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公开(公告)号：US11613758B2
公开(公告)日：2023-03-28
申请号：US17524332
申请日：2021-11-11
Inventor： Jeff Hasty , Lev Tsimring , Muhammad Omar Din , Arthur Prindle , Sangeeta Bhatia , Tal Danino
Abstract: Some embodiments described herein relate to cells which have been genetically engineered to release a polypeptide when a population of the cells reaches a desired density. In some embodiments, the released polypeptide may be a therapeutic polypeptide. In some embodiments, the therapeutic polypeptide kills tumor cells or which inhibits the growth of tumor cells.
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公开(公告)号：US20240350559A1
公开(公告)日：2024-10-24
申请号：US18541238
申请日：2023-12-15
Applicant: The Regents of the University of California
Inventor： Jeff Hasty , Michael Julius Liao , Muhammad Omar Din
IPC: A61K35/74 , C07K14/245 , C12N1/20 , A61K35/00
CPC classification number: A61K35/74 , C07K14/245 , C12N1/20 , A61K2035/115
Abstract: Provided herein are multi-strain population control systems, methods, kits, and compositions. Also provided are methods, systems, kits, and compositions for culturing bacterial cells in multi-strain ecosystems, and temporally arranged multi-strain ecosystems or cultures using a synchronized lysis circuit in combination with multiple toxin/antitoxin systems to cycle continuously over a long period of time.
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公开(公告)号：US11896626B2
公开(公告)日：2024-02-13
申请号：US16972405
申请日：2019-06-07
Applicant: The Regents of the University of California
Inventor： Jeff Hasty , Michael Julius Liao , Muhammad Omar Din
IPC: A61K35/74 , C07K14/245 , C12N1/20 , A61K35/00
CPC classification number: A61K35/74 , C07K14/245 , C12N1/20 , A61K2035/115
Abstract: Provided herein are multi-strain population control systems, methods, kits, and compositions. Also provided are methods, systems, kits, and compositions for culturing bacterial cells in multi-strain ecosystems, and temporally arranged multi-strain ecosystems or cultures using a synchronized lysis circuit in combination with multiple toxin/antitoxin systems to cycle continuously over a long period of time.
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公开(公告)号：US20230294097A1
公开(公告)日：2023-09-21
申请号：US17923129
申请日：2021-05-04
Applicant: The Regents of the University of California
Inventor： Jeff Hasty , Muhammad Omar Din , Aida Martin Galan
IPC: B01L3/00
CPC classification number: B01L3/502761 , B01L2200/0652 , B01L2300/0645 , B01L2300/0877
Abstract: Disclosed herein is a method of measuring a cell population, the method including culturing a cell population in a growth medium, wherein the cell population includes a cell strain including a control gene and a promoter sequence; positioning first and second electrodes in contact with the growth medium, wherein the first and second electrodes are connected to different terminals of an electrical source; applying an electrical signal between the two electrodes; measuring an electrical parameter of the growth medium as a function of time; and determining information about the cell population based upon the measured electrical parameter.
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公开(公告)号：US20230126966A1
公开(公告)日：2023-04-27
申请号：US18072256
申请日：2022-11-30
Applicant: The Regents of the University of California
Inventor： Jeff Hasty , Lev Tsimring , Spencer R. Scott , Muhammad Omar Din
Abstract: Provided are bacterial strains, methods of culturing bacterial cells using synthetic quorum-regulated lysis, and uses thereof.
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Patent Agency Ranking
公开(公告)号：US20220251579A1
公开(公告)日：2022-08-11
申请号：US17524332
申请日：2021-11-11
Inventor： Jeff Hasty , Lev Tsimring , Muhammad Omar Din , Arthur Prindle , Sangeeta Bhatia , Tal Danino
Abstract: Some embodiments described herein relate to cells which have been genetically engineered to release a polypeptide when a population of the cells reaches a desired density. In some embodiments, the released polypeptide may be a therapeutic polypeptide. In some embodiments, the therapeutic polypeptide kills tumor cells or which inhibits the growth of tumor cells.
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公开(公告)号：US20210284953A1
公开(公告)日：2021-09-16
申请号：US16614613
申请日：2018-05-18
Applicant: The Regents of the University of California
Inventor： Jeff Hasty , Lev Tsimring , Spencer R. Scott , Muhammad Omar Din
Abstract: Provided are bacterial strains, methods of culturing bacterial cells using synthetic quorum-regulated lysis, and uses thereof.
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公开(公告)号：US11174486B2
公开(公告)日：2021-11-16
申请号：US15565131
申请日：2016-04-07
Inventor： Jeff Hasty , Lev Tsimring , Muhammad Omar Din , Arthur Prindle , Sangeeta Bhatia , Tal Danino
Abstract: Some embodiments described herein relate to cells which have been genetically engineered to release a polypeptide when a population of the cells reaches a desired density. In some embodiments, the released polypeptide may be a therapeutic polypeptide. In some embodiments, the therapeutic polypeptide kills tumor cells or which inhibits the growth of tumor cells.
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公开(公告)号：US20210169941A1
公开(公告)日：2021-06-10
申请号：US16972405
申请日：2019-06-07
Applicant: The Regents of the University of California
Inventor： Jeff Hasty , Michael Julius Liao , Muhammad Omar Din
IPC: A61K35/74 , C12N1/20 , C07K14/245
Abstract: Provided herein are multi-strain population control systems, methods, kits, and compositions. Also provided are methods, systems, kits, and compositions for culturing bacterial cells in multi-strain ecosystems, and temporally arranged multi-strain ecosystems or cultures using a synchronized lysis circuit in combination with multiple toxin/antitoxin systems to cycle continuously over a long period of time.
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公开(公告)号：US20180148729A1
公开(公告)日：2018-05-31
申请号：US15565131
申请日：2016-04-07
Inventor： Jeff Hasty , Lev Tsimring , Muhammad Omar Din , Arthur Prindle , Sangeeta Bhatia , Tal Danino
CPC classification number: C12N15/74 , A61K35/74 , A61K38/16 , C12N1/06 , C12N1/20 , C12N15/63 , C12P21/02
Abstract: Some embodiments described herein relate to cells which have been genetically engineered to release a polypeptide when a population of the cells reaches a desired density. In some embodiments, the released polypeptide may be a therapeutic polypeptide. In some embodiments, the therapeutic polypeptide kills tumor cells or which inhibits the growth of tumor cells.
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