公开(公告)号：US20170361007A1

公开(公告)日：2017-12-21

申请号：US15527590

申请日：2015-11-18

Applicant: The Regents of the University of California

Inventor： Shuvo Roy ,  Torin Yeager ,  Emily Abada ,  Ajay S. Dharia

IPC: A61M1/16 ,  B01D71/70 ,  A61M1/26 ,  B01D69/12 ,  B01D69/02 ,  B01D53/22

Abstract: Provided herein is a gas exchange composite membrane and methods of making the same. The gas exchange composite membrane may find use in a method of exchanging gas with blood in a subject in need of blood oxygenation support, which method is also disclosed. Also provided herein are systems and kits that find use in performing the methods of exchanging gas with blood.

公开(公告)号：US20170156658A1

公开(公告)日：2017-06-08

申请号：US15379220

申请日：2016-12-14

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Michel Maharbiz ,  Vivek Subramanian ,  Ana Claudia Arias ,  Sarah Swisher ,  Amy Liao ,  Monica Lin ,  Felippe Pavinatto ,  Yasser Khan ,  Daniel Cohen ,  Elisabeth Leeflang ,  Shuvo Roy ,  Michael Harrison ,  David Young

IPC: A61B5/00 ,  A61B5/053

Abstract: Methods and apparatus for real-time, quantifiable monitoring of high-risk areas of biological tissue are described. The methods and apparatus use impedance spectroscopy to detect subtle changes in tissue health.

公开(公告)号：US12226736B2

公开(公告)日：2025-02-18

申请号：US17055326

申请日：2019-05-17

Applicant: The Regents of the University of California

Inventor： Shuvo Roy ,  Benjamin W. Chui ,  Nathan Wright

IPC: B01D61/18 ,  A61M1/16 ,  A61M1/34 ,  B01D61/28 ,  B01D69/02 ,  B01D69/06

Abstract: Filtration membrane with improved mechanical stability and increased resistance to pressure is provided. The filtration membrane is useful for in vivo implantable filtration devices, such as, an artificial kidney. In vivo implantable filtration devices are also provided.

公开(公告)号：US11938253B2

公开(公告)日：2024-03-26

申请号：US16868836

申请日：2020-05-07

Applicant: The Regents of the University of California

Inventor： Shuvo Roy ,  Torin Yeager ,  Emily Abada ,  Ajay S. Dharia

IPC: A61M1/16 ,  A61M1/26 ,  B01D53/22 ,  B01D69/02 ,  B01D69/12 ,  B01D71/70

CPC classification number: A61M1/1698 ,  A61M1/267 ,  B01D53/228 ,  B01D69/02 ,  B01D69/12 ,  B01D71/70 ,  A61M2202/0478 ,  A61M2209/088 ,  B01D2257/104 ,  B01D2325/02 ,  B01D2325/04 ,  B01D2325/20

Abstract: Provided herein is a gas exchange composite membrane and methods of making the same. The gas exchange composite membrane may find use in a method of exchanging gas with blood in a subject in need of blood oxygenation support, which method is also disclosed. Also provided herein are systems and kits that find use in performing the methods of exchanging gas with blood.

公开(公告)号：US20220193615A1

公开(公告)日：2022-06-23

申请号：US17456344

申请日：2021-11-23

Applicant: The Regents of the University of California

Inventor： Shuvo Roy

IPC: B01D63/08 ,  B01D61/28 ,  B01D71/02 ,  A61M1/16 ,  A61M1/36 ,  B01D61/24

Abstract: Parallel plate devices for hemofiltration or hemodialysis are provided. A parallel plate device includes a parallel plate assembly having an aligned stack of stackable plate subunits, each stackable plate subunit having a through channel for blood, where the blood channels are opened up at opposite ends of the parallel plate assembly. The parallel plate assembly is configured to form filtrate/dialysate channels interleaved with the blood channels, adjacent channels being separated by a silicon nanoporous filtration membrane. A blood conduit adaptor is attached to the parallel plate assembly at each of the ends, and is configured to distribute blood to or collect blood from the blood channels. Also provided are systems and methods for using the parallel plate devices.

公开(公告)号：US10695480B2

公开(公告)日：2020-06-30

申请号：US15527590

申请日：2015-11-18

Applicant: The Regents of the University of California

Inventor： Shuvo Roy ,  Torin Yeager ,  Emily Abada ,  Ajay S. Dharia

IPC: A61M1/16 ,  B01D53/22 ,  B01D69/02 ,  B01D69/12 ,  A61M1/26 ,  B01D71/70

Abstract: Provided herein is a gas exchange composite membrane and methods of making the same. The gas exchange composite membrane may find use in a method of exchanging gas with blood in a subject in need of blood oxygenation support, which method is also disclosed. Also provided herein are systems and kits that find use in performing the methods of exchanging gas with blood.

公开(公告)号：US12201945B2

公开(公告)日：2025-01-21

申请号：US18204702

申请日：2023-06-01

Applicant: The Regents of the University of California

Inventor： Shuvo Roy

IPC: B01D63/08 ,  A61M1/16 ,  A61M1/36 ,  B01D61/24 ,  B01D61/28 ,  B01D71/02

Abstract: Parallel plate devices for hemofiltration or hemodialysis are provided. A parallel plate device includes a parallel plate assembly having an aligned stack of stackable plate subunits, each stackable plate subunit having a through channel for blood, where the blood channels are opened up at opposite ends of the parallel plate assembly. The parallel plate assembly is configured to form filtrate/dialysate channels interleaved with the blood channels, adjacent channels being separated by a silicon nanoporous filtration membrane. A blood conduit adaptor is attached to the parallel plate assembly at each of the ends, and is configured to distribute blood to or collect blood from the blood channels. Also provided are systems and methods for using the parallel plate devices.

公开(公告)号：US20240399041A1

公开(公告)日：2024-12-05

申请号：US18605528

申请日：2024-03-14

Applicant: The Regents of the University of California ,  Vanderbilt University

Inventor： Shuvo Roy ,  William Fissell ,  Nathan Wright ,  Mark Goodin ,  Steven G. Goebel ,  Amanda Buck ,  Joey Groszek

IPC: A61M1/34 ,  A61M1/16 ,  A61M5/165 ,  B01D63/08 ,  F28F9/02

Abstract: Hemofilters for in vivo filtration of blood are disclosed. The hemofilters disclosed herein provide an optimal flow of blood through the filtration channels while maintaining a pressure gradient across the filtration channel walls to enhance filtration and minimize turbulence and stagnation of blood in the hemofilter.

公开(公告)号：US20230277987A1

公开(公告)日：2023-09-07

申请号：US18020031

申请日：2021-08-05

Applicant: The Regents of the University of California

Inventor： Benjamin W. Chui ,  Shuvo Roy ,  Nathan Wright

IPC: B01D69/10 ,  B01D71/02

CPC classification number: B01D69/10 ,  B01D71/0213 ,  B01D71/0215 ,  B01D2325/021 ,  B01D2325/08

Abstract: The present disclosure provides an improved filtration membrane suitable for filtration of blood in vivo. The improved filtration membrane is resistant to breakage with minimal areal penalty due to presence of a system of supports on the backside of the membrane. The minimal areal penalty is achieved by using supports that provide a hierarchical scaffolding that comprises ribs of two different heights as disclosed herein.

公开(公告)号：US20210121618A1

公开(公告)日：2021-04-29

申请号：US17092616

申请日：2020-11-09

Applicant: The Regents of the University of California

Inventor： Rishi Kant ,  Shuvo Roy ,  Benjamin W. Chui ,  Kenneth G. Goldman

IPC: A61M1/16 ,  B01D39/16 ,  B01D67/00 ,  B01D69/02 ,  B01D69/10 ,  B01D61/14 ,  B01D63/08 ,  B01D69/06 ,  C23F1/00

Abstract: The present technology provides micro fabricated filtration devices, methods of making such devices, and uses for microfabricated filtration devices. The devices may allow diffusion to occur between two fluids with improved transport resistance characteristics as compared to conventional filtration devices. The devices may include a compound structure that includes a porous membrane overlying a support structure. The support structure may define a cavity and a plurality of recesses formed in a way that can allow modified convective flow of a first fluid to provide improved diffusive transport between the first fluid and a second fluid through the membrane.