公开(公告)号：US12012478B2

公开(公告)日：2024-06-18

申请号：US18124219

申请日：2023-03-21

申请人： The Regents of the University of Colorado, a body corporate ,  Universita degli Studi di Trieste

发明人： Daewon Park ,  Brisa Pena Castellanos ,  Susanna Bosi ,  Luisa Mestroni ,  Maurizio Prato

IPC分类号： C08G18/74 ,  B82Y5/00 ,  B82Y30/00 ,  B82Y40/00 ,  C01B32/174 ,  C08G18/38 ,  C08G83/00 ,  C08J5/00 ,  C08K3/04 ,  C12N5/077

CPC分类号： C08G18/74 ,  C01B32/174 ,  C08G83/001 ,  C08J5/005 ,  C08K3/041 ,  C12N5/0657 ,  B82Y5/00 ,  B82Y30/00 ,  B82Y40/00 ,  C01B2202/06 ,  C01B2202/28 ,  C01P2006/22 ,  C08G18/3829 ,  C12N2513/00 ,  C12N2533/30 ,  C12N2533/70

摘要： Polymers suitable for forming carbon nanotube-functionalized reverse thermal gel compositions, compositions including the polymers, and methods of forming and using the polymers and compositions are disclosed. The compositions have reverse thermal gelling properties and transform from a liquid/solution to a gel—e.g., near or below body temperature. The polymers and compositions can be injected into or proximate an area in need of treatment.

公开(公告)号：US20200216601A1

公开(公告)日：2020-07-09

申请号：US16649560

申请日：2018-09-19

申请人： The Regents of the University of Colorado, a body corporate ,  Universita degli Studi di Trieste

发明人： Daewon Park ,  Brisa Pena Castellanos ,  Susanna Bosi ,  Luisa Mestroni ,  Maurizio Prato

IPC分类号： C08G18/74 ,  C01B32/174 ,  C08K3/04 ,  C08J5/00

摘要： Polymers suitable for forming carbon nanotube-functionalized reverse thermal gel compositions, compositions including the polymers, and methods of forming and using the polymers and compositions are disclosed. The compositions have reverse thermal gelling properties and transform from a liquid/solution to a gel—e.g., near or below body temperature. The polymers and compositions can be injected into or proximate an area in need of treatment.

公开(公告)号：US20230220148A1

公开(公告)日：2023-07-13

申请号：US18124219

申请日：2023-03-21

申请人： The Regents of the University of Colorado, a body corporate ,  Universita degli Studi di Trieste

发明人： Daewon Park ,  Brisa Pena Castellanos ,  Susanna Bosi ,  Luisa Mestroni ,  Maurizio Prato

IPC分类号： C12N5/077 ,  C08G83/00 ,  C01B32/174

CPC分类号： C12N5/0657 ,  C08G83/001 ,  C01B32/174 ,  C01B2202/06 ,  C01P2006/22 ,  B82Y40/00

摘要： Polymers suitable for forming carbon nanotube-functionalized reverse thermal gel compositions, compositions including the polymers, and methods of forming and using the polymers and compositions are disclosed. The compositions have reverse thermal gelling properties and transform from a liquid/solution to a gel—e.g., near or below body temperature. The polymers and compositions can be injected into or proximate an area in need of treatment.

公开(公告)号：US10258606B2

公开(公告)日：2019-04-16

申请号：US14746362

申请日：2015-06-22

申请人： The Regents of the University of Colorado, A Body Corporate

发明人： Matthew R. G. Taylor ,  Luisa Mestroni

IPC分类号： C12Q1/68 ,  A61K31/4045 ,  A61K31/404 ,  C12Q1/6883

摘要： The present invention concerns the use of methods for evaluating β-adrenergic receptor targeting agent treatment for a patient, particularly one with a heart condition. In general, the disclosed methods entail determining the presence or absence of one or more polymorphisms in an endothelin gene system member. Based on the results of this determination, a β-adrenergic receptor targeting agent may be prescribed, administered or a treatment regimen altered, including the administration of a β-blocker. Accordingly, methods of treatment are also described.

公开(公告)号：US20170145384A1

公开(公告)日：2017-05-25

申请号：US15380853

申请日：2016-12-15

申请人： THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE

发明人： Luisa Mestroni ,  Laura Ballerini ,  Carlin Long ,  John Caldwell ,  Maurizio Prato ,  Valentina Martinelli ,  Giada Cellot ,  Francesca Maria Toma ,  Lorena Zentilin

IPC分类号： C12N5/077 ,  C12N5/00

CPC分类号： C12N5/0658 ,  B82Y5/00 ,  B82Y30/00 ,  B82Y40/00 ,  C01B32/174 ,  C01B2202/06 ,  C12N5/0068 ,  C12N5/0657 ,  C12N2533/00 ,  C12N2533/10 ,  G01N33/5044 ,  Y10S977/752 ,  Y10S977/847 ,  Y10S977/915

摘要： Embodiments include compositions of carbon nanotubes complexed with myocyte cells. Embodiments also include methods for making compositions of carbon nanotubes, and methods for modulating the electrophysical, proliferative, and viability potential of myocytes.

公开(公告)号：US20150366843A1

公开(公告)日：2015-12-24

申请号：US14746362

申请日：2015-06-22

申请人： The Regents of the University of Colorado, A Body Corporate

发明人： Matthew R.G. Taylor ,  Luisa Mestroni

IPC分类号： A61K31/4045

CPC分类号： A61K31/4045 ,  A61K31/404 ,  C12Q1/6883 ,  C12Q2600/106 ,  C12Q2600/156 ,  C12Q2600/172 ,  Y10T436/143333

摘要： The present invention concerns the use of methods for evaluating β-adrenergic receptor targeting agent treatment for a patient, particularly one with a heart condition. In general, the disclosed methods entail determining the presence or absence of one or more polymorphisms in an endothelin gene system member. Based on the results of this determination, a β-adrenergic receptor targeting agent may be prescribed, administered or a treatment regimen altered, including the administration of a β-blocker. Accordingly, methods of treatment are also described.

摘要翻译： 本发明涉及用于评估患者，特别是患有心脏病的患者的肾上腺素能受体靶向剂治疗方法的用途。 通常，所公开的方法需要确定内皮素基因系统成员中存在或不存在一种或多种多态性。 基于该测定的结果，可以规定，给药或改变治疗方案，包括给药一种β-阻滞剂的β-肾上腺素能受体靶向剂。 因此，还描述了治疗方法。

公开(公告)号：US11608407B2

公开(公告)日：2023-03-21

申请号：US16649560

申请日：2018-09-19

申请人： The Regents of the University of Colorado ,  Universita degli Studi di Trieste

发明人： Daewon Park ,  Brisa Pena Castellanos ,  Susanna Bosi ,  Luisa Mestroni ,  Maurizio Prato

IPC分类号： C08G18/74 ,  C08K3/04 ,  C01B32/174 ,  C08J5/00 ,  B82Y30/00 ,  B82Y40/00 ,  C08G18/38

摘要： Polymers suitable for forming carbon nanotube-functionalized reverse thermal gel compositions, compositions including the polymers, and methods of forming and using the polymers and compositions are disclosed. The compositions have reverse thermal gelling properties and transform from a liquid/solution to a gel—e.g., near or below body temperature. The polymers and compositions can be injected into or proximate an area in need of treatment.