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公开(公告)号：US10471134B2
公开(公告)日：2019-11-12
申请号：US16058898
申请日：2018-08-08
IPC分类号： A61K38/16 , A61K38/47 , C12N9/24 , A23L2/52 , A61K31/715 , A61K35/741 , A23C9/12 , C12P21/00 , C12P19/04 , A23L33/195 , A61K38/40 , C07K14/79 , A61K38/00
摘要： Provided herein are deglycosylating enzymes that remove a broad range of N-glycans from N-glycosylated proteins. Further provided are methods of recombinantly producing and expressing the deglycosylating enzymes. The presently described deglycosylating enzymes can be used to produce free glycans for characterization, and for prebiotic and immunostimulatory uses. In addition, the presently described deglycosylating enzymes can be used to produce deglycosylated proteins for characterization, to improve digestion, and to reduce immunogenicity.
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公开(公告)号：US09327016B2
公开(公告)日：2016-05-03
申请号：US14378190
申请日：2013-02-14
IPC分类号： C12N9/24 , A61K38/01 , A61K38/16 , A61K38/47 , A23L2/52 , A61K31/715 , A61K35/741 , A23L1/305 , A23C9/12 , C12P21/00 , C12P19/04 , A61K38/00
CPC分类号： A61K38/47 , A23C9/1216 , A23L2/52 , A23L33/195 , A61K31/715 , A61K35/741 , A61K38/00 , A61K38/40 , C07K14/79 , C12N9/2402 , C12N9/2497 , C12P19/04 , C12P21/005 , C12Y302/01096 , Y02P20/52 , A61K2300/00
摘要： Provided herein are deglycosylating enzymes that remove a broad range of N-glycans from N-glycosylated proteins. Further provided are methods of recombinantly producing and expressing the deglycosylating enzymes. The presently described deglycosylating enzymes can be used to produce free glycans for characterization, and for prebiotic and immunostimulatory uses. In addition, the presently described deglycosylating enzymes can be used to produce deglycosylated proteins for characterization, to improve digestion, and to reduce immunogenicity.
摘要翻译： 本文提供了去糖基化酶，其从N-糖基化蛋白质中除去宽范围的N-聚糖。 还提供了重组产生和表达去糖基化酶的方法。 目前描述的去糖基化酶可用于产生用于表征的游离聚糖，以及益生元和免疫刺激用途。 此外，目前描述的去糖基化酶可以用于产生去糖基化的蛋白质用于表征，以改善消化和降低免疫原性。
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公开(公告)号：US11633461B2
公开(公告)日：2023-04-25
申请号：US17232509
申请日：2021-04-16
IPC分类号： C12N9/24 , C12P19/04 , A61K38/00 , A61K35/74 , A61K38/47 , A23L33/195 , A23L2/52 , A61K31/715 , A61K35/741 , A23C9/12 , C12P21/00 , A61K38/40 , C07K14/79
摘要： Provided herein are deglycosylating enzymes that remove a broad range of N-glycans from N-glycosylated proteins. Further provided are methods of recombinantly producing and expressing the deglycosylating enzymes. The presently described deglycosylating enzymes can be used to produce free glycans for characterization, and for prebiotic and immunostimulatory uses. In addition, the presently described deglycosylating enzymes can be used to produce deglycosylated proteins for characterization, to improve digestion, and to reduce immunogenicity.
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公开(公告)号：US10165788B2
公开(公告)日：2019-01-01
申请号：US14305868
申请日：2014-06-16
IPC分类号： A61K35/745 , A23L1/30 , A23L33/135
摘要： Pre-biotic compositions containing oligosaccharides and probiotic compositions useful for treatment of a subject are provided herein. Also provided are methods for administering probiotic or pre-biotic compositions.
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公开(公告)号：US10071142B2
公开(公告)日：2018-09-11
申请号：US15079949
申请日：2016-03-24
IPC分类号： C12N9/24 , C12P19/04 , A61K38/01 , A61K38/47 , A23L2/52 , A61K31/715 , A61K35/741 , A23C9/12 , C12P21/00 , A23L33/195 , A61K38/40 , C07K14/79 , A61K38/00
CPC分类号： A61K38/47 , A23C9/1216 , A23L2/52 , A23L33/195 , A61K31/715 , A61K35/741 , A61K38/00 , A61K38/40 , C07K14/79 , C12N9/2402 , C12N9/2497 , C12P19/04 , C12P21/005 , C12Y302/01096 , Y02P20/52 , A61K2300/00
摘要： Provided herein are deglycosylating enzymes that remove a broad range of N-glycans from N-glycosylated proteins. Further provided are methods of recombinantly producing and expressing the deglycosylating enzymes. The presently described deglycosylating enzymes can be used to produce free glycans for characterization, and for prebiotic and immunostimulatory uses. In addition, the presently described deglycosylating enzymes can be used to produce deglycosylated proteins for characterization, to improve digestion, and to reduce immunogenicity.
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公开(公告)号：US11000576B2
公开(公告)日：2021-05-11
申请号：US16871811
申请日：2020-05-11
IPC分类号： C12N9/24 , C12P21/00 , C12P19/04 , A61K38/47 , A23L2/00 , A23L33/195 , A23L2/52 , A61K31/715 , A61K35/741 , A23C9/12 , A61K38/40 , C07K14/79 , A61K38/00
摘要： Provided herein are deglycosylating enzymes that remove a broad range of N-glycans from N-glycosylated proteins. Further provided are methods of recombinantly producing and expressing the deglycosylating enzymes. The presently described deglycosylating enzymes can be used to produce free glycans for characterization, and for prebiotic and immunostimulatory uses. In addition, the presently described deglycosylating enzymes can be used to produce deglycosylated proteins for characterization, to improve digestion, and to reduce immunogenicity.
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公开(公告)号：US10688160B2
公开(公告)日：2020-06-23
申请号：US16559333
申请日：2019-09-03
IPC分类号： C12N9/34 , C12N9/24 , C12P21/00 , C12P19/04 , A61K38/47 , A61K31/715 , A23C9/12 , A23L2/52 , A23L33/195 , A61K35/741 , A61K38/40 , C07K14/79 , A61K38/00
摘要： Provided herein are deglycosylating enzymes that remove a broad range of N-glycans from N-glycosylated proteins. Further provided are methods of recombinantly producing and expressing the deglycosylating enzymes. The presently described deglycosylating enzymes can be used to produce free glycans for characterization, and for prebiotic and immunostimulatory uses. In addition, the presently described deglycosylating enzymes can be used to produce deglycosylated proteins for characterization, to improve digestion, and to reduce immunogenicity.
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公开(公告)号：US20160287680A1
公开(公告)日：2016-10-06
申请号：US15079949
申请日：2016-03-24
CPC分类号： A61K38/47 , A23C9/1216 , A23L2/52 , A23L33/195 , A61K31/715 , A61K35/741 , A61K38/00 , A61K38/40 , C07K14/79 , C12N9/2402 , C12N9/2497 , C12P19/04 , C12P21/005 , C12Y302/01096 , Y02P20/52 , A61K2300/00
摘要： Provided herein are deglycosylating enzymes that remove a broad range of N-glycans from N-glycosylated proteins. Further provided are methods of recombinantly producing and expressing the deglycosylating enzymes. The presently described deglycosylating enzymes can be used to produce free glycans for characterization, and for prebiotic and immunostimulatory uses. In addition, the presently described deglycosylating enzymes can be used to produce deglycosylated proteins for characterization, to improve digestion, and to reduce immunogenicity.
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公开(公告)号：US20150110771A1
公开(公告)日：2015-04-23
申请号：US14378190
申请日：2013-02-14
CPC分类号： A61K38/47 , A23C9/1216 , A23L2/52 , A23L33/195 , A61K31/715 , A61K35/741 , A61K38/00 , A61K38/40 , C07K14/79 , C12N9/2402 , C12N9/2497 , C12P19/04 , C12P21/005 , C12Y302/01096 , Y02P20/52 , A61K2300/00
摘要： Provided herein are deglycosylating enzymes that remove a broad range of N-glycans from N-glycosylated proteins. Further provided are methods of recombinantly producing and expressing the deglycosylating enzymes. The presently described deglycosylating enzymes can be used to produce free glycans for characterization, and for prebiotic and immunostimulatory uses. In addition, the presently described deglycosylating enzymes can be used to produce deglycosylated proteins for characterization, to improve digestion, and to reduce immunogenicity.
摘要翻译： 本文提供了去糖基化酶，其从N-糖基化蛋白质中除去宽范围的N-聚糖。 还提供了重组产生和表达去糖基化酶的方法。 目前描述的去糖基化酶可用于产生用于表征的游离聚糖，以及益生元和免疫刺激用途。 此外，目前描述的去糖基化酶可以用于产生去糖基化的蛋白质用于表征，以改善消化和降低免疫原性。
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10.发明申请公开(公告)号：US20150010670A1
公开(公告)日：2015-01-08
申请号：US14305868
申请日：2014-06-16
CPC分类号： A61K35/745 , A23L33/135 , A23V2002/00 , A23Y2220/17 , A23Y2220/63 , A23Y2220/73 , A23Y2300/19 , A23Y2300/29 , A23Y2300/31 , A23Y2300/39 , A23Y2300/55 , A23Y2300/59 , A23V2200/32 , A23V2200/3202 , A23V2200/3204 , A23V2250/28
摘要： Pre-biotic compositions containing oligosaccharides and probiotic compositions useful for treatment of a subject are provided herein. Also provided are methods for administering probiotic or pre-biotic compositions.
摘要翻译： 本文提供了含有寡糖的预生物组合物和用于治疗受试者的益生菌组合物。 还提供了用于施用益生菌或预生物组合物的方法。
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