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公开(公告)号:US20180264098A1
公开(公告)日:2018-09-20
申请号:US15994074
申请日:2018-05-31
申请人: The Government of the USA as represented by the Secretary of the Dept. of Health and Human Service
IPC分类号: A61K39/108
摘要: Methods of producing a pathogen with reduced replicative fitness are disclosed, as are attenuated pathogens produced using the methods. In particular examples, the method includes deoptimizing one or more codons in a coding sequence, thereby reducing the replicative fitness of the pathogen. Methods of using the attenuated pathogens as immunogenic compositions are also disclosed.
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公开(公告)号:US20170354727A1
公开(公告)日:2017-12-14
申请号:US15684355
申请日:2017-08-23
申请人: The Government of the USA as represented by the Secretary of the Dept. of Health and Human Service
IPC分类号: A61K39/108 , C12N15/67 , C12N7/00 , A61K39/00 , C07K14/245
CPC分类号: A61K39/0258 , A61K39/00 , A61K2039/522 , A61K2039/5254 , C07K14/245 , C12N7/00 , C12N15/67 , C12N2710/16162 , C12N2710/16662 , C12N2710/16762 , C12N2760/16162 , C12N2760/18462 , C12N2760/18562 , C12N2770/20062 , C12N2770/24162 , C12N2770/32162 , C12N2770/32762 , C12N2770/36262 , Y02A50/466 , Y02A50/472 , Y02A50/476
摘要: Methods of producing a pathogen with reduced replicative fitness are disclosed, as are attenuated pathogens produced using the methods. In particular examples, the method includes deoptimizing one or more codons in a coding sequence, thereby reducing the replicative fitness of the pathogen. Methods of using the attenuated pathogens as immunogenic compositions are also disclosed.
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