公开(公告)号：US20180306800A1

公开(公告)日：2018-10-25

申请号：US15959158

申请日：2018-04-20

申请人： The Regents of the University of Colorado, a body corporate

发明人： Xuedong Liu ,  Gail Eckhardt ,  Gan Zhang ,  Conggang Zhang ,  Zeyu Liu ,  Eric Bunker

IPC分类号： G01N33/574 ,  A61P35/00 ,  A61K31/44 ,  A61K31/495 ,  A61K31/704 ,  A61K39/395 ,  A61K38/15 ,  A61K31/277 ,  C12Q1/6886

CPC分类号： G01N33/57492 ,  A61K31/277 ,  A61K31/44 ,  A61K31/495 ,  A61K31/704 ,  A61K38/15 ,  A61K39/39558 ,  A61P35/00 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/158

摘要： Methods and materials involved in assessing samples (e.g., cancer cells) for the status of PINK1-Parkin pathway biomarkers, as well as materials and methods for identifying cancer patients likely to respond to a particular cancer treatment regimen.

公开(公告)号：US20240102991A1

公开(公告)日：2024-03-28

申请号：US18386764

申请日：2023-11-03

申请人： The Regents of the University of Colorado, a body corporate

发明人： Xuedong Liu ,  Douglas A. Chapnick ,  William Old ,  Tristan D. Mcclure-Begley ,  Eric Bunker

IPC分类号： G01N33/50 ,  C12M1/34 ,  C12Q1/6825 ,  G01N21/64 ,  G01N33/542 ,  G01N33/554 ,  G01N33/58

CPC分类号： G01N33/5008 ,  C12M1/3476 ,  C12Q1/6825 ,  G01N21/64 ,  G01N21/6428 ,  G01N21/6452 ,  G01N33/542 ,  G01N33/554 ,  G01N33/582 ,  B01L2300/0636 ,  C12Q2500/00 ,  C12Q2560/00 ,  C12Q2563/107 ,  C12Q2563/179 ,  C12Q2565/1015 ,  C12Q2600/136 ,  G01N2500/04 ,  G01N2800/52

摘要： Provided are FRET-based biosensor constructs, and multiplexed platforms or arrays of these biosensor constructs useful for screening candidate drug molecules for efficacy and/or specificity of drug activity. Optionally the biosensor constructs may be located on an inner membrane within a cell or engineered to be located on the cell's surface. The cells or cell lines displaying the biosensors on a cell surface may be arranged as an array of cells for high throughput evaluation of the efficacy and/or specificity of drug candidates, such as a library of candidate drug compounds.

公开(公告)号：US20210181181A1

公开(公告)日：2021-06-17

申请号：US16954100

申请日：2018-12-14

申请人： The Regents of the University of Colorado, a body corporate

发明人： Xuedong Liu ,  Douglas A. Chapnick ,  William Old ,  Tristan D. Mcclure-Begley ,  Eric Bunker

IPC分类号： G01N33/50 ,  G01N21/64

摘要： Provided are FRET-based biosensor constructs, and multiplexed platforms or arrays of these biosensor constructs useful for screening candidate drug molecules for efficacy and/or specificity of drug activity. Optionally the biosensor constructs may be located on an inner membrane within a cell or engineered to be located on the cell's surface. The cells or cell lines displaying the biosensors on a cell surface may be arranged as an array of cells for high throughput evaluation of the efficacy and/or specificity of drug candidates, such as a library of candidate drug compounds.