公开(公告)号：US20160338626A1

公开(公告)日：2016-11-24

申请号：US15112816

申请日：2015-01-21

申请人： The Regents of the University of California

发明人： Joseph WANG ,  Patrick MERCIER

IPC分类号： A61B5/1486 ,  G01N27/327 ,  H01M8/16 ,  A61B5/145 ,  A61B5/00

摘要： Methods, systems, and devices are disclosed mouth-based biosensors and biofuel cells. In one aspect, an electrochemical sensor device for detecting analytes in saliva includes a substrate including an electrically insulative material, a first electrode disposed on the substrate at a first location, in which the first electrode includes a surface including a chemical agent (e.g., a catalyst or a reactant) corresponding to an analyte in saliva; and a second electrode disposed on the substrate at a second location separated from the first electrode by a spacing region, the first and second electrodes capable of sustaining a redox reaction involving the chemical agent and the analyte to produce an electrical signal, such that, when the device is present in the mouth of a user and electrically coupled to an electrical circuit, the device is operable to detect the analyte in the user's saliva.

摘要翻译： 方法，系统和装置公开了基于嘴的生物传感器和生物燃料电池。 在一个方面，一种用于检测唾液中分析物的电化学传感器装置包括：基片，其包括电绝缘材料;第一电极，设置在第一位置的基底上，第一电极包括包含化学试剂的表面（例如， 催化剂或反应物），其对应于唾液中的分析物; 以及第二电极，其在与所述第一电极隔开间隔区域的第二位置处设置在所述基板上，所述第一和第二电极能够维持涉及所述化学试剂和所述分析物的氧化还原反应以产生电信号，使得当 该装置存在于用户的口中并电耦合到电路，该装置可操作以检测用户唾液中的分析物。

公开(公告)号：US20230258633A1

公开(公告)日：2023-08-17

申请号：US18014220

申请日：2021-07-07

申请人： The Regents of the University of California

发明人： Timothy RODWELL ,  Antonino CATANZARO ,  Marva SEIFERT ,  Joseph WANG ,  Eva Vargas ORGAZ ,  Victor Ruiz Valdepenas MONTIEL

IPC分类号： G01N33/569 ,  G01N27/327 ,  G01N33/553 ,  C07K16/12 ,  C07K16/10

CPC分类号： G01N33/569 ,  G01N27/327 ,  G01N33/553 ,  C07K16/1289 ,  C07K16/10 ,  G01N2333/35 ,  G01N2333/165

摘要： In one aspect, the disclosure relates to test strips for detecting and/or monitoring the treatment of a disease in a subject. The test strips are inexpensive and disposable and can be used directly with clinical biological samples from patients including, but not limited to, blood, plasma, saliva, and urine. Also disclosed are methods of using the test strips to quantify antigens produced by a virus or microorganism causing an infectious disease. The methods can be conducted at a point of care for a patient and do not require expensive equipment or extensive operator training. The methods are also rapid to complete and can be used to monitor progress in the treatment of a disease This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

公开(公告)号：US20190035996A1

公开(公告)日：2019-01-31

申请号：US16048686

申请日：2018-07-30

申请人： Samsung Electronics Co., Ltd. ,  THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, A CALIFORNIA CORPORATION

发明人： Renkun CHEN ,  Joseph WANG ,  Sunmi SHIN ,  Rajan KUMAR ,  Jongwook ROH

IPC分类号： H01L35/26 ,  H01L35/32 ,  H01L35/34 ,  C09D11/52 ,  C09D11/08 ,  C09D11/037

摘要： A thermoelectric material ink including a binder with a cellulosic ether, a thermoelectric element, and a thermoelectric device that are manufactured using the thermoelectric material ink, and a method of manufacturing the thermoelectric device are provided. A printed thermoelectric device having high thermoelectric performance may be manufactured using the thermoelectric material ink.

公开(公告)号：US20220008737A1

公开(公告)日：2022-01-13

申请号：US17293897

申请日：2019-11-14

申请人： The Regents of the University of California

发明人： Joseph WANG ,  Krishnan CHAKRAVARTHY ,  Itthipon JEERAPAN

IPC分类号： A61N1/378 ,  A61N1/36 ,  H01M8/16 ,  H01M4/86 ,  H01M8/00

摘要： Disclosed are devices, systems and methods for implantable a biofuel cells. In some aspects, a biofuel cell device for extracting energy from a biological fluid includes a substrate including two compartments each with one or more openings; an anode assembly disposed in the substrate and including an anode electrode and functionalization material to facilitate an oxidative process that releases electrons captured at the anode electrode; and a cathode assembly disposed in the substrate separated from the anode assembly and including a catalytic material facilitate a chemical reduction process such that the biofuel cell device extracts electrical energy from the substance in the biological fluid.

公开(公告)号：US20230003725A1

公开(公告)日：2023-01-05

申请号：US17757216

申请日：2020-12-11

申请人： Joseph WANG ,  Hazhir TEYMOURIAN ,  Netz ARROYO ,  Eyal DASSAU ,  The Regents of the University of California

发明人： Joseph WANG ,  Hazhir TEYMOURIAN ,  Netz ARROYO ,  Eyal DASSAU ,  Farshad TEHRANI

IPC分类号： G01N33/543 ,  C12Q1/00 ,  A61B5/145 ,  A61B5/1468

摘要： Methods, apparatus, systems, and methods are described that relate to microneedle-assisted aptamer-based electrochemical sensing for label-free, continuous real-time monitoring of biomarkers in a biofluid. One example device for electrochemical monitoring of one or more analytes in a biofluid includes a substrate and at least two microneedles coupled to the substrate. Each microneedle in the at least two microneedles includes a protruded needle structure and an electrode probe structure. The electrode probe structure of a first microneedle in the at least two microneedles includes an aptamer sequence which is specific for a first analyte and the electrode probe structure of the first microneedle is operable as a working electrode for detection of the first analyte using a first electrochemical detection technique.

公开(公告)号：US20220071003A1

公开(公告)日：2022-03-03

申请号：US17500931

申请日：2021-10-13

申请人： The Regents of the University of California

发明人： Joseph WANG ,  Rajan Kumar ,  Ying Shirley Meng ,  Jae Wook Shin ,  Lu Yin

IPC分类号： H05K1/02 ,  C08F297/04 ,  C08L53/02 ,  H01M4/38 ,  H01M4/48 ,  H01M4/62 ,  H01M4/66 ,  H01M10/24 ,  H05K1/03 ,  H05K1/11 ,  H05K1/16 ,  H05K3/32 ,  A61B5/1477

摘要： Disclosed are compositions, devices, systems and fabrication methods for stretchable composite materials and stretchable electronics devices. In some aspects, an elastic composite material for a stretchable electronics device includes a first material having a particular electrical, mechanical or optical property; and a multi-block copolymer configured to form a hyperelastic binder that creates contact between the first material and the multi-block copolymer, in which the elastic composite material is structured to stretch at least 500% in at least one direction of the material and to exhibit the particular electrical, mechanical or optical property imparted from the first material. In some aspects, the stretchable electronics device includes a stretchable battery, biofuel cell, sensor, supercapacitor or other device able to be mounted to skin, clothing or other surface of a user or object.