公开(公告)号：US10820862B2

公开(公告)日：2020-11-03

申请号：US14504736

申请日：2014-10-02

申请人： THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS ,  WASHINGTON UNIVERSITY IN ST. LOUIS

发明人： John A. Rogers ,  Igor Efimov ,  Sarah Gutbrod ,  Lizhi Xu ,  Andrew Bonifas ,  Richard Chad Webb ,  Ahyeon Koh

IPC分类号： A61B5/00 ,  A61B5/03 ,  A61B5/11 ,  A61H23/02 ,  A61B5/145 ,  A61B5/0205 ,  A61B5/042 ,  A61N2/00 ,  A61B5/1473 ,  A61N1/05 ,  A61B18/14 ,  A61N5/06 ,  A61N1/375 ,  A61N1/362 ,  A61B18/00 ,  A61B5/01 ,  A61F7/00 ,  A61B5/053

摘要： Provided are devices and methods capable of interfacing with biological tissues, such as organs like the heart, in real-time and using techniques which provide the ability to monitor and control complex physical, chemical, biochemical and thermal properties of the tissues as a function of time. The described devices and methods utilize micro scale sensors and actuators to spatially monitor and control a variety of physical, chemical and biological tissue parameters, such as temperature, pH, spatial position, force, pressure, electrophysiology and to spatially provide a variety of stimuli, such as heat, light, voltage and current.

公开(公告)号：US11160458B2

公开(公告)日：2021-11-02

申请号：US15501379

申请日：2015-08-11

申请人： The Board of Trustees of the University of Illinois

发明人： John A. Rogers ,  Li Gao ,  Viktor Malyarchuk ,  Richard Chad Webb

IPC分类号： A61B5/01 ,  A61B5/00 ,  A61B5/318 ,  A61B5/369 ,  A61B5/389 ,  A61B5/02 ,  A61B5/0205 ,  A61B5/026 ,  A61B5/028 ,  A61B5/0537

摘要： Provided are tissue-mounted devices and methods for monitoring a thermal transport property (e.g., thermal conductivity, thermal diffusivity, heat capacity) of tissue, such as skin. The devices conformally mount to the tissue and have one or more thermal actuators and a plurality of sensors. The actuator applies heat to the tissue and the sensors to detect a spatio temporal distribution of a physiological tissue parameter or physical property resulting from the heating. This spatio temporal information may be correlated with a rate, velocity and/or direction of blood flow, the presence of a vascular occlusion, circulation changes due to inflammation, hydration level and other physiological parameters.