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公开(公告)号：US20240131329A1
公开(公告)日：2024-04-25
申请号：US18499304
申请日：2023-10-31
发明人： Yi-Kai Lo , Wentai Liu
CPC分类号： A61N1/36007 , A61N1/0509 , A61N1/37518
摘要： Systems and methods for implementation of a disposable miniaturized implant for treatment of Post-Operative Ileums (POI), a miniaturized implant for treating chronic GI dysmotility (e.g., dysphagia, gastroesophageal reflux disease (GERD), nausea, functional dyspepsia, blockage of transit, and gastroparesis, inflammatory bowel disease) and obesity, by providing electrical stimulation to the part of bowel going through surgery to expedite the healing process while recording the smooth muscle activities simultaneously, or providing stimulation on a treatment location of the GI tract or the branch of the vagus nerve. Systems and methods are also provided for non-invasive, transcutaneous stimulation of anatomy within the abdomen of the patient.
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公开(公告)号：US11129983B2
公开(公告)日：2021-09-28
申请号：US16043414
申请日：2018-07-24
发明人： Yi-Kai Lo , Wentai Liu , Victor R. Edgerton , Chih-Wei Chang
摘要： A wireless implant and associated system for motor function recovery after spinal cord injury, and more particularly a multi-channel wireless implant with small package size. The wireless implant can further be used in various medical applications, such as retinal prostheses, gastrointestinal implant, vagus nerve stimulation, and cortical neuromodulation. The system also includes a method and its implementation to acquire the impedance model of the electrode-tissue interface of the implant.
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公开(公告)号：US10391310B2
公开(公告)日：2019-08-27
申请号：US15470542
申请日：2017-03-27
发明人： Wentai Liu , James C. Y. Dunn , Benjamin M. Wu , Yi-Kai Lo , Chih-Wei Chang , Justin P. Wagner
摘要： A gastrointestinal stimulation apparatus and methods with an electronic controller and a flexible and stretchable electrode array with a central branch and orthogonal bilateral branches that wrap around a section of the gastrointestinal tract and can accommodate repetitive contraction and relaxation movements of the tract. Array branches have a flexible spring structure, stimulation electrodes, recording electrodes, sensors controlled by a controller and adhesion nodes that fix the branches to the tissue. The electrode array can sense the normal peristalsis from upstream tissue and produce a stimulus signal to stimulate the incapable intestine section to generate stimulation-induced contractions. Electrodes on the incapable intestine section can be used for stimulation or recording, the recorded signal from the incapable intestine section can be sent back to the electronics to form a closed loop control system. An impedance measurement using current stimulation can be used to capture low frequency contraction signals.
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公开(公告)号：US09538928B2
公开(公告)日：2017-01-10
申请号：US14108118
申请日：2013-12-16
发明人： Yi-Kai Lo , Wentai Liu
IPC分类号： A61B5/04 , A61B5/0476 , H03F3/45 , A61B5/0478 , A61B5/0482 , A61B5/00
CPC分类号： A61B5/04001 , A61B5/04012 , A61B5/0476 , A61B5/0478 , A61B5/0482 , A61B5/7203 , A61B5/7225 , H03F3/45192 , H03F3/45475 , H03F3/45928 , H03F2200/165 , H03F2200/168 , H03F2200/171 , H03F2200/408 , H03F2203/45362 , H03F2203/45512 , H03F2203/45528 , H03F2203/45544 , H03F2203/45631 , H03F2203/45686 , H03F2203/45726
摘要： A neuron recording system was provided. By using the gain-boosted topology, the amplifier input impedance can be increased while simultaneously reducing the noise. The system can be configured to record local field potentials (LFPs) and neuron spikes, respectively, with low-power consumption. With the flexible digital controller module (DCM), any subset of the recording channels can be activated for recording with independent sampling rate at each channel. A wireless interface to transmit recorded neuron data and an on-chip neuron processor to perform real-time signal processing can be incorporated in the system.
摘要翻译： 提供神经元记录系统。 通过使用增益升压拓扑，可以增加放大器输入阻抗，同时降低噪声。 该系统可以配置为分别以低功耗记录局部场电位（LFP）和神经元峰值。 使用灵活的数字控制器模块（DCM），可以激活记录通道的任何子集，以便在每个通道独立采样率进行记录。 用于发送记录的神经元数据的无线接口和用于执行实时信号处理的片上神经元处理器可以并入系统中。
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公开(公告)号：US11944814B2
公开(公告)日：2024-04-02
申请号：US17459468
申请日：2021-08-27
发明人： Yi-Kai Lo , Wentai Liu , Victor R. Edgerton , Chih-Wei Chang
CPC分类号： A61N1/36003 , A61N1/0551 , A61N1/3787 , A61N1/08
摘要： A wireless implant and associated system for motor function recovery after spinal cord injury, and more particularly a multi-channel wireless implant with small package size. The wireless implant can further be used in various medical applications, such as retinal prostheses, gastrointestinal implant, vagus nerve stimulation, and cortical neuromodulation. The system also includes a method and its implementation to acquire the impedance model of the electrode-tissue interface of the implant.
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公开(公告)号：US10027362B2
公开(公告)日：2018-07-17
申请号：US15176411
申请日：2016-06-08
发明人： Wentai Liu , Mau-Chung Frank Chang , Yen-Cheng Kuan , Yi-Kai Lo , Yan Zhao
IPC分类号： H04B7/00 , H04B1/3827 , A61B5/0476 , G06F3/01 , A61B5/00 , H02J50/10 , H04L5/00 , H04W4/80
摘要： A wireless wearable high data throughput (big data) brain machine interface apparatus is presented. An implanted recording and transmitting module collects neural data from a plurality of implanted electrodes and wirelessly transmits this over a short distance to a wearable (not implanted) receiving and forwarding module, which communicates the data over a wired communication to a mobile post processing device. The post processing device can send this neural data to an external display or computer enabled device for viewing and/or manipulation. High data throughput is supported by aggregating multiple groups of electrodes by multiple n-channel recording elements, which are multiplexed and then modulated into high frequency wireless communications to the wearable module. Embodiments include use of multiple radiators (multiple polarizations and/or spatially distributed), with beam alignment adjustment.
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7.发明申请公开(公告)号：US20170273594A1
公开(公告)日：2017-09-28
申请号：US15481715
申请日：2017-04-07
发明人： Wentai Liu , Yi-Kai Lo
CPC分类号： A61B5/0531 , A61B5/4238 , A61B5/4255 , A61B5/721 , A61B5/7225 , A61B5/7278 , A61B2560/0223 , A61N1/36125
摘要： A system and method of suppressing stimulation artifacts when performing electrophysiological electrical stimulation and recording. An artifact waveform is captured associated with a stimulus output, and then the artifact waveform calibrated during another stimulus output for accurately representing the actual artifact waveform received within each measured response to a stimulus. During actual stimulus generation and response recording, the calibrated artifact waveform is subtracted in at least one of the amplifier stages so that the artifacts are removed from the amplified response to the stimulus thus providing an accurate output without saturating the amplifiers.
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8.发明申请公开(公告)号：US20160038739A1
公开(公告)日：2016-02-11
申请号：US14823869
申请日：2015-08-11
发明人： Wentai Liu , Kuanfu Chen , Yi-Kai Lo
CPC分类号： A61N1/36046 , A61N1/0543 , A61N1/36067 , A61N1/36082 , A61N1/36153 , A61N1/37223 , A61N1/3787
摘要： A high channel count high-voltage neural stimulator provides an external circuit which communicates power and data to a neural stimulator implant circuit. Data from the external device, such as image data from a camera in an epiretinal application, are communicated to the implant. Multiple pixels circuits, within each implant demultiplex the digital signals, then output separate nerve stimulator outputs from multiple outputs, each configured for connection to a nerve, by sharing a single level conversion driver circuit. In at least one example, the implant circuits can be clustered in a master-slave configuration to increase the number of available neural stimulation outputs.
摘要翻译： 高通道数高电压神经刺激器提供外部电路，其将功率和数据传送到神经刺激器注入电路。 来自外部设备的数据，例如来自外部应用的来自相机的图像数据，被传送到植入物。 每个植入物中的多个像素电路解复用数字信号，然后通过共享一个电平转换驱动器电路，从多个输出端输出单独的神经刺激器输出，每个输出被配置为连接到神经。 在至少一个示例中，植入电路可以以主从配置聚类以增加可用的神经刺激输出的数量。
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公开(公告)号：US20240226549A9
公开(公告)日：2024-07-11
申请号：US18499304
申请日：2023-11-01
发明人： Yi-Kai Lo , Wentai Liu
CPC分类号： A61N1/36007 , A61N1/0509 , A61N1/37518
摘要： Systems and methods for implementation of a disposable miniaturized implant for treatment of Post-Operative Ileums (POI), a miniaturized implant for treating chronic GI dysmotility (e.g., dysphagia, gastroesophageal reflux disease (GERD), nausea, functional dyspepsia, blockage of transit, and gastroparesis, inflammatory bowel disease) and obesity, by providing electrical stimulation to the part of bowel going through surgery to expedite the healing process while recording the smooth muscle activities simultaneously, or providing stimulation on a treatment location of the GI tract or the branch of the vagus nerve. Systems and methods are also provided for non-invasive, transcutaneous stimulation of anatomy within the abdomen of the patient.
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公开(公告)号：US20230402189A1
公开(公告)日：2023-12-14
申请号：US18332091
申请日：2023-06-09
发明人： Ying Li , Wentai Liu , Yi-Kai Lo
IPC分类号： G16H50/50 , A61N1/36 , G16H20/40 , G16H30/40 , G16H70/20 , A61B5/055 , A61B5/00 , A61B6/03 , A61N1/08 , A61N1/20 , G06F17/11 , G06F30/23 , A61B5/369 , A61B5/389
CPC分类号： G16H50/50 , A61N1/36031 , G16H20/40 , G16H30/40 , G16H70/20 , A61B5/055 , A61B5/4848 , A61B6/032 , A61N1/08 , A61N1/205 , A61N1/36003 , A61N1/36007 , A61N1/36014 , G06F17/11 , G06F30/23 , A61B5/369 , A61B5/389 , G06F2111/10
摘要： Methods, apparatus, and systems are disclosed for optimization techniques and a realistic 3D model to design optimal parameters for transcutaneous stimulation to achieve focalized stimulation of a target tissue such as the spinal cord, brain or other internal organ. The methods, apparatus, and systems include generation of a 3D model from a CT/MRI image, as well as an optimization algorithm that enables stimulation of any target location (e.g., on the dorsal root, or on the dorsal column) with any orientation at high precision.
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