the derivatives are C16 urea derivatives of AmB. Certain of the derivatives are C3, C5, C8, C9, C11, C13, or C15 deoxy derivatives of AmB. Certain of the derivatives include C3′ or C4′ modifications of the mycosamine appendage of AmB. Also provided are methods of making AmB derivatives of the invention, pharmaceutical compositions comprising AmB derivatives of the invention, and methods of use of AmB derivatives of the invention.
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公开(公告)号：US11117920B2
公开(公告)日：2021-09-14
申请号：US16443728
申请日：2019-06-17
发明人： Martin D. Burke , Stephen Davis , Brice E. Uno , Justin Struble , Ian Dailey , Kaitlyn C. Gray , David M. Knapp , Pulin Wang , Nagarjuna Palyam
摘要： Provided are certain derivatives of amphotericin B (AmB) characterized by reduced toxicity and retained anti-fungal activity. Certain of the derivatives are C16 urea derivatives of AmB. Certain of the derivatives are C3, C5, C8, C9, C11, C13, or C15 deoxy derivatives of AmB. Certain of the derivatives include C3′ or C4′ modifications of the mycosamine appendage of AmB. Also provided are methods of making AmB derivatives of the invention, pharmaceutical compositions comprising AmB derivatives of the invention, and methods of use of AmB derivatives of the invention.
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公开(公告)号：US11028114B2
公开(公告)日：2021-06-08
申请号：US16530109
申请日：2019-08-02
发明人： Martin D. Burke , Stephen Davis , Brice E. Uno , Justin Struble , Ian Dailey , Kaitlyn C. Gray , David M. Knapp , Pulin Wang , Nagarjuna Palyam
摘要： Provided are certain derivatives of amphotericin B (AmB) characterized by reduced toxicity and retained anti-fungal activity. Certain of the derivatives are C16 urea derivatives of AmB. Certain of the derivatives are C3, C5, C8, C9, C11, C13, or C15 deoxy derivatives of AmB. Certain of the derivatives include C3′ or C4′ modifications of the mycosamine appendage of AmB. Also provided are methods of making AmB derivatives of the invention, pharmaceutical compositions comprising AmB derivatives of the invention, and methods of use of AmB derivatives of the invention.
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公开(公告)号：US10323057B2
公开(公告)日：2019-06-18
申请号：US15026520
申请日：2014-10-06
发明人： Martin D. Burke , Stephen Davis , Brice E. Uno , Justin Struble , Ian Dailey , Kaitlyn C. Gray , David M. Knapp , Pulin Wang , Nagarjuna Palyam
摘要： Provided are certain derivatives of amphotericin B (AmB) characterized by reduced toxicity and retained anti-fungal activity. Certain of the derivatives are C16 urea derivatives of AmB. Certain of the derivatives are C3, C5, C8, C9, C11, C13, or C15 deoxy derivatives of AmB. Certain of the derivatives include C3′ or C4′ modifications of the mycosamine appendage of AmB. Also provided are methods of making AmB derivatives of the invention, pharmaceutical compositions comprising AmB derivatives of the invention, and methods of use of AmB derivatives of the invention.
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公开(公告)号：US20130296573A1
公开(公告)日：2013-11-07
申请号：US13654820
申请日：2012-10-18
IPC分类号： C07F5/04 , C07F5/02 , C07D213/55 , C07C51/353 , C07C67/343 , C07C45/68 , C07D307/81
CPC分类号： C07F5/025 , C07C45/68 , C07C51/353 , C07C67/343 , C07D213/55 , C07D307/81 , C07F5/02 , C07F5/04 , Y02P20/55
摘要： A protected organoboronic acid includes a boron having an sp3 hybridization, a conformationally rigid protecting group bonded to the boron, and an organic group bonded to the boron through a boron-carbon bond. A method of performing a chemical reaction includes contacting a protected organoboronic acid with a reagent, the protected organoboronic acid including a boron having an sp3 hybridization, a conformationally rigid protecting group bonded to the boron, and an organic group bonded to the boron through a boron-carbon bond. The organic group is chemically transformed, and the boron is not chemically transformed.
摘要翻译： 受保护的有机硼酸包括具有sp 3杂交的硼，与硼结合的构象刚性保护基，以及通过硼 - 碳键与硼结合的有机基团。 进行化学反应的方法包括使受保护的有机硼酸与试剂接触，被保护的有机硼酸包括具有sp3杂交的硼，与硼结合的构象刚性保护基，和通过硼键合到硼上的有机基团 碳键。 有机基团被化学转化，并且硼不被化学转化。
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