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公开(公告)号：US20210378991A1
公开(公告)日：2021-12-09
申请号：US17407043
申请日：2021-08-19
IPC分类号： A61K31/137 , A61N1/05 , A61N1/36 , A61K31/4168 , A61K31/4178 , A61K31/496 , A61K31/4985 , A61K31/506 , A61K31/517 , A61K31/527
摘要： In various embodiments, methods are provided for applying transcutaneous and/or epidural spinal cord stimulation with and without selective pharmaceuticals to restore voluntary control of hand function in tetraplegic subjects.
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公开(公告)号：US20210299441A1
公开(公告)日：2021-09-30
申请号：US17347187
申请日：2021-06-14
摘要： A neuromodulation system, device, and method are disclosed. In an embodiment, a neuromodulation method includes providing a neuromodulation system including a processor, a signal generator communicatively coupled to the processor, and at least one transcutaneous electrode communicatively coupled to the signal generator. The method also includes causing the at least one transcutaneous electrode to be applied a human patient having at least one dysfunctional spinal circuit. The method further includes facilitating transcutaneous electrical stimulation of the patient's spinal cord via the processor in cooperation with the signal generator causing activation of at least one spinal network (“SN”) to enable or improve voluntary movements of the patient's arms, trunk, and legs, or autonomic control of at least one of sexual activity, vasomotor activity, speech, swallowing, chewing, cardiovascular function, respiratory activity, body temperature, metabolic processes, or cognitive function.
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公开(公告)号：US20240198100A1
公开(公告)日：2024-06-20
申请号：US18555491
申请日：2022-04-13
发明人： Daniel C. Lu
CPC分类号： A61N1/3601 , A61N1/0456 , A61N1/36017 , A61N1/36031 , A61N1/36034
摘要： Systems and methods for conditioning respiratory muscles in a patient are described. In some variations, a method for conditioning respiratory muscles in a patient may include administering a stimulation signal to a thoracic spinal cord region of a patient, where the stimulation signal is effective to augment and/or sustain activation of one or more respiratory muscles in the patient, thereby maintaining strength of the one or more respiratory muscles. In some variations, the method includes administering the stimulation signa in response to detecting an inspiratory phase of the patient, such as via one or more sensors.
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4.发明申请公开(公告)号：US20220313993A1
公开(公告)日：2022-10-06
申请号：US17837913
申请日：2022-06-10
IPC分类号： A61N1/36 , A61K31/00 , A61K31/197 , A61N1/04 , G16H20/40
摘要： In various embodiments, non-invasive methods to induce motor control in a mammal subject to spinal cord or other neurological injuries are provided. In some embodiments the methods involve administering transcutaneous electrical spinal cord stimulation (tSCS) to the mammal at a frequency and intensity that induces locomotor activity.
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公开(公告)号：US20220161042A1
公开(公告)日：2022-05-26
申请号：US17381156
申请日：2021-07-20
发明人： Daniel C. Lu
摘要： In various embodiments methods and devices are provided for facilitating locomotor function and/or voiding of bladder and/or bowel in a subject with a neuromotor disorder. In certain embodiments the methods involve providing magnetic stimulation of the spinal cord at a location, frequency and intensity sufficient to facilitate locomotor function and/or voiding of bladder and/or bowel.
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公开(公告)号：US11097122B2
公开(公告)日：2021-08-24
申请号：US15344381
申请日：2016-11-04
发明人： Daniel C. Lu
摘要： In various embodiments methods and devices are provided for facilitating locomotor function and/or voiding of bladder and/or bowel in a subject with a neuromotor disorder. In certain embodiments the methods involve providing magnetic stimulation of the spinal cord at a location, frequency and intensity sufficient to facilitate locomotor function and/or voiding of bladder and/or bowel.
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公开(公告)号：US20230271004A1
公开(公告)日：2023-08-31
申请号：US18141816
申请日：2023-05-01
CPC分类号： A61N1/36003 , A61N1/0456 , A61N1/36025 , A61N1/36071 , A61N1/36021 , A61N1/36057 , A61N1/36171 , A61N1/36175 , A61N1/36178
摘要： A neuromodulation system, device, and method are disclosed. In an embodiment, a neuromodulation system includes a processor, a signal generator, a first electrode, and a second electrode. The processor in cooperation with the signal generator, the first electrode, and the second electrode are configured to deliver a transcutaneous stimulation to a mammal. The transcutaneous stimulation is configured by the processor for inducing voluntary movement in the mammal. The first electrode is positioned transcutaneously on a spinal cord and/or spinal cord dorsal roots of the mammal. Additionally, the second electrode is placed transcutaneously on or over at least one of the spinal cord and/or the spinal cord dorsal roots, a muscle, a nerve, or on or near a target end organ or bodily structure of the mammal. The second electrode is in communication with the first electrode through a hardwire or wireless connection.
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公开(公告)号：US20210236837A1
公开(公告)日：2021-08-05
申请号：US17269970
申请日：2019-08-21
发明人： Daniel C. Lu
摘要： In various embodiments methods and devices are provided for facilitating locomotor function and/or voiding of bladder and/or bowel in a subject with a neuromotor disorder. In certain embodiments the methods involve providing magnetic stimulation of the spinal cord at a location, frequency and intensity sufficient to facilitate locomotor function and/or voiding of bladder and/or bowel.
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公开(公告)号：US10751533B2
公开(公告)日：2020-08-25
申请号：US15505053
申请日：2015-08-21
发明人： Victor Reggie Edgerton , Parag Gad , Roland R. Roy , Yury P. Gerasimenko , Daniel C. Lu , Hui Zhong
IPC分类号： A61N1/36 , A61K31/506 , A61K45/06 , A61H3/00 , A61K31/475 , A61K31/496 , A63B21/06 , A63B22/02
摘要： In various embodiments methods and devices are provided for regulating bladder function in a subject after a spinal cord and/or brain injury. In certain embodiments the methods comprise applying a pattern of electrical stimulation to the Lumbosacral spinal cord at a frequency and intensity sufficient to initiate micturition and/or to improve the amount of bladder emptying. In certain embodiments the electrical stimulation is at a frequency and intensity sufficient to improve the amount of bladder emptying (e.g., to provide at least 30% emptying or at least 40% emptying, or at least 50% emptying, or at least 60% emptying, or at least 70% emptying, or at least 80% emptying, or at least 90% emptying, or at least 95% emptying.
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公开(公告)号：US10137299B2
公开(公告)日：2018-11-27
申请号：US15025201
申请日：2014-09-26
IPC分类号： A61N1/36 , A61N1/05 , A61K31/527 , A61K31/137 , A61K31/4168 , A61K31/4178 , A61K31/496 , A61K31/4985 , A61K31/506 , A61K31/517
摘要： In various embodiments, methods are provided for applying transcutaneous and/or epidural spinal cord stimulation with and without selective pharmaceuticals to restore voluntary control of hand function in tetraplegic subjects.
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