公开(公告)号：US20190183395A1

公开(公告)日：2019-06-20

申请号：US16285920

申请日：2019-02-26

Applicant: The George Washington University

Inventor： Matthew Kay ,  Angel Moreno ,  Rafael Jaimes

IPC: A61B5/1486 ,  A61B1/06 ,  A61B5/1459 ,  A61B1/04 ,  A61B5/00

CPC classification number: A61B5/1486 ,  A61B1/043 ,  A61B1/0684 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/1459 ,  A61B5/4866 ,  A61B5/6852 ,  A61B2017/00057 ,  A61B2018/00351 ,  A61F7/00 ,  A61F2007/0056 ,  A61F2007/126 ,  G01J1/4257 ,  G01J1/429 ,  G01J2001/4247 ,  G01J2001/4252

Abstract: The invention provides for a system for in vivo real time measurement of NADH recovery kinetics, comprising: 1) a specific pulse sequence to non-destructively, yet effectively, photobleach NADH for measurement of NADH recovery kinetics; 2) illumination light parameters to acquire NADH fluorescence before and after photobleaching, without causing fluorescence bleaching artifacts, for measurement of NADH recovery kinetics; and 3) configurations for devices capable of photobleaching NADH by at least 10% within tissues for effective measurement of NADH recovery kinetics in tissues within a living subject or excised tissues and organs.

公开(公告)号：US20200061149A1

公开(公告)日：2020-02-27

申请号：US16563635

申请日：2019-09-06

Applicant: The George Washington University ,  The U.S. Government as represented by The Department of Veterans Affairs

Inventor： Matthew Kay ,  Kara Garrott ,  Jhansi Dyavanapalli ,  David Mendelowitz ,  Trachiotis Gregory

IPC: A61K38/095 ,  A61K9/00 ,  A61P9/10

Abstract: Methods of treating a subject having heart failure including heart failure with reduced ejection fraction, heart failure with preserved ejection fraction, and left ventricular hypertrophy-induced heart failure. The methods include activating hypothalamic oxytocin neurons in the brain of the subject and/or administering intranasally to the subject a therapeutically effective amount of oxytocin. Intranasal formulations for the treatment of a subject diagnosed with heart failure are also provided.

公开(公告)号：US11445950B2

公开(公告)日：2022-09-20

申请号：US16285920

申请日：2019-02-26

Applicant: The George Washington University

Inventor： Matthew Kay ,  Angel Moreno ,  Rafael Jaimes

IPC: A61B5/1486 ,  A61B5/00 ,  A61F7/00 ,  G01J1/42 ,  A61B1/04 ,  A61B1/06 ,  A61B5/1459 ,  A61B18/00 ,  A61F7/12 ,  A61B17/00

Abstract: The invention provides for a system for in vivo real time measurement of NADH recovery kinetics, comprising: 1) a specific pulse sequence to non-destructively, yet effectively, photobleach NADH for measurement of NADH recovery kinetics; 2) illumination light parameters to acquire NADH fluorescence before and after photobleaching, without causing fluorescence bleaching artifacts, for measurement of NADH recovery kinetics; and 3) configurations for devices capable of photobleaching NADH by at least 10% within tissues for effective measurement of NADH recovery kinetics in tissues within a living subject or excised tissues and organs.

公开(公告)号：US20220008500A1

公开(公告)日：2022-01-13

申请号：US17349771

申请日：2021-06-16

Applicant: The George Washington University ,  The U.S. Government as represented by The Department of Veterans Affairs

Inventor： Matthew Kay ,  Kara Garrott ,  Jhansi Dyavanapalli ,  David Mendelowitz ,  Gregory Trachiotis

IPC: A61K38/095 ,  A61P9/10 ,  A61K9/00

Abstract: Methods of treating a subject having heart failure including heart failure with reduced ejection fraction, heart failure with preserved ejection fraction, and left ventricular hypertrophy-induced heart failure. The methods include activating hypothalamic oxytocin neurons in the brain of the subject and/or administering intranasally to the subject a therapeutically effective amount of oxytocin. Intranasal formulations for the treatment of a subject diagnosed with heart failure are also provided.