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公开(公告)号：US11638820B2
公开(公告)日：2023-05-02
申请号：US17140896
申请日：2021-01-04
摘要： A neuromodulation system and a method of inducing voluntary movement in a mammal with a spinal injury are disclosed. In an example, a neuromodulation system includes a processor, a signal generator, and at least one electrode. The processor, in cooperation with the signal generator and the at least one electrode are configured to deliver a transcutaneous stimulation to a mammal. The transcutaneous stimulation includes during a first time period, a transcutaneous electrical spinal cord stimulation (“tESCS”) applied to the mammal during physical conditioning of the mammal. The transcutaneous stimulation also includes during a second time period after the first time period, the tESCS applied to the mammal during reduced or no physical conditioning of the mammal. The tESCS applied during the first time period and the second time period is used to establish a functional baseline of the mammal.
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公开(公告)号：US20240001116A1
公开(公告)日：2024-01-04
申请号：US18142318
申请日：2023-05-02
CPC分类号： A61N1/36003 , A61N1/0456 , A61N1/3616 , A61N1/36025 , A61N1/36171 , A61N1/06
摘要： A neuromodulation system, device, and method are disclosed. In an embodiment, a neuromodulation system includes a processor, a signal generator, a first electrode, and a second electrode. The processor in cooperation with the signal generator, the first electrode, and the second electrode are configured to deliver a transcutaneous stimulation to a mammal. The transcutaneous stimulation is configured by the processor for inducing voluntary movement in the mammal. The first electrode is positioned transcutaneously on a spinal cord and/or spinal cord dorsal roots of the mammal. Additionally, the second electrode is placed transcutaneously on or over at least one of the spinal cord and/or the spinal cord dorsal roots, a muscle, a nerve, or on or near a target end organ or bodily structure of the mammal. The second electrode is in communication with the first electrode through a hardwire or wireless connection.
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3.发明申请公开(公告)号：US20190022371A1
公开(公告)日：2019-01-24
申请号：US15750499
申请日：2016-08-05
发明人： Chih-Wei Chang , Victor Reggie Edgerton , Wentai Liu , Yuri Gerasimenko , Parag Gad , Yi-Kai Lo
摘要： In various embodiments, a transcutaneous needle electrode and uses thereof are provided. In certain embodiments the needle electrodes comprise a plurality of electrically conductive needles, where the needles are solid, or where the needles are hollow and have a closed tip, where the needles have an average tip diameter less than about 10 μm and an average length greater than about 20-50 μm wherein the electrically conductive needles are electrically coupled to one or more electrical leads.
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4.发明申请公开(公告)号：US20170274209A1
公开(公告)日：2017-09-28
申请号：US15505053
申请日：2015-08-21
发明人： Victor Reggie Edgerton , Parag Gad , Roland R. Roy , Yury P. Gerasimenko , Daniel C. Lu , Hui Zhong
IPC分类号： A61N1/36 , A61K31/475 , A61H3/00 , A61K31/496 , A63B22/02 , A63B21/06
摘要： In various embodiments methods and devices are provided for regulating bladder function in a subject after a spinal cord and/or brain injury. In certain embodiments the methods comprise applying a pattern of electrical stimulation to the Lumbosacral spinal cord at a frequency and intensity sufficient to initiate micturition and/or to improve the amount of bladder emptying. In certain embodiments the electrical stimulation is at a frequency and intensity sufficient to improve the amount of bladder emptying (e.g., to provide at least 30% emptying or at least 40% emptying, or at least 50% emptying, or at least 60% emptying, or at least 70% emptying, or at least 80% emptying, or at least 90% emptying, or at least 95% emptying.
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公开(公告)号：US20170246452A1
公开(公告)日：2017-08-31
申请号：US15506696
申请日：2015-08-27
发明人： Wentai Liu , Victor Reggie Edgerton , Chih-Wei Chang , Parag Gad
摘要： In certain embodiments an electrode array for epidural stimulation of the spinal cord is provided where the array comprises a plurality of electrodes disposed on a flexible polymer substrate; said electrodes being electrically connected to one or more lead wires and/or connection points on an electrical connector; where the electrodes of said array are bonded to said polymer so that the electrodes can carry an electrical stimulation signal having a voltage, frequency, and current sufficient to provide epidural stimulation of a spinal cord and/or brain in vivo or in a physiological saline solution, without separation of all or a part of an electrode from the polymer substrate.
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公开(公告)号：US20220233848A1
公开(公告)日：2022-07-28
申请号：US17611534
申请日：2020-05-20
申请人： The Regents of the University of California , Scuola lnternazionale Superiore di Studi Avanzati (SISSA) , University of Southern California
IPC分类号： A61N1/05 , A61B5/389 , A61N1/02 , A61N1/04 , A61N1/06 , A61N1/36 , A61N1/372 , A61B5/308 , A61B5/313
摘要： In various embodiments electrical stimulators are provided for transcutaneous and/or epidural stimulation. In certain embodiments the stimulator provides one or more channels configured to provide one or more of the following stimulation patterns: i) monophasic electrical stimulation with a DC offset; ii) monophasic electrical stimulation with charge balance; iii) delayed biphasic electrical stimulation with a DC offset; iv) delayed biphasic electrical stimulation with charge balance; v) amplitude modulated dynamic stimulation; and/or vi) frequency modulated dynamic stimulation.
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公开(公告)号：US11298533B2
公开(公告)日：2022-04-12
申请号：US15753963
申请日：2016-08-26
摘要： In various embodiments a method of synergistically using a neuromodulation stimulator and a robotic exoskeleton for the restoration of voluntary movement and greater muscle activation in chronically paralyzed subjects is provided. The noninvasive neuromodulation system delivers signals to facilitate the restoration and/or enhancement of neurological function where at least one effect is strengthened stepping capacity that can be further substantiated when coupled with robotic exoskeleton assistance.
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公开(公告)号：US20180280693A1
公开(公告)日：2018-10-04
申请号：US15753963
申请日：2016-08-26
摘要： In various embodiments a method of synergistically using a neuromodulation stimulator and a robotic exoskeleton for the restoration of voluntary movement and greater muscle activation in chronically paralyzed subjects is provided. The noninvasive neuromodulation system delivers signals to facilitate the restoration and/or enhancement of neurological function where at least one effect is strengthened stepping capacity that can be further substantiated when coupled with robotic exoskeleton assistance.
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公开(公告)号：US20210121692A1
公开(公告)日：2021-04-29
申请号：US17140896
申请日：2021-01-04
摘要： A neuromodulation system and a method of inducing voluntary movement in a mammal with a spinal injury are disclosed. In an example, a neuromodulation system includes a processor, a signal generator, and at least one electrode. The processor, in cooperation with the signal generator and the at least one electrode are configured to deliver a transcutaneous stimulation to a mammal. The transcutaneous stimulation includes during a first time period, a transcutaneous electrical spinal cord stimulation (“tESCS”) applied to the mammal during physical conditioning of the mammal. The transcutaneous stimulation also includes during a second time period after the first time period, the tESCS applied to the mammal during reduced or no physical conditioning of the mammal. The tESCS applied during the first time period and the second time period is used to establish a functional baseline of the mammal.
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公开(公告)号：US10773074B2
公开(公告)日：2020-09-15
申请号：US15506696
申请日：2015-08-27
发明人： Wentai Liu , Victor Reggie Edgerton , Chih-Wei Chang , Parag Gad
摘要： In certain embodiments an electrode array for epidural stimulation of the spinal cord is provided where the array comprises a plurality of electrodes disposed on a flexible polymer substrate; said electrodes being electrically connected to one or more lead wires and/or connection points on an electrical connector; where the electrodes of said array are bonded to said polymer so that the electrodes can carry an electrical stimulation signal having a voltage, frequency, and current sufficient to provide epidural stimulation of a spinal cord and/or brain in vivo or in a physiological saline solution, without separation of all or a part of an electrode from the polymer substrate.
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