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公开(公告)号：US20200046843A1
公开(公告)日：2020-02-13
申请号：US16457763
申请日：2019-06-28
发明人： Roger Tsien , Todd Aguilera , Emilia Olson , Tao Jiang , Quyen Nguyen
摘要： Disclosed herein, in certain embodiments, is a selective transport molecule with increased in vivo circulation. In some embodiments, a selective transport molecule disclosed herein has the formula (A-X-B-C)-M, wherein C is a cargo moiety; A is a peptide with a sequence comprising 5 to 9 consecutive acidic amino acids, wherein the amino acids are selected from: aspartates and glutamates; B is a peptide with a sequence comprising 5 to 20 consecutive basic amino acids; X is a linker; and M is a macromolecular carrier.
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公开(公告)号：US20200318154A1
公开(公告)日：2020-10-08
申请号：US16907284
申请日：2020-06-21
发明人： Ting Xu , Brian Panganiban , Tao Jiang
摘要： Compositions comprise statistically random heteropolymers complexed with active proteins, and are formulated and used in stimuli-responsive materials and nanoreactors composed of proteins and synthetic materials.
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公开(公告)号：US20170029466A1
公开(公告)日：2017-02-02
申请号：US14753975
申请日：2015-06-29
发明人： Tao Jiang , Emilia S. Olson , Michael Whitney , Roger Tsien
CPC分类号： C07K7/08 , A61K38/00 , A61K41/0095 , A61K47/64 , A61K47/645 , A61K47/65 , A61K49/0032 , A61K49/0043 , A61K49/0056 , A61K49/085 , A61K49/14 , A61K49/146 , A61K51/088 , C07K14/00 , C07K14/4728
摘要： A generic structure for the peptides of the present invention includes A-X-B-C, where C is a cargo moiety, the B portion includes basic amino acids, X is a cleavable linker sequence, and the A portion includes acidic amino acids. The intact structure is not significantly taken up by cells; however, upon extracellular cleavage of X, the B-C portion is taken up, delivering the cargo to targeted cells. Cargo may be, for example, a contrast agent for diagnostic imaging, a chemotherapeutic drug, or a radiation-sensitizer for therapy. X may be cleaved extracellularly or intracellularly. The molecules of the present invention may be linear, cyclic, branched, or have a mixed structure.
摘要翻译： 本发明的肽的一般结构包括A-X-B-C，其中C是货物部分，B部分包括碱性氨基酸，X是可切割的接头序列，A部分包括酸性氨基酸。 完整结构不被细胞所占据; 然而，在X的细胞外裂解时，B-C部分被吸收，将货物运送到靶细胞。 货物可以是例如用于诊断成像的对比剂，化学治疗药物或用于治疗的放射线敏化剂。 X可能在细胞外或细胞内裂解。 本发明的分子可以是直链，环状，支链或具有混合结构。
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公开(公告)号：US11246940B2
公开(公告)日：2022-02-15
申请号：US16457763
申请日：2019-06-28
发明人： Roger Tsien , Todd Aguilera , Emilia Olson , Tao Jiang , Quyen Nguyen
摘要： Disclosed herein, in certain embodiments, is a selective transport molecule with increased in vivo circulation. In some embodiments, a selective transport molecule disclosed herein has the formula (A-X-B-C)-M, wherein C is a cargo moiety; A is a peptide with a sequence comprising 5 to 9 consecutive acidic amino acids, wherein the amino acids are selected from: aspartates and glutamates; B is a peptide with a sequence comprising 5 to 20 consecutive basic amino acids; X is a linker; and M is a macromolecular carrier.
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公开(公告)号：US11629372B2
公开(公告)日：2023-04-18
申请号：US16907284
申请日：2020-06-21
发明人： Ting Xu , Brian Panganiban , Tao Jiang
摘要： Compositions comprise statistically random heteropolymers complexed with active proteins, and are formulated and used in stimuli-responsive materials and nanoreactors composed of proteins and synthetic materials.
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公开(公告)号：US10259845B2
公开(公告)日：2019-04-16
申请号：US14753975
申请日：2015-06-29
发明人： Tao Jiang , Emilia S. Olson , Michael Whitney , Roger Tsien
IPC分类号： A61K51/00 , A61M36/14 , C07K7/08 , A61K41/00 , A61K49/00 , A61K49/08 , A61K49/14 , A61K51/08 , C07K14/47 , C07K14/00 , A61K47/65 , A61K47/64 , A61K38/00
摘要： A generic structure for the peptides of the present invention includes A-X-B-C, where C is a cargo moiety, the B portion includes basic amino acids, X is a cleavable linker sequence, and the A portion includes acidic amino acids. The intact structure is not significantly taken up by cells; however, upon extracellular cleavage of X, the B-C portion is taken up, delivering the cargo to targeted cells. Cargo may be, for example, a contrast agent for diagnostic imaging, a chemotherapeutic drug, or a radiation-sensitizer for therapy. X may be cleaved extracellularly or intracellularly. The molecules of the present invention may be linear, cyclic, branched, or have a mixed structure.
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公开(公告)号：US20170305968A1
公开(公告)日：2017-10-26
申请号：US15427427
申请日：2017-02-08
发明人： Roger Tsien , Todd Aguilera , Emilia Olson , Tao Jiang , Quyen Nguyen
CPC分类号： A61K47/64 , A61K47/595 , A61K47/60 , A61K47/62 , A61K47/6911 , A61K49/0032 , A61K49/0056 , C07K7/06
摘要： Disclosed herein, in certain embodiments, is a selective transport molecule with increased in vivo circulation. In some embodiments, a selective transport molecule disclosed herein has the formula (A-X-B-C)-M, wherein C is a cargo moiety; A is a peptide with a sequence comprising 5 to 9 consecutive acidic amino acids, wherein the amino acids are selected from: aspartates and glutamates; B is a peptide with a sequence comprising 5 to 20 consecutive basic amino acids; X is a linker; and M is a macromolecular carrier.
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公开(公告)号：US20230220442A1
公开(公告)日：2023-07-13
申请号：US18178505
申请日：2023-03-04
发明人： Ting Xu , Brian Panganiban , Tao Jiang
CPC分类号： C12Q1/34 , C08L89/00 , C12N9/16 , C12Y301/08001 , G01N33/68 , C08L2203/02
摘要： Compositions comprise statistically random heteropolymers complexed with active proteins, and are formulated and used in stimuli-responsive materials and nanoreactors composed of proteins and synthetic materials.
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