公开(公告)号：US20120310539A1

公开(公告)日：2012-12-06

申请号：US13471370

申请日：2012-05-14

申请人： David K. Crockett ,  Perry G. Ridge ,  Andrew Wilson

发明人： David K. Crockett ,  Perry G. Ridge ,  Andrew Wilson

IPC分类号： G06F19/00

CPC分类号： G06N5/046 ,  C12Q2500/00 ,  G16B20/00 ,  G16B40/00 ,  G16B50/00

摘要： A computer-implemented, gene-specific prediction tool for classifying and interpreting gene tests is described. The prediction tool includes a predictor using a consensus framework. The predictor employs a weighted metric of existing and complementary prediction algorithms and calculated reference intervals of disease outcomes to calculate a consensus score used in interpreting gene tests.

摘要翻译： 描述了用于分类和解释基因测试的计算机实现的基因特异性预测工具。 预测工具包括使用共识框架的预测变量。 预测器采用现有和补充预测算法的加权度量，并计算疾病预后的参考间隔，以计算用于解释基因测试的共识评分。

公开(公告)号：US20240102991A1

公开(公告)日：2024-03-28

申请号：US18386764

申请日：2023-11-03

申请人： The Regents of the University of Colorado, a body corporate

发明人： Xuedong Liu ,  Douglas A. Chapnick ,  William Old ,  Tristan D. Mcclure-Begley ,  Eric Bunker

IPC分类号： G01N33/50 ,  C12M1/34 ,  C12Q1/6825 ,  G01N21/64 ,  G01N33/542 ,  G01N33/554 ,  G01N33/58

CPC分类号： G01N33/5008 ,  C12M1/3476 ,  C12Q1/6825 ,  G01N21/64 ,  G01N21/6428 ,  G01N21/6452 ,  G01N33/542 ,  G01N33/554 ,  G01N33/582 ,  B01L2300/0636 ,  C12Q2500/00 ,  C12Q2560/00 ,  C12Q2563/107 ,  C12Q2563/179 ,  C12Q2565/1015 ,  C12Q2600/136 ,  G01N2500/04 ,  G01N2800/52

摘要： Provided are FRET-based biosensor constructs, and multiplexed platforms or arrays of these biosensor constructs useful for screening candidate drug molecules for efficacy and/or specificity of drug activity. Optionally the biosensor constructs may be located on an inner membrane within a cell or engineered to be located on the cell's surface. The cells or cell lines displaying the biosensors on a cell surface may be arranged as an array of cells for high throughput evaluation of the efficacy and/or specificity of drug candidates, such as a library of candidate drug compounds.

公开(公告)号：US11939625B2

公开(公告)日：2024-03-26

申请号：US17258932

申请日：2019-08-24

申请人： CHANGSHA UNIVERSITY OF SCIENCE AND TECHNOLOGY

发明人： Zhong Cao ,  Jia Yang ,  Chen Liu ,  Zhongliang Xiao ,  Dan Li ,  Ling Zhang ,  Yuyang Zhang ,  Jiaxin Li

IPC分类号： C12Q1/6809 ,  G01N27/26

CPC分类号： C12Q1/6809 ,  G01N27/26 ,  C12Q2500/00 ,  C12Q2545/10 ,  C12Q2560/00 ,  C12Q2565/607

摘要： A method and a sensor for detecting L-cystine are disclosed. The method is implemented by assembling a sodium 3,3′-dithiodipropane sulfonate (SPS) membrane on a surface of Au membrane layer of an Au electrode and using an extended gate of field effect transistor (FET) and in-situ signal amplification of the FET to detect L-cystine sensitively. The polyanion of the SPS membrane adsorbs and binds a positively charged target L-cystine through electrostatic interaction, thus forming an electric double layer structure to generate a membrane potential identifying a monovalent organic ammonium ion. The sensor includes the FET, wherein a gate-extended gold electrode is arranged on the FET, and the SPS membrane is assembled on the surface of the Au membrane layer of the gate-extended gold electrode. The sensor has an excellent Nernst response to L-cystine.

公开(公告)号：US08744982B2

公开(公告)日：2014-06-03

申请号：US13471294

申请日：2012-05-14

申请人： David K. Crockett ,  Perry G. Ridge

发明人： David K. Crockett ,  Perry G. Ridge

IPC分类号： G06N5/04

CPC分类号： G06N5/046 ,  C12Q2500/00 ,  G06F19/18 ,  G06F19/24 ,  G06F19/28

摘要： A gene-specific prediction tool for classifying and interpreting gene tests is described. The prediction tool includes a classifier trained and tested using databases of gene variants and their known phenotypes. The classifier uses differences between features of amino acids in obtaining attributes used to perform classification and generate predictions, including for benign and pathologic outcomes, for uncertain gene variants.

摘要翻译： 描述了用于分类和解释基因测试的基因特异性预测工具。 预测工具包括使用基因变体数据库及其已知表型进行训练和测试的分类器。 分类器在获得用于分类的属性中使用氨基酸的特征之间的差异，并产生不确定基因变体的预测，包括良性和病理结果。

公开(公告)号：US11891652B2

公开(公告)日：2024-02-06

申请号：US16766029

申请日：2018-11-23

申请人： Queen Mary University of London

发明人： Matteo Palma ,  Xinzhao Xu ,  Pierrick Clement

IPC分类号： C12Q1/6825 ,  G01N33/543 ,  B82Y35/00 ,  B82Y40/00

CPC分类号： C12Q1/6825 ,  B82Y35/00 ,  B82Y40/00 ,  C12Q2500/00 ,  C12Q2560/00 ,  G01N2333/005 ,  G01N2333/195 ,  G01N2333/37 ,  G01N2458/00

摘要： The invention relates to a method of assembling a biosensor device comprising two or more biosensor units, wherein each unit comprises one or more biosensors comprising one or more carbon nanotubes (CNTs) coated with nucleic acid and one or more sensor molecules coupled to the nucleic acid, wherein each one of the one or more sensor molecules is capable of binding to a target molecule in a sample. Each biosensor unit is capable of detecting a different target molecule in a sample, and each unit comprises one or more biosensors each capable of detecting the same target molecule. The invention further relates to biosensor devices and methods for detecting target molecules in a sample using the same.

公开(公告)号：US20120310863A1

公开(公告)日：2012-12-06

申请号：US13471294

申请日：2012-05-14

申请人： David K. Crockett ,  Perry G. Ridge

发明人： David K. Crockett ,  Perry G. Ridge

IPC分类号： G06F19/24 ,  G06F15/18

CPC分类号： G06N5/046 ,  C12Q2500/00 ,  G06F19/18 ,  G06F19/24 ,  G06F19/28

摘要： A gene-specific prediction tool for classifying and interpreting gene tests is described. The prediction tool includes a classifier trained and tested using databases of gene variants and their known phenotypes. The classifier uses differences between features of amino acids in obtaining attributes used to perform classification and generate predictions, including for benign and pathologic outcomes, for uncertain gene variants.

摘要翻译： 描述了用于分类和解释基因测试的基因特异性预测工具。 预测工具包括使用基因变体数据库及其已知表型进行训练和测试的分类器。 分类器在获得用于分类的属性中使用氨基酸的特征之间的差异，并产生不确定基因变体的预测，包括良性和病理结果。