公开(公告)号：US20180010965A1

公开(公告)日：2018-01-11

申请号：US15705064

申请日：2017-09-14

Applicant: The General Hospital Corporation

Inventor： Milen Shishkov ,  Guillermo J. Tearney ,  Brett Eugene Bouma ,  Dvir Yelin ,  Nicusor Iftimia

IPC: G01J3/18 ,  B24B9/14 ,  G01J3/02 ,  A61B1/002 ,  G02B23/26 ,  G02B23/24

CPC classification number: G02B23/2453 ,  A61B1/00167 ,  A61B1/00188 ,  A61B1/002 ,  A61B5/0062 ,  A61B5/0066 ,  A61B5/0068 ,  A61B5/0084 ,  A61B5/0086 ,  B24B9/14 ,  G01J3/02 ,  G01J3/0205 ,  G01J3/0208 ,  G01J3/0218 ,  G01J3/0256 ,  G01J3/18 ,  G02B5/18 ,  G02B23/2469 ,  G02B23/26

Abstract: Exemplary apparatus for method for forming at least one spectral encoding endoscopy configuration. For example, it is possible to modify a spacer configuration and an lens optics configuration to have respective predetermined lengths, and also to modify a dispersive optics configuration to have a further predetermined length. Further, the modified spacer and modified lens optics configurations can be attached to one another to form a combined spacer-lens optics configuration. The modified dispersive optics configuration can be attached to a substrate to form to form a grating substrate configuration. Additionally, the combined spacer-lens optics configuration can be connected to an optical fiber, and the modified attached dispersed optics configuration can be connected to the modified attached lens optics configuration to form the spectral encoding endoscopy configuration(s) which can extends along a particular axis. The dispersive optics configuration can be modified to be at a predetermined angle with respect to the particular axis.

公开(公告)号：US09186067B2

公开(公告)日：2015-11-17

申请号：US13901921

申请日：2013-05-24

Applicant: The General Hospital Corporation

Inventor： Guillermo J. Tearney ,  Milen Shishkov ,  Brett Eugene Bouma ,  Benjamin J. Vakoc

IPC: A61B18/18 ,  A61B5/00 ,  A61B18/24 ,  A61B17/00 ,  A61B17/22 ,  A61B18/20 ,  A61B19/00

CPC classification number: A61B5/0084 ,  A61B5/0066 ,  A61B5/6852 ,  A61B18/24 ,  A61B2017/00057 ,  A61B2017/22051 ,  A61B2018/207 ,  A61B2090/306 ,  A61B2090/3614

Abstract: An apparatus for applying electro-magnetic radiations to a sample is provided. The apparatus can include an arrangement which has a specific portion with a plurality of channels. One channel(s) can facilitate a first radiation to be forwarded to the sample within an anatomical structure, and another channel(s) can facilitate a second radiation to be forwarded to the sample. The first radiation can have a first wavelength band, and the second radiation can have a second wavelength band, which can be substantially different from the first wavelength band. The first radiation can be delivered to a first area of the sample, and the second radiation can be delivered to a second area of the sample. Each of the channels can facilitate a particular radiation(s) to be forwarded to the sample that is within an anatomical structure of the sample, the radiations being delivered to different areas of the sample.

Abstract translation: 提供了一种用于向样品施加电磁辐射的装置。 该装置可以包括具有多个通道的具体部分的装置。 一个通道可以促进在解剖结构内转发到样品的第一辐射，并且另一个通道可有助于将第二辐射转发到样品。 第一辐射可以具有第一波长带，并且第二辐射可以具有与第一波长带实质上不同的第二波长带。 第一辐射可以被传送到样品的第一区域，并且第二辐射可以被传送到样品的第二区域。 每个通道可以促进将特定辐射转发到样品的解剖结构内的样品，辐射被递送到样品的不同区域。

公开(公告)号：US20130338510A1

公开(公告)日：2013-12-19

申请号：US13901921

申请日：2013-05-24

Applicant: The General Hospital Corporation

Inventor： Guillermo J. Tearney ,  Milen Shishkov ,  Brett Eugene Bouma ,  Benjamin J. Vakoc

IPC: A61B5/00

CPC classification number: A61B5/0084 ,  A61B5/0066 ,  A61B5/6852 ,  A61B18/24 ,  A61B2017/00057 ,  A61B2017/22051 ,  A61B2018/207 ,  A61B2090/306 ,  A61B2090/3614

Abstract: An apparatus for applying electro-magnetic radiations to a sample is provided. The apparatus can include an arrangement which has a specific portion with a plurality of channels. One channel(s) can facilitate a first radiation to be forwarded to the sample within an anatomical structure, and another channel(s) can facilitate a second radiation to be forwarded to the sample. The first radiation can have a first wavelength band, and the second radiation can have a second wavelength band, which can be substantially different from the first wavelength band. The first radiation can be delivered to a first area of the sample, and the second radiation can be delivered to a second area of the sample. Each of the channels can facilitate a particular radiation(s) to be forwarded to the sample that is within an anatomical structure of the sample, the radiations being delivered to different areas of the sample.

Abstract translation: 提供了一种用于向样品施加电磁辐射的装置。 该装置可以包括具有多个通道的具体部分的装置。 一个通道可以促进在解剖结构内转发到样品的第一辐射，并且另一个通道可有助于将第二辐射转发到样品。 第一辐射可以具有第一波长带，并且第二辐射可以具有与第一波长带实质上不同的第二波长带。 第一辐射可以被传送到样品的第一区域，并且第二辐射可以被传送到样品的第二区域。 每个通道可以促进将特定辐射转发到样品的解剖结构内的样品，辐射被递送到样品的不同区域。

公开(公告)号：US10939825B2

公开(公告)日：2021-03-09

申请号：US15359279

申请日：2016-11-22

Applicant: The General Hospital Corporation ,  Trustees of Boston University

Inventor： Guillermo J. Tearney ,  Brett Eugene Bouma ,  Hongki Yoo ,  Milen Shishkov ,  Joseph Gardecki ,  Roman Shubochkin ,  Theodore Morse ,  Farouc Amin Jaffer

IPC: A61B5/00 ,  G01N21/65 ,  G01B9/02 ,  G01N21/64 ,  G01N21/47

Abstract: Exemplary systems, devices, methods, apparatus and computer-accessible media for providing and/or utilizing optical frequency domain imaging (OFDI) and fluorescence of structures and, e.g., multimodality imaging using OFDI techniques and fluorescence imaging techniques are described. For example, an arrangement can provide at least one electro-magnetic radiation to an anatomical structure. Such exemplary arrangement can include at least one optical core and at least one cladding at least partially surrounding the fiber(s). A region between the optical core(s) and the cladding(s) can have an index that is different from indexes of the optical core(s) and the cladding(s). The arrangement can also include at least one apparatus which is configured to transmit the radiation(s) via the optical core(s) and the cladding(s) to the anatomical structure.

公开(公告)号：US09791317B2

公开(公告)日：2017-10-17

申请号：US15376144

申请日：2016-12-12

Applicant: The General Hospital Corporation

Inventor： Milen Shishkov ,  Guillermo J. Tearney ,  Brett Eugene Bouma ,  Dvir Yelin ,  Nicusor Iftimia

IPC: G01J3/18 ,  G02B6/24 ,  G02B6/26 ,  B24B9/14 ,  G01J3/02 ,  A61B1/002 ,  G02B23/24 ,  G02B23/26

CPC classification number: G02B23/2453 ,  A61B1/00167 ,  A61B1/00188 ,  A61B1/002 ,  A61B5/0062 ,  A61B5/0066 ,  A61B5/0068 ,  A61B5/0084 ,  A61B5/0086 ,  B24B9/14 ,  G01J3/02 ,  G01J3/0205 ,  G01J3/0208 ,  G01J3/0218 ,  G01J3/0256 ,  G01J3/18 ,  G02B5/18 ,  G02B23/2469 ,  G02B23/26

Abstract: Exemplary apparatus for method for forming at least one spectral encoding endoscopy configuration. For example, it is possible to modify a spacer configuration and an lens optics configuration to have respective predetermined lengths, and also to modify a dispersive optics configuration to have a further predetermined length. Further, the modified spacer and modified lens optics configurations can be attached to one another to form a combined spacer-lens optics configuration. The modified dispersive optics configuration can be attached to a substrate to form to form a grating substrate configuration. Additionally, the combined spacer-lens optics configuration can be connected to an optical fiber, and the modified attached dispersed optics configuration can be connected to the modified attached lens optics configuration to form the spectral encoding endoscopy configuration(s) which can extends along a particular axis. The dispersive optics configuration can be modified to be at a predetermined angle with respect to the particular axis.

公开(公告)号：US20170160132A1

公开(公告)日：2017-06-08

申请号：US15376144

申请日：2016-12-12

Applicant: The General Hospital Corporation

Inventor： Milen Shishkov ,  Guillermo J. Tearney ,  Brett Eugene Bouma ,  Dvir Yelin ,  Nicusor lftimia

IPC: G01J3/18 ,  G02B23/26 ,  B24B9/14 ,  G02B23/24 ,  A61B1/002 ,  G01J3/02

CPC classification number: G02B23/2453 ,  A61B1/00167 ,  A61B1/00188 ,  A61B1/002 ,  A61B5/0062 ,  A61B5/0066 ,  A61B5/0068 ,  A61B5/0084 ,  A61B5/0086 ,  B24B9/14 ,  G01J3/02 ,  G01J3/0205 ,  G01J3/0208 ,  G01J3/0218 ,  G01J3/0256 ,  G01J3/18 ,  G02B5/18 ,  G02B23/2469 ,  G02B23/26

Abstract: Exemplary apparatus for method for forming at least one spectral encoding endoscopy configuration. For example, it is possible to modify a spacer configuration and an lens optics configuration to have respective predetermined lengths, and also to modify a dispersive optics configuration to have a further predetermined length. Further, the modified spacer and modified lens optics configurations can be attached to one another to form a combined spacer-lens optics configuration. The modified dispersive optics configuration can be attached to a substrate to form to form a grating substrate configuration. Additionally, the combined spacer-lens optics configuration can be connected to an optical fiber, and the modified attached dispersed optics configuration can be connected to the modified attached lens optics configuration to form the spectral encoding endoscopy configuration(s) which can extends along a particular axis. The dispersive optics configuration can be modified to be at a predetermined angle with respect to the particular axis.

公开(公告)号：US11553841B2

公开(公告)日：2023-01-17

申请号：US17191343

申请日：2021-03-03

Applicant: THE GENERAL HOSPITAL CORPORATION ,  Trustees of Boston University

Inventor： Guillermo J. Tearney ,  Brett Eugene Bouma ,  Hongki Yoo ,  Milen Shishkov ,  Joseph Gardecki ,  Roman Shubochkin ,  Theodore Morse ,  Farouc Amin Jaffer

IPC: A61B5/00 ,  G01N21/65 ,  G01B9/02015 ,  G01B9/02091 ,  G01B9/02 ,  G01N21/64 ,  G01N21/47

Abstract: Exemplary systems, devices, methods, apparatus and computer-accessible media for providing and/or utilizing optical frequency domain imaging (OFDI) and fluorescence of structures and, e.g., multimodality imaging using OFDI techniques and fluorescence imaging techniques are described. For example, an arrangement can provide at least one electro-magnetic radiation to an anatomical structure. Such exemplary arrangement can include at least one optical core and at least one cladding at least partially surrounding the fiber(s). A region between the optical core(s) and the cladding(s) can have an index that is different from indexes of the optical core(s) and the cladding(s). The arrangement can also include at least one apparatus which is configured to transmit the radiation(s) via the optical core(s) and the cladding(s) to the anatomical structure.

公开(公告)号：US20150045622A1

公开(公告)日：2015-02-12

申请号：US14465960

申请日：2014-08-22

Applicant: The General Hospital Corporation

Inventor： Milen Shishkov ,  Guillermo J. Tearney ,  Brett Eugene Bouma ,  Dvir Yelin ,  Nicusor Iftimia

IPC: A61B1/00

CPC classification number: G02B23/2453 ,  A61B1/00167 ,  A61B1/00188 ,  A61B1/002 ,  A61B5/0062 ,  A61B5/0066 ,  A61B5/0068 ,  A61B5/0084 ,  A61B5/0086 ,  B24B9/14 ,  G01J3/02 ,  G01J3/0205 ,  G01J3/0208 ,  G01J3/0218 ,  G01J3/0256 ,  G01J3/18 ,  G02B5/18 ,  G02B23/2469 ,  G02B23/26

Abstract: Exemplary apparatus for obtaining information for a structure can be provided. For example, the exemplary apparatus can include at least one first optical fiber arrangement which is configured to transceive at least one first electro-magnetic radiation, and can include at least one fiber. The exemplary apparatus can also include at least one second focusing arrangement in optical communication with the optical fiber arrangement. The second arrangement can be configured to focus and provide there through the first electro-magnetic radiation to generate the focused electro-magnetic radiation. Further, the exemplary apparatus can include at least at least one dispersive third arrangement which can receive a particular radiation (e.g., the first electro-magnetic radiation(s) and/or the focused electro-magnetic radiation), and forward a dispersed radiation thereof to at least one section of the structure.

Abstract translation: 可以提供用于获得结构信息的示例性装置。 例如，示例性装置可以包括被配置为收发至少一个第一电磁辐射的至少一个第一光纤布置，并且可以包括至少一个光纤。 示例性装置还可以包括与光纤布置光学通信的至少一个第二聚焦装置。 第二布置可以被配置成通过第一电磁辐射聚焦并提供到其上，以产生聚焦的电磁辐射。 此外，示例性装置可以包括至少一个能够接收特定辐射（例如，第一电磁辐射和/或聚焦电磁辐射）的分散第三装置，并且将其分散的辐射 到结构的至少一个部分。

公开(公告)号：US11490797B2

公开(公告)日：2022-11-08

申请号：US13898798

申请日：2013-05-21

Applicant: The General Hospital Corporation

Inventor： Michalina Gora ,  Dongkyun Kang ,  Norman S. Nishioka ,  Brett Eugene Bouma ,  Guillermo J. Tearney ,  Robert Carruth ,  Kevin Gallagher ,  Jenny Sauk ,  Moon Gu Lee ,  Nima Tabatabaei ,  Milen Shishkov

IPC: A61B1/04 ,  A61B1/00 ,  A61B1/06 ,  A61B5/00

Abstract: An exemplary apparatus for obtaining data for at least one portion within at least one luminal or hollow sample can be provided. For example, the apparatus can include a first optical arrangement configured to transceive at least one electromagnetic radiation to and from the portion(s). The apparatus can also include a wavelength dispersive second arrangement, which can be configured to disperse the electromagnetic radiation(s). A housing can be provided with a shape of a pill, and enclosing the first and second arrangements.

公开(公告)号：US20210267460A1

公开(公告)日：2021-09-02

申请号：US17191343

申请日：2021-03-03

Applicant: THE GENERAL HOSPITAL CORPORATION ,  Trustees of Boston University

Inventor： Guillermo J. Tearney ,  Brett Eugene Bouma ,  Hongki Yoo ,  Milen Shishkov ,  Joseph Gardecki ,  Roman Shubochkin ,  Theodore Morse ,  Farouc Amin Jaffer

IPC: A61B5/00 ,  G01N21/65 ,  G01B9/02 ,  G01N21/64

Abstract: Exemplary systems, devices, methods, apparatus and computer-accessible media for providing and/or utilizing optical frequency domain imaging (OFDI) and fluorescence of structures and, e.g., multimodality imaging using OFDI techniques and fluorescence imaging techniques are described. For example, an arrangement can provide at least one electro-magnetic radiation to an anatomical structure. Such exemplary arrangement can include at least one optical core and at least one cladding at least partially surrounding the fiber(s). A region between the optical core(s) and the cladding(s) can have an index that is different from indexes of the optical core(s) and the cladding(s). The arrangement can also include at least one apparatus which is configured to transmit the radiation(s) via the optical core(s) and the cladding(s) to the anatomical structure.