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公开(公告)号：US10918653B2
公开(公告)日：2021-02-16
申请号：US16667196
申请日：2019-10-29
IPC分类号： A61K31/702 , A61K31/715 , A61K31/726 , A61K35/741 , A61K35/745 , A61K36/062 , A23L33/00 , A23L33/135 , A23L33/28 , C08B37/00 , C08L5/00 , C12P19/14 , C12P19/18
摘要： Oligosaccharides from bovine milk, whey and dairy products, and methods of producing bovine milk oligosaccharides are provided.
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公开(公告)号：US20170000811A1
公开(公告)日：2017-01-05
申请号：US15216974
申请日：2016-07-22
发明人： Mariana Barboza , J. Bruce German , Carlito B. Lebrilla , David Mills , Samara Freeman-Sharkey , William Robert King
IPC分类号： A61K31/702 , A23L33/135 , A61K9/00 , A61K35/745 , A61K38/47 , A23L33/21 , A23L33/00
CPC分类号： A61K31/702 , A23L5/00 , A23L7/00 , A23L29/30 , A23L33/125 , A23L33/135 , A23L33/21 , A23L33/40 , A23V2002/00 , A61K9/0095 , A61K35/745 , A61K38/47 , A61K2035/115 , C12Y302/01108 , A23V2250/28 , A23V2200/3204 , A23V2200/3202 , A23V2200/32
摘要： The present invention provides galacto-oligosaccharide compositions that preferentially stimulate growth of specific Bifidobacterium species and subspecies.
摘要翻译： 本发明提供优选刺激特异性双歧杆菌物种和亚种生长的半乳寡聚糖组合物。
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公开(公告)号：US09327016B2
公开(公告)日：2016-05-03
申请号：US14378190
申请日：2013-02-14
IPC分类号： C12N9/24 , A61K38/01 , A61K38/16 , A61K38/47 , A23L2/52 , A61K31/715 , A61K35/741 , A23L1/305 , A23C9/12 , C12P21/00 , C12P19/04 , A61K38/00
CPC分类号： A61K38/47 , A23C9/1216 , A23L2/52 , A23L33/195 , A61K31/715 , A61K35/741 , A61K38/00 , A61K38/40 , C07K14/79 , C12N9/2402 , C12N9/2497 , C12P19/04 , C12P21/005 , C12Y302/01096 , Y02P20/52 , A61K2300/00
摘要： Provided herein are deglycosylating enzymes that remove a broad range of N-glycans from N-glycosylated proteins. Further provided are methods of recombinantly producing and expressing the deglycosylating enzymes. The presently described deglycosylating enzymes can be used to produce free glycans for characterization, and for prebiotic and immunostimulatory uses. In addition, the presently described deglycosylating enzymes can be used to produce deglycosylated proteins for characterization, to improve digestion, and to reduce immunogenicity.
摘要翻译： 本文提供了去糖基化酶，其从N-糖基化蛋白质中除去宽范围的N-聚糖。 还提供了重组产生和表达去糖基化酶的方法。 目前描述的去糖基化酶可用于产生用于表征的游离聚糖，以及益生元和免疫刺激用途。 此外，目前描述的去糖基化酶可以用于产生去糖基化的蛋白质用于表征，以改善消化和降低免疫原性。
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公开(公告)号：US08999705B2
公开(公告)日：2015-04-07
申请号：US13720866
申请日：2012-12-19
IPC分类号： C12N9/24 , C12P19/00 , C07H21/04 , A23C9/20 , A23L1/29 , C12N9/18 , C12N9/88 , C12N9/90 , C12P19/04 , C12N9/38
CPC分类号： C12N9/24 , A23C9/206 , A23L33/40 , A23V2002/00 , C12N9/18 , C12N9/2402 , C12N9/2471 , C12N9/88 , C12N9/90 , C12P19/00 , C12P19/04 , C12Y301/01053 , C12Y302/01018 , C12Y302/01023 , C12Y302/01051 , C12Y302/01052 , C12Y403/03007 , C12Y501/03009 , A23V2250/28 , A23V2200/3202
摘要： This invention provides nucleic acids and proteins involved in oligosaccharide modification in the species Bifidobacteria. The invention provides methods for utilizing the proteins of the invention to generate human milk oligosaccharides or oligosaccharide mimics. The invention also provides compositions containing the human milk oligosaccharides or oligosaccharide mimics and methods for use.
摘要翻译： 本发明提供了在双歧杆菌物种中参与寡糖修饰的核酸和蛋白质。 本发明提供了利用本发明的蛋白质产生人乳低聚糖或寡糖模拟物的方法。 本发明还提供含有人乳低聚糖或寡糖模拟物的组合物和使用方法。
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公开(公告)号：US11633461B2
公开(公告)日：2023-04-25
申请号：US17232509
申请日：2021-04-16
IPC分类号： C12N9/24 , C12P19/04 , A61K38/00 , A61K35/74 , A61K38/47 , A23L33/195 , A23L2/52 , A61K31/715 , A61K35/741 , A23C9/12 , C12P21/00 , A61K38/40 , C07K14/79
摘要： Provided herein are deglycosylating enzymes that remove a broad range of N-glycans from N-glycosylated proteins. Further provided are methods of recombinantly producing and expressing the deglycosylating enzymes. The presently described deglycosylating enzymes can be used to produce free glycans for characterization, and for prebiotic and immunostimulatory uses. In addition, the presently described deglycosylating enzymes can be used to produce deglycosylated proteins for characterization, to improve digestion, and to reduce immunogenicity.
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公开(公告)号：US10196663B2
公开(公告)日：2019-02-05
申请号：US15275075
申请日：2015-03-30
摘要： Provided are methods and yeast cultures for producing glycolipids and glycolipid compositions.
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公开(公告)号：US10165788B2
公开(公告)日：2019-01-01
申请号：US14305868
申请日：2014-06-16
IPC分类号： A61K35/745 , A23L1/30 , A23L33/135
摘要： Pre-biotic compositions containing oligosaccharides and probiotic compositions useful for treatment of a subject are provided herein. Also provided are methods for administering probiotic or pre-biotic compositions.
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公开(公告)号：US10071142B2
公开(公告)日：2018-09-11
申请号：US15079949
申请日：2016-03-24
IPC分类号： C12N9/24 , C12P19/04 , A61K38/01 , A61K38/47 , A23L2/52 , A61K31/715 , A61K35/741 , A23C9/12 , C12P21/00 , A23L33/195 , A61K38/40 , C07K14/79 , A61K38/00
CPC分类号： A61K38/47 , A23C9/1216 , A23L2/52 , A23L33/195 , A61K31/715 , A61K35/741 , A61K38/00 , A61K38/40 , C07K14/79 , C12N9/2402 , C12N9/2497 , C12P19/04 , C12P21/005 , C12Y302/01096 , Y02P20/52 , A61K2300/00
摘要： Provided herein are deglycosylating enzymes that remove a broad range of N-glycans from N-glycosylated proteins. Further provided are methods of recombinantly producing and expressing the deglycosylating enzymes. The presently described deglycosylating enzymes can be used to produce free glycans for characterization, and for prebiotic and immunostimulatory uses. In addition, the presently described deglycosylating enzymes can be used to produce deglycosylated proteins for characterization, to improve digestion, and to reduce immunogenicity.
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公开(公告)号：US20190119707A1
公开(公告)日：2019-04-25
申请号：US16164764
申请日：2018-10-18
发明人： Kyria Boundy-Mills , Luis Antonio Garay Almada , Irnayuli Rosaleida Sitepu , J. Bruce German , Tomas Cajka , Oliver Fiehn
IPC分类号： C12P7/64
摘要： Provided are methods and yeast cultures for producing polyol lipids and polyol lipid compositions.
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公开(公告)号：US10238674B2
公开(公告)日：2019-03-26
申请号：US15655396
申请日：2017-07-20
IPC分类号： A61K31/702 , A61K31/715 , A61K35/741 , A61K35/745 , A61K31/726 , C08B37/00 , C08L5/00 , C12P19/14 , C12P19/18 , A23L33/135 , A23L33/28 , A23L33/00 , A61K36/062
摘要： Oligosaccharides from bovine milk, whey and dairy products, and methods of producing bovine milk oligosaccharides are provided.
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